MXPA06013917A - Nuevos derivados de piperidina sustituidos con alquilo y su uso como inhibidores de la recaptacion del neurotransmisor monoamino. - Google Patents
Nuevos derivados de piperidina sustituidos con alquilo y su uso como inhibidores de la recaptacion del neurotransmisor monoamino.Info
- Publication number
- MXPA06013917A MXPA06013917A MXPA06013917A MXPA06013917A MXPA06013917A MX PA06013917 A MXPA06013917 A MX PA06013917A MX PA06013917 A MXPA06013917 A MX PA06013917A MX PA06013917 A MXPA06013917 A MX PA06013917A MX PA06013917 A MXPA06013917 A MX PA06013917A
- Authority
- MX
- Mexico
- Prior art keywords
- tetramethyl
- phenoxy
- disorder
- piperidine
- chloro
- Prior art date
Links
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- 150000003053 piperidines Chemical class 0.000 title claims abstract description 7
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 230000001561 neurotransmitter reuptake Effects 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 79
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
- -1 trifluoromethoxy, cyano, hydroxy, amino Chemical group 0.000 claims description 69
- 239000000203 mixture Substances 0.000 claims description 49
- 150000003839 salts Chemical class 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 239000002858 neurotransmitter agent Substances 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Medicinal Chemistry (AREA)
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- Hospice & Palliative Care (AREA)
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- Pregnancy & Childbirth (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400961 | 2004-06-18 | ||
| US58135904P | 2004-06-22 | 2004-06-22 | |
| PCT/EP2005/052731 WO2005123679A2 (en) | 2004-06-18 | 2005-06-14 | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06013917A true MXPA06013917A (es) | 2007-03-07 |
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| Country | Link |
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| EP (1) | EP1761493A2 (enExample) |
| JP (1) | JP2008502651A (enExample) |
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| MX (1) | MXPA06013917A (enExample) |
| TW (1) | TW200604173A (enExample) |
| WO (1) | WO2005123679A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2570075A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1896415A1 (en) * | 2005-06-08 | 2008-03-12 | NeuroSearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20110046179A1 (en) * | 2006-08-30 | 2011-02-24 | Eriksen Birgitte L | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| MX2010009581A (es) * | 2008-03-05 | 2010-09-30 | Neurosearch As | Derivados novedosos de 4-bencidriloxi-tetraalquil-piperidina y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
| US8546576B2 (en) * | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| US20170204060A1 (en) * | 2014-05-21 | 2017-07-20 | Solvay Specialty Polymers Usa, Llc | Piperidine-based stabilizers and polymers end-capped with the same |
| EP3145911B1 (en) * | 2014-05-21 | 2020-07-08 | Solvay Specialty Polymers USA, L.L.C. | Stabilizer compounds |
| MX374426B (es) | 2015-01-22 | 2025-03-06 | Evonik Operations Gmbh | Sintesis de compuestos de triacetonadiamina mediante procedimiento de aminacion reductora de triacetonadiamina y derivados de los mismos. |
| MX2016000701A (es) | 2015-01-22 | 2016-11-24 | Evonik Degussa Gmbh | Proceso para preparar un compuesto de triacetonamina n-metil sustituida. |
| DE102016212378A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Synthese von Triacetondiaminverbindungen durch reduktive Aminierung ausgehend von Triacetondiamin und dessen Derivaten |
| DE102016212379A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung einer N-methylsubstituierten Triacetonaminverbindung |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684765A (en) * | 1970-01-08 | 1972-08-15 | Sankyo Co | Stabilization of synthetic polymers |
| GB1411782A (en) | 1972-02-24 | 1975-10-29 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US3907813A (en) * | 1973-09-11 | 1975-09-23 | Janssen Pharmaceutica Nv | Stereoisomeric forms of 4-anilino-3-methyl piperidines |
| US3923992A (en) * | 1974-05-23 | 1975-12-02 | Univ Mississippi | Analgetic composition and method of use |
| FR2361880A1 (fr) * | 1976-04-29 | 1978-03-17 | Science Union & Cie | Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| DE3218645A1 (de) * | 1982-05-18 | 1983-11-24 | Hoechst Ag, 6230 Frankfurt | Fluoranverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbbilder in kopiersystemen |
| JPS63206757A (ja) | 1987-02-23 | 1988-08-26 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US4939161A (en) * | 1989-05-12 | 1990-07-03 | Boc, Inc. | Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides |
| WO1991003511A1 (en) | 1989-09-09 | 1991-03-21 | Sandoz Ltd | Synthetic polyamides and their salts |
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| JPH11348418A (ja) | 1998-04-08 | 1999-12-21 | Seiko Epson Corp | 記録媒体および記録液 |
| US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| WO2002089803A1 (fr) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition d'ionophorese |
| DE60331762D1 (de) | 2002-11-01 | 2010-04-29 | Neurosearch As | Neue piperidinderivate und deren verwendung als monoaminneurotransmitter-wiederaufnahmehemmer |
| CA2570075A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
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2005
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- 2005-06-14 MX MXPA06013917A patent/MXPA06013917A/es not_active Application Discontinuation
- 2005-06-14 US US11/579,060 patent/US7547788B2/en not_active Expired - Fee Related
- 2005-06-14 JP JP2007515944A patent/JP2008502651A/ja not_active Abandoned
- 2005-06-14 EP EP05761133A patent/EP1761493A2/en not_active Withdrawn
- 2005-06-14 WO PCT/EP2005/052731 patent/WO2005123679A2/en not_active Ceased
- 2005-06-14 CN CNA2005800172558A patent/CN1960974A/zh active Pending
- 2005-06-17 TW TW094120094A patent/TW200604173A/zh unknown
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2009
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2010
- 2010-12-16 US US12/970,274 patent/US20110086880A1/en not_active Abandoned
Also Published As
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|---|---|
| US7547788B2 (en) | 2009-06-16 |
| AR050341A1 (es) | 2006-10-18 |
| JP2008502651A (ja) | 2008-01-31 |
| WO2005123679A2 (en) | 2005-12-29 |
| US7915419B2 (en) | 2011-03-29 |
| US20070167487A1 (en) | 2007-07-19 |
| WO2005123679A3 (en) | 2006-03-02 |
| TW200604173A (en) | 2006-02-01 |
| CN1960974A (zh) | 2007-05-09 |
| US20110086880A1 (en) | 2011-04-14 |
| US20090215820A1 (en) | 2009-08-27 |
| CA2570075A1 (en) | 2005-12-29 |
| EP1761493A2 (en) | 2007-03-14 |
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