CA2570075A1 - Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors - Google Patents
Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors Download PDFInfo
- Publication number
- CA2570075A1 CA2570075A1 CA002570075A CA2570075A CA2570075A1 CA 2570075 A1 CA2570075 A1 CA 2570075A1 CA 002570075 A CA002570075 A CA 002570075A CA 2570075 A CA2570075 A CA 2570075A CA 2570075 A1 CA2570075 A1 CA 2570075A1
- Authority
- CA
- Canada
- Prior art keywords
- tetramethyl
- piperidine
- phenoxy
- disorder
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000217 alkyl group Chemical group 0.000 title claims abstract description 34
- 230000001561 neurotransmitter reuptake Effects 0.000 title claims abstract description 11
- 150000003053 piperidines Chemical class 0.000 title claims abstract description 7
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- 238000000034 method Methods 0.000 claims abstract description 54
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims description 51
- -1 trifluoromethoxy, cyano, hydroxy, amino Chemical group 0.000 claims description 44
- 150000003839 salts Chemical class 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 208000002193 Pain Diseases 0.000 claims description 20
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 10
- 230000002265 prevention Effects 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 7
- ZSMSGPANWYJSDF-UHFFFAOYSA-N 4-(2,2,6,6-tetramethylpiperidin-4-yl)oxyphenol Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(O)C=C1 ZSMSGPANWYJSDF-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/56—Nitrogen atoms
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Landscapes
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- Engineering & Computer Science (AREA)
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- Veterinary Medicine (AREA)
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- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Rheumatology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
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- Immunology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Pregnancy & Childbirth (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400961 | 2004-06-18 | ||
| DKPA200400961 | 2004-06-18 | ||
| US58135904P | 2004-06-22 | 2004-06-22 | |
| US60/581,359 | 2004-06-22 | ||
| PCT/EP2005/052731 WO2005123679A2 (en) | 2004-06-18 | 2005-06-14 | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2570075A1 true CA2570075A1 (en) | 2005-12-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002570075A Abandoned CA2570075A1 (en) | 2004-06-18 | 2005-06-14 | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7547788B2 (enExample) |
| EP (1) | EP1761493A2 (enExample) |
| JP (1) | JP2008502651A (enExample) |
| CN (1) | CN1960974A (enExample) |
| AR (1) | AR050341A1 (enExample) |
| CA (1) | CA2570075A1 (enExample) |
| MX (1) | MXPA06013917A (enExample) |
| TW (1) | TW200604173A (enExample) |
| WO (1) | WO2005123679A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2570075A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1896415A1 (en) * | 2005-06-08 | 2008-03-12 | NeuroSearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20110046179A1 (en) * | 2006-08-30 | 2011-02-24 | Eriksen Birgitte L | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| MX2010009581A (es) * | 2008-03-05 | 2010-09-30 | Neurosearch As | Derivados novedosos de 4-bencidriloxi-tetraalquil-piperidina y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
| US8546576B2 (en) * | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| US20170204060A1 (en) * | 2014-05-21 | 2017-07-20 | Solvay Specialty Polymers Usa, Llc | Piperidine-based stabilizers and polymers end-capped with the same |
| EP3145911B1 (en) * | 2014-05-21 | 2020-07-08 | Solvay Specialty Polymers USA, L.L.C. | Stabilizer compounds |
| MX374426B (es) | 2015-01-22 | 2025-03-06 | Evonik Operations Gmbh | Sintesis de compuestos de triacetonadiamina mediante procedimiento de aminacion reductora de triacetonadiamina y derivados de los mismos. |
| MX2016000701A (es) | 2015-01-22 | 2016-11-24 | Evonik Degussa Gmbh | Proceso para preparar un compuesto de triacetonamina n-metil sustituida. |
| DE102016212378A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Synthese von Triacetondiaminverbindungen durch reduktive Aminierung ausgehend von Triacetondiamin und dessen Derivaten |
| DE102016212379A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung einer N-methylsubstituierten Triacetonaminverbindung |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3684765A (en) * | 1970-01-08 | 1972-08-15 | Sankyo Co | Stabilization of synthetic polymers |
| GB1411782A (en) | 1972-02-24 | 1975-10-29 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US3907813A (en) * | 1973-09-11 | 1975-09-23 | Janssen Pharmaceutica Nv | Stereoisomeric forms of 4-anilino-3-methyl piperidines |
| US3923992A (en) * | 1974-05-23 | 1975-12-02 | Univ Mississippi | Analgetic composition and method of use |
| FR2361880A1 (fr) * | 1976-04-29 | 1978-03-17 | Science Union & Cie | Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| DE3218645A1 (de) * | 1982-05-18 | 1983-11-24 | Hoechst Ag, 6230 Frankfurt | Fluoranverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbbilder in kopiersystemen |
| JPS63206757A (ja) | 1987-02-23 | 1988-08-26 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US4939161A (en) * | 1989-05-12 | 1990-07-03 | Boc, Inc. | Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides |
| WO1991003511A1 (en) | 1989-09-09 | 1991-03-21 | Sandoz Ltd | Synthetic polyamides and their salts |
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| JPH11348418A (ja) | 1998-04-08 | 1999-12-21 | Seiko Epson Corp | 記録媒体および記録液 |
| US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| WO2002089803A1 (fr) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition d'ionophorese |
| DE60331762D1 (de) | 2002-11-01 | 2010-04-29 | Neurosearch As | Neue piperidinderivate und deren verwendung als monoaminneurotransmitter-wiederaufnahmehemmer |
| CA2570075A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2005
- 2005-06-14 CA CA002570075A patent/CA2570075A1/en not_active Abandoned
- 2005-06-14 MX MXPA06013917A patent/MXPA06013917A/es not_active Application Discontinuation
- 2005-06-14 US US11/579,060 patent/US7547788B2/en not_active Expired - Fee Related
- 2005-06-14 JP JP2007515944A patent/JP2008502651A/ja not_active Abandoned
- 2005-06-14 EP EP05761133A patent/EP1761493A2/en not_active Withdrawn
- 2005-06-14 WO PCT/EP2005/052731 patent/WO2005123679A2/en not_active Ceased
- 2005-06-14 CN CNA2005800172558A patent/CN1960974A/zh active Pending
- 2005-06-17 TW TW094120094A patent/TW200604173A/zh unknown
- 2005-06-17 AR ARP050102507A patent/AR050341A1/es unknown
-
2009
- 2009-05-07 US US12/437,233 patent/US7915419B2/en not_active Expired - Fee Related
-
2010
- 2010-12-16 US US12/970,274 patent/US20110086880A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7547788B2 (en) | 2009-06-16 |
| AR050341A1 (es) | 2006-10-18 |
| JP2008502651A (ja) | 2008-01-31 |
| WO2005123679A2 (en) | 2005-12-29 |
| US7915419B2 (en) | 2011-03-29 |
| US20070167487A1 (en) | 2007-07-19 |
| WO2005123679A3 (en) | 2006-03-02 |
| TW200604173A (en) | 2006-02-01 |
| CN1960974A (zh) | 2007-05-09 |
| US20110086880A1 (en) | 2011-04-14 |
| US20090215820A1 (en) | 2009-08-27 |
| MXPA06013917A (es) | 2007-03-07 |
| EP1761493A2 (en) | 2007-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20120614 |