JP2008500345A5 - - Google Patents
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- JP2008500345A5 JP2008500345A5 JP2007515217A JP2007515217A JP2008500345A5 JP 2008500345 A5 JP2008500345 A5 JP 2008500345A5 JP 2007515217 A JP2007515217 A JP 2007515217A JP 2007515217 A JP2007515217 A JP 2007515217A JP 2008500345 A5 JP2008500345 A5 JP 2008500345A5
- Authority
- JP
- Japan
- Prior art keywords
- dry particle
- interferon
- surfactant
- particle preparation
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002245 particle Substances 0.000 claims description 24
- 239000004094 surface-active agent Substances 0.000 claims description 13
- 230000002209 hydrophobic effect Effects 0.000 claims description 9
- 108010045648 interferon omega 1 Proteins 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims 15
- 108010050904 Interferons Proteins 0.000 claims 12
- 102000014150 Interferons Human genes 0.000 claims 12
- 229940079322 interferon Drugs 0.000 claims 12
- 239000000872 buffer Substances 0.000 claims 6
- 235000014633 carbohydrates Nutrition 0.000 claims 5
- 239000003381 stabilizer Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 claims 1
- 235000010983 sucrose acetate isobutyrate Nutrition 0.000 claims 1
- 239000001797 sucrose acetate isobutyrate Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57466204P | 2004-05-25 | 2004-05-25 | |
| US65022605P | 2005-02-03 | 2005-02-03 | |
| PCT/US2005/017914 WO2005115333A2 (en) | 2004-05-25 | 2005-05-23 | A biomolecule-containing formulation of increased stability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500345A JP2008500345A (ja) | 2008-01-10 |
| JP2008500345A5 true JP2008500345A5 (https=) | 2008-07-17 |
Family
ID=35451371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515217A Withdrawn JP2008500345A (ja) | 2004-05-25 | 2005-05-23 | 増加された安定度をもつ生体分子含有調製物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20050266087A1 (https=) |
| EP (1) | EP1755650B8 (https=) |
| JP (1) | JP2008500345A (https=) |
| KR (1) | KR20070046791A (https=) |
| AR (1) | AR049118A1 (https=) |
| AT (1) | ATE400291T1 (https=) |
| AU (1) | AU2005247439B2 (https=) |
| BR (1) | BRPI0511593A (https=) |
| CA (1) | CA2568714A1 (https=) |
| DE (1) | DE602005008053D1 (https=) |
| ES (1) | ES2309768T3 (https=) |
| IL (1) | IL179279A (https=) |
| MX (1) | MXPA06013755A (https=) |
| NZ (1) | NZ551258A (https=) |
| PE (1) | PE20060456A1 (https=) |
| TW (1) | TW200611712A (https=) |
| WO (1) | WO2005115333A2 (https=) |
Families Citing this family (49)
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| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| TW200420306A (en) * | 2002-06-17 | 2004-10-16 | Alza Corp | Osmotic delivery system with early zero order push power engine |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| ATE387236T1 (de) * | 2003-03-31 | 2008-03-15 | Alza Corp | Osmotische pumpe mit mitteln zum ableiten des innendrucks |
| CA2520766A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| CN1905861A (zh) * | 2003-10-31 | 2007-01-31 | 阿尔扎公司 | 具有自保持、快启动薄膜插塞的渗透泵 |
| JP2007526792A (ja) * | 2003-11-06 | 2007-09-20 | アルザ・コーポレーシヨン | 移植可能な浸透ポンプと一緒の使用のためのモジュール型の吸入速度低下器 |
| US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| SI2415484T1 (sl) | 2004-09-17 | 2014-10-30 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| CA2596966A1 (en) * | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc. | Implantable osmotic device for continuous delivery of suspension formulations |
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| US7959938B2 (en) * | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
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| EP2049081B1 (en) * | 2006-08-09 | 2012-11-14 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| HRP20130259T1 (hr) | 2007-04-23 | 2013-04-30 | Intarcia Therapeutics, Inc. | Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe |
| US20080268270A1 (en) * | 2007-04-30 | 2008-10-30 | Wenjie Chen | High impact polymer interlayers |
| JP2011506319A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法 |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| KR101760953B1 (ko) | 2008-09-04 | 2017-07-24 | 아밀린 파마슈티칼스, 엘엘씨. | 비-수성 담체를 이용한 서방성 제형물 |
| CN102176900B (zh) | 2008-09-17 | 2017-09-26 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| JP5643762B2 (ja) * | 2008-10-15 | 2014-12-17 | インターシア セラピューティクス，インコーポレイティド | 高濃度薬物粒子、製剤、懸濁液、及びこれらの使用 |
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| WO2010146536A1 (en) | 2009-06-18 | 2010-12-23 | Koninklijke Philips Electronics N.V. | Suspension of particles with drug |
| WO2011007327A2 (en) | 2009-07-16 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Suspension for therapeutic use and device for delivering said suspension |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| US9072668B2 (en) | 2010-03-09 | 2015-07-07 | Janssen Biotech, Inc. | Non-aqueous high concentration reduced viscosity suspension formulations of antibodies |
| JP2013543898A (ja) * | 2010-11-24 | 2013-12-09 | デュレクト コーポレイション | 生体分解性薬物送達組成物 |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| AU2014233453A1 (en) | 2013-03-15 | 2015-10-01 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| HUE071943T2 (hu) | 2015-02-03 | 2025-10-28 | Amryt Endo Inc | Akromegália kezelése oktreotid orális alkalmazásával |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
| CN117159480B (zh) * | 2023-11-01 | 2024-03-01 | 江西赛基生物技术有限公司 | 一种重组人IFN-γ蛋白冻干小球及其制备方法和应用 |
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| US20070027105A1 (en) * | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| EP2049081B1 (en) * | 2006-08-09 | 2012-11-14 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| HRP20130259T1 (hr) * | 2007-04-23 | 2013-04-30 | Intarcia Therapeutics, Inc. | Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe |
| DK2240155T3 (da) * | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
-
2005
- 2005-05-19 US US11/132,830 patent/US20050266087A1/en not_active Abandoned
- 2005-05-23 MX MXPA06013755A patent/MXPA06013755A/es active IP Right Grant
- 2005-05-23 KR KR1020067027172A patent/KR20070046791A/ko not_active Ceased
- 2005-05-23 AU AU2005247439A patent/AU2005247439B2/en not_active Ceased
- 2005-05-23 PE PE2005000567A patent/PE20060456A1/es not_active Application Discontinuation
- 2005-05-23 NZ NZ551258A patent/NZ551258A/en unknown
- 2005-05-23 BR BRPI0511593-0A patent/BRPI0511593A/pt not_active IP Right Cessation
- 2005-05-23 ES ES05753131T patent/ES2309768T3/es not_active Expired - Lifetime
- 2005-05-23 WO PCT/US2005/017914 patent/WO2005115333A2/en not_active Ceased
- 2005-05-23 JP JP2007515217A patent/JP2008500345A/ja not_active Withdrawn
- 2005-05-23 CA CA002568714A patent/CA2568714A1/en not_active Abandoned
- 2005-05-23 DE DE602005008053T patent/DE602005008053D1/de not_active Expired - Lifetime
- 2005-05-23 EP EP05753131A patent/EP1755650B8/en not_active Expired - Lifetime
- 2005-05-23 AT AT05753131T patent/ATE400291T1/de not_active IP Right Cessation
- 2005-05-24 TW TW094116804A patent/TW200611712A/zh unknown
- 2005-05-24 AR ARP050102150A patent/AR049118A1/es not_active Application Discontinuation
-
2006
- 2006-11-14 IL IL179279A patent/IL179279A/en not_active IP Right Cessation
-
2008
- 2008-01-11 US US12/008,553 patent/US20080112994A1/en not_active Abandoned
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