JP2008247753A5 - - Google Patents
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- Publication number
- JP2008247753A5 JP2008247753A5 JP2007087739A JP2007087739A JP2008247753A5 JP 2008247753 A5 JP2008247753 A5 JP 2008247753A5 JP 2007087739 A JP2007087739 A JP 2007087739A JP 2007087739 A JP2007087739 A JP 2007087739A JP 2008247753 A5 JP2008247753 A5 JP 2008247753A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- chloro
- fluorobenzyl
- acid
- reactive derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- XWGYOMHQGQZRLC-UHFFFAOYSA-N 4-amino-5-chloro-2-ethoxybenzoic acid Chemical compound CCOC1=CC(N)=C(Cl)C=C1C(O)=O XWGYOMHQGQZRLC-UHFFFAOYSA-N 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- JHSPPBBJOLKJDH-UHFFFAOYSA-N [4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine Chemical compound C1COC(CN)CN1CC1=CC=C(F)C=C1 JHSPPBBJOLKJDH-UHFFFAOYSA-N 0.000 claims 3
- 150000008065 acid anhydrides Chemical class 0.000 claims 3
- -1 alkyl chlorocarbonate Chemical compound 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- YPELFRMCRYSPKZ-UHFFFAOYSA-N 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide Chemical compound CCOC1=CC(N)=C(Cl)C=C1C(=O)NCC1OCCN(CC=2C=CC(F)=CC=2)C1 YPELFRMCRYSPKZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000002780 morpholines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007087739A JP2008247753A (ja) | 2007-03-29 | 2007-03-29 | ４−アミノ−５−クロロ−２−エトキシ−ｎ−［［４−（４−フルオロベンジル）−２−モルホリニル］メチル］ベンズアミドの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007087739A JP2008247753A (ja) | 2007-03-29 | 2007-03-29 | ４−アミノ−５−クロロ−２−エトキシ−ｎ−［［４−（４−フルオロベンジル）−２−モルホリニル］メチル］ベンズアミドの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008247753A JP2008247753A (ja) | 2008-10-16 |
| JP2008247753A5 true JP2008247753A5 (enExample) | 2009-08-20 |
Family
ID=39973142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007087739A Pending JP2008247753A (ja) | 2007-03-29 | 2007-03-29 | ４−アミノ−５−クロロ−２−エトキシ−ｎ−［［４−（４−フルオロベンジル）−２−モルホリニル］メチル］ベンズアミドの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2008247753A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101123281B1 (ko) * | 2008-10-17 | 2012-03-19 | 주식회사 엘지생명과학 | 치환된 벤즈아미드 유도체 및 그의 약제학상 허용되는 염의제조방법 |
| KR100953527B1 (ko) * | 2009-05-13 | 2010-04-21 | 주식회사 파마코스텍 | 모사프리드의 신규 제조방법 |
| JP5460209B2 (ja) * | 2009-09-28 | 2014-04-02 | 株式会社トクヤマ | ４−アミノ−５−クロロ−２−エトキシ−ｎ−〔［４−（４−フルオロベンジル）−２−モルホリニル］メチル〕ベンズアミドの精製方法 |
| WO2011107903A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Highly pure mosapride citrate dihydrate and processes for its preparation |
| JP5743474B2 (ja) * | 2010-09-28 | 2015-07-01 | 株式会社トクヤマ | ４−アミノ−５−クロロ−２−エトキシ−ｎ−〔［４−（４−フルオロベンジル）−２−モルホリニル］メチル〕ベンズアミドクエン酸塩２水和物の製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08268988A (ja) * | 1995-03-31 | 1996-10-15 | Dai Ichi Seiyaku Co Ltd | アミノベンズアミド化合物とその製法 |
| HUP0201980A3 (en) * | 2002-06-13 | 2008-06-30 | Richter Gedeon Nyrt | Process for preparing a benzamide derivative and intermediates thereof |
-
2007
- 2007-03-29 JP JP2007087739A patent/JP2008247753A/ja active Pending
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