JP2008137909A - Mixture for embalming corpse, method for preparing the same and method for applying the embalming mixture to corpse and treating the corpse therewith - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a mixture for embalming a corpse and to provide a method for preparing the same and a method for applying the embalming mixture to a corpse and treating the corpse therewith. <P>SOLUTION: The mixture for embalming a corpse is obtained and the method for preparing the same and an application thereof are provided. The mixture for embalming a corpse comprises mainly 0.15-10% in a volume ratio of an isothiazoline ketone compound, 5-30% of a dihydric alcohol, 3-20% of glycerin, 0-15% of an alcohol, 5-50% of n-hexyl alcohol, 1-15% of dimethyl sulfoxide, 1-18% of a plant extract and 0-30% of pure water and 0.1-15% in a weight ratio of a nipagin ester or 1-15% of urotropine. An antiseptic is injected into the aortic arch to exert a rapid and effective antiseptic action on a corpse. The embalming mixture has wide antimicrobial properties, has a high action rate, excellent compatibility with an enzyme and low toxicity and is suitable for embalming a corpse in an environment, especially, humidity, etc. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to the field of antiseptic technology, and specifically relates to a mortuary preservative mixture, a method for preparing the same, and a method for applying an antiseptic mixture to a corpse.

The inventor has already applied the preservatives disclosed in Chinese Patent ZL01132050B, and at the same time published in Chinese patent application CN200410053606.8 a mortuary antiseptic mixture for short-term septic preservation.
Chinese patent ZL01132050B Chinese patent application CN200410053606.8 Chinese patent application CN200410066612.7

  The inventor has also applied the mortuary antiseptic mixture used for long-term septic preservation published in Chinese patent application CN200410066612.7. These preservatives are used to treat the body from different angles, adapt to various customs, natural environment, and equipment requirements, and basically have a good antiseptic effect.

  Both the above preservatives and the body preservatives used in the existing technology use peroxides. Peroxides have a good antiseptic effect, but they always produce gas as soon as they are preserved, often leading to swelling and deformation of the body, increasing the psychological distress of the dead family.

  In addition, in a humid environment, the antiseptic effect of the above-mentioned preservatives is insufficient. In addition, in order to enhance the performance of these preservative mixtures and adapt to the various environmental and local preservative requirements, the inventor has repeatedly studied to create a new mortuary antiseptic mixture.

  The technical problem to be solved by the present invention is to provide a new body preservative mixture that better guarantees the integrity of the body and is adaptable to various environments.

  The new body preservative mixture of the present invention has a volume ratio of 0.15 to 10% isothiazoline ketone compound, 5 to 30% dihydric alcohol, 3 to 20% glycerin, 0 to 15% alcohol, 5 to 50 % Regular hexyl alcohol, 1-15% dimethyl sulfoxide, 1-18% plant extract, 0-30% clean water and 0.1-15% by weight Nipagin ester or 1-15% urotropin It is composed of a mixture of

  The plant extract described in the present invention is an extract extracted with alcohol using lilac, galangin, salamander, tonkin nikkei and peony skin as raw materials, and the most important important proportion of each raw material is lilac: galangin: sansho: Tonkin Nikkei: Peony skin = 1-2: 1-3: 0.5-1: 2-4: 1-4.

  The isothiazoline ketone compounds described in the present invention include 2-methyl-4-isothiazoline-3-ketone, 2-methyl-3 (2H) -isothiazoline ketone, 2-methyl-3 (H) -isothiazoketone, 1.2-benzo The optimal one was selected from one or more of isothiazoline-3-ketone and 5-chloro-2-methyl-4-inch azoline ketone-3-ketone.

  As the dihydric alcohol described in the present invention, an optimal one was selected from glycol, propylene glycol and mixtures thereof.

If necessary, an appropriate amount of perfume can be added to the preservative mixture of the present invention to adapt to environmental demands.
The present invention has selected an excellent blending method that can be used alone or in combination according to various requirements of the object to be preserved and the necessity of the preservation operation. They consist of:

  Formulation A: isothiazoline ketone compound having a volume ratio of 0.15 to 5%, 5 to 20% dihydric alcohol, 3 to 15% glycerin, 5 to 30% regular hexyl alcohol, and 1 to 15% dimethyl Composition composed of sulfoxide, 1-18% plant extract, 5-30% clean water and 1-10% urotropin by weight.

  Formulation A: isothiazoline ketone compound having a volume ratio of 5-8%, 5-20% dihydric alcohol, 3-15% glycerin, 5-30% regular hexyl alcohol, 1-10% dimethyl sulfoxide, Composition composed of 1-18% plant extract, 5-25% clean water and 5-15% urotropin by weight.

Another technical problem that needs to be solved by the present invention is the method of formulating the preservative mixture described above.
1) According to the composition ratio, plant lilac, carangin, salamander, tonkin nikki and peony skin are crushed and 100 grams is taken, soaked in 100 milliliters of alcohol for 24 hours, and the leachate is filtered with activated carbon. Decolorize and prepare for use.
2) Dissolve urotropin in clean water according to the blending ratio to prepare a solution for use. Alternatively, Nipagin ester is dissolved in alcohol to make a solution and ready for use.
3) Add the isothiazoline ketone compound to the dihydric alcohol according to the blending ratio, stir, and then add glycerin and normal hexyl alcohol in order. Stir 20-40 minutes each time each material is added and leave for a while before adding dimethyl sulfoxide and stirring continuously. Add the preparations prepared in steps 1) and 2) according to the ratio and stir evenly for 24 hours.

Another technique to be solved by the present invention is to publish an application in the short-term preservation of the bodies of the above-mentioned preservation mixture.
The active ingredients of the mortuary preservative mixture of the present invention are mainly balaoxybenzoate and isothiazoline ketone compounds, which have the same principle in that they suppress cell growth and promote cell apoptosis. They can soak into the membrane immediately after contact with the cell membrane and suppress cell activity. Pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinic dehydrogenase and NADH dehydrogenase are key enzymes that promote the circulation of cell metabolism.

  Furthermore, the antiseptic mixture of the present invention acts on these four different enzymes to suppress cell growth metabolism and macromolecular synthesis, and rapidly lower the level of intracellular energy. Due to the breakdown of the energy system, the cells are unable to synthesize the compounds necessary for daily metabolism and ultimately achieve the purpose of preserving.

  Although all bacteria and fungi have some circulation, the preservative mixture of the present invention has a very wide range of applications and has many target points of action, which greatly increases the chemical resistance of mutant microorganisms. Be lowered. As the circulation is interrupted, the energy produced by the cells and the production capacity of biologically active substances such as synthetic enzymes are drastically reduced, further improving the antiseptic effect.

  After entering the body, urotropin can coagulate bacterial proteins in an acidic environment and kill the bacteria directly. At the same time, it solidifies the connective tissue between the epidermis and the dermis-creating a layer barrier, preventing the leaking of gases and liquids that have already rotted, and blocking the development of rot, effectively preventing the epidermis from peeling off. Indirectly deodorizing effect. In addition, since the epidermis dries, the invasion of sterilization from the outside world and the growth of mold can be reduced.

  In the present invention, two mixing methods, A and B, which are optimal for the requirements of various antiseptic objects and the necessity of the antiseptic operation were selected. The A and B preparations can be punctured and injected into the main artery of the corpse, thereby fulfilling the systemic antiseptic action. The preparation liquids A and B can be used alone or in combination. The combined use of A and B preparations provides the highest antiseptic effect, and allows the body to be preserved for at least 25 days at room temperature.

  Under normal circumstances, the preparation method of A is the basic preparation solution, and the preparation solution of B can be used in combination with the preparation solution of A. The usage amount of the A and B preparations is determined by the number of days the body is stored and the degree of corruption. A preparation liquid must use at least 500 ml for each body, and B preparation liquid can be decided by the preservation | save days of a body and the extent of decay. The inventor proposes as follows.

  If the body is stored for less than 15 days, inject about 1500 ml of B preparation. When storing for 20 days, inject about 2500 ml of B preparation. If stored for 25 days, inject about 3000 ml of B preparation. In case of storage for more than 25 days, inject about 3500 ml of B preparation. If it is clear that the corpse has decayed, the injection amount of the B preparation liquid is raised accordingly by 500 to 1000 ml.

  A and B preparations puncture the aortic arch with antiseptic solution to preserve the whole body, leaving the traditional method of injecting antiseptic solution into the artery with a conventional blade, eliminating the need to make a cut. It is most effective for preserving the whole body and can accept a mourning family.

A specific operation method for puncturing and injecting antiseptic solution into the aortic arch of the present invention is as follows.
1. Partial anatomy and surface projection of the arterial arch.
Partial dissection: The aortic arch extends from the upward facing aorta. The back of the sternum, the front of the trachea
The left is the pulmonary artery and the right is the cavity vein.
Surface projection: between the midline of the sternum, a few ribs. Do not exceed the left edge of the sternum. Aortic
The anatomical position is fixed, and elements such as age, gender, body type, weight, and disease
Not affected.
2. Injection point: The bottom part of the incision on the sternum.
3. Injection angle: 25-45 ° C to the skin.
4). Depth: about 10-12 cm.
5. Needle sensation: 6-7cm injection gives a sense of resistance.
After that, there is no response.
6). Observation of successful injection.
1) Injected outside the aortic arch, the injection line can enter but cannot be extracted.
2) When injecting into blood vessels, clearly distinguish between arteries and veins and look at blood color and volume.
3) When injected into the trachea, in addition to the interval at the time of puncture, there is much injection and little extraction,
The night body overflows from the nose.
7). Injection rate: The injection rate is preferably 100 ml / min.

  In the present invention, the preservative mixture A, B preparation liquid is injected into the aorta to increase the preservative speed, spread evenly throughout the body, block spoilage, and suppress autolysis. Gases and liquids produced by spoilage will form a tension gas and water tank when leaked under the epidermis, and will very easily peel, swell, deform, darken and produce odor. The A and B preparations effectively suppress surface bacteria and fix the connection between the dermis and epidermis and prevent the epidermis from loosening and peeling off. The combined use of the antiseptic mixture A and B enhances the antiseptic effect of the corpse, further prevents odor and tissue softening, and maintains the corpse in its complete form.

When the test for controlling related bacteria was performed using the mortuary antiseptic mixture of the present invention, the specific results were as follows.
1. Bacterial species tested Beer yeast, black Aspergillus, yellow Aspergillus, discolored Aspergillus, bituminous Aspergillus, addressed pseudomyelinous bacillus, bulb hair shell Aspergillus, green Koji mold, Kleidomycetes, Staphylococcus aureus, Streptococcus, Bacillus Fungi, Escherichia coli, fluorescent pseudomonas gonococcus, giant spore gonococcus.
2. Inspection conditions:
Temperature: 36 ± 1 ° C for bacteria, 28 ± 1 ° C for mold and yeast Time: 24 hours for bacteria and yeast, 72 hours for mold Method of inspection: Plate anti-bacterial ring method 4. Sample inspection:
4. Preparation method of the present preservative mixture A Control:
The fungus species of the test was controlled by itself without adding any preservatives.
6). Test results:
(++ in the table is a bacterium that can be used for growing test with full field of flat plate observed with the naked eye)

  In the tests described above, the preservative mixture of the present invention has been shown to have a wide range of antibacterial properties, fast speed of action, good compatibility with enzymes, and no influence on reactions associated with enzymes or antibodies. . Preservation treatment was applied to 200 bodies using the A preparation liquid (of which 10 were applied in an environment of 30 to 35 degrees Celsius and 70 to 93% humidity). The body shape was completely symmetrical and seemed to be sleeping, the limbs were soft, odorless, and no swelling was seen in the chest and abdomen.

The antiseptic mixture of the present invention has a bactericidal action in the pH range of 2 to 9, and the active ingredient basically remains unchanged even when the product is left at room temperature for one year. No gas is produced during the preservative process and the toxicity is low. It is particularly suitable for the preservation of dead bodies in humid environments.
Specific implementation method

Preparation of A preparation liquid:
40 ml of 2-methyl-3 (2H) -isothiazoline
Glycol 160ml
Glycerin 100ml
Regular hexyl alcohol 220ml
Urotropin 70g
Dimethyl sulfoxide 50ml
60 ml of plant extract
200ml of clean water
1) The weight ratio to be acquired is lilac: galangin: salamander: nikkei: peony skin = 1: 1: 1: 2: 1. Lilac, galangin, salamander, nikkei, peony skin is crushed and taken 100 grams. Soak in 100 milliliters of alcohol for 24 hours. The leachate is filtered through activated carbon and decolorized for use.
2) According to the blending ratio, 80 g of urotropine is dissolved in 200 ml of clean water and prepared for use.
3) Add an isothiazoline ketone compound in glycol according to the blending ratio and stir, then add glycerin and normal hexyl alcohol in turn and stir for 20-40 minutes each time the substance is added. After a while, dimethyl sulfoxide is added and stirring is continued, and 70 ml of the plant extract obtained in step 1) and the preparation liquid obtained in step 2) are added and stirred evenly for 24 hours to complete. .

Preparation of B preparation liquid:
2-methyl-4-isothiazoline-3-ketone 50ml
Glycol 160ml
Glycerin 70ml
200 ml of regular hexyl alcohol
Urotropin 80g
Dimethyl sulfoxide 50ml
70 ml of plant extract
200ml of clean water
1) The weight ratio to be obtained is: lilac: galangin: samsho: nickel: peony skin = 1: 1: 1: 2: 1, smashed with lilac, galangin, salamander, nikkei, peony skin, 100 grams Soak in 100 milliliters of alcohol for 24 hours. The leachate is filtered through activated carbon and decolorized for use.
2) According to the blending ratio, 80 g of urotropine is dissolved in 200 ml of clean water and prepared for use.
3) Add an isothiazoline ketone compound in glycol according to the blending ratio and stir, then add glycerin and normal hexyl alcohol in turn and stir for 20-40 minutes each time the substance is added. After a while, dimethyl sulfoxide was added and stirred continuously, and 70 ml of the plant extract obtained in step 1) and the preparation solution obtained in step 2) were added and stirred evenly. is there.

Preparation of A preparation liquid:
30 ml of 2-methyl-3 (H) isothiazoline ketone
120 ml of propylene glycol
Glycerin 80ml
Regular hexyl alcohol 220ml
Urotropin 80g
Dimethyl sulfoxide 80ml
60 ml of plant extract
250ml of clean water
The blending method is the same as in Example 1, and the breakdown is: lilac: galangin: sangsha: nickel; peony skin = 1: 2: 1: 2: 1.

Preparation of B preparation liquid:
60 ml of 2-methyl-3 (2H) -isothiazoline ketone
Glycol 150ml
Glycerin 100ml
120 ml of regular hexyl alcohol
Urotrobin 120g
Dimethyl sulfoxide 70ml
Plant extract 120ml
180ml of clean water
The blending method is the same as in Example 2, and the breakdown is: lilac: galangin: sangsha: nickel: peony skin = 1: 2: 1: 2: 1.

Preparation of A preparation liquid:
1.2-Benzisothiazoline ketone-3-ketone 10ml
10 ml of 2-methyl-4-isothiazoline-3-ketone
Glycol 180ml
Glycerin 120ml
Regular hexyl alcohol 180ml
Urotropin 60g
Dimethyl sulfoxide 90ml
130 ml of plant extract
180ml of clean water
The blending method is the same as in Example 1, and the breakdown is: lilac: galangin: sangsha: nickel: peony skin = 2: 3: 1: 2: 4.

Preparation of B preparation liquid:
1.2-Benzisothiazoline ketone-3-ketone 40 ml
25 ml of 5-chloro-2-methyl-4-isothiazoline-3-ketone
90ml glycol
Glycerin 125ml
Regular hexyl alcohol 250ml
Urotropin 110g
Dimethyl sulfoxide 65ml
90 ml of plant extract
165ml of clean water
The blending method is the same as in Example 2, and the breakdown is: lilac: galangin, salamander: nicky: peony skin = 2: 3: 1: 2: 4.

    When the antiseptic mixtures A and B obtained in Examples 1 and 2 were used. First, after bathing the body, wipe the whole body dry. Then, the aortic arch is punctured from the depression on the sternum, and 500 ml of the antiseptic mixture A solution is first injected. Subsequently, 2500 ml of the preservative mixture B is injected. The results of preserving were as follows.

Claims (9)

  A mortuary preservative mixture comprising a volume ratio of 0.15 to 15% isothiazoline ketone compound, 5 to 30% dihydric alcohol, 3 to 20% glycerin, 0 to 15% alcohol, 5 -50% regular hexyl alcohol, 1-15% dimethyl sulfoxide, 1-18% plant extract, 0-30% clean water and 0.1-15% by weight Nipagin ester or 1-15 A body preservative mixture characterized in that it is a mixture of 1% urotropin.   A mortuary preservative mixture comprising a 0.15 to 15% volume ratio of isothiazoline ketone compounds, 5 to 20% dihydric alcohol, 3 to 15% glycerin, and 5 to 30% positive hexyl alcohol. 1 to 15% dimethyl sulfoxide, 1 to 18% plant extract, 5 to 30% clean water, and 1 to 10% urotropine in a weight ratio. blend.   A mortuary preservative mixture comprising 5-8% isothiazoline ketone compounds, 5-20% dihydric alcohol, 3-15% glycerin, 5-30% regular hexyl alcohol, A body preservative mixture characterized by mixing 10% dimethyl sulfoxide, 1-18% plant extract, 5-25% clean water, and 5-15% urotropine by weight.   The mortuary preservative mixture according to any one of claims 1 to 3, wherein the isothiazoline ketone compound is 2-methyl-4-isothiazolin-ketone, 2-methyl-3 (2H) -ishithiazoketone, 2 One or more selected from the group consisting of -methyl-3 (H) -isothiazoketone, 1.2-benzisothiazoline-3-ketone and 5-chloro-2-methyl-4-isothiazoline-3 ketone A body antiseptic mixture characterized by   The body antiseptic mixture according to any one of claims 1 to 4, wherein the dihydric alcohol is selected from glycol, propylene glycol, or a mixture thereof. Body antiseptic mixture.   The mortuary preservative mixture according to any one of claims 1 to 3, wherein the weight ratio of the plant extract is: lilac: galangin: salamander: nikkei: peony skin = 1-2: 1 to 3: 0. A mortuary preservative mixture, characterized in that it is 5-1: 2-4: 1-4. A method for preparing a mortuary preservative mixture according to claim 1, wherein the method comprises:
1) According to the composition ratio, plant lilac, galangin, salamander, tonkin nikkei and peony skin are crushed and 100 grams is taken, soaked in 100 milliliters of alcohol for 24 hours, and the leachate is filtered with activated carbon. Decolorizing and preparing for use;
2) dissolving urotropin in clean water according to the blending ratio to prepare a solution for use, or dissolving Nipagin ester in alcohol to prepare a solution and preparing for use;
3) After adding the isothiazoline ketone compound to the dihydric alcohol according to the blending ratio and stirring, glycerin and normal hexyl alcohol were added in order, stirring for 20 to 40 minutes each time each substance was added, and after a while, Adding dimethyl sulfoxide followed by stirring,
A preparation method of a mortuary antiseptic mixture, wherein the preparation liquid prepared in the above steps 1) and 2) is added according to the ratio, stirred uniformly, and allowed to stand for 24 hours.   A method for applying an antiseptic mixture to a body, wherein the body antiseptic mixture according to claim 1 is applied to the body as a body preservative.   An application treatment method to a corpse using the mortuary preservative mixture according to claim 2 or claim 3 as a corpse preservative, wherein the application treatment method injects the antiseptic solution into the aortic arch of the corpse, and the injection rate is A method for applying an antiseptic mixture to a corpse, characterized in that it is 100 ml / min.