CN101601377B - Long-term antiseptic preserving fluid of remains and application thereof - Google Patents
Long-term antiseptic preserving fluid of remains and application thereof Download PDFInfo
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- CN101601377B CN101601377B CN2008100388721A CN200810038872A CN101601377B CN 101601377 B CN101601377 B CN 101601377B CN 2008100388721 A CN2008100388721 A CN 2008100388721A CN 200810038872 A CN200810038872 A CN 200810038872A CN 101601377 B CN101601377 B CN 101601377B
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Abstract
The invention relates to an antiseptic preserving fluid of remains, which comprises the following raw materials in percentage by weight: 15-40% of glycerine, 5-80% of alcohol, 1-20% of propionic acid, 0.5-25% of hexamine, 0.1-15% of 5chlorine-2-4methyl-4isothiazole-3ketone and the balance of water. The preserving fluid is applied to the remains of people and fish, amphibian and reptile and animal specimens gathered in the field and injected into the remains mainly through the axillary artery and/or the femoral artery of the remains, and the remains can be antiseptically preserved for 15-100 days under the conditions of a room temperature of 18-27 DEG C and a relative humidity of 45-60 percent. The invention has the advantages of reasonable formula, safe ingredient, accordance to environmental protection, no poison and harm to operators, no stimulation, no damages and blackening of tissues and organs by the antiseptic preservation of the remains, maintenance of a natural stateof the remains, simple preparation method, convenient use and benefit to popularization.
Description
[technical field]
The present invention relates to the technical field that human remains and spoil preserve, specifically, is a kind of remains (corpse) antiseptic preserving fluid and application that should the midium or long term antiseptic preserving fluid.
[background technology]
People's living or death is the natural law.From various reasons, people often need keep several days or a period of time with the deceased's remains, and this has just related to the problem that Gentle Repose is preserved.Be exactly aspect zooscopy, also have pair zoological specimens to carry out the problem of anticorrosion preservation.
In the world, ancient Egypt is the country that implements the Gentle Repose technology the earliest, and the most outstanding is the technology of making mummy.Ancient times, Ethiopia Russia was more similar with the ancient Egyptian than the mode that clan preserves the dead; Chatting the mode that sharp people preserves the dead ancient times is that they are placed in the special container, with honey or wax sealing; Ancient times, Jew smeared remains with special sesame oil and spices.Because the support that lack of scientific is theoretical, the Gentle Repose technical development is slow.After 16th century, along with the Applied Anatomy technology has disclosed the blood circulation system of human body, promoted the development of Gentle Repose technology, since then, human beginning application cycle Systems Theory instructs anticorrosive work.18th century rose, and the Gentle Repose skill begins fast development.The technology that relates to has: use that alcohol is preserved and fixing remains; Use acetic acid and prevent that remains are corrupt; Utilization arsenic injection prevents that remains are corrupt; Using glycerine carries out anticorrosion and preservation.Though the antiseptic effect of alcohol, glycerine, acetic acid is not fairly obvious, application is arranged all in the prescription of multiple preservative.19th-century sixties, the Germany scientist invention has also been adopted with formalin tissue has been fixed, after further be applied to the fixing of corpse dissected by medical college.In afterwards more than 100 year, through many scholars' effort, the range of application of formalin further enlarges, and by 1876, the Argentine was applied in remains with formalin and has preserved the field.
The Gentle Repose technology of China with have some different abroad; The social usage of China does not allow remains are made, can only be to the protecting of remains, for example: adopt wooden making coffins such as camphor tree, cypress, pine, paulownia; Place desiccant sealings such as charcoal, lime in the coffin, prevent that remains are corrupt; Or inner and outer coffin and usefulness, the coffin pit of construction secure seal.
Take a broad view of Gentle Repose of all times, nothing more than taking nature anticorrosion and artificial anticorrosion.And Gentle Repose mainly is artificial anticorrosion, promptly relies on chemicals and protein generation cross-linking reaction and is achieved.Now; Formalin because to toxic elements in human body, carcinogenic factor and contaminated environment are arranged and by many countries forbidding; And inorganic peroxide (like hydrogen peroxide) and organic peroxide (like Peracetic acid) are also because of poisonous; Skin to the people has strong spread effect, and is also influential and be limited to use to respiratory system.
In disclosed patent documentation, the introduction of Gentle Repose composition is arranged, after interpretation of result, find existing Gentle Repose product and application thereof; The deficiency that exists is very obvious; For example: use the back remains to be prone to flatulence, each organ of internal organ is prone to blackout, and remains time of preserving is also long etc.And also there is short partially problem of anticorrosion phase in our the own antiseptic preserving fluid of research before.The existence of these problems will influence the promotion and application of anticorrosive composite and antiseptic preserving fluid, influences the anticorrosion preservation of remains (corpse), the progress of especially medium-term and long-term anticorrosion preservation work.
[summary of the invention]
The objective of the invention is to overcome the deficiency of prior art; On the basis of short-term antiseptic preserving fluid; Change dosage, change prescription percentage, change injecting method; Provide a kind of nontoxic, harmless to the operator, meet national environmental standard, the antiseptic preserving fluid that remains can medium-term and long-term (15～100 days) be preserved; Another object of the present invention is to provide said Gentle Repose to preserve the new application method of liquid.
For realizing above-mentioned purpose, the technical scheme that the present invention takes is:
A kind of Gentle Repose is preserved liquid, contains glycerine, ethanol, propionic acid, hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone, and its raw material weight percentage is:
Glycerine (glycerine) 15～40%,
Alcohol (ethanol) 5～80%,
Propionic acid 1～20%,
Hexa 0.5～25%,
5 chloro-2-4 methyl-4 isothiazole-3 ketone 0.1～15% of making a din,
Water adds to total amount.
The percentage by weight of said raw material is:
Glycerine 10～20%,
Ethanol 30～60%,
Propionic acid 1～10%,
Hexamethyl tetramine 0.5～1%,
5 chloro-2-4 methyl-4 isothiazoline-3 ketone 0.1～3%,
Surplus is a water.
A kind of Gentle Repose is preserved liquid, contains glycerine, ethanol, propionic acid, hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone, and its raw material weight percentage is:
Glycerine 35%,
Ethanol 35%,
Propionic acid 15%,
Hexa 1%,
5 chloro-2-4 methyl-4 isothiazoline-3 ketone 1%,
Water adds to total amount.
Described glycerine, ethanol, propionic acid, hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone are nontoxic genus medical grade material, press national regulation and set dosage.For observing the infiltration situation of antiseptic preserving fluid in remains, can in antiseptic preserving fluid, be added into 0.5% dyestuff, like water-soluble Yihong, naphthol green B.
Described glycerine (glycerine) is water white transparency odorless and the thick liquid that has sweet taste, can mix arbitrarily with water and ethanol; Its formed solution is more stable, therefore is of great value solvent and preservation liquid.Glycerine has very big hygroscopicity, can prevent drying, can make human body soft and transparent, can also reduce the tension force on moisture content surface and the freezing point of water, and the solution of glycerine and water (1: 10) is neutral reaction to litmus reagent, is insoluble to ether, chloroform volatile oil and fat oil.
Preserve in the liquid at Gentle Repose of the present invention, glycerine is a kind of good medicine of selecting for use, utilize its anti-corrosive properties, hygroscopicity and solution that the special dissolubility of some inorganic salts medicine is made into more stable; The corrosion-resistant remains are difficult for dry; Soft, it is transparent that connective tissue slightly is, and the more important thing is that glycerine can adsorb the medicine (like ethanol etc.) that mixes with it; It is inner and surperficial to be trapped in remains (corpse); Make said medicine not volatile and lost, reach the antiseptic effect that strengthens said medicine, improve anticorrosion and sterilizing ability.Glycerine has double action hydrophilic and dehydration, and strengthens along with the expansion of concentration, and high concentration glycerine can make protein denaturation, plays antisepsis, does not organize serious dehydration but also can not make.In addition, glycerine can alleviate the volatilization of formaldehyde, reduces penetrating odor, improves environment.
Described alcohol (ethanol) has stronger dehydration, can remove the moisture of cell surface and cell interior, and the protein molecular structure is loosened, and makes protein denaturation and solidify.Here it is alcohol disinfecting, virus killing, protective tissue, prevent corrupt basic principle.The good penetrability of alcohol (95% alcohol) to organizing, 1.7 millimeters of permeable immersions in 4 hours, 3.5 millimeters of permeable immersions in 8 hours, 5.0 millimeters of permeable immersions in 12 hours, so, use alcohol can strengthen penetration, shorten the anticorrosion set time.But alcohol concentration is too high to solidify cell, the rapid sex change of tissue surface protein, forms layer protecting film, hinders the antiseptic preserving fluid entering on the contrary and organizes the deep.
Described propionic acid belongs to acid preservative; All kinds of moulds, aerobic spore-bearing bacilli or gram-Negative bacillus there is stronger inhibitory action; To the mushroom that can cause that food is clamminess; Fungistatic effect like bacillus subtilis is fine, and its growth to yeast when mould fungus inhibition is grown does not have influence basically.According to the research report, there are not toxicity in propionic acid and its esters.
Described hexa is the colourless crystallization material, is medically using as the urinary tract disinfectant, and some country is used for salt marsh catfish, Spanish mackerel, toxicity ADI0～0.15 milligram/kilogram.
Described 5 chloro-2-4 methyl-4 isothiazoline-3 ketone are a kind of broad-spectrum mould inhibitor and preservative, pH value be 3.5～9.5 o'clock effective, no foaminess is to 1～9 milligram of the least concentration average out to of nearly all mould, bacterium.
Do not contain inorganic peroxide, organic peroxide and formalin in the chemical raw material that the present invention uses.
For realizing above-mentioned purpose, Gentle Repose of the present invention is preserved being applied as of liquid:
At people's remains, and the application in the medium-term and long-term anticorrosion preservation of the fish of field acquisition, amphibious reptiles and zoological specimens.
The anticorrosion preservation of described midium or long term was meant under the condition of 18～27 ℃ of room temperatures, relative moisture 45～60% anticorrosion preservation 15～100 days.
The method for using that Gentle Repose of the present invention is preserved liquid is:
(1) axillary artery through remains (corpse) and/or femoral artery injection Gentle Repose is preserved 4000～6000 milliliters of liquid, by the characteristics of hematological system the whole body of remains is carried out preservative treatment.
(2) on the basis of method (1), local injection is carried out at the position that antiseptic preserving fluid does not put in place.
(3) soak into Gentle Repose preservation liquid with cotton ball whole remains are carried out wiping, the remains surface is carried out disinfection, further strengthen effect in the infiltration of body surface the anticorrosion preservation of remains (corpse) through antiseptic preserving fluid.
The principle of so using is:
The first, after people (or animal) death since blood vessel in nutritious; Bacterium is everlasting and grows in a large number here, breeds; Because hematological system spreads all over whole body, be the corrupt easily main reasons of remains (corpse), therefore; Must inject a large amount of Gentle Reposes to hematological system and preserve liquid, carry out the preservative treatment of emphasis.4000～6000 milliliters consumption is that the blood volume that can hold with hematological system is similar, guarantees that antiseptic preserving fluid can reach the various piece of hematological system.
The second, to antiseptic preserving fluid to the remains position carry out local dead chick.Owing to reasons such as before death thrombus, portion of tissue necrosis, the hematological system of remains is not necessarily unobstructed, therefore, be necessary to antiseptic preserving fluid to the remains position carry out local dead chick.
The 3rd, with impregnating fluid the remains whole body is smeared wiping, can further strengthen Disinfection Effect through the effect of subcutaneous infiltration to remains.
The good effect that Gentle Repose of the present invention is preserved liquid and application thereof is:
(1) prescription is reasonable, and composition safety meets environmental protection requirement, and anticorrosion storage life is 15～100 days under nature.
(2) nontoxic, non-stimulated to the operator, and easy to operate.
(3) the anticorrosion preservation to remains can not cause organizing, the destruction of organ, blackout, and can keep nature, softness and not stiff.
(4) preparation method is easy, and is workable, is convenient to promote the use of.
[embodiment]
The some embodiment that below provide Gentle Repose of the present invention to preserve liquid, but the invention is not restricted to following embodiment.
Embodiment 1
The percentage by weight that Gentle Repose of the present invention is preserved liquid is:
Glycerine 20%, ethanol 20%, propionic acid 10%, hexa 0.5%, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone 1.5%, surplus are water.
Embodiment 2
The percentage by weight that Gentle Repose of the present invention is preserved liquid is:
Glycerine 15%, ethanol 30%, propionic acid 2%, hexa 1%, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone 1.5%, surplus are water.
Embodiment 3
The percentage by weight that Gentle Repose of the present invention is preserved liquid is:
Glycerine 35%, ethanol 35%, propionic acid 15%, hexa 1%, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone 1%, surplus are water.
Embodiment 4
The percentage by weight that Gentle Repose of the present invention is preserved liquid is:
Glycerine 15%, ethanol 50%, propionic acid 3%, hexa 15%, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone 5%, surplus are water.
Embodiment 5
The percentage by weight that Gentle Repose of the present invention is preserved liquid is:
Glycerine 25%, ethanol 40%, propionic acid 3%, hexa 10%, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone 5%, surplus are water.
The preparation method that Gentle Repose of the present invention is preserved liquid is:
(1) uses at least two glasswares, carry out proportioning by the percentage by weight of said raw material;
(2) using a glassware, glycerine is sneaked in the ethanol, fully stir, make its even mixing, is to be first liquid, places on one side;
(3) using the another glassware, earlier hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone are dissolved in the aquae destillata, add propionic acid again and fully stir, make its even mixing, is to be second liquid;
(4) with first liquid with pour second liquid into and mix, fully stir, mix, promptly get remains midium or long term antiseptic preserving fluid of the present invention.
Gentle Repose of the present invention is preserved liquid graduate check of preventive medicine through Shanghai City, and assay and evaluation are:
One, acute oral toxicity test: the nontoxic level in true border.
Two, acute skin irritation property test: belong to nonirritant.
Gentle Repose of the present invention is preserved the detection of liquid through central laboratory of Shanghai Mucun Biotechnology Co., Ltd. employing inhibition zone method, and testing result is:
Bacterium inhibition zone (mm): 43;
Mould inhibition zone (mm): 0.
In force, employing is preserved liquid by the Gentle Repose of the component configuration of embodiment 3 12 tool remains has been carried out test injection, and the conclusion that draws through 10 months observations is: Gentle Repose of the present invention is preserved liquid and had very tangible anticorrosion preservation effect; For observing the infiltration situation of antiseptic preserving fluid in remains, 0.5% dyestuff has been added in some test in antiseptic preserving fluid, like water-soluble Yihong, naphthol green B.The case observed and recorded of experiment is seen following introduction, is to be embodiment 6～17.
Embodiment 6
Time: 17 days-September 28 August in 2007
Place: certain funeral parlor
Embodiment 7
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Embodiment 8
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Embodiment 9
Time: on November 8th, 2007
Place: certain funeral parlor
Embodiment 10
-30 days on the 14th November in 2007
Place: certain funeral parlor
Embodiment 11
Time: 15 days-November 30 November in 2007
Place: certain funeral parlor
Embodiment 12
Time: on April 8th, 1 2008 on December 19th, 2007
Place: certain funeral parlor
Embodiment 13
Time: on April 8th, 1 2008 on December 9th, 2007
Place: certain funeral parlor
Embodiment 14
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Embodiment 15
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Embodiment 16
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Embodiment 17
Time: on March 12nd, 1 2008 on October 25th, 2007
Place: certain funeral parlor
Claims (6)
1. a Gentle Repose is preserved liquid, contains glycerine, ethanol, propionic acid, hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone, it is characterized in that its raw material weight percentage is:
2. Gentle Repose according to claim 1 is preserved liquid, it is characterized in that the percentage by weight of said raw material is:
3. a Gentle Repose is preserved liquid, contains glycerine, ethanol, propionic acid, hexa, 5 chloro-2-4 methyl-4 isothiazoline-3 ketone, it is characterized in that its raw material weight percentage is:
4. a Gentle Repose as claimed in claim 1 is preserved the application method of liquid, it is characterized in that its application mode is:
(1) preserves liquid through the axillary artery and/or the femoral artery injection Gentle Repose of remains;
(2) local injection is carried out at the position that antiseptic preserving fluid is not put in place;
(3) soak into Gentle Repose preservation liquid with cotton ball wiping is carried out on whole remains surface.
5. Gentle Repose according to claim 4 is preserved the application method of liquid, it is characterized in that, it is 4000～6000 milliliters that Gentle Repose is preserved the liquid injection volume.
6. a Gentle Repose as claimed in claim 1 is preserved the application in fish, amphibious reptiles and the anticorrosion preservation of zoological specimens that liquid gathers in the open air.
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| CN101878754B (en) * | 2010-07-06 | 2012-07-18 | 上海市殡葬服务中心 | Wash-free hair conditioner for body preservation |
| CN101889568B (en) * | 2010-07-06 | 2012-07-18 | 苏州博克精细化学品有限公司 | Bath lotion for preservation of remains |
| CN101878755B (en) * | 2010-07-06 | 2012-06-06 | 苏州博克精细化学品有限公司 | Shampoo for body preservation |
| CN101878753B (en) * | 2010-07-06 | 2012-08-08 | 上海市殡葬服务中心 | Face cleaner for body preservation |
| CN102524240B (en) * | 2010-12-10 | 2014-10-29 | 民政部一零一研究所 | Efficient and environment-friendly remains preservative and application thereof |
| CN103988834A (en) * | 2014-05-18 | 2014-08-20 | 南阳医学高等专科学校 | Animal specimen preserving fluid |
| CN104365581B (en) * | 2014-11-05 | 2016-08-24 | 中山大学 | A kind of Novel specimen preserves liquid |
| CN104585159B (en) * | 2014-12-25 | 2017-02-22 | 上海海洋大学 | Traditional Chinese medicine preservative for fish stripping specimen and preparation method of traditional Chinese medicine preservative |
| CN109805001B (en) * | 2017-11-22 | 2021-01-01 | 哈尔滨格林标本技术开发有限公司 | Formaldehyde-free tissue fixation preservative solution and preparation method thereof |
| CN108812637A (en) * | 2018-06-15 | 2018-11-16 | 河南科技大学 | A kind of fur sample environment-friendly type ointment preservative and preparation method thereof |
| CN113180032A (en) * | 2021-04-13 | 2021-07-30 | 毕爱胜 | Anticorrosive liquid and preparation method, anticorrosive method and application thereof |
| CN114271261B (en) * | 2021-12-31 | 2022-12-30 | 广州市殡葬服务中心 | Efficient composite remains preservative and preparation method and preservation method thereof |
| CN114503977B (en) * | 2022-01-26 | 2023-03-03 | 民政部一零一研究所 | Remains preservative with detumescence, fading and odor removing functions and preparation method thereof |
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| CN1732775A (en) * | 2004-08-10 | 2006-02-15 | 任祖翰 | Composition for short-term remains preservation, its preparation process and application |
| CN1751566A (en) * | 2004-09-23 | 2006-03-29 | 李慧 | Long-term antiseptic agent composition for remains, and prepn. method and application thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732775A (en) * | 2004-08-10 | 2006-02-15 | 任祖翰 | Composition for short-term remains preservation, its preparation process and application |
| CN1751566A (en) * | 2004-09-23 | 2006-03-29 | 李慧 | Long-term antiseptic agent composition for remains, and prepn. method and application thereof |
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Effective date of registration: 20200119 Address after: 200030 5th floor, building 1, Lane 80, wending Road, Xuhui District, Shanghai Patentee after: Shanghai Funeral and Interment Service Center Address before: 200235 Shanghai city Xuhui District Caoxi Road No. 210 Patentee before: Shanghai Inst. of Embalming |