JP2007535493A5 - - Google Patents
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- JP2007535493A5 JP2007535493A5 JP2006542793A JP2006542793A JP2007535493A5 JP 2007535493 A5 JP2007535493 A5 JP 2007535493A5 JP 2006542793 A JP2006542793 A JP 2006542793A JP 2006542793 A JP2006542793 A JP 2006542793A JP 2007535493 A5 JP2007535493 A5 JP 2007535493A5
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- JP
- Japan
- Prior art keywords
- compound
- peptide
- bound
- component
- peptide component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 12
- NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 claims 7
- 101000829980 Homo sapiens Ral guanine nucleotide dissociation stimulator Proteins 0.000 claims 7
- 102100023320 Ral guanine nucleotide dissociation stimulator Human genes 0.000 claims 7
- -1 amphiphile compound Chemical class 0.000 claims 7
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- XQQUSYWGKLRJRA-RABCQHRBSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O XQQUSYWGKLRJRA-RABCQHRBSA-N 0.000 claims 6
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 108010088381 isoleucyl-lysyl-valyl-alanyl-valine Proteins 0.000 claims 6
- 238000002823 phage display Methods 0.000 claims 6
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 claims 6
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52744203P | 2003-12-05 | 2003-12-05 | |
| US60/527,442 | 2003-12-05 | ||
| PCT/US2004/040546 WO2005056576A2 (en) | 2003-12-05 | 2004-12-06 | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535493A JP2007535493A (ja) | 2007-12-06 |
| JP2007535493A5 true JP2007535493A5 (enExample) | 2008-06-26 |
| JP4741510B2 JP4741510B2 (ja) | 2011-08-03 |
Family
ID=34676744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542793A Expired - Fee Related JP4741510B2 (ja) | 2003-12-05 | 2004-12-06 | 分岐ペプチド両親媒性物質、関連するエピトープ化合物およびその自己集合構造物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7452679B2 (enExample) |
| EP (1) | EP1696944A4 (enExample) |
| JP (1) | JP4741510B2 (enExample) |
| KR (1) | KR20070004561A (enExample) |
| CN (1) | CN1905893A (enExample) |
| AU (1) | AU2004297211A1 (enExample) |
| CA (1) | CA2549391A1 (enExample) |
| MX (1) | MXPA06006387A (enExample) |
| WO (1) | WO2005056576A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11087873B2 (en) | 2000-05-18 | 2021-08-10 | Carefusion 303, Inc. | Context-aware healthcare notification system |
| US10353856B2 (en) | 2011-03-17 | 2019-07-16 | Carefusion 303, Inc. | Scalable communication system |
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| WO2004018628A2 (en) | 2002-08-21 | 2004-03-04 | Northwestern University | Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| WO2004046167A2 (en) | 2002-11-14 | 2004-06-03 | Northwestern University | Synthesis and self-assembly of abc triblock bola peptide |
| JP4837553B2 (ja) | 2003-02-11 | 2011-12-14 | ノースウエスタン ユニバーシティ | ナノ結晶表面被膜の方法及び材料ならびにその上へのペプチド両親媒性物質ナノ繊維の付着物 |
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| EP2217260B1 (en) * | 2007-12-04 | 2016-11-09 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic peptide matrices for treatment of osteoporosis |
| US8883967B2 (en) | 2009-03-27 | 2014-11-11 | Kansas State University Research Foundation | Branched amphipathic oligo-peptides that self-assemble into vesicles |
| WO2010120830A1 (en) | 2009-04-13 | 2010-10-21 | Northwestern University | Novel peptide-based scaffolds for cartilage regeneration and methods for their use |
| US20100322979A1 (en) * | 2009-06-22 | 2010-12-23 | University Of South Carolina | Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles |
| ES2659409T3 (es) | 2010-03-12 | 2018-03-15 | The Regents Of The University Of California | Conjugados de lípido-péptido-polímero y nanopartículas de los mismos |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| US9949927B2 (en) | 2012-04-10 | 2018-04-24 | The Regents Of The University Of California | Bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| US9169294B2 (en) * | 2013-03-11 | 2015-10-27 | Northwestern University | Anti-angiogenic molecules, nanostructures and uses thereof |
| CN105074766A (zh) | 2013-03-13 | 2015-11-18 | 康尔福盛303公司 | 预测性用药安全 |
| JP6660288B2 (ja) | 2013-03-13 | 2020-03-11 | ケアフュージョン ３０３、インコーポレイテッド | 患者固有投薬管理システム |
| US9821278B2 (en) | 2014-08-25 | 2017-11-21 | The Governors Of The University Of Alberta | Functionalized beta-sheet peptide stabilized membrane proteins, constructs comprising same, and methods of forming and using same |
| US20160159869A1 (en) | 2014-12-09 | 2016-06-09 | Northwestern University | Bmp-2-binding peptide amphiphile nanofibers |
| DE102015000363A1 (de) | 2015-01-20 | 2016-07-21 | Emc Microcollections Gmbh | Neue modular funktionalisierbare Peptid-Hydrogele |
| AU2016215049B2 (en) | 2015-02-06 | 2021-12-02 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| US20170051016A1 (en) | 2015-08-17 | 2017-02-23 | Northwestern University | Anti-inflammatory nanofibers |
| EP4406963A3 (en) | 2015-08-28 | 2025-04-02 | Molecular Transfer, Inc. | Transfection complexes and methods of using the same |
| WO2017066545A1 (en) | 2015-10-14 | 2017-04-20 | Northwestern University | Nanofiber paste for growth factor delivery and bone regeneration |
| WO2018017604A1 (en) * | 2016-07-18 | 2018-01-25 | Cell Idx, Inc. | Reagent compounds, compositions, kits, and methods for amplified assays |
| US10738294B2 (en) | 2016-09-26 | 2020-08-11 | Northwestern University | Tissue factor (TF)—targeted nanotherapy |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| SG11201903382SA (en) | 2016-10-21 | 2019-05-30 | Univ Northwestern | Anti-microbial supramolecular structures |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| US12122811B2 (en) | 2018-04-06 | 2024-10-22 | Northwestern University | BDNF mimetic peptide amphiphiles |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| US12409205B2 (en) | 2018-04-13 | 2025-09-09 | Northwestern University | Nanomolecules for the treatment of inflammatory bowel diseases |
| US12214076B2 (en) | 2019-02-18 | 2025-02-04 | Northwestern University | Drug delivery vehicles for atherosclerosis nanomedicine |
| CN110917136B (zh) * | 2019-11-25 | 2021-08-24 | 中国人民解放军陆军军医大学 | 一种抗肿瘤的纳米乳佐剂鼻腔粘膜疫苗及其制备方法 |
| US11964000B2 (en) | 2020-04-10 | 2024-04-23 | Northwestern University | Cancer treatment methods using nanofiber stabilized growth factors |
| US11998589B2 (en) | 2020-07-13 | 2024-06-04 | Northwestern University | PEGylated peptide amphiphile nanofibers and methods of use |
| US12247063B2 (en) | 2020-07-13 | 2025-03-11 | Northwestern University | Cell surface modification by coating with peptide amphiphiles (PAs) |
| US12116461B2 (en) | 2020-08-21 | 2024-10-15 | Northwestern University | Host-guest interactions for pa superstructure formation |
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| AU2003215280A1 (en) * | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| AU2003222167A1 (en) * | 2002-04-02 | 2003-10-20 | Northwestern University | Peptide amphiphile solutions and self assembled peptide nanofiber networks |
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| US7554021B2 (en) * | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| AU2003304280A1 (en) | 2002-11-12 | 2005-01-21 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| WO2004046167A2 (en) | 2002-11-14 | 2004-06-03 | Northwestern University | Synthesis and self-assembly of abc triblock bola peptide |
| JP4837553B2 (ja) | 2003-02-11 | 2011-12-14 | ノースウエスタン ユニバーシティ | ナノ結晶表面被膜の方法及び材料ならびにその上へのペプチド両親媒性物質ナノ繊維の付着物 |
| MXPA06006387A (es) | 2003-12-05 | 2006-09-04 | Univ Northwestern | Peptidos anfifilicos ramificados, compuestos epitopes relacionados y estructuras auto-ensambladas de los mismos. |
| MXPA06006388A (es) | 2003-12-05 | 2006-09-04 | Univ Northwestern | Peptidos anfifilicos de auto-ensamble y metodos relacionados para el suministro del factor de crecimiento. |
| US20050214257A1 (en) | 2003-12-23 | 2005-09-29 | Northwestern University | Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation |
| MX2007008826A (es) * | 2005-01-21 | 2007-11-15 | Univ Northwestern | Metodos y composiciones para encapsulacion de celulas. |
| US7851445B2 (en) | 2005-03-04 | 2010-12-14 | Northwestern University | Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use |
-
2004
- 2004-12-06 MX MXPA06006387A patent/MXPA06006387A/es not_active Application Discontinuation
- 2004-12-06 CN CNA2004800406518A patent/CN1905893A/zh active Pending
- 2004-12-06 US US11/005,314 patent/US7452679B2/en not_active Expired - Fee Related
- 2004-12-06 CA CA002549391A patent/CA2549391A1/en not_active Abandoned
- 2004-12-06 JP JP2006542793A patent/JP4741510B2/ja not_active Expired - Fee Related
- 2004-12-06 EP EP04817012A patent/EP1696944A4/en not_active Withdrawn
- 2004-12-06 KR KR1020067013465A patent/KR20070004561A/ko not_active Withdrawn
- 2004-12-06 AU AU2004297211A patent/AU2004297211A1/en not_active Abandoned
- 2004-12-06 WO PCT/US2004/040546 patent/WO2005056576A2/en not_active Ceased
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