JP2004535461A5 - - Google Patents
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- Publication number
- JP2004535461A5 JP2004535461A5 JP2003513312A JP2003513312A JP2004535461A5 JP 2004535461 A5 JP2004535461 A5 JP 2004535461A5 JP 2003513312 A JP2003513312 A JP 2003513312A JP 2003513312 A JP2003513312 A JP 2003513312A JP 2004535461 A5 JP2004535461 A5 JP 2004535461A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- peptide
- alanine
- copper
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 67
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 60
- 238000000034 method Methods 0.000 claims 54
- ZRPDXDBGEYHEBJ-UHFFFAOYSA-N alpha-(hydroxymethyl)serine Chemical compound OCC(N)(CO)C(O)=O ZRPDXDBGEYHEBJ-UHFFFAOYSA-N 0.000 claims 52
- 239000010949 copper Substances 0.000 claims 35
- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 34
- 229960003767 alanine Drugs 0.000 claims 34
- 235000004279 alanine Nutrition 0.000 claims 34
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 33
- 229910052802 copper Inorganic materials 0.000 claims 33
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 31
- 229960005261 aspartic acid Drugs 0.000 claims 31
- 235000003704 aspartic acid Nutrition 0.000 claims 31
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 31
- 239000004475 Arginine Substances 0.000 claims 30
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 30
- 239000004471 Glycine Substances 0.000 claims 30
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 30
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 30
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 30
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 30
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 30
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 30
- 229960003121 arginine Drugs 0.000 claims 30
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 30
- 235000009697 arginine Nutrition 0.000 claims 30
- 229960002989 glutamic acid Drugs 0.000 claims 30
- 235000013922 glutamic acid Nutrition 0.000 claims 30
- 239000004220 glutamic acid Substances 0.000 claims 30
- 229960002449 glycine Drugs 0.000 claims 30
- 229960004295 valine Drugs 0.000 claims 30
- 239000004474 valine Substances 0.000 claims 30
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 28
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 28
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 28
- 239000004472 Lysine Substances 0.000 claims 28
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 28
- 239000004473 Threonine Substances 0.000 claims 28
- 229960001230 asparagine Drugs 0.000 claims 28
- 235000009582 asparagine Nutrition 0.000 claims 28
- 229960003646 lysine Drugs 0.000 claims 28
- 229960002898 threonine Drugs 0.000 claims 28
- 235000008521 threonine Nutrition 0.000 claims 28
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical group [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims 24
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 24
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 24
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 24
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 24
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 24
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 24
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 24
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 24
- 229940024606 amino acid Drugs 0.000 claims 24
- 235000001014 amino acid Nutrition 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 24
- 229910001431 copper ion Inorganic materials 0.000 claims 24
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 24
- 229960002743 glutamine Drugs 0.000 claims 24
- 235000004554 glutamine Nutrition 0.000 claims 24
- 229960003136 leucine Drugs 0.000 claims 24
- 229960003104 ornithine Drugs 0.000 claims 24
- 125000001424 substituent group Chemical group 0.000 claims 24
- 229960004799 tryptophan Drugs 0.000 claims 24
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 21
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 21
- 229960001153 serine Drugs 0.000 claims 21
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 20
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 20
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 20
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 20
- 239000002738 chelating agent Substances 0.000 claims 20
- 125000000524 functional group Chemical group 0.000 claims 20
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 20
- 229960002885 histidine Drugs 0.000 claims 20
- 229960000310 isoleucine Drugs 0.000 claims 20
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 20
- 229930182817 methionine Natural products 0.000 claims 20
- 239000002184 metal Substances 0.000 claims 18
- 229910052751 metal Inorganic materials 0.000 claims 18
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 claims 16
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 16
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 16
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 16
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 16
- 235000018417 cysteine Nutrition 0.000 claims 16
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 claims 16
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims 16
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 claims 16
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 16
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 16
- 101800004937 Protein C Proteins 0.000 claims 15
- 101800001700 Saposin-D Proteins 0.000 claims 15
- 102400000827 Saposin-D Human genes 0.000 claims 15
- 229960000856 protein c Drugs 0.000 claims 15
- 229940000635 beta-alanine Drugs 0.000 claims 10
- 241001465754 Metazoa Species 0.000 claims 8
- 102000035195 Peptidases Human genes 0.000 claims 8
- 108091005804 Peptidases Proteins 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 8
- BBJIPMIXTXKYLZ-UHFFFAOYSA-N isoglutamic acid Chemical compound OC(=O)CC(N)CC(O)=O BBJIPMIXTXKYLZ-UHFFFAOYSA-N 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 8
- UWQDKRIZSROAKS-FJXKBIBVSA-N Gly-Met-Thr Chemical compound [H]NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O UWQDKRIZSROAKS-FJXKBIBVSA-N 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- SLHOOKXYTYAJGQ-XVYDVKMFSA-N Asp-Ala-His Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CNC=N1 SLHOOKXYTYAJGQ-XVYDVKMFSA-N 0.000 claims 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 4
- PLBJMUUEGBBHRH-ZLUOBGJFSA-N Cys-Ala-Asn Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O PLBJMUUEGBBHRH-ZLUOBGJFSA-N 0.000 claims 4
- 150000008574 D-amino acids Chemical class 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims 4
- 101710111620 Protein C activator Proteins 0.000 claims 4
- 125000003636 chemical group Chemical group 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 229960004452 methionine Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- OABOXRPGTFRBFZ-IMJSIDKUSA-N Cys-Cys Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(O)=O OABOXRPGTFRBFZ-IMJSIDKUSA-N 0.000 claims 2
- PFMUCCYYAAFKTH-YFKPBYRVSA-N Gly-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)CN PFMUCCYYAAFKTH-YFKPBYRVSA-N 0.000 claims 2
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000014171 autosomal dominant thrombophilia due to protein C deficiency Diseases 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 230000015271 coagulation Effects 0.000 claims 2
- 238000005345 coagulation Methods 0.000 claims 2
- 108010004073 cysteinylcysteine Proteins 0.000 claims 2
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 201000005665 thrombophilia Diseases 0.000 claims 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- 244000003416 Asparagus officinalis Species 0.000 claims 1
- 235000005340 Asparagus officinalis Nutrition 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 229940013688 formic acid Drugs 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30700501P | 2001-07-19 | 2001-07-19 | |
| US34451401P | 2001-12-28 | 2001-12-28 | |
| PCT/US2002/022951 WO2003007686A2 (en) | 2001-07-19 | 2002-07-19 | Use of copper chelators to inhibit the inactivation of protein c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004535461A JP2004535461A (ja) | 2004-11-25 |
| JP2004535461A5 true JP2004535461A5 (enExample) | 2006-04-20 |
Family
ID=26975490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513312A Pending JP2004535461A (ja) | 2001-07-19 | 2002-07-19 | プロテインｃの不活性化を抑制するための銅キレート剤の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20030055003A1 (enExample) |
| EP (1) | EP1417055A4 (enExample) |
| JP (1) | JP2004535461A (enExample) |
| AU (1) | AU2002354951A1 (enExample) |
| WO (1) | WO2003007686A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1324234A (zh) | 1998-09-25 | 2001-11-28 | 格利科克斯有限公司 | 果糖胺氧化酶,拮抗剂和抑制剂 |
| US20030158111A1 (en) * | 1999-10-01 | 2003-08-21 | David Bar-Or | Methods and products for oral care |
| US7592304B2 (en) * | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| CA2475738A1 (en) * | 2002-03-08 | 2003-09-18 | Eli Lilly And Company | Activated protein c formulations |
| CA2478997C (en) | 2002-03-08 | 2013-12-17 | Protemix Corporation Limited | Use of copper chelating tetraamines for the treatment of cardiovascular disease and heart failure |
| AU2003258909B2 (en) | 2002-08-20 | 2010-07-08 | Philera New Zealand Limited | Dosage forms and related therapies |
| US20070258970A1 (en) * | 2003-12-09 | 2007-11-08 | Robert Blumenthal | Methods for Inhibiting Hiv and Other Viral Infections by Modulating Ceramide Metabolism |
| EA018643B1 (ru) * | 2004-02-23 | 2013-09-30 | Цайтэн Чжан | Раствор металлсодержащего хелатного полимера и его применение (варианты) |
| EP1778618B1 (en) * | 2004-07-19 | 2013-12-25 | PhilERA New Zealand Limited | Synthesis of triethylenetetramines |
| JP5103748B2 (ja) * | 2005-02-16 | 2012-12-19 | 東レ株式会社 | 医薬組成物 |
| WO2006104398A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
| WO2006104402A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
| CA2647811A1 (en) | 2006-03-30 | 2007-10-11 | Asahi Kasei Pharma Corporation | Substituted bicyclic derivative and use thereof |
| RU2479579C2 (ru) | 2008-04-28 | 2013-04-20 | Асахи Касеи Фарма Корпорейшн | Производное фенилпропионовой кислоты и его применение |
| WO2009140408A2 (en) | 2008-05-13 | 2009-11-19 | University Of Kansas | Metal abstraction peptide (map) tag and associated methods |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4461724A (en) * | 1981-10-28 | 1984-07-24 | Nippon Zoki Pharmaceutical Co., Ltd. | Peptide compounds, a process for manufacturing them, pharmaceutical compositions containing them, and methods for treating ulcer and thrombus with them |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| WO1988006457A1 (fr) * | 1987-03-04 | 1988-09-07 | Nippon Hypox Laboratories Incorporated | Composition medicinale contenant de l'albumine en tant que support et procede de preparation |
| JP2739050B2 (ja) * | 1988-01-28 | 1998-04-08 | ヘキスト薬品工業株式会社 | 抗血液凝固剤 |
| US5270447A (en) * | 1988-05-20 | 1993-12-14 | The United States Of America As Represented By The Department Of Health & Human Services | Metalloproteinase peptides: role in diagnosis and therapy |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| US5093117A (en) * | 1989-01-24 | 1992-03-03 | Baxter International Inc. | Compositions and method for the treatment or prophylaxis of sepsis or septic shock |
| WO1991009960A1 (en) * | 1989-12-29 | 1991-07-11 | Zymogenetics, Inc. | Hybrid protein c |
| JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
| US5571786A (en) * | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
| WO1994014836A1 (en) * | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
| JP3043558B2 (ja) * | 1993-10-29 | 2000-05-22 | 財団法人化学及血清療法研究所 | ヒト活性化プロテインｃ調製物及びその製法 |
| US5538945A (en) * | 1994-06-17 | 1996-07-23 | Procyte Corporation | Stimulation of hair growth by peptide copper complexes |
| PL195642B1 (pl) * | 1997-04-28 | 2007-10-31 | Lilly Co Eli | Sposób przetwarzania wodnego roztworu aktywowanego białka C |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| PT947585E (pt) * | 1998-03-19 | 2001-11-30 | Instrumentation Lab Spa | Metodo in vitro melhorado, kits e reagentes para a peaquisa de defeitos de coagulacao sanguinea |
| US5932548A (en) * | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
| EP1124573A1 (en) * | 1998-10-22 | 2001-08-22 | Eli Lilly And Company | Methods for treating sepsis |
-
2002
- 2002-07-19 JP JP2003513312A patent/JP2004535461A/ja active Pending
- 2002-07-19 US US10/199,285 patent/US20030055003A1/en not_active Abandoned
- 2002-07-19 WO PCT/US2002/022951 patent/WO2003007686A2/en not_active Ceased
- 2002-07-19 EP EP02752462A patent/EP1417055A4/en not_active Withdrawn
- 2002-07-19 AU AU2002354951A patent/AU2002354951A1/en not_active Abandoned
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