JP2005517636A5 - - Google Patents
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- Publication number
- JP2005517636A5 JP2005517636A5 JP2003545202A JP2003545202A JP2005517636A5 JP 2005517636 A5 JP2005517636 A5 JP 2005517636A5 JP 2003545202 A JP2003545202 A JP 2003545202A JP 2003545202 A JP2003545202 A JP 2003545202A JP 2005517636 A5 JP2005517636 A5 JP 2005517636A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- product
- alanine
- acid
- valine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 60
- ZRPDXDBGEYHEBJ-UHFFFAOYSA-N alpha-(hydroxymethyl)serine Chemical compound OCC(N)(CO)C(O)=O ZRPDXDBGEYHEBJ-UHFFFAOYSA-N 0.000 claims 54
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 34
- 229960003767 alanine Drugs 0.000 claims 34
- 235000004279 alanine Nutrition 0.000 claims 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims 33
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 32
- 229960005261 aspartic acid Drugs 0.000 claims 32
- 235000003704 aspartic acid Nutrition 0.000 claims 32
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 32
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 30
- 239000004471 Glycine Substances 0.000 claims 30
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 30
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 30
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 30
- 229960002989 glutamic acid Drugs 0.000 claims 30
- 235000013922 glutamic acid Nutrition 0.000 claims 30
- 239000004220 glutamic acid Substances 0.000 claims 30
- 229960002449 glycine Drugs 0.000 claims 30
- 229960004295 valine Drugs 0.000 claims 30
- 239000004474 valine Substances 0.000 claims 30
- 239000004475 Arginine Substances 0.000 claims 29
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 29
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 29
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 29
- 229960003121 arginine Drugs 0.000 claims 29
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 29
- 235000009697 arginine Nutrition 0.000 claims 29
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 28
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 28
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 28
- 239000004472 Lysine Substances 0.000 claims 28
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 28
- 239000004473 Threonine Substances 0.000 claims 28
- 235000001014 amino acid Nutrition 0.000 claims 28
- 229960001230 asparagine Drugs 0.000 claims 28
- 235000009582 asparagine Nutrition 0.000 claims 28
- 229960003646 lysine Drugs 0.000 claims 28
- 229960002898 threonine Drugs 0.000 claims 28
- 235000008521 threonine Nutrition 0.000 claims 28
- 229940024606 amino acid Drugs 0.000 claims 27
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 25
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 24
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 24
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 24
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 24
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 24
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 24
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 24
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 24
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 24
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 24
- 229960002743 glutamine Drugs 0.000 claims 24
- 235000004554 glutamine Nutrition 0.000 claims 24
- 229960003136 leucine Drugs 0.000 claims 24
- 229960003104 ornithine Drugs 0.000 claims 24
- 229960004799 tryptophan Drugs 0.000 claims 24
- 238000000034 method Methods 0.000 claims 23
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 22
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 22
- 229960001153 serine Drugs 0.000 claims 22
- 239000002184 metal Substances 0.000 claims 21
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 20
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 20
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 20
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 20
- 229960002885 histidine Drugs 0.000 claims 20
- 229960000310 isoleucine Drugs 0.000 claims 20
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 20
- 229930182817 methionine Natural products 0.000 claims 20
- 230000002087 whitening effect Effects 0.000 claims 18
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 claims 16
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 16
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 16
- 235000018417 cysteine Nutrition 0.000 claims 16
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 16
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 claims 16
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims 16
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 claims 16
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 16
- 229960005190 phenylalanine Drugs 0.000 claims 16
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 16
- 229960004441 tyrosine Drugs 0.000 claims 16
- 241001465754 Metazoa Species 0.000 claims 15
- 238000004519 manufacturing process Methods 0.000 claims 13
- 229910021645 metal ion Inorganic materials 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 229940000635 beta-alanine Drugs 0.000 claims 12
- 239000003937 drug carrier Substances 0.000 claims 12
- 239000000539 dimer Substances 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- BBJIPMIXTXKYLZ-UHFFFAOYSA-N isoglutamic acid Chemical compound OC(=O)CC(N)CC(O)=O BBJIPMIXTXKYLZ-UHFFFAOYSA-N 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 125000003636 chemical group Chemical group 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 125000000524 functional group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 206010061218 Inflammation Diseases 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 6
- 238000000605 extraction Methods 0.000 claims 6
- 230000004054 inflammatory process Effects 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 238000001356 surgical procedure Methods 0.000 claims 6
- 150000008574 D-amino acids Chemical class 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229960004452 methionine Drugs 0.000 claims 4
- 230000003239 periodontal effect Effects 0.000 claims 4
- UWQDKRIZSROAKS-FJXKBIBVSA-N Gly-Met-Thr Chemical compound [H]NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O UWQDKRIZSROAKS-FJXKBIBVSA-N 0.000 claims 3
- 208000035473 Communicable disease Diseases 0.000 claims 2
- PLBJMUUEGBBHRH-ZLUOBGJFSA-N Cys-Ala-Asn Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O PLBJMUUEGBBHRH-ZLUOBGJFSA-N 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 208000026062 Tissue disease Diseases 0.000 claims 2
- 208000007565 gingivitis Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000002324 mouth wash Substances 0.000 claims 2
- 229940051866 mouthwash Drugs 0.000 claims 2
- 201000001245 periodontitis Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 2
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- OABOXRPGTFRBFZ-IMJSIDKUSA-N Cys-Cys Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(O)=O OABOXRPGTFRBFZ-IMJSIDKUSA-N 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- PFMUCCYYAAFKTH-YFKPBYRVSA-N Gly-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)CN PFMUCCYYAAFKTH-YFKPBYRVSA-N 0.000 claims 1
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims 1
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 125000002009 alkene group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 150000001924 cycloalkanes Chemical group 0.000 claims 1
- 108010004073 cysteinylcysteine Proteins 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 125000005908 glyceryl ester group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33166501P | 2001-11-20 | 2001-11-20 | |
| US36073602P | 2002-02-27 | 2002-02-27 | |
| US10/186,168 US20030130185A1 (en) | 2000-09-29 | 2002-06-27 | Metal-binding compounds and uses therefor |
| PCT/US2002/037136 WO2003043518A2 (en) | 2001-11-20 | 2002-11-19 | Methods and products for oral care |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007335135A Division JP2008101024A (ja) | 2001-11-20 | 2007-12-26 | オーラル・ケアのための方法および製品 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517636A JP2005517636A (ja) | 2005-06-16 |
| JP2005517636A5 true JP2005517636A5 (enExample) | 2006-04-06 |
Family
ID=27392064
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545202A Pending JP2005517636A (ja) | 2001-11-20 | 2002-11-19 | オーラル・ケアのための方法および製品 |
| JP2007335135A Withdrawn JP2008101024A (ja) | 2001-11-20 | 2007-12-26 | オーラル・ケアのための方法および製品 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007335135A Withdrawn JP2008101024A (ja) | 2001-11-20 | 2007-12-26 | オーラル・ケアのための方法および製品 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1482960A4 (enExample) |
| JP (2) | JP2005517636A (enExample) |
| AU (1) | AU2002348301B2 (enExample) |
| CA (1) | CA2467747A1 (enExample) |
| NZ (1) | NZ547077A (enExample) |
| WO (1) | WO2003043518A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220405B2 (en) * | 2003-09-08 | 2007-05-22 | E. I. Du Pont De Nemours And Company | Peptide-based conditioners and colorants for hair, skin, and nails |
| EP2151235B1 (de) * | 2008-07-21 | 2011-02-16 | Dr. Falk Pharma Gmbh | Pharmazeutische Formulierung zur Behandlung des oberen Verdauungstraktes |
| PH12013501078A1 (en) | 2010-12-20 | 2018-03-21 | Colgate Palmolive Co | Gelatin encapsulated oral care composition containing hydrophilic active hydrophobic structuring agent and oil carrier |
| US10946075B1 (en) * | 2014-03-15 | 2021-03-16 | Suzanne J Paxton-Pierson | Radioprotection, radiomitigation and radiorecovery |
| EP3944887A1 (de) * | 2020-07-31 | 2022-02-02 | Siemens Aktiengesellschaft | Fasermaterialverbund mit reaktiven sauerstoffspezies neutralisierendem bereich |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4461724A (en) * | 1981-10-28 | 1984-07-24 | Nippon Zoki Pharmaceutical Co., Ltd. | Peptide compounds, a process for manufacturing them, pharmaceutical compositions containing them, and methods for treating ulcer and thrombus with them |
| JPH08501779A (ja) * | 1992-09-15 | 1996-02-27 | クリエイティブ バイオモレキュルズ，インコーポレイテッド | モルフォゲン誘導歯周組織再生 |
| US5538945A (en) * | 1994-06-17 | 1996-07-23 | Procyte Corporation | Stimulation of hair growth by peptide copper complexes |
| AU770999C (en) * | 1999-10-01 | 2005-04-21 | Ampio Pharmaceuticals, Inc. | Metal-binding compounds and uses therefor |
| WO2002064620A2 (en) * | 2001-02-13 | 2002-08-22 | Dmi Biosciences, Inc. | Metal-binding compounds and uses therefor |
-
2002
- 2002-11-19 AU AU2002348301A patent/AU2002348301B2/en not_active Ceased
- 2002-11-19 NZ NZ547077A patent/NZ547077A/en not_active IP Right Cessation
- 2002-11-19 WO PCT/US2002/037136 patent/WO2003043518A2/en not_active Ceased
- 2002-11-19 EP EP02782326A patent/EP1482960A4/en not_active Withdrawn
- 2002-11-19 CA CA002467747A patent/CA2467747A1/en not_active Abandoned
- 2002-11-19 JP JP2003545202A patent/JP2005517636A/ja active Pending
-
2007
- 2007-12-26 JP JP2007335135A patent/JP2008101024A/ja not_active Withdrawn
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