JP2007533828A5 - - Google Patents
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- Publication number
- JP2007533828A5 JP2007533828A5 JP2007509542A JP2007509542A JP2007533828A5 JP 2007533828 A5 JP2007533828 A5 JP 2007533828A5 JP 2007509542 A JP2007509542 A JP 2007509542A JP 2007509542 A JP2007509542 A JP 2007509542A JP 2007533828 A5 JP2007533828 A5 JP 2007533828A5
- Authority
- JP
- Japan
- Prior art keywords
- dye
- donor
- acceptor
- cyanine
- xanthine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000975 dye Substances 0.000 claims 28
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 5
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims 4
- 229940075420 xanthine Drugs 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical compound C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 claims 2
- JKOCGAMDKVAHCI-UHFFFAOYSA-N 6,7-Benzocoumarin Chemical compound C1=CC=C2C=C(OC(=O)C=C3)C3=CC2=C1 JKOCGAMDKVAHCI-UHFFFAOYSA-N 0.000 claims 2
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 claims 2
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 claims 2
- 229960000956 coumarin Drugs 0.000 claims 2
- 235000001671 coumarin Nutrition 0.000 claims 2
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 claims 2
- 239000001022 rhodamine dye Substances 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56492404P | 2004-04-23 | 2004-04-23 | |
| US60/564,924 | 2004-04-23 | ||
| PCT/US2005/013141 WO2005108994A1 (en) | 2004-04-23 | 2005-04-18 | Fluorescence resonance energy transfer enzyme substrates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007533828A JP2007533828A (ja) | 2007-11-22 |
| JP2007533828A5 true JP2007533828A5 (enExample) | 2008-05-29 |
| JP4965434B2 JP4965434B2 (ja) | 2012-07-04 |
Family
ID=34966026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509542A Expired - Fee Related JP4965434B2 (ja) | 2004-04-23 | 2005-04-18 | 蛍光共鳴エネルギー移動酵素基質 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090162838A1 (enExample) |
| EP (1) | EP1738171B1 (enExample) |
| JP (1) | JP4965434B2 (enExample) |
| CN (1) | CN1985171B (enExample) |
| AT (1) | ATE428113T1 (enExample) |
| DE (1) | DE602005013757D1 (enExample) |
| ES (1) | ES2324721T3 (enExample) |
| WO (1) | WO2005108994A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0421693D0 (en) | 2004-09-30 | 2004-11-03 | Amersham Biosciences Uk Ltd | Method for measuring binding of a test compound to a G-protein coupled receptor |
| JP5541894B2 (ja) * | 2009-09-25 | 2014-07-09 | アイシン精機株式会社 | 色素およびその製造方法 |
| IT1405070B1 (it) * | 2010-10-14 | 2013-12-16 | Univ Bologna Alma Mater | Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile |
| CA2826238A1 (en) * | 2011-03-25 | 2012-10-04 | Almac Sciences (Scotland) Limited | Enzyme assays |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| CN104655596A (zh) * | 2013-11-18 | 2015-05-27 | 李捷 | 一种含红细胞血液样品的质量检测方法及检测试剂盒 |
| CN104109176B (zh) * | 2014-06-06 | 2016-07-06 | 浙江工业大学 | 一种化合物及其应用于碱性磷酸酶活性的荧光检测方法 |
| CN106405111A (zh) * | 2016-09-10 | 2017-02-15 | 天津大学 | 基于弹性蛋白酶荧光底物检测乳腺癌肿瘤标志物ca153的酶联免疫试剂盒制备方法 |
| WO2018159810A1 (ja) * | 2017-03-03 | 2018-09-07 | 国立大学法人東京大学 | アルカリフォスファターゼ検出用蛍光プローブ及びその使用 |
| EP3673076A4 (en) * | 2017-08-24 | 2021-05-26 | Commonwealth Scientific and Industrial Research Organisation | Bret sensor molecules for detecting hydrolases |
| CN116046735B (zh) * | 2022-12-26 | 2025-08-22 | 南京大学 | 一种利用染料组成的传感器阵列检测全氟化合物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795729A (en) * | 1996-02-05 | 1998-08-18 | Biometric Imaging, Inc. | Reductive, energy-transfer fluorogenic probes |
| GB0002261D0 (en) * | 2000-02-02 | 2000-03-22 | Amersham Pharm Biotech Uk Ltd | Fluorescent detection method & reagent |
| US20020168641A1 (en) * | 2001-03-09 | 2002-11-14 | Bruce Mortensen | Fluorescein-cyanine 5 as a fluorescence resonance energy transfer pair |
-
2005
- 2005-04-18 JP JP2007509542A patent/JP4965434B2/ja not_active Expired - Fee Related
- 2005-04-18 DE DE602005013757T patent/DE602005013757D1/de not_active Expired - Lifetime
- 2005-04-18 US US11/568,193 patent/US20090162838A1/en not_active Abandoned
- 2005-04-18 CN CN2005800199847A patent/CN1985171B/zh not_active Expired - Fee Related
- 2005-04-18 EP EP05736155A patent/EP1738171B1/en not_active Expired - Lifetime
- 2005-04-18 WO PCT/US2005/013141 patent/WO2005108994A1/en not_active Ceased
- 2005-04-18 AT AT05736155T patent/ATE428113T1/de not_active IP Right Cessation
- 2005-04-18 ES ES05736155T patent/ES2324721T3/es not_active Expired - Lifetime
-
2011
- 2011-07-15 US US13/183,518 patent/US20120208223A1/en not_active Abandoned
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