JP2007532479A - Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター - Google Patents

Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター Download PDF

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Publication number
JP2007532479A
JP2007532479A JP2006541606A JP2006541606A JP2007532479A JP 2007532479 A JP2007532479 A JP 2007532479A JP 2006541606 A JP2006541606 A JP 2006541606A JP 2006541606 A JP2006541606 A JP 2006541606A JP 2007532479 A JP2007532479 A JP 2007532479A
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pharmaceutical composition
alkyl
group
compound according
cycloalkyl
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Japanese (ja)
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JP2007532479A5 (enExample
Inventor
スリカンス ベンカトラマン，
ビョー エム． ギリジャバラバン，
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2007532479A publication Critical patent/JP2007532479A/ja
Publication of JP2007532479A5 publication Critical patent/JP2007532479A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2006541606A 2003-11-20 2004-11-19 Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター Pending JP2007532479A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52371503P 2003-11-20 2003-11-20
PCT/US2004/039131 WO2005051980A1 (en) 2003-11-20 2004-11-19 Depeptidized inhibitors of hepatitis c virus ns3 protease

Publications (2)

Publication Number Publication Date
JP2007532479A true JP2007532479A (ja) 2007-11-15
JP2007532479A5 JP2007532479A5 (enExample) 2007-12-27

Family

ID=34632818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006541606A Pending JP2007532479A (ja) 2003-11-20 2004-11-19 Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター

Country Status (7)

Country Link
US (2) US7253160B2 (enExample)
EP (1) EP1689770A1 (enExample)
JP (1) JP2007532479A (enExample)
CN (1) CN1902216A (enExample)
CA (1) CA2546290A1 (enExample)
MX (1) MXPA06005683A (enExample)
WO (1) WO2005051980A1 (enExample)

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CN1133649C (zh) 1996-10-18 2004-01-07 沃泰克斯药物股份有限公司 丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7176208B2 (en) 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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ES2572980T3 (es) * 2005-06-02 2016-06-03 Merck Sharp & Dohme Corp. Combinación de inhibidores de la proteasa del VHC con un tensioactivo
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
US8119602B2 (en) 2005-06-02 2012-02-21 Schering Corporation Administration of HCV protease inhibitors in combination with food to improve bioavailability
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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JP5755449B2 (ja) 2007-12-21 2015-07-29 セルジーン アビロミクス リサーチ， インコーポレイテッド Ｈｃｖプロテアーゼ阻害剤およびその使用
CN101951769B (zh) * 2007-12-21 2014-12-31 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
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Also Published As

Publication number Publication date
MXPA06005683A (es) 2006-12-14
CA2546290A1 (en) 2005-06-09
CN1902216A (zh) 2007-01-24
WO2005051980A8 (en) 2006-09-08
WO2005051980A1 (en) 2005-06-09
EP1689770A1 (en) 2006-08-16
US7442695B2 (en) 2008-10-28
US20070258947A1 (en) 2007-11-08
US20050164921A1 (en) 2005-07-28
US7253160B2 (en) 2007-08-07

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