CN1902216A - 丙肝病毒ns3蛋白酶的去肽化抑制剂 - Google Patents

丙肝病毒ns3蛋白酶的去肽化抑制剂 Download PDF

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Publication number
CN1902216A
CN1902216A CNA2004800399478A CN200480039947A CN1902216A CN 1902216 A CN1902216 A CN 1902216A CN A2004800399478 A CNA2004800399478 A CN A2004800399478A CN 200480039947 A CN200480039947 A CN 200480039947A CN 1902216 A CN1902216 A CN 1902216A
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CN
China
Prior art keywords
compound
alkyl
pharmaceutical composition
cycloalkyl
aryl
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Pending
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CNA2004800399478A
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English (en)
Chinese (zh)
Inventor
S·文卡特拉曼
V·M·吉里加瓦拉布汉
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Merck Sharp & Dohme LLC
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Schering Corp
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Publication of CN1902216A publication Critical patent/CN1902216A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2004800399478A 2003-11-20 2004-11-19 丙肝病毒ns3蛋白酶的去肽化抑制剂 Pending CN1902216A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52371503P 2003-11-20 2003-11-20
US60/523,715 2003-11-20

Publications (1)

Publication Number Publication Date
CN1902216A true CN1902216A (zh) 2007-01-24

Family

ID=34632818

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800399478A Pending CN1902216A (zh) 2003-11-20 2004-11-19 丙肝病毒ns3蛋白酶的去肽化抑制剂

Country Status (7)

Country Link
US (2) US7253160B2 (enExample)
EP (1) EP1689770A1 (enExample)
JP (1) JP2007532479A (enExample)
CN (1) CN1902216A (enExample)
CA (1) CA2546290A1 (enExample)
MX (1) MXPA06005683A (enExample)
WO (1) WO2005051980A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951769A (zh) * 2007-12-21 2011-01-19 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途

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Publication number Priority date Publication date Assignee Title
CN101951769A (zh) * 2007-12-21 2011-01-19 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
CN101951769B (zh) * 2007-12-21 2014-12-31 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
US9676785B2 (en) 2007-12-21 2017-06-13 Celgene Car Llc HCV protease inhibitors and uses thereof

Also Published As

Publication number Publication date
CA2546290A1 (en) 2005-06-09
WO2005051980A8 (en) 2006-09-08
US20050164921A1 (en) 2005-07-28
EP1689770A1 (en) 2006-08-16
JP2007532479A (ja) 2007-11-15
WO2005051980A1 (en) 2005-06-09
US7442695B2 (en) 2008-10-28
US7253160B2 (en) 2007-08-07
MXPA06005683A (es) 2006-12-14
US20070258947A1 (en) 2007-11-08

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