JP2007530671A5 - - Google Patents
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- JP2007530671A5 JP2007530671A5 JP2007506106A JP2007506106A JP2007530671A5 JP 2007530671 A5 JP2007530671 A5 JP 2007530671A5 JP 2007506106 A JP2007506106 A JP 2007506106A JP 2007506106 A JP2007506106 A JP 2007506106A JP 2007530671 A5 JP2007530671 A5 JP 2007530671A5
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- 239000000203 mixture Substances 0.000 claims description 26
- 238000009472 formulation Methods 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 7
- 230000005520 electrodynamics Effects 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 229940112141 dry powder inhaler Drugs 0.000 claims 9
- 239000004480 active ingredient Substances 0.000 claims 8
- 230000004888 barrier function Effects 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 238000007789 sealing Methods 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000013583 drug formulation Substances 0.000 claims 4
- 230000005684 electric field Effects 0.000 claims 4
- 239000011888 foil Substances 0.000 claims 4
- 230000000144 pharmacologic effect Effects 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000007774 longterm Effects 0.000 claims 3
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- 229920001184 polypeptide Polymers 0.000 claims 3
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 2
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- 229920002307 Dextran Polymers 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
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- 229930195725 Mannitol Natural products 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 2
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- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
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- 239000002622 gonadotropin Substances 0.000 claims 2
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- 150000002500 ions Chemical class 0.000 claims 2
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229960001021 lactose monohydrate Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 238000000465 moulding Methods 0.000 claims 2
- -1 opiates Chemical compound 0.000 claims 2
- 239000002831 pharmacologic agent Substances 0.000 claims 2
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- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229960002052 salbutamol Drugs 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 229960004793 sucrose Drugs 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- WSVLPVUVIUVCRA-RJMJUYIDSA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[(2r,3s,4r,5r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate Chemical class O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-RJMJUYIDSA-N 0.000 claims 1
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims 1
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- 102000055006 Calcitonin Human genes 0.000 claims 1
- 108060001064 Calcitonin Proteins 0.000 claims 1
- 102400000739 Corticotropin Human genes 0.000 claims 1
- 101800000414 Corticotropin Proteins 0.000 claims 1
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 claims 1
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims 1
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 claims 1
- 102000009025 Endorphins Human genes 0.000 claims 1
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- 102000004190 Enzymes Human genes 0.000 claims 1
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- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 1
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- 108010088406 Glucagon-Like Peptides Proteins 0.000 claims 1
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- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
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- 229960002646 scopolamine Drugs 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
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- 239000005720 sucrose Substances 0.000 claims 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims 1
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- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims 1
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| SE0400844A SE528121C2 (sv) | 2004-03-29 | 2004-03-29 | Preparering av torrpulver för på förhand uppmätt DPI |
| PCT/SE2005/000418 WO2005092289A1 (en) | 2004-03-29 | 2005-03-23 | Dry powder preparations for pre-metered dpi |
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| JP2007530671A JP2007530671A (ja) | 2007-11-01 |
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| GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| EP2402001A1 (en) * | 2005-05-18 | 2012-01-04 | Pulmatrix, Inc. | Formulations for alteration of biophysical properties of mucosal lining |
| US20070101991A1 (en) * | 2005-11-08 | 2007-05-10 | Mederio Ag | Optimizing release of dry medicament powder |
| DK1947010T3 (da) * | 2005-11-21 | 2010-05-17 | Mannkind Corp | Pulverdoserings- og affølingsapparatur samt fremgagnsmåder |
| GB0616299D0 (en) * | 2006-08-16 | 2006-09-27 | Cambridge Consultants | Drug Capsules for dry power inhalers |
| US7908992B2 (en) * | 2007-01-09 | 2011-03-22 | R.P. Scherer Technologies, Llc | System and method for dusting soft capsules |
| CA2728808A1 (en) * | 2008-02-01 | 2009-08-06 | Vectura Limited | Pulmonary formulations of triptans |
| PL2334560T3 (pl) | 2008-08-05 | 2014-04-30 | Mannkind Corp | Moduły dozownika proszku i zespoły dozownika proszku |
| CA2754691C (en) | 2009-03-26 | 2019-07-30 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| GB0905840D0 (en) * | 2009-04-06 | 2009-05-20 | Sagentia Ltd | Apparatus and methods |
| EP2464346A1 (en) | 2010-08-30 | 2012-06-20 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| AU2011296343B2 (en) | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| RU2017144619A (ru) | 2010-09-29 | 2019-02-20 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| EP3470057B1 (en) | 2010-09-29 | 2021-11-03 | Pulmatrix Operating Company, Inc. | Cationic dry powders comprising magnesium salt |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| WO2014007772A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising glucose anhydrous |
| WO2014007771A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising muscarinic receptor antagonist |
| WO2014007770A2 (en) * | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising corticosteroid and sorbitol |
| JP6473738B2 (ja) | 2013-04-01 | 2019-02-20 | パルマトリックス，インコーポレイテッド | チオトロピウム乾燥粉末 |
| CN103287602A (zh) * | 2013-06-27 | 2013-09-11 | 顺天保暖制品（昆山）有限公司 | 一种包装机上的分体式量杯 |
| CN105828819A (zh) * | 2014-04-08 | 2016-08-03 | 桑萨（巴巴多斯）公司 | 烟碱制剂及其制备方法 |
| WO2016067252A1 (en) | 2014-10-31 | 2016-05-06 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| US20170071248A1 (en) * | 2015-09-16 | 2017-03-16 | Sansa Corporation (Barbados) Inc. | System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US9585835B1 (en) | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| EP3327409B1 (en) * | 2016-11-29 | 2019-09-11 | Mettler-Toledo GmbH | Automated dosage-dispensing system for powdery substances, and method of ascertaining that the system is ready for operation |
| US20200276087A1 (en) * | 2017-09-21 | 2020-09-03 | Hoffmann-La Roche Inc. | Pharmaceutical manufacturing installation and method of manufacturing of a pharmaceutical product |
| CA3075720A1 (en) * | 2017-10-02 | 2019-04-11 | Novartis Ag | Method for preparing a pharmaceutical product |
| CN121221570A (zh) * | 2019-11-06 | 2025-12-30 | 曼金德公司 | 氯法齐明的组合物，含它们的组合，它们的制备方法，含它们的用途和治疗方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9911770D0 (en) * | 1999-05-21 | 1999-07-21 | Glaxo Group Ltd | Powder loading method |
| US3860618A (en) * | 1967-08-08 | 1975-01-14 | Philip Saxton Hartley | Chromone |
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| US6536427B2 (en) * | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| US6794357B1 (en) * | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| SK283569B6 (sk) * | 1993-10-01 | 2003-09-11 | Astra Aktiebolag | Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom |
| SE9400462D0 (sv) * | 1994-02-11 | 1994-02-11 | Astra Ab | Filling device |
| DK0969816T3 (da) * | 1997-03-20 | 2005-03-14 | Schering Corp | Fremstilling af pulveragglomerater |
| HUP0203626A2 (en) * | 1999-10-11 | 2003-02-28 | Ml Lab Plc | Medicament delivery device with moisture resistant coating |
| DE60025019T2 (de) * | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| ES2525087T5 (es) * | 2000-05-10 | 2018-06-28 | Novartis Ag | Polvos basados en fosfolípidos para administración de fármacos |
| GB0014082D0 (en) * | 2000-06-10 | 2000-08-02 | Glaxo Group Ltd | Method and apparatus for transferring a defined quantity of powder |
| SE516554C2 (sv) * | 2000-08-31 | 2002-01-29 | Microdrug Ag | Uppmätt elektrodos |
| SE517227C2 (sv) * | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator för torrt pulver med folieskärare |
| SE522558C2 (sv) * | 2001-07-13 | 2004-02-17 | Microdrug Ag | Förfarande och anordning för styrning av överföring av elektriskt laddade partiklar av ett medicinskt pulver till en målarea på ett substratelement vid en dosutformningsprocess |
| US7931022B2 (en) * | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
| GB0202912D0 (en) * | 2002-02-07 | 2002-03-27 | Meridica Ltd | Method and apparatus for introducing powder into a pocket |
| SE524990C2 (sv) * | 2002-04-12 | 2004-11-09 | Microdrug Ag | Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver |
| GB0225621D0 (en) * | 2002-11-02 | 2002-12-11 | Glaxo Group Ltd | Medicament carrier |
-
2004
- 2004-03-29 SE SE0400844A patent/SE528121C2/sv not_active IP Right Cessation
-
2005
- 2005-03-22 US US11/085,523 patent/US20050211244A1/en not_active Abandoned
- 2005-03-23 ES ES05722259T patent/ES2311217T3/es not_active Expired - Lifetime
- 2005-03-23 WO PCT/SE2005/000418 patent/WO2005092289A1/en not_active Ceased
- 2005-03-23 ZA ZA200606963A patent/ZA200606963B/en unknown
- 2005-03-23 DK DK05722259T patent/DK1732515T3/da active
- 2005-03-23 RU RU2006131829/15A patent/RU2006131829A/ru not_active Application Discontinuation
- 2005-03-23 MX MXPA06009286A patent/MXPA06009286A/es not_active Application Discontinuation
- 2005-03-23 EP EP05722259A patent/EP1732515B1/en not_active Revoked
- 2005-03-23 JP JP2007506106A patent/JP2007530671A/ja active Pending
- 2005-03-23 AT AT05722259T patent/ATE399534T1/de not_active IP Right Cessation
- 2005-03-23 AU AU2005225335A patent/AU2005225335A1/en not_active Abandoned
- 2005-03-23 DE DE602005007876T patent/DE602005007876D1/de not_active Expired - Fee Related
- 2005-03-23 CN CN200580009403.1A patent/CN1933815A/zh active Pending
- 2005-03-23 CA CA002556443A patent/CA2556443A1/en not_active Abandoned
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