JP2007530622A5 - - Google Patents
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- Publication number
- JP2007530622A5 JP2007530622A5 JP2007505480A JP2007505480A JP2007530622A5 JP 2007530622 A5 JP2007530622 A5 JP 2007530622A5 JP 2007505480 A JP2007505480 A JP 2007505480A JP 2007505480 A JP2007505480 A JP 2007505480A JP 2007530622 A5 JP2007530622 A5 JP 2007530622A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- tinnitus
- drug
- preventing
- tinnitus according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000009205 Tinnitus Diseases 0.000 claims 21
- 231100000886 tinnitus Toxicity 0.000 claims 21
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 210000003027 ear inner Anatomy 0.000 claims 8
- 206010029350 Neurotoxicity Diseases 0.000 claims 5
- 206010044221 Toxic encephalopathy Diseases 0.000 claims 5
- 231100000228 neurotoxicity Toxicity 0.000 claims 5
- 230000007135 neurotoxicity Effects 0.000 claims 5
- 210000003477 cochlea Anatomy 0.000 claims 4
- 230000002964 excitative effect Effects 0.000 claims 3
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 210000000860 cochlear nerve Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical group C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 1
- 206010036626 Presbyacusis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 230000003492 excitotoxic effect Effects 0.000 claims 1
- 231100000063 excitotoxicity Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 229960003299 ketamine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 231100000189 neurotoxic Toxicity 0.000 claims 1
- 230000002887 neurotoxic effect Effects 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 230000008736 traumatic injury Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/812,298 US8268866B2 (en) | 2004-03-29 | 2004-03-29 | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US10/812,298 | 2004-03-29 | ||
| PCT/EP2005/003254 WO2005094799A2 (en) | 2004-03-29 | 2005-03-29 | Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011013018A Division JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530622A JP2007530622A (ja) | 2007-11-01 |
| JP2007530622A5 true JP2007530622A5 (enExample) | 2008-01-24 |
| JP4927706B2 JP4927706B2 (ja) | 2012-05-09 |
Family
ID=34966520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505480A Expired - Fee Related JP4927706B2 (ja) | 2004-03-29 | 2005-03-29 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
| JP2011013018A Pending JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011013018A Pending JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8268866B2 (enExample) |
| EP (2) | EP1729753B1 (enExample) |
| JP (2) | JP4927706B2 (enExample) |
| KR (2) | KR101451414B1 (enExample) |
| CN (2) | CN1972677B (enExample) |
| AU (1) | AU2005229543B2 (enExample) |
| BR (1) | BRPI0508251A (enExample) |
| CA (1) | CA2558896C (enExample) |
| CY (1) | CY1110495T1 (enExample) |
| DE (1) | DE602005015562D1 (enExample) |
| DK (1) | DK1729753T3 (enExample) |
| ES (1) | ES2330350T3 (enExample) |
| IL (1) | IL177490A (enExample) |
| MX (1) | MXPA06011078A (enExample) |
| NZ (1) | NZ549399A (enExample) |
| PL (1) | PL1729753T3 (enExample) |
| PT (1) | PT1729753E (enExample) |
| RU (1) | RU2380094C2 (enExample) |
| SI (1) | SI1729753T1 (enExample) |
| WO (1) | WO2005094799A2 (enExample) |
| ZA (1) | ZA200607161B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8268866B2 (en) * | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| EP1861104A4 (en) * | 2005-03-04 | 2011-12-14 | Neurosystec Corp | IMPROVED GACYCLIDINE FORMULATIONS |
| EA017264B1 (ru) * | 2005-09-28 | 2012-11-30 | Аурис Медикаль Аг | Применение композиции арилциклоалкиламида для получения лекарственного препарата для лечения нарушения внутреннего уха |
| US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
| US8175712B2 (en) * | 2006-09-05 | 2012-05-08 | The Penn State Research Foundation | Homotopic conditioning of the brain stem baroreflex of a subject |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| BRPI0910850B1 (pt) | 2008-04-21 | 2022-06-14 | Otonomy, Inc. | Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva |
| BRPI0912482A2 (pt) | 2008-05-14 | 2020-08-18 | Otonomy, Inc | composições de corticosteróide de liberação controlada e métodos para o tratamento de distúrbios auriculares |
| US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| US8349353B2 (en) * | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| US20100016218A1 (en) * | 2008-07-14 | 2010-01-21 | Otonomy, Inc. | Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders |
| WO2010011605A2 (en) * | 2008-07-21 | 2010-01-28 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
| US8399018B2 (en) * | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| US8496957B2 (en) * | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| CA2751761A1 (en) | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| CN106344495A (zh) * | 2008-12-22 | 2017-01-25 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放耳感觉细胞调节剂组合物 |
| EP2665474A1 (en) * | 2011-01-20 | 2013-11-27 | Merz Pharma GmbH & Co. KGaA | Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss |
| CA2849085C (en) | 2011-12-12 | 2019-10-01 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
| JP2016534121A (ja) | 2013-08-27 | 2016-11-04 | オトノミ—，インク． | 小児の耳の病気の処置 |
| EP3139744A4 (en) * | 2014-04-23 | 2017-12-20 | Auris Medical AG | Methods and compositions for treating and preventing tinnitus |
| US11207316B2 (en) | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
| CA3029281A1 (en) | 2016-06-29 | 2018-01-04 | Otonomy, Inc. | Triglyceride otic formulations and uses thereof |
| WO2018053173A1 (en) | 2016-09-16 | 2018-03-22 | Otonomy, Inc. | Otic gel formulations for treating otitis externa |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
| CH535201A (de) | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
| AU5171293A (en) * | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| US5421818A (en) * | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
| USRE38115E1 (en) * | 1994-09-22 | 2003-05-06 | Center For Neurologic Study | Dextromethorphan and an oxidase inhibitor for treating intractable conditions |
| US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
| US5654337A (en) * | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| DE19528388A1 (de) * | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| TW450807B (en) | 1995-09-15 | 2001-08-21 | Pfizer | Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents |
| US5746961A (en) * | 1995-12-04 | 1998-05-05 | Michael J. Stevenson | Method for enhancement of the surfaces of molded plastic products |
| WO1997038698A1 (en) | 1996-04-18 | 1997-10-23 | University Technology Corporation | Methods for treating middle and inner ear disorders |
| WO1998010757A2 (en) | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | The use of functional n-methyl-d-aspartate antagonists to ameliorate or prevent aminoglycoside-induced ototoxicity |
| US6045528A (en) * | 1997-06-13 | 2000-04-04 | Intraear, Inc. | Inner ear fluid transfer and diagnostic system |
| US6309410B1 (en) * | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
| DE19853299C2 (de) * | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
| US6120484A (en) * | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
| US6017961A (en) * | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
| DE19936719A1 (de) | 1999-08-06 | 2001-02-15 | Gruenenthal Gmbh | Substituierte 1,5-Dihydropyrrol-2-on-Derivate |
| US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
| JP2001187737A (ja) | 1999-10-18 | 2001-07-10 | Toyama Chem Co Ltd | 聴力改善剤 |
| DE10025238A1 (de) | 2000-05-22 | 2001-11-29 | Gruenenthal Gmbh | Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel |
| BRPI0002693B8 (pt) | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
| DE10048969A1 (de) | 2000-08-23 | 2002-03-14 | Mueller Schwefe Gerhard | Verwendung von Flupirtin zur Tinnitusbehandlung |
| DE10044649A1 (de) | 2000-09-08 | 2002-07-04 | Gruenenthal Gmbh | Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine |
| US6924273B2 (en) * | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
| DE10124953A1 (de) | 2001-05-21 | 2002-12-12 | Marlies Knipper | Substanz für die therapeutische Behandlung von Tinnitus |
| US6638981B2 (en) * | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| US20030143195A1 (en) * | 2002-01-30 | 2003-07-31 | Pinsker Judy Senior | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
| US6638081B2 (en) * | 2002-03-22 | 2003-10-28 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector |
| CA2497867A1 (en) | 2002-09-06 | 2004-03-18 | Durect Corporation | Delivery of modulators of glutamate-mediated neurotransmission to the inner ear |
| US6969383B2 (en) * | 2002-09-27 | 2005-11-29 | Medtronic, Inc. | Method for treating severe tinnitus |
| US6656172B1 (en) * | 2002-09-27 | 2003-12-02 | Medtronic, Inc. | Method for treating severe tinnitus |
| WO2004043902A1 (de) | 2002-11-12 | 2004-05-27 | Grünenthal GmbH | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| EP1438942A1 (en) | 2003-01-17 | 2004-07-21 | Schering Oy | An otorhinological drug delivery device |
| CN100581621C (zh) | 2003-05-16 | 2010-01-20 | 拉瓦勒大学 | Cns氯化物调节及其用途 |
| WO2005055921A2 (en) | 2003-12-12 | 2005-06-23 | Eran Eilat | Compositions for treatment of ear disorders and methods of use thereof |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
-
2004
- 2004-03-29 US US10/812,298 patent/US8268866B2/en not_active Expired - Fee Related
-
2005
- 2005-03-29 SI SI200530751T patent/SI1729753T1/sl unknown
- 2005-03-29 CN CN200580009886.5A patent/CN1972677B/zh not_active Expired - Fee Related
- 2005-03-29 EP EP05736619A patent/EP1729753B1/en not_active Expired - Lifetime
- 2005-03-29 MX MXPA06011078A patent/MXPA06011078A/es active IP Right Grant
- 2005-03-29 KR KR1020137020276A patent/KR101451414B1/ko not_active Expired - Fee Related
- 2005-03-29 BR BRPI0508251-0A patent/BRPI0508251A/pt not_active Application Discontinuation
- 2005-03-29 PL PL05736619T patent/PL1729753T3/pl unknown
- 2005-03-29 WO PCT/EP2005/003254 patent/WO2005094799A2/en not_active Ceased
- 2005-03-29 JP JP2007505480A patent/JP4927706B2/ja not_active Expired - Fee Related
- 2005-03-29 DE DE602005015562T patent/DE602005015562D1/de not_active Expired - Lifetime
- 2005-03-29 RU RU2006138153/14A patent/RU2380094C2/ru active
- 2005-03-29 ES ES05736619T patent/ES2330350T3/es not_active Expired - Lifetime
- 2005-03-29 ZA ZA200607161A patent/ZA200607161B/en unknown
- 2005-03-29 KR KR1020127007363A patent/KR101429735B1/ko not_active Expired - Fee Related
- 2005-03-29 NZ NZ549399A patent/NZ549399A/en not_active IP Right Cessation
- 2005-03-29 PT PT05736619T patent/PT1729753E/pt unknown
- 2005-03-29 AU AU2005229543A patent/AU2005229543B2/en not_active Ceased
- 2005-03-29 CA CA2558896A patent/CA2558896C/en not_active Expired - Lifetime
- 2005-03-29 DK DK05736619T patent/DK1729753T3/da active
- 2005-03-29 EP EP09005167A patent/EP2077108A1/en not_active Withdrawn
- 2005-03-29 CN CN201510076933.3A patent/CN104906079B/zh not_active Expired - Fee Related
-
2006
- 2006-08-15 IL IL177490A patent/IL177490A/en active IP Right Grant
-
2009
- 2009-09-10 CY CY20091100944T patent/CY1110495T1/el unknown
-
2011
- 2011-01-25 JP JP2011013018A patent/JP2011105740A/ja active Pending
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