JP2007530601A5 - - Google Patents
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- Publication number
- JP2007530601A5 JP2007530601A5 JP2007505341A JP2007505341A JP2007530601A5 JP 2007530601 A5 JP2007530601 A5 JP 2007530601A5 JP 2007505341 A JP2007505341 A JP 2007505341A JP 2007505341 A JP2007505341 A JP 2007505341A JP 2007530601 A5 JP2007530601 A5 JP 2007530601A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- optionally substituted
- alkyl
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 52
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 230000004770 neurodegeneration Effects 0.000 claims 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims 5
- 230000000926 neurological effect Effects 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000012440 Acetylcholinesterase Human genes 0.000 claims 2
- 108010022752 Acetylcholinesterase Proteins 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 229940022698 acetylcholinesterase Drugs 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 2
- 230000001076 estrogenic effect Effects 0.000 claims 2
- 208000015756 familial Alzheimer disease Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000006396 nitration reaction Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000018282 ACys amyloidosis Diseases 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims 1
- 208000032849 Hereditary cerebral hemorrhage with amyloidosis Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000034799 Tauopathies Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000001896 anti-amyloidogenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000006999 cognitive decline Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 238000006193 diazotization reaction Methods 0.000 claims 1
- -1 halo compound Chemical class 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 230000000324 neuroprotective effect Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2004901804A AU2004901804A0 (en) | 2004-04-02 | Neurologically-active compounds | |
| AU2004901802A AU2004901802A0 (en) | 2004-04-02 | Process for the preparation of intermediates | |
| AU2004901804 | 2004-04-02 | ||
| AU2004901802 | 2004-04-02 | ||
| AU2004907359A AU2004907359A0 (en) | 2004-12-24 | Neurologically-active compounds | |
| AU2004907359 | 2004-12-24 | ||
| PCT/AU2005/000477 WO2005095360A1 (en) | 2004-04-02 | 2005-04-01 | Neurologically-active compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530601A JP2007530601A (ja) | 2007-11-01 |
| JP2007530601A5 true JP2007530601A5 (OSRAM) | 2009-06-25 |
| JP4937111B2 JP4937111B2 (ja) | 2012-05-23 |
Family
ID=35063693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505341A Expired - Fee Related JP4937111B2 (ja) | 2004-04-02 | 2005-04-01 | 神経学的に活性な化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8084459B2 (OSRAM) |
| EP (1) | EP1737831B1 (OSRAM) |
| JP (1) | JP4937111B2 (OSRAM) |
| BR (1) | BRPI0508183B8 (OSRAM) |
| CA (1) | CA2563038C (OSRAM) |
| DK (1) | DK1737831T3 (OSRAM) |
| ES (1) | ES2425476T3 (OSRAM) |
| IL (1) | IL178330A (OSRAM) |
| MX (1) | MXPA06011236A (OSRAM) |
| NZ (1) | NZ551004A (OSRAM) |
| WO (1) | WO2005095360A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1558585B1 (en) * | 2002-10-04 | 2013-09-25 | Prana Biotechnology Limited | Neurologically-active compounds |
| CA2563038C (en) | 2004-04-02 | 2013-10-29 | Gaik Beng Kok | Neurologically-active compounds |
| JP5302012B2 (ja) * | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| NZ572591A (en) * | 2006-04-14 | 2012-01-12 | Prana Biotechnology Ltd | 3N-substituted 8-hydroxy-quinazolin-4-ones |
| JP4876690B2 (ja) * | 2006-04-21 | 2012-02-15 | 三菱瓦斯化学株式会社 | キナゾリン−４−オン誘導体の製造法 |
| CA2687750C (en) * | 2007-07-06 | 2016-10-18 | Boehringer Ingelheim International Gmbh | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
| CA2704710C (en) * | 2007-09-26 | 2016-02-02 | Celgene Corporation | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising the same |
| ES2634492T3 (es) | 2008-12-24 | 2017-09-28 | Prana Biotechnology Ltd | Compuestos de quinazolinona |
| US8592485B2 (en) * | 2010-06-17 | 2013-11-26 | Healthpartners Research Foundation | Methods and pharmaceutical compositions for treating the animal central nervous system for psychiatric disorders |
| WO2012066330A1 (en) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Compounds useful as a2a receptor inhibitors |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| US8877766B2 (en) * | 2013-02-15 | 2014-11-04 | Peter F. Kador | Neuroprotective multifunctional antioxidants and their monofunctional analogs |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| EP3253738A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| WO2016126935A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| US10781178B2 (en) | 2015-08-12 | 2020-09-22 | The General Hospital Corporation | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents |
| CA3077267C (en) | 2017-09-28 | 2021-02-16 | Cstone Pharmaceuticals (Suzhou) Co., Ltd. | Fused heteroaryl ring derivatives useful as a2a receptor inhibitor |
| CN110330487B (zh) * | 2019-07-31 | 2023-03-24 | 西南大学 | 喹唑酮噻唑化合物及其制备方法和应用 |
| CU20220065A7 (es) | 2020-05-04 | 2023-06-13 | Amgen Inc | Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2 |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| IL308167A (en) * | 2021-05-04 | 2023-12-01 | Vigil Neuroscience Inc | Heterocyclic compounds as agonists for an excitatory receptor expressed on myeloid cells 2 and methods of use |
| WO2023086801A1 (en) * | 2021-11-09 | 2023-05-19 | Vigil Neuroscience, Inc. | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
| US20250042897A1 (en) * | 2021-11-09 | 2025-02-06 | Vigil Neuroscience, Inc. | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
| WO2025059726A1 (en) * | 2023-09-22 | 2025-03-27 | Alterity Therapeutics Limited | Novel therapy |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE505711A (OSRAM) * | 1950-09-09 | |||
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| AU4858596A (en) | 1995-09-15 | 1997-04-01 | Torrey Pines Institute For Molecular Studies | Synthesis of quinazolinone libraries |
| WO1998021186A1 (en) | 1996-11-13 | 1998-05-22 | Cephalon, Inc. | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors |
| AU5380398A (en) | 1996-12-17 | 1998-07-15 | E.I. Du Pont De Nemours And Company | Fungicidal quinazolinones |
| US6337332B1 (en) * | 1998-09-17 | 2002-01-08 | Pfizer Inc. | Neuropeptide Y receptor antagonists |
| EP1123274B1 (en) * | 1998-10-22 | 2004-12-29 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| US6559160B1 (en) | 1999-08-27 | 2003-05-06 | Chemocentryx, Inc. | Compounds and methods for modulating cxcr3 function |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| EP1686120A3 (en) | 1999-10-27 | 2007-05-30 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| EP1278748B1 (en) | 2000-04-25 | 2011-03-23 | ICOS Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| WO2002048115A2 (en) | 2000-12-11 | 2002-06-20 | E. I. Du Pont De Nemours And Company | Quinazolinones and pyridinopyrimidinones for controlling invertebrate pests |
| WO2003039460A2 (en) | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US7053216B2 (en) | 2001-11-19 | 2006-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of Rho C activity |
| WO2003043995A1 (en) | 2001-11-20 | 2003-05-30 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| WO2003070701A2 (en) | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Syntheses of quinazolinones |
| AU2003228283A1 (en) * | 2002-03-07 | 2003-09-22 | X-Ceptor Therapeutics, Inc. | Quinazolinone modulators of nuclear receptors |
| EP1513534A2 (en) | 2002-04-04 | 2005-03-16 | Cv Therapeutics, Inc. | Compounds for increasing abca-1 expression useful for treating coronary artery disease and atherosclerosis |
| AU2002950217A0 (en) * | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| AU2003262747A1 (en) * | 2002-08-21 | 2004-03-11 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| EP1558585B1 (en) | 2002-10-04 | 2013-09-25 | Prana Biotechnology Limited | Neurologically-active compounds |
| US9301829B2 (en) | 2003-07-30 | 2016-04-05 | Boston Scientific Scimed, Inc. | Embolic protection aspirator |
| US20050054614A1 (en) | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| US20050043239A1 (en) * | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
| US7939539B2 (en) | 2003-11-25 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Quinazolinone compounds as anticancer agents |
| US20050239809A1 (en) | 2004-01-08 | 2005-10-27 | Watts Stephanie W | Methods for treating and preventing hypertension and hypertension-related disorders |
| CA2563038C (en) | 2004-04-02 | 2013-10-29 | Gaik Beng Kok | Neurologically-active compounds |
| CA2566436C (en) | 2004-05-13 | 2011-05-10 | Vanderbilt University | Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis |
| JPWO2005115993A1 (ja) | 2004-05-31 | 2008-03-27 | 萬有製薬株式会社 | キナゾリン誘導体 |
| WO2005120511A1 (en) | 2004-06-04 | 2005-12-22 | Icos Corporation | Methods for treating mast cell disorders |
| US20050282834A1 (en) * | 2004-06-09 | 2005-12-22 | Fady Malik | Compositions, devices and methods for treating cardiovascular disease |
-
2005
- 2005-04-01 CA CA2563038A patent/CA2563038C/en not_active Expired - Lifetime
- 2005-04-01 US US11/547,056 patent/US8084459B2/en not_active Expired - Lifetime
- 2005-04-01 BR BRPI0508183A patent/BRPI0508183B8/pt not_active IP Right Cessation
- 2005-04-01 JP JP2007505341A patent/JP4937111B2/ja not_active Expired - Fee Related
- 2005-04-01 EP EP05714346.3A patent/EP1737831B1/en not_active Expired - Lifetime
- 2005-04-01 MX MXPA06011236A patent/MXPA06011236A/es active IP Right Grant
- 2005-04-01 WO PCT/AU2005/000477 patent/WO2005095360A1/en not_active Ceased
- 2005-04-01 DK DK05714346.3T patent/DK1737831T3/da active
- 2005-04-01 ES ES05714346T patent/ES2425476T3/es not_active Expired - Lifetime
- 2005-04-01 NZ NZ551004A patent/NZ551004A/en not_active IP Right Cessation
-
2006
- 2006-09-27 IL IL178330A patent/IL178330A/en active IP Right Grant
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