JP2007530462A - 血清に安定な両性リポソーム - Google Patents
血清に安定な両性リポソーム Download PDFInfo
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- JP2007530462A JP2007530462A JP2007504251A JP2007504251A JP2007530462A JP 2007530462 A JP2007530462 A JP 2007530462A JP 2007504251 A JP2007504251 A JP 2007504251A JP 2007504251 A JP2007504251 A JP 2007504251A JP 2007530462 A JP2007530462 A JP 2007530462A
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- Prior art keywords
- liposome
- preparation according
- chol
- molar composition
- membrane
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- 210000002966 serum Anatomy 0.000 title abstract description 32
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- 238000009472 formulation Methods 0.000 claims abstract description 26
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- 238000002360 preparation method Methods 0.000 claims description 46
- 150000002632 lipids Chemical class 0.000 claims description 40
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 31
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims description 22
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 17
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 16
- 235000012000 cholesterol Nutrition 0.000 claims description 15
- 125000002091 cationic group Chemical group 0.000 claims description 11
- 125000000129 anionic group Chemical group 0.000 claims description 10
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- 230000003834 intracellular effect Effects 0.000 abstract description 5
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
- 229930006000 Sucrose Natural products 0.000 description 9
- -1 cationic lipid Chemical class 0.000 description 9
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 9
- 239000005720 sucrose Substances 0.000 description 9
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 8
- HIHOWBSBBDRPDW-PTHRTHQKSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate Chemical compound C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HIHOWBSBBDRPDW-PTHRTHQKSA-N 0.000 description 8
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
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- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| DE200410016020 DE102004016020A1 (de) | 2004-03-28 | 2004-03-28 | Serumstabile amphotere Liposomen |
| DE102004054730A DE102004054730A1 (de) | 2004-03-28 | 2004-11-05 | Serumstabile amphotere Liposomen |
| PCT/DE2005/000589 WO2005094783A2 (de) | 2004-03-28 | 2005-03-29 | Serumstabile amphotere liposomen |
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| JP2007530462A true JP2007530462A (ja) | 2007-11-01 |
| JP2007530462A5 JP2007530462A5 (enExample) | 2008-05-15 |
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| DE (1) | DE102004054730A1 (enExample) |
| WO (1) | WO2005094783A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019027055A1 (ja) * | 2017-08-04 | 2019-02-07 | 協和発酵キリン株式会社 | 核酸含有脂質ナノ粒子 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498315B2 (en) * | 2004-06-01 | 2009-03-03 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| JP2008518998A (ja) * | 2004-11-05 | 2008-06-05 | ノヴォソム アクチェンゲゼルシャフト | 活性物質としてオリゴヌクレオチドを含む医薬組成物におけるまたはそれに関する改善 |
| EP1764090A1 (en) * | 2005-09-15 | 2007-03-21 | Novosom AG | Amphoteric liposomes for local drug applications |
| US20060159737A1 (en) * | 2004-11-19 | 2006-07-20 | Steffen Panzner | Pharmaceutical compositions for local administration |
| US8017159B2 (en) * | 2005-11-16 | 2011-09-13 | Idexx Laboratories, Inc. | Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same |
| US8367628B2 (en) * | 2005-12-01 | 2013-02-05 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| EP3000480A1 (en) | 2005-12-01 | 2016-03-30 | ProNAi Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
| EP2004141A2 (en) * | 2006-03-17 | 2008-12-24 | Novosom AG | An efficient method for loading amphoteric liposomes with nucleic acid active substances |
| EP2094238A2 (en) * | 2006-10-13 | 2009-09-02 | Novosom AG | Improvements in or relating to amphoteric liposomes |
| JP5711535B2 (ja) * | 2007-10-12 | 2015-05-07 | マリーナ バイオテック，インコーポレイテッド | 中性脂質を含む両性リポソーム |
| GB0720486D0 (en) * | 2007-10-19 | 2007-11-28 | Univ Edinburgh | Cationic lipids |
| EP2306978A2 (en) * | 2008-06-06 | 2011-04-13 | Mirna Therapeutics, Inc. | Compositions for the in vivo delivery of rnai agents |
| NZ611439A (en) * | 2010-12-30 | 2015-05-29 | Samyang Biopharmaceuticals | Carrier for negatively charged drugs comprising a cationic lipid and a preparation method thereof |
| WO2012109495A1 (en) | 2011-02-09 | 2012-08-16 | Metabolic Solutions Development Company, Llc | Cellular targets of thiazolidinediones |
| CN104884637A (zh) | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
| WO2016125163A1 (en) * | 2015-02-04 | 2016-08-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES |
| GB2632565B (en) | 2020-04-09 | 2025-06-04 | Verve Therapeutics Inc | Base editing of PCSK9 and methods of using same for treatment of disease |
| JP2023549011A (ja) | 2020-09-15 | 2023-11-22 | ヴァーヴ・セラピューティクス，インコーポレーテッド | 遺伝子編集のための脂質製剤 |
| CN118001254B (zh) * | 2024-04-09 | 2024-07-26 | 北京悦康科创医药科技股份有限公司 | 靶向抗原呈递细胞的脂质组合物及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002066012A2 (de) * | 2001-02-21 | 2002-08-29 | Novosom Ag | Amphotere liposomen und verwendung dieser |
| WO2003070735A2 (de) * | 2002-02-19 | 2003-08-28 | Novosom Ag | Komponenten für die herstellung amphoterer liposomen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6649780B1 (en) * | 1998-12-22 | 2003-11-18 | Valentis, Inc. | Cationic lipids |
| US20060159737A1 (en) * | 2004-11-19 | 2006-07-20 | Steffen Panzner | Pharmaceutical compositions for local administration |
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2004
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- 2005-03-29 US US10/594,553 patent/US8236770B2/en not_active Expired - Fee Related
- 2005-03-29 WO PCT/DE2005/000589 patent/WO2005094783A2/de not_active Ceased
- 2005-03-29 CA CA2561247A patent/CA2561247C/en not_active Expired - Fee Related
- 2005-03-29 JP JP2007504251A patent/JP2007530462A/ja active Pending
- 2005-03-29 AU AU2005229485A patent/AU2005229485A1/en not_active Abandoned
- 2005-03-29 EP EP05740433A patent/EP1734928A2/de not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002066012A2 (de) * | 2001-02-21 | 2002-08-29 | Novosom Ag | Amphotere liposomen und verwendung dieser |
| WO2003070735A2 (de) * | 2002-02-19 | 2003-08-28 | Novosom Ag | Komponenten für die herstellung amphoterer liposomen |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019027055A1 (ja) * | 2017-08-04 | 2019-02-07 | 協和発酵キリン株式会社 | 核酸含有脂質ナノ粒子 |
| JPWO2019027055A1 (ja) * | 2017-08-04 | 2020-08-20 | 協和キリン株式会社 | 核酸含有脂質ナノ粒子 |
| US11633365B2 (en) | 2017-08-04 | 2023-04-25 | Kyowa Kirin Co., Ltd. | Nucleic acid-containing lipid nanoparticle |
| JP7429536B2 (ja) | 2017-08-04 | 2024-02-08 | 協和キリン株式会社 | 核酸含有脂質ナノ粒子 |
| JP2024026137A (ja) * | 2017-08-04 | 2024-02-28 | 協和キリン株式会社 | 核酸含有脂質ナノ粒子 |
| JP7754908B2 (ja) | 2017-08-04 | 2025-10-15 | 協和キリン株式会社 | 核酸含有脂質ナノ粒子 |
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| US20080311181A1 (en) | 2008-12-18 |
| CA2561247C (en) | 2014-12-09 |
| US8236770B2 (en) | 2012-08-07 |
| WO2005094783A3 (de) | 2006-03-02 |
| AU2005229485A1 (en) | 2005-10-13 |
| EP1734928A2 (de) | 2006-12-27 |
| WO2005094783A2 (de) | 2005-10-13 |
| DE102004054730A1 (de) | 2006-05-11 |
| AU2005229485A2 (en) | 2005-10-13 |
| CA2561247A1 (en) | 2005-10-13 |
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