CA2561247C - Serum-stable amphoteric liposomes - Google Patents
Serum-stable amphoteric liposomes Download PDFInfo
- Publication number
- CA2561247C CA2561247C CA2561247A CA2561247A CA2561247C CA 2561247 C CA2561247 C CA 2561247C CA 2561247 A CA2561247 A CA 2561247A CA 2561247 A CA2561247 A CA 2561247A CA 2561247 C CA2561247 C CA 2561247C
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- Prior art keywords
- chol
- dmpc
- popc
- mochol
- liposomal formulation
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- DSNRWDQKZIEDDB-GCMPNPAFSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-GCMPNPAFSA-N 0.000 description 1
- HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
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- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 description 1
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- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 description 1
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 description 1
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- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410016020 DE102004016020A1 (de) | 2004-03-28 | 2004-03-28 | Serumstabile amphotere Liposomen |
| DE102004016020.1 | 2004-03-28 | ||
| DE102004054730A DE102004054730A1 (de) | 2004-03-28 | 2004-11-05 | Serumstabile amphotere Liposomen |
| DE102004054730.0 | 2004-11-05 | ||
| PCT/DE2005/000589 WO2005094783A2 (de) | 2004-03-28 | 2005-03-29 | Serumstabile amphotere liposomen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2561247A1 CA2561247A1 (en) | 2005-10-13 |
| CA2561247C true CA2561247C (en) | 2014-12-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2561247A Expired - Fee Related CA2561247C (en) | 2004-03-28 | 2005-03-29 | Serum-stable amphoteric liposomes |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8236770B2 (enExample) |
| EP (1) | EP1734928A2 (enExample) |
| JP (1) | JP2007530462A (enExample) |
| AU (1) | AU2005229485A1 (enExample) |
| CA (1) | CA2561247C (enExample) |
| DE (1) | DE102004054730A1 (enExample) |
| WO (1) | WO2005094783A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8815599B2 (en) * | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US20060135455A1 (en) * | 2004-06-01 | 2006-06-22 | Reza Sheikhnejad | Methods and compositions for the inhibition of gene expression |
| AU2005300638A1 (en) * | 2004-11-05 | 2006-05-11 | Novosom Ag | Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent |
| EP1764090A1 (en) * | 2005-09-15 | 2007-03-21 | Novosom AG | Amphoteric liposomes for local drug applications |
| US20060159737A1 (en) * | 2004-11-19 | 2006-07-20 | Steffen Panzner | Pharmaceutical compositions for local administration |
| WO2007107304A2 (en) * | 2006-03-17 | 2007-09-27 | Novosom Ag | An efficient method for loading amphoteric liposomes with nucleic acid active substances |
| US8017159B2 (en) * | 2005-11-16 | 2011-09-13 | Idexx Laboratories, Inc. | Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same |
| CA2631931C (en) | 2005-12-01 | 2014-04-29 | Pronai Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
| EP1957044B1 (en) * | 2005-12-01 | 2013-03-13 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| AU2007306556B2 (en) * | 2006-10-13 | 2014-04-10 | Marina Biotech, Inc. | Improvements in or relating to amphoteric liposomes |
| AU2008309880B2 (en) * | 2007-10-12 | 2014-07-10 | Biontech Delivery Technologies Gmbh | Amphoteric liposomes comprising neutral lipids |
| GB0720486D0 (en) * | 2007-10-19 | 2007-11-28 | Univ Edinburgh | Cationic lipids |
| WO2009149418A2 (en) * | 2008-06-06 | 2009-12-10 | Asuragen, Inc. | Novel compositions for the in vivo delivery of rnai agents |
| WO2012091523A2 (en) * | 2010-12-30 | 2012-07-05 | Samyang Biopharmaceuticals Corporation | Carrier for negatively charged drugs comprising a cationic lipid and a preparation method thereof |
| WO2012109495A1 (en) | 2011-02-09 | 2012-08-16 | Metabolic Solutions Development Company, Llc | Cellular targets of thiazolidinediones |
| CA2890725A1 (en) | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
| WO2016125163A1 (en) * | 2015-02-04 | 2016-08-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES |
| US11633365B2 (en) | 2017-08-04 | 2023-04-25 | Kyowa Kirin Co., Ltd. | Nucleic acid-containing lipid nanoparticle |
| GB2632564B (en) | 2020-04-09 | 2025-06-18 | Verve Therapeutics Inc | Base editing of angptl3 and methods of using same for treatment of disease |
| WO2022060871A1 (en) | 2020-09-15 | 2022-03-24 | Verve Therapeutics, Inc. | Lipid formulations for gene editing |
| CN118001254B (zh) * | 2024-04-09 | 2024-07-26 | 北京悦康科创医药科技股份有限公司 | 靶向抗原呈递细胞的脂质组合物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6649780B1 (en) * | 1998-12-22 | 2003-11-18 | Valentis, Inc. | Cationic lipids |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
| DE10207178A1 (de) * | 2002-02-19 | 2003-09-04 | Novosom Ag | Komponenten für die Herstellung amphoterer Liposomen |
| US20060159737A1 (en) * | 2004-11-19 | 2006-07-20 | Steffen Panzner | Pharmaceutical compositions for local administration |
-
2004
- 2004-11-05 DE DE102004054730A patent/DE102004054730A1/de not_active Ceased
-
2005
- 2005-03-29 JP JP2007504251A patent/JP2007530462A/ja active Pending
- 2005-03-29 AU AU2005229485A patent/AU2005229485A1/en not_active Abandoned
- 2005-03-29 EP EP05740433A patent/EP1734928A2/de not_active Withdrawn
- 2005-03-29 US US10/594,553 patent/US8236770B2/en not_active Expired - Fee Related
- 2005-03-29 CA CA2561247A patent/CA2561247C/en not_active Expired - Fee Related
- 2005-03-29 WO PCT/DE2005/000589 patent/WO2005094783A2/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005094783A3 (de) | 2006-03-02 |
| US8236770B2 (en) | 2012-08-07 |
| AU2005229485A2 (en) | 2005-10-13 |
| JP2007530462A (ja) | 2007-11-01 |
| AU2005229485A1 (en) | 2005-10-13 |
| CA2561247A1 (en) | 2005-10-13 |
| WO2005094783A2 (de) | 2005-10-13 |
| EP1734928A2 (de) | 2006-12-27 |
| DE102004054730A1 (de) | 2006-05-11 |
| US20080311181A1 (en) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180329 |