JP2007530450A5 - - Google Patents
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- JP2007530450A5 JP2007530450A5 JP2006547424A JP2006547424A JP2007530450A5 JP 2007530450 A5 JP2007530450 A5 JP 2007530450A5 JP 2006547424 A JP2006547424 A JP 2006547424A JP 2006547424 A JP2006547424 A JP 2006547424A JP 2007530450 A5 JP2007530450 A5 JP 2007530450A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkenyl
- aryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003118 aryl group Chemical group 0.000 claims description 40
- 125000001072 heteroaryl group Chemical group 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 15
- 125000004450 alkenylene group Chemical group 0.000 claims description 10
- 125000000732 arylene group Chemical group 0.000 claims description 10
- 125000005549 heteroarylene group Chemical group 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims 75
- 125000003342 alkenyl group Chemical group 0.000 claims 41
- 125000000623 heterocyclic group Chemical group 0.000 claims 40
- 125000000304 alkynyl group Chemical group 0.000 claims 30
- 125000002947 alkylene group Chemical group 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 27
- -1 heteroarylalkylenyl Chemical group 0.000 claims 26
- 125000004432 carbon atom Chemical group C* 0.000 claims 20
- 125000004663 dialkyl amino group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 229910052799 carbon Inorganic materials 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000005842 heteroatom Chemical group 0.000 claims 16
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- 125000004104 aryloxy group Chemical group 0.000 claims 14
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 14
- 125000004414 alkyl thio group Chemical group 0.000 claims 13
- 125000005466 alkylenyl group Chemical group 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 10
- 125000005529 alkyleneoxy group Chemical group 0.000 claims 10
- 125000005532 aryl alkyleneoxy group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000004438 haloalkoxy group Chemical group 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000004419 alkynylene group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000005110 aryl thio group Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 150000004678 hydrides Chemical class 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 4
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical class C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 description 1
- IRNQWWPSQJKGCD-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-imidazo[4,5-c][1,5]naphthyridin-6-amine Chemical compound C1N=C2C(N)=CC=NC2=C2NCNC21 IRNQWWPSQJKGCD-UHFFFAOYSA-N 0.000 description 1
- YHEPBWTXCZVUHG-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-6-amine Chemical compound N1=C2C(N)=CC=CC2=C2NC=NC2=C1 YHEPBWTXCZVUHG-UHFFFAOYSA-N 0.000 description 1
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical compound C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- UTOMICFLROGMAE-UHFFFAOYSA-N quinoline-3,4-diamine Chemical compound C1=CC=CC2=C(N)C(N)=CN=C21 UTOMICFLROGMAE-UHFFFAOYSA-N 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53302403P | 2003-12-29 | 2003-12-29 | |
| PCT/US2004/043474 WO2005066172A1 (en) | 2003-12-29 | 2004-12-22 | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530450A JP2007530450A (ja) | 2007-11-01 |
| JP2007530450A5 true JP2007530450A5 (enExample) | 2008-02-07 |
Family
ID=34748841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547424A Pending JP2007530450A (ja) | 2003-12-29 | 2004-12-22 | ピペラジン、［１，４］ジアゼパン、［１，４］ジアゾカン、および［１，５］ジアゾカン縮合イミダゾ環化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7888349B2 (enExample) |
| EP (1) | EP1699792A1 (enExample) |
| JP (1) | JP2007530450A (enExample) |
| CN (1) | CN1922178A (enExample) |
| AU (1) | AU2004312510A1 (enExample) |
| CA (1) | CA2552101A1 (enExample) |
| WO (1) | WO2005066172A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6797718B2 (en) | 2002-06-07 | 2004-09-28 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
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| CA2597324C (en) | 2005-02-09 | 2015-06-30 | Coley Pharmaceutical Group, Inc. | Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines |
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| AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
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-
2004
- 2004-12-22 CA CA002552101A patent/CA2552101A1/en not_active Abandoned
- 2004-12-22 EP EP04815538A patent/EP1699792A1/en not_active Withdrawn
- 2004-12-22 AU AU2004312510A patent/AU2004312510A1/en not_active Abandoned
- 2004-12-22 WO PCT/US2004/043474 patent/WO2005066172A1/en not_active Ceased
- 2004-12-22 US US10/596,895 patent/US7888349B2/en not_active Expired - Fee Related
- 2004-12-22 JP JP2006547424A patent/JP2007530450A/ja active Pending
- 2004-12-22 CN CNA2004800422008A patent/CN1922178A/zh active Pending
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