JP2007527411A5 - - Google Patents
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- JP2007527411A5 JP2007527411A5 JP2006536832A JP2006536832A JP2007527411A5 JP 2007527411 A5 JP2007527411 A5 JP 2007527411A5 JP 2006536832 A JP2006536832 A JP 2006536832A JP 2006536832 A JP2006536832 A JP 2006536832A JP 2007527411 A5 JP2007527411 A5 JP 2007527411A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkyl
- independently selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims 38
- 229910052799 carbon Inorganic materials 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- 125000005842 heteroatom Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 230000005764 inhibitory process Effects 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 150000001602 bicycloalkyls Chemical group 0.000 claims 15
- 108090000613 Cathepsin S Proteins 0.000 claims 14
- 102100035654 Cathepsin S Human genes 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108010076667 Caspases Proteins 0.000 claims 10
- 102000011727 Caspases Human genes 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000002757 morpholinyl group Chemical group 0.000 claims 8
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 229920001774 Perfluoroether Polymers 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004193 piperazinyl group Chemical group 0.000 claims 4
- 125000005936 piperidyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- -1 morpholine-4-carbonyl Chemical group 0.000 claims 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 3
- 125000005062 perfluorophenyl group Chemical group FC1=C(C(=C(C(=C1F)F)F)F)* 0.000 claims 3
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- JLPJFSCQKHRSQR-UHFFFAOYSA-N oxolan-3-one Chemical compound O=C1CCOC1 JLPJFSCQKHRSQR-UHFFFAOYSA-N 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 0 *BC(*)(*)OC(NC(*1)C(OS)OC1=O)=O Chemical compound *BC(*)(*)OC(NC(*1)C(OS)OC1=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51373503P | 2003-10-21 | 2003-10-21 | |
| US10/970,344 US7297714B2 (en) | 2003-10-21 | 2004-10-20 | Inhibitors of cathepsin S |
| PCT/US2004/035062 WO2005039496A2 (en) | 2003-10-21 | 2004-10-21 | Inhibitors of cathepsin s |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527411A JP2007527411A (ja) | 2007-09-27 |
| JP2007527411A5 true JP2007527411A5 (https=) | 2007-11-29 |
Family
ID=34526893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006536832A Pending JP2007527411A (ja) | 2003-10-21 | 2004-10-21 | カテプシンｓの阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7297714B2 (https=) |
| EP (1) | EP1677782A4 (https=) |
| JP (1) | JP2007527411A (https=) |
| AU (1) | AU2004283708B2 (https=) |
| BR (1) | BRPI0415824A (https=) |
| CA (1) | CA2542963A1 (https=) |
| MX (1) | MXPA06004440A (https=) |
| WO (1) | WO2005039496A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008051763A1 (en) * | 2006-10-23 | 2008-05-02 | Irm Llc | Cathepsin proteases inhibitors |
| US20160038600A1 (en) | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
| TWI402072B (zh) * | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶ｓ抑制劑化合物 |
| CN105616391B (zh) * | 2010-12-17 | 2021-03-19 | 尼昂克技术公司 | 使用异紫苏醇的方法和装置 |
| WO2020201572A1 (en) | 2019-04-05 | 2020-10-08 | Université De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| DE69718012T2 (de) * | 1996-09-12 | 2003-09-25 | Idun Pharmaceuticals, Inc. | C-terminale modifizierte (n-substituierte)-2-indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie |
| ES2242394T3 (es) * | 1998-05-05 | 2005-11-01 | Warner-Lambert Company Llc | Inhibidores de tipo succinamida de la enzima convertidora de la interleuquina 1 beta. |
| JP2002537293A (ja) * | 1999-02-20 | 2002-11-05 | アストラゼネカ アクチボラグ | カテプシンｌおよび／またはカテプシンｓの阻害剤としてのアセタミドアセトニトリル誘導体 |
| DE60021254T2 (de) * | 1999-03-15 | 2006-04-20 | AXYS Pharmaceuticals, Inc., South San Francisco | N-cyanomethylamide als protease inhibitoren |
| US6355618B1 (en) | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| CA2379747C (en) * | 1999-07-30 | 2008-09-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel succinate derivative compounds useful as cysteine protease inhibitors |
| ES2199856T3 (es) * | 1999-09-13 | 2004-03-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nuevos compuestos heterociclicos, utiles como inhibidores reversibles de cisteina proteasas. |
| CO5280088A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Inhibidores de proteasa |
| WO2002040462A2 (en) * | 2000-11-17 | 2002-05-23 | Medivir Uk Limited | Cysteine protease inhibitors |
| DE60127860T2 (de) | 2000-11-21 | 2008-01-17 | Vertex Pharmaceuticals Inc., Cambridge | Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung |
| US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| US20030144234A1 (en) * | 2001-08-30 | 2003-07-31 | Buxton Francis Paul | Methods for the treatment of chronic pain and compositions therefor |
| US6900237B2 (en) * | 2001-09-14 | 2005-05-31 | Axys Pharmaceuticals, Inc. | Sulfonamide compounds as protease inhibitors |
| EP1448554A1 (en) * | 2001-10-09 | 2004-08-25 | SmithKline Beecham Corporation | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases |
-
2004
- 2004-10-20 US US10/970,344 patent/US7297714B2/en not_active Expired - Fee Related
- 2004-10-21 BR BRPI0415824-5A patent/BRPI0415824A/pt not_active IP Right Cessation
- 2004-10-21 MX MXPA06004440A patent/MXPA06004440A/es active IP Right Grant
- 2004-10-21 JP JP2006536832A patent/JP2007527411A/ja active Pending
- 2004-10-21 AU AU2004283708A patent/AU2004283708B2/en not_active Ceased
- 2004-10-21 CA CA002542963A patent/CA2542963A1/en not_active Abandoned
- 2004-10-21 EP EP04796113A patent/EP1677782A4/en not_active Withdrawn
- 2004-10-21 WO PCT/US2004/035062 patent/WO2005039496A2/en not_active Ceased
-
2007
- 2007-08-20 US US11/841,694 patent/US20080021025A1/en not_active Abandoned
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