JP2007527411A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007527411A5 JP2007527411A5 JP2006536832A JP2006536832A JP2007527411A5 JP 2007527411 A5 JP2007527411 A5 JP 2007527411A5 JP 2006536832 A JP2006536832 A JP 2006536832A JP 2006536832 A JP2006536832 A JP 2006536832A JP 2007527411 A5 JP2007527411 A5 JP 2007527411A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkyl
- independently selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims 38
- 229910052799 carbon Inorganic materials 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- 125000005842 heteroatom Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 230000005764 inhibitory process Effects 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 150000001602 bicycloalkyls Chemical group 0.000 claims 15
- 108090000613 Cathepsin S Proteins 0.000 claims 14
- 102100035654 Cathepsin S Human genes 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108010076667 Caspases Proteins 0.000 claims 10
- 102000011727 Caspases Human genes 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000002757 morpholinyl group Chemical group 0.000 claims 8
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 229920001774 Perfluoroether Polymers 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004193 piperazinyl group Chemical group 0.000 claims 4
- 125000005936 piperidyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- -1 morpholine-4-carbonyl Chemical group 0.000 claims 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 3
- 125000005062 perfluorophenyl group Chemical group FC1=C(C(=C(C(=C1F)F)F)F)* 0.000 claims 3
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- JLPJFSCQKHRSQR-UHFFFAOYSA-N oxolan-3-one Chemical compound O=C1CCOC1 JLPJFSCQKHRSQR-UHFFFAOYSA-N 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 0 *BC(*)(*)OC(NC(*1)C(OS)OC1=O)=O Chemical compound *BC(*)(*)OC(NC(*1)C(OS)OC1=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51373503P | 2003-10-21 | 2003-10-21 | |
| US10/970,344 US7297714B2 (en) | 2003-10-21 | 2004-10-20 | Inhibitors of cathepsin S |
| PCT/US2004/035062 WO2005039496A2 (en) | 2003-10-21 | 2004-10-21 | Inhibitors of cathepsin s |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527411A JP2007527411A (ja) | 2007-09-27 |
| JP2007527411A5 true JP2007527411A5 (https=) | 2007-11-29 |
Family
ID=34526893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006536832A Pending JP2007527411A (ja) | 2003-10-21 | 2004-10-21 | カテプシンｓの阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7297714B2 (https=) |
| EP (1) | EP1677782A4 (https=) |
| JP (1) | JP2007527411A (https=) |
| AU (1) | AU2004283708B2 (https=) |
| BR (1) | BRPI0415824A (https=) |
| CA (1) | CA2542963A1 (https=) |
| MX (1) | MXPA06004440A (https=) |
| WO (1) | WO2005039496A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090064463A (ko) * | 2006-10-23 | 2009-06-18 | 아이알엠 엘엘씨 | 카텝신 프로테아제 억제제 |
| US20160038600A1 (en) | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
| TWI402072B (zh) * | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶ｓ抑制劑化合物 |
| ES3056006T3 (en) * | 2010-12-17 | 2026-02-17 | Univ Southern California | Methods and devices for using isoperillyl alcohol |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| KR20000036056A (ko) * | 1996-09-12 | 2000-06-26 | 아이디유엔 파마슈티칼즈, 인코포레이티드 | 인터루킨-1β 전환 효소 및 관련 프로테아제의 억제제로서의 Ｃ-말단 변형된 (Ｎ-치환된)-2-인돌릴 디펩티드 |
| ES2242394T3 (es) * | 1998-05-05 | 2005-11-01 | Warner-Lambert Company Llc | Inhibidores de tipo succinamida de la enzima convertidora de la interleuquina 1 beta. |
| EP1155010A1 (en) * | 1999-02-20 | 2001-11-21 | AstraZeneca AB | Acetamido acetonitrile derivatives as inhibitors of cathepsin l and/or cathepsin s |
| CN1362947A (zh) * | 1999-03-15 | 2002-08-07 | Axys药物公司 | 用作蛋白酶抑制剂的n－氰基甲基酰胺 |
| CN1176941C (zh) | 1999-04-09 | 2004-11-24 | 西托维亚公司 | Caspase抑制剂及其应用 |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| JP2003506364A (ja) * | 1999-07-30 | 2003-02-18 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | システインプロテアーゼインヒビターとして有益な新規スクシネート誘導体化合物 |
| YU17402A (sh) * | 1999-09-13 | 2004-11-25 | Boehringer Ingelheim Pharmaceuticals Inc. | Nova spiroheterociklična jedinjenja upotrebljiva kao reverzibilni inhibitori cisteinskih proteaza |
| CO5280088A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Inhibidores de proteasa |
| JP2004513942A (ja) * | 2000-11-17 | 2004-05-13 | メディヴァー ユーケイ リミテッド | システインプロテアーゼインヒビター |
| AU2002232541A1 (en) | 2000-11-21 | 2002-06-03 | Vertex Pharmaceuticals Incorporated | Imidazole and benzimidazole caspase inhibitors and uses thereof |
| US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| US20030144234A1 (en) * | 2001-08-30 | 2003-07-31 | Buxton Francis Paul | Methods for the treatment of chronic pain and compositions therefor |
| US6900237B2 (en) * | 2001-09-14 | 2005-05-31 | Axys Pharmaceuticals, Inc. | Sulfonamide compounds as protease inhibitors |
| WO2003031437A1 (en) * | 2001-10-09 | 2003-04-17 | Smithkline Beecham Corporation | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases |
-
2004
- 2004-10-20 US US10/970,344 patent/US7297714B2/en not_active Expired - Fee Related
- 2004-10-21 CA CA002542963A patent/CA2542963A1/en not_active Abandoned
- 2004-10-21 WO PCT/US2004/035062 patent/WO2005039496A2/en not_active Ceased
- 2004-10-21 AU AU2004283708A patent/AU2004283708B2/en not_active Ceased
- 2004-10-21 EP EP04796113A patent/EP1677782A4/en not_active Withdrawn
- 2004-10-21 BR BRPI0415824-5A patent/BRPI0415824A/pt not_active IP Right Cessation
- 2004-10-21 JP JP2006536832A patent/JP2007527411A/ja active Pending
- 2004-10-21 MX MXPA06004440A patent/MXPA06004440A/es active IP Right Grant
-
2007
- 2007-08-20 US US11/841,694 patent/US20080021025A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI600638B (zh) | 作爲蛋白質去乙醯酶抑制劑之反式醯胺化合物及其使用方法 | |
| US10905665B2 (en) | Chemical modulators of signaling pathways and therapeutic use | |
| JP2021519766A (ja) | ＸＩＩａ因子インヒビター | |
| WO1993003013A1 (fr) | Derives d'indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant | |
| RS56717B1 (sr) | Derivati dolastatina 10 i auristatina | |
| JP4417551B2 (ja) | ヘミアスターリン類似体 | |
| CA2327282A1 (en) | Treatment of parasitic diseases by inhibition of cysteine proteases of the papain superfamily | |
| KR20210102887A (ko) | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 | |
| JPH08508720A (ja) | ピロールーアミジン化合物およびその薬剤的に受容できる塩、その製造法ならびにこれを含む医薬組成物 | |
| JP2002503714A (ja) | 抗腫瘍剤 | |
| JPH05140063A (ja) | ジペプチド誘導体及びそれを有効成分とする骨疾患の予防及び治療剤 | |
| CZ159197A3 (cs) | Inhibitory metalloproteinázy, způsob jejich výroby a farmaceutický prostředek s jejich obsahem | |
| EA001863B1 (ru) | Акрилоилзамещенные производные дистамицина, способы их получения, применение в качестве противоопухолевых средств и фармкомпозиции | |
| SG11202110271TA (en) | Inhibitors of the n-terminal domain of the androgen receptor | |
| WO2006043655A1 (ja) | 吸入用医薬組成物 | |
| JP2007527411A5 (https=) | ||
| JP4604161B2 (ja) | フェニルアラニン誘導体 | |
| JP7442192B2 (ja) | がん特異的酵素活性を利用したプロドラッグ型抗がん剤 | |
| WO2024089159A1 (en) | Main protease inhibitors | |
| WO2019063955A1 (fr) | Agents inhibant la proteine tctp pour le traitement de maladies proliferatives, de maladies infectieuses, d'allergies, d'inflammations et/ou de l'asthme | |
| JPH0651677B2 (ja) | ジペプチド誘導体及びその製法並びに用途 | |
| JP2024526865A (ja) | 腎癌の標的治療のための新規化合物及び組成物 | |
| CN109476605B (zh) | 具有抗肿瘤活性的苯并-n-羟基酰胺化合物 | |
| US20070082922A1 (en) | Huperzine a prodrugs and uses thereof | |
| US11149062B2 (en) | HDAC inhibitors and methods of treatment using the same |