JP2007524645A5 - - Google Patents
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- Publication number
- JP2007524645A5 JP2007524645A5 JP2006520347A JP2006520347A JP2007524645A5 JP 2007524645 A5 JP2007524645 A5 JP 2007524645A5 JP 2006520347 A JP2006520347 A JP 2006520347A JP 2006520347 A JP2006520347 A JP 2006520347A JP 2007524645 A5 JP2007524645 A5 JP 2007524645A5
- Authority
- JP
- Japan
- Prior art keywords
- bnoh
- meoh
- ratio
- octreotide
- pamoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 5
- 239000006184 cosolvent Substances 0.000 description 4
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 3
- 108010016076 Octreotide Proteins 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229960002700 octreotide Drugs 0.000 description 3
- 239000012074 organic phase Substances 0.000 description 3
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 1
- 238000000710 polymer precipitation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48766303P | 2003-07-15 | 2003-07-15 | |
| US60/487,663 | 2003-07-15 | ||
| PCT/US2004/022816 WO2005009356A2 (en) | 2003-07-15 | 2004-07-15 | Method for the preparation of controlled release formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011100206A Division JP2011144207A (ja) | 2003-07-15 | 2011-04-27 | 制御放出処方物の調製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007524645A JP2007524645A (ja) | 2007-08-30 |
| JP2007524645A5 true JP2007524645A5 (enExample) | 2012-07-19 |
| JP5165239B2 JP5165239B2 (ja) | 2013-03-21 |
Family
ID=34102710
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520347A Expired - Fee Related JP5165239B2 (ja) | 2003-07-15 | 2004-07-15 | 制御放出処方物の調製のための方法 |
| JP2011100206A Pending JP2011144207A (ja) | 2003-07-15 | 2011-04-27 | 制御放出処方物の調製のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011100206A Pending JP2011144207A (ja) | 2003-07-15 | 2011-04-27 | 制御放出処方物の調製のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8871269B2 (enExample) |
| EP (2) | EP1651136B1 (enExample) |
| JP (2) | JP5165239B2 (enExample) |
| CN (2) | CN1852687B (enExample) |
| AU (1) | AU2004259208B2 (enExample) |
| BR (1) | BRPI0412059A (enExample) |
| CA (1) | CA2532302C (enExample) |
| ES (1) | ES2625343T3 (enExample) |
| WO (1) | WO2005009356A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2548550A1 (en) | 2003-04-10 | 2013-01-23 | Surmodics Pharmaceuticals, Inc. | Emulsion-based micro particles |
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| ES2625343T3 (es) | 2003-07-15 | 2017-07-19 | Evonik Corporation | Método para la preparación de formulaciones de liberación controlada |
| EP2462923A3 (en) * | 2003-07-18 | 2012-08-29 | Oakwood Laboratories L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
| CN100588423C (zh) * | 2003-07-23 | 2010-02-10 | Pr药品有限公司 | 控释组合物 |
| EP2286791B1 (en) * | 2003-12-30 | 2014-03-26 | Durect Corporation | Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents |
| EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| US20100290982A1 (en) * | 2007-04-13 | 2010-11-18 | University Of North Texas Health Science Center At Fort Worth | Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles |
| BRPI0810899A2 (pt) | 2007-04-13 | 2014-10-29 | Univ North Texas | Formulação de nanopartículas de plga ativadas carregadas com agente ativo para substâncias nano-terapêuticas anticâncer direcionais. |
| CA2683698C (en) * | 2007-04-19 | 2013-09-10 | Hyun Hee Kwak | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| GB0709322D0 (en) * | 2007-05-15 | 2007-06-20 | Nordic Bioscience As | Exposure agent for detection of vitamin d |
| WO2008145183A1 (en) * | 2007-05-30 | 2008-12-04 | Nestec S.A. | Oil-in-water emulsion and its use for the delayed release of active elements |
| US8435544B2 (en) | 2007-10-08 | 2013-05-07 | Lux Biosciences, Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors |
| ES2324009B1 (es) * | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
| US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
| JP5222550B2 (ja) * | 2007-12-27 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
| US9161943B2 (en) * | 2007-12-31 | 2015-10-20 | Industrial Technology Research Institute | Sustained release composition and manufacturing method thereof |
| EP2244679A4 (en) * | 2008-02-08 | 2013-10-09 | Qps Llc | NON-POLYMERIC COMPOSITIONS FOR CONTROLLED MEDICINAL PRODUCTION |
| EP2315571A4 (en) * | 2008-07-16 | 2013-05-01 | Surmodics Pharmaceuticals Inc | METHOD FOR PRODUCING MICROPARTICLES WITH BIOACTIVE PEPTIDES |
| EP2440185B1 (en) | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| IN2012DN00407A (enExample) * | 2009-08-05 | 2015-08-21 | Pieris Ag | |
| US20110151028A1 (en) * | 2009-12-19 | 2011-06-23 | Filiberto Zadini | Topical vaginal preparation |
| ES2362604B1 (es) * | 2009-12-22 | 2012-06-28 | Bcn Peptides, S.A. | Formulación tópica oftálmica de péptidos. |
| SG10201501821RA (en) * | 2010-03-11 | 2015-05-28 | Wyeth Llc | Oral formulations and lipophilic salts of methylnaltrexone |
| JP5222917B2 (ja) * | 2010-09-21 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
| TWI501781B (zh) * | 2010-12-10 | 2015-10-01 | Ind Tech Res Inst | 可控制釋放的組合物及其製造方法 |
| US20160151511A1 (en) | 2014-12-02 | 2016-06-02 | Antriabio, Inc. | Proteins and protein conjugates with increased hydrophobicity |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US20190117573A1 (en) * | 2017-10-19 | 2019-04-25 | Hyalo Technologies, LLC | Composition and method of preparation of risperidone extended release preparation |
| US20230062487A1 (en) * | 2020-01-24 | 2023-03-02 | W. L. Gore & Associates, Inc. | Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof |
| CN111643483B (zh) * | 2020-07-06 | 2022-03-29 | 济南大学 | 一种用于制备加兰他敏缓释微球的方法 |
| AU2022226584A1 (en) | 2021-02-24 | 2023-08-17 | Oakwood Laboratories, Llc | Microsphere formulations comprising lurasidone and methods for making and using the same |
| CA3216277A1 (en) * | 2021-04-23 | 2022-10-27 | Bradley MINROVIC | Microsphere formulations comprising multiple non-identical peptides and methods for making the same |
| US20250009644A1 (en) * | 2021-12-02 | 2025-01-09 | University Of Connecticut | Long-acting injectable in situ forming biodegradable implants comprising non-steroidal anti-inflammatory drugs |
| CN116421578A (zh) * | 2023-03-31 | 2023-07-14 | 辉粒药业(苏州)有限公司 | 生长抑素类似物缓释微球及其制备方法 |
| CN120958013A (zh) * | 2023-04-03 | 2025-11-14 | 辉凌公司 | 制造肽盐的方法 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780195A (en) * | 1969-10-22 | 1973-12-18 | Balchem Corp | Encapsulation process |
| US3664963A (en) * | 1969-10-22 | 1972-05-23 | Balchem Corp | Encapsulation process |
| DE2059494B2 (de) * | 1970-12-03 | 1972-03-16 | Licentia Gmbh | Biegsamer hohlleiter |
| JPS523342B2 (enExample) * | 1972-01-26 | 1977-01-27 | ||
| US3865352A (en) * | 1973-11-16 | 1975-02-11 | Minnesota Mining & Mfg | Static mixing device |
| DE2604832A1 (de) * | 1976-02-07 | 1977-08-11 | Basf Ag | Verfahren zur analyse von loesungen |
| US4171981A (en) * | 1977-04-29 | 1979-10-23 | The Mead Corporation | Process for the production of hot melt coating compositions containing microcapsules |
| US4183681A (en) * | 1978-05-19 | 1980-01-15 | Exxon Research & Engineering Co. | Emulsion preparation method using a packed tube emulsifier |
| US4299501A (en) * | 1979-08-10 | 1981-11-10 | Ortho Pharmaceutical Corporation | Continuous process for the preparation of semisolid dispersions |
| US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| US4933105A (en) * | 1980-06-13 | 1990-06-12 | Sandoz Pharm. Corp. | Process for preparation of microspheres |
| US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| DE3732370A1 (de) | 1987-09-25 | 1989-04-06 | Hoechst Ag | Verfahren zur vermischung von lebenden zellen oder mikroorganismen mit einer viskosen fluessigkeit und mischungen, die nach diesem verfahren hergestellt wurden |
| DE69024953T3 (de) * | 1989-05-04 | 2005-01-27 | Southern Research Institute, Birmingham | Einkapselungsverfahren |
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5112604A (en) * | 1989-09-01 | 1992-05-12 | Riker Laboratories, Inc. | Oral suspension formulation |
| MY107937A (en) * | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| US6120805A (en) * | 1990-04-06 | 2000-09-19 | Rhone-Poulenc Rorer Sa | Microspheres, process for their preparation and their use |
| FR2660556B1 (fr) | 1990-04-06 | 1994-09-16 | Rhone Poulenc Sante | Microspheres, leur procede de preparation et leur utilisation. |
| US5733566A (en) * | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| NZ260909A (en) * | 1993-07-05 | 1995-04-27 | Takeda Chemical Industries Ltd | Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution |
| EP2283821A1 (en) * | 1993-11-19 | 2011-02-16 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
| JP2832143B2 (ja) * | 1993-12-28 | 1998-12-02 | 信越化学工業株式会社 | シリコーン微粒子およびその製造方法 |
| WO1997004747A1 (en) | 1995-07-27 | 1997-02-13 | Dunn James M | Drug delivery systems for macromolecular drugs |
| US5629277A (en) * | 1995-10-04 | 1997-05-13 | William L. Brown | Paint removing composition |
| US6140040A (en) * | 1995-10-06 | 2000-10-31 | Advanced Minerals Corporation | Method of mechanically separating microparticles suspended in fluids using particulate media |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| JPH10273447A (ja) * | 1997-01-29 | 1998-10-13 | Takeda Chem Ind Ltd | 徐放性マイクロスフィア、その製造法および用途 |
| WO1998032423A1 (en) * | 1997-01-29 | 1998-07-30 | Takeda Chemical Industries, Ltd. | Sustained-release microspheres, their production and use |
| SE9701161D0 (sv) * | 1997-03-27 | 1997-03-27 | Karolinska Innovations Ab | New use I |
| MY118835A (en) * | 1997-04-18 | 2005-01-31 | Ipsen Pharma Biotech | Sustained release compositions and the process for their preparation |
| PT1042001E (pt) * | 1997-12-16 | 2002-09-30 | Chiron Corp | Uso de microparticulas combinadas com emulsoes submicronicas oleo-em-agua |
| CA2316273A1 (en) * | 1998-01-16 | 1999-07-22 | Takeda Chemical Industries, Ltd. | Sustained-release composition, method of its production and use thereof |
| US6270700B1 (en) * | 1998-07-23 | 2001-08-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Encapsulation of water soluble peptides |
| JP3012608B1 (ja) * | 1998-09-17 | 2000-02-28 | 農林水産省食品総合研究所長 | マイクロチャネル装置及び同装置を用いたエマルションの製造方法 |
| US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| EP1044683A1 (en) * | 1999-04-15 | 2000-10-18 | Debio Recherche Pharmaceutique S.A. | One-step dispersion method for the microencapsulation of water soluble substances |
| US6291013B1 (en) * | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| US7919119B2 (en) * | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| CA2386654A1 (en) * | 1999-10-08 | 2001-04-19 | The Procter & Gamble Company | Apparatus and process for in-line preparation of hipes |
| AUPQ529000A0 (en) * | 2000-01-28 | 2000-02-17 | Research Laboratories Of Australia Pty Ltd | Toner characterization cell |
| US6953593B2 (en) * | 2000-02-01 | 2005-10-11 | Lipoprotein Technologies, Inc. | Sustained-release microencapsulated delivery system |
| US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| JP2002126043A (ja) * | 2000-07-17 | 2002-05-08 | Takeda Chem Ind Ltd | 凍結乾燥物の製造法 |
| US6565873B1 (en) | 2000-10-25 | 2003-05-20 | Salvona Llc | Biodegradable bioadhesive controlled release system of nano-particles for oral care products |
| WO2002036169A2 (en) | 2000-10-31 | 2002-05-10 | Pr Pharmaceuticals, Inc. | Methods and compositions for enhanced delivery of bioactive molecules |
| CN1249464C (zh) | 2001-01-15 | 2006-04-05 | 3M创新有限公司 | 在可见光波长区域具有高且平滑透射率的多层红外反射薄膜及由该薄膜制造的层压制品 |
| CA2435415A1 (en) | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Microparticles of biodegradable polymer encapsulating a biologically active substance |
| TWI332407B (en) * | 2001-06-29 | 2010-11-01 | Takeda Chemical Industries Ltd | Controlled release composition and method of producting the same |
| JP2005525403A (ja) | 2002-05-03 | 2005-08-25 | ピーアール ファーマシューティカルズ， インコーポレイテッド | エストラジオール代謝産物の徐放性組成物 |
| CN1938040A (zh) * | 2003-03-05 | 2007-03-28 | Pr药品有限公司 | 缩宫素控释制剂及其应用方法 |
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| EP2548550A1 (en) * | 2003-04-10 | 2013-01-23 | Surmodics Pharmaceuticals, Inc. | Emulsion-based micro particles |
| JP2006522816A (ja) | 2003-04-11 | 2006-10-05 | ピーアール ファーマシューティカルズ， インコーポレイテッド | 部位特異的タンパク質結合体を調製する方法 |
| ES2625343T3 (es) | 2003-07-15 | 2017-07-19 | Evonik Corporation | Método para la preparación de formulaciones de liberación controlada |
| CN100588423C (zh) * | 2003-07-23 | 2010-02-10 | Pr药品有限公司 | 控释组合物 |
-
2004
- 2004-07-15 ES ES04778360.0T patent/ES2625343T3/es not_active Expired - Lifetime
- 2004-07-15 EP EP04778360.0A patent/EP1651136B1/en not_active Expired - Lifetime
- 2004-07-15 JP JP2006520347A patent/JP5165239B2/ja not_active Expired - Fee Related
- 2004-07-15 EP EP11187402A patent/EP2462896A1/en not_active Withdrawn
- 2004-07-15 BR BRPI0412059-0A patent/BRPI0412059A/pt not_active IP Right Cessation
- 2004-07-15 US US10/564,494 patent/US8871269B2/en active Active
- 2004-07-15 AU AU2004259208A patent/AU2004259208B2/en not_active Ceased
- 2004-07-15 CA CA2532302A patent/CA2532302C/en not_active Expired - Fee Related
- 2004-07-15 CN CN200480026606.7A patent/CN1852687B/zh not_active Expired - Fee Related
- 2004-07-15 CN CN2012104691508A patent/CN102935069A/zh active Pending
- 2004-07-15 WO PCT/US2004/022816 patent/WO2005009356A2/en not_active Ceased
-
2011
- 2011-04-27 JP JP2011100206A patent/JP2011144207A/ja active Pending
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