JP2007524360A - Ｎｅｌｌペプチドの発現系及びｎｅｌｌペプチドの骨形成活性 - Google Patents

Ｎｅｌｌペプチドの発現系及びｎｅｌｌペプチドの骨形成活性 Download PDF

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Publication number
JP2007524360A
JP2007524360A JP2006503442A JP2006503442A JP2007524360A JP 2007524360 A JP2007524360 A JP 2007524360A JP 2006503442 A JP2006503442 A JP 2006503442A JP 2006503442 A JP2006503442 A JP 2006503442A JP 2007524360 A JP2007524360 A JP 2007524360A
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seq
peptide
nell1
nucleic acid
cell
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Japanese (ja)
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JP2007524360A5 (https=
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カン ティン，
俊一 黒田
ベン ウー，
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University of California
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University of California
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Priority claimed from PCT/US2003/029281 external-priority patent/WO2004024893A2/en
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Publication of JP2007524360A publication Critical patent/JP2007524360A/ja
Publication of JP2007524360A5 publication Critical patent/JP2007524360A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006503442A 2003-02-07 2004-02-09 Ｎｅｌｌペプチドの発現系及びｎｅｌｌペプチドの骨形成活性 Pending JP2007524360A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44567203P 2003-02-07 2003-02-07
PCT/US2003/029281 WO2004024893A2 (en) 2002-09-13 2003-09-15 Nell-1 enhanced bone mineralization
PCT/US2004/003808 WO2004072100A2 (en) 2003-02-07 2004-02-09 Nell peptide expression systems and bone formation activity of nell peptide

Publications (2)

Publication Number Publication Date
JP2007524360A true JP2007524360A (ja) 2007-08-30
JP2007524360A5 JP2007524360A5 (https=) 2009-09-03

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JP2006503442A Pending JP2007524360A (ja) 2003-02-07 2004-02-09 Ｎｅｌｌペプチドの発現系及びｎｅｌｌペプチドの骨形成活性

Country Status (9)

Country Link
US (3) US7544486B2 (https=)
EP (1) EP1594889B1 (https=)
JP (1) JP2007524360A (https=)
CN (1) CN101018562A (https=)
AT (1) ATE504649T1 (https=)
CA (1) CA2515208A1 (https=)
DE (1) DE602004032107D1 (https=)
ES (1) ES2366950T3 (https=)
WO (1) WO2004072100A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010016469A1 (ja) * 2008-08-04 2010-02-11 片山化学工業株式会社 Ｎｅｌｌ－１による組織・臓器異所再生制御技術
JP2010540557A (ja) * 2007-09-28 2010-12-24 ユーティー−バッテル・エルエルシー 細胞シグナル伝達タンパク質ｎｅｌｌ１を用いた、創傷治癒及び筋再生の促進方法

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3646191B2 (ja) * 1996-03-19 2005-05-11 大塚製薬株式会社 ヒト遺伝子
US6005088A (en) 1996-03-19 1999-12-21 Otsuka Pharmaceutical Co., Ltd. Human NPIK gene
US7884066B2 (en) 1999-10-05 2011-02-08 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
DE602004032107D1 (de) * 2003-02-07 2011-05-19 Univ California Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids
EP1694352A2 (en) * 2003-11-19 2006-08-30 DeveloGen Aktiengesellschaft Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
US7691607B2 (en) 2004-02-09 2010-04-06 The Regents Of The University Of California Expression system of NELL peptide
CN101115839B (zh) * 2004-08-30 2011-05-04 杨梦甦 通过rh核心蛋白聚糖-Fc融合蛋白抑制纤维发生的方法
US7833968B2 (en) 2005-02-16 2010-11-16 The Regents Of The University Of California Pharmaceutical compositions for treating or preventing bone conditions
US8206735B2 (en) * 2006-07-11 2012-06-26 Foresee Pharmaceuticals, Llc Pharmaceutical compositions for sustained release delivery of peptides
JP2008212265A (ja) * 2007-03-01 2008-09-18 Niigata Univ 培養人工骨及びその作製方法
EP2200630B1 (en) 2007-09-28 2013-05-01 Ut-Battelle, Llc Nell1 for use in treating cardiovascular disorders
EP2214697A4 (en) * 2007-10-30 2011-05-18 Univ California NELL-1 COMPOSITIONS
JP2011016723A (ja) * 2007-11-02 2011-01-27 Katayama Kagaku Kogyo Kk 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具
GB2463474B (en) * 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
CA2739608A1 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
US20110002893A1 (en) * 2008-11-03 2011-01-06 Ut-Battelle, Llc Diagnosis and treatment of congenital heart defects using nell1
US9447155B2 (en) 2009-03-25 2016-09-20 The Regents Of The University Of California Isoform Nell-1 peptide
WO2011022071A2 (en) * 2009-08-20 2011-02-24 The Regents Of The University Of California Cardiac compositions
EP2525808A2 (en) 2010-01-19 2012-11-28 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for male reproductive disorders
WO2011091244A1 (en) * 2010-01-21 2011-07-28 NellOne Therapeutics, Inc. Methods to treat or prevent a skin condition using a nell1 peptide
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2014152497A2 (en) 2013-03-15 2014-09-25 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for cognitive disorders
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
JP7175608B2 (ja) 2014-11-19 2022-11-21 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 加齢に伴うフレイルのための治療としてのオステオカルシン
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US10973953B1 (en) 2016-08-18 2021-04-13 Musculoskeletal Transplant Foundation Methods and compositions for preparing transplant tissue
US10752663B2 (en) 2016-08-29 2020-08-25 NellOne Therapeutics, Inc. Methods and compositions for regenerating tissues
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11364323B2 (en) 2018-09-17 2022-06-21 Rejuvablast LLC Combination grafts for tissue repair or regeneration applications
AU2019204031A1 (en) 2019-05-31 2020-12-17 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN110420350B (zh) * 2019-08-28 2021-10-22 深圳先进技术研究院 复合生物玻璃的粘附温敏水凝胶及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024821A1 (en) * 1999-10-05 2001-04-12 The Regents Of The University Of California Nell-1 enhanced bone mineralization

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4409332A (en) * 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
US5395502A (en) * 1988-11-14 1995-03-07 Anthony R. Torres Apparatus for performing and universally detecting capillary isoelectric focusing without mobilization using concentration gradient imaging systems
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5674725A (en) * 1991-07-11 1997-10-07 British Technology Group Limited Implant materials having a phosphatase and an organophosphorus compound for in vivo mineralization of bone
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6083690A (en) * 1995-06-02 2000-07-04 Osteoscreen, Inc. Methods and compositions for identifying osteogenic agents
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
JP3646191B2 (ja) * 1996-03-19 2005-05-11 大塚製薬株式会社 ヒト遺伝子
US6005088A (en) * 1996-03-19 1999-12-21 Otsuka Pharmaceutical Co., Ltd. Human NPIK gene
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US6462019B1 (en) * 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
DE69934694T2 (de) * 1998-08-10 2007-10-04 Agensys, Inc., Santa Monica Bpc-1: ein ausgeschiedenes gehirnspezifisches protein das von prostata- und blasen-krebszellen exprimiert und ausgeschieden wird
WO2004024893A2 (en) 2002-09-13 2004-03-25 The Regents Of The University Of California Nell-1 enhanced bone mineralization
US20030039968A1 (en) 2001-07-10 2003-02-27 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
DE602004032107D1 (de) * 2003-02-07 2011-05-19 Univ California Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids
TWI296483B (en) * 2005-12-07 2008-05-01 Marketech Int Corp Apparatus and method for adjusting input image based on characteristics of display system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024821A1 (en) * 1999-10-05 2001-04-12 The Regents Of The University Of California Nell-1 enhanced bone mineralization

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
JPN6009067905, Ｂｉｏｃｈｅｍ． Ｂｉｏｐｈｙｓ． Ｒｅｓ． Ｃｏｍｍｕｎ．, 1999, Ｖｏｌ． ２６５, ｐ． ７５２−７５７ *
JPN6009067908, Ｂｉｏｃｈｅｍ． Ｂｉｏｐｈｙｓ． Ｒｅｓ． Ｃｏｍｍｕｎ．, 1999, Ｖｏｌ． ２６５, ｐ． ７９−８６ *
JPN6009067909, Ｇｅｎｏｍｉｃｓ．, 1996, Ｖｏｌ． ３８, ｐ． ２７３−２７６ *
JPN6009067911, Ｊ． Ｖｉｒｏｌ．, 1994, Ｖｏｌ． ６８， Ｎｏ． ２, ｐ． ７６６−７７５ *
JPN6009067913, Ａｒｃｈ． Ｂｉｏｃｈｅｍ． Ｂｉｏｐｈｙｓ．, 2000, Ｖｏｌ． ３７４， Ｎｏ． １, ｐ． ３−７ *
JPN6009067914, Ｇｅｎｅ, 1991, Ｖｏｌ． ９８, ｐ． １７７−１８３ *
JPN6009067916, Ｂｉｏｔｅｃｈｎｏｌ． Ｐｒｏｇ．, 1993, Ｖｏｌ． ９, ｐ． ２５−３０ *
JPN6009067918, Ｂｉｏｔｅｃｈｎｏｌ． Ｐｒｏｇ．, 1993, Ｖｏｌ． ９, ｐ． ６７５−６７８ *
JPN6009067920, 生化学, 2002, 第７４巻、第８号, ｐ． ８０４ *
JPN6009067921, Ｉｎ Ｖｉｔｒｏ Ｃｅｌｌ． Ｄｅｖ． Ｂｉｏｌ．, 1993, Ｖｏｌ． ２９Ａ, ｐ． ３８８−３９０ *
JPN6009067923, Ｎａｔｉｏｎａｌ Ｃｅｎｔｅｒ ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｆｏｒｍａｔｉｏｎ， Ｐｒｏｔｅｉｎ， ［ｏｎｌｉｎｅ］, 2002 *
JPN6009067926, Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ．, 2002, Ｖｏｌ． １１０， Ｎｏ． ６, ｐ． ８６１−８７０ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540557A (ja) * 2007-09-28 2010-12-24 ユーティー−バッテル・エルエルシー 細胞シグナル伝達タンパク質ｎｅｌｌ１を用いた、創傷治癒及び筋再生の促進方法
WO2010016469A1 (ja) * 2008-08-04 2010-02-11 片山化学工業株式会社 Ｎｅｌｌ－１による組織・臓器異所再生制御技術
JP5641477B2 (ja) * 2008-08-04 2014-12-17 学校法人昭和大学 Ｎｅｌｌ−１による組織・臓器異所再生制御技術

Also Published As

Publication number Publication date
DE602004032107D1 (de) 2011-05-19
ATE504649T1 (de) 2011-04-15
US8048646B2 (en) 2011-11-01
WO2004072100A2 (en) 2004-08-26
EP1594889A2 (en) 2005-11-16
EP1594889A4 (en) 2008-03-19
US20060292670A1 (en) 2006-12-28
EP1594889B1 (en) 2011-04-06
US20100249376A1 (en) 2010-09-30
CN101018562A (zh) 2007-08-15
US20090226505A1 (en) 2009-09-10
WO2004072100A3 (en) 2007-03-15
US7544486B2 (en) 2009-06-09
US7807787B2 (en) 2010-10-05
ES2366950T3 (es) 2011-10-26
CA2515208A1 (en) 2004-08-26

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