ES2366950T3 - Sistemas de expresión de péptidos nell y actividad de formación ósea de péptidos nell. - Google Patents
Sistemas de expresión de péptidos nell y actividad de formación ósea de péptidos nell. Download PDFInfo
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- ES2366950T3 ES2366950T3 ES04709500T ES04709500T ES2366950T3 ES 2366950 T3 ES2366950 T3 ES 2366950T3 ES 04709500 T ES04709500 T ES 04709500T ES 04709500 T ES04709500 T ES 04709500T ES 2366950 T3 ES2366950 T3 ES 2366950T3
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- peptide
- nell1
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- nell2
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44567203P | 2003-02-07 | 2003-02-07 | |
| US445672P | 2003-02-07 | ||
| WOUS03/29281 | 2003-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2366950T3 true ES2366950T3 (es) | 2011-10-26 |
Family
ID=32869406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04709500T Expired - Lifetime ES2366950T3 (es) | 2003-02-07 | 2004-02-09 | Sistemas de expresión de péptidos nell y actividad de formación ósea de péptidos nell. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7544486B2 (https=) |
| EP (1) | EP1594889B1 (https=) |
| JP (1) | JP2007524360A (https=) |
| CN (1) | CN101018562A (https=) |
| AT (1) | ATE504649T1 (https=) |
| CA (1) | CA2515208A1 (https=) |
| DE (1) | DE602004032107D1 (https=) |
| ES (1) | ES2366950T3 (https=) |
| WO (1) | WO2004072100A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3646191B2 (ja) * | 1996-03-19 | 2005-05-11 | 大塚製薬株式会社 | ヒト遺伝子 |
| US6005088A (en) | 1996-03-19 | 1999-12-21 | Otsuka Pharmaceutical Co., Ltd. | Human NPIK gene |
| US7884066B2 (en) | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| US7687462B2 (en) * | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
| DE602004032107D1 (de) * | 2003-02-07 | 2011-05-19 | Univ California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
| EP1694352A2 (en) * | 2003-11-19 | 2006-08-30 | DeveloGen Aktiengesellschaft | Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
| CN101115839B (zh) * | 2004-08-30 | 2011-05-04 | 杨梦甦 | 通过rh核心蛋白聚糖-Fc融合蛋白抑制纤维发生的方法 |
| US7833968B2 (en) | 2005-02-16 | 2010-11-16 | The Regents Of The University Of California | Pharmaceutical compositions for treating or preventing bone conditions |
| US8206735B2 (en) * | 2006-07-11 | 2012-06-26 | Foresee Pharmaceuticals, Llc | Pharmaceutical compositions for sustained release delivery of peptides |
| JP2008212265A (ja) * | 2007-03-01 | 2008-09-18 | Niigata Univ | 培養人工骨及びその作製方法 |
| EP2200630B1 (en) | 2007-09-28 | 2013-05-01 | Ut-Battelle, Llc | Nell1 for use in treating cardiovascular disorders |
| WO2009042859A1 (en) * | 2007-09-28 | 2009-04-02 | Ut-Battelle, Llc | Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell 1 |
| EP2214697A4 (en) * | 2007-10-30 | 2011-05-18 | Univ California | NELL-1 COMPOSITIONS |
| JP2011016723A (ja) * | 2007-11-02 | 2011-01-27 | Katayama Kagaku Kogyo Kk | 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 |
| JP5641477B2 (ja) * | 2008-08-04 | 2014-12-17 | 学校法人昭和大学 | Ｎｅｌｌ−１による組織・臓器異所再生制御技術 |
| GB2463474B (en) * | 2008-09-11 | 2012-05-02 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
| CA2739608A1 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| US20110002893A1 (en) * | 2008-11-03 | 2011-01-06 | Ut-Battelle, Llc | Diagnosis and treatment of congenital heart defects using nell1 |
| US9447155B2 (en) | 2009-03-25 | 2016-09-20 | The Regents Of The University Of California | Isoform Nell-1 peptide |
| WO2011022071A2 (en) * | 2009-08-20 | 2011-02-24 | The Regents Of The University Of California | Cardiac compositions |
| EP2525808A2 (en) | 2010-01-19 | 2012-11-28 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for male reproductive disorders |
| WO2011091244A1 (en) * | 2010-01-21 | 2011-07-28 | NellOne Therapeutics, Inc. | Methods to treat or prevent a skin condition using a nell1 peptide |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| WO2014152497A2 (en) | 2013-03-15 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for cognitive disorders |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| JP7175608B2 (ja) | 2014-11-19 | 2022-11-21 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 加齢に伴うフレイルのための治療としてのオステオカルシン |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US10973953B1 (en) | 2016-08-18 | 2021-04-13 | Musculoskeletal Transplant Foundation | Methods and compositions for preparing transplant tissue |
| US10752663B2 (en) | 2016-08-29 | 2020-08-25 | NellOne Therapeutics, Inc. | Methods and compositions for regenerating tissues |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11364323B2 (en) | 2018-09-17 | 2022-06-21 | Rejuvablast LLC | Combination grafts for tissue repair or regeneration applications |
| AU2019204031A1 (en) | 2019-05-31 | 2020-12-17 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| CN110420350B (zh) * | 2019-08-28 | 2021-10-22 | 深圳先进技术研究院 | 复合生物玻璃的粘附温敏水凝胶及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US5395502A (en) * | 1988-11-14 | 1995-03-07 | Anthony R. Torres | Apparatus for performing and universally detecting capillary isoelectric focusing without mobilization using concentration gradient imaging systems |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5674725A (en) * | 1991-07-11 | 1997-10-07 | British Technology Group Limited | Implant materials having a phosphatase and an organophosphorus compound for in vivo mineralization of bone |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| US5763416A (en) * | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
| US5942496A (en) * | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
| US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
| US6008208A (en) * | 1995-10-23 | 1999-12-28 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| JP3646191B2 (ja) * | 1996-03-19 | 2005-05-11 | 大塚製薬株式会社 | ヒト遺伝子 |
| US6005088A (en) * | 1996-03-19 | 1999-12-21 | Otsuka Pharmaceutical Co., Ltd. | Human NPIK gene |
| US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
| DE69934694T2 (de) * | 1998-08-10 | 2007-10-04 | Agensys, Inc., Santa Monica | Bpc-1: ein ausgeschiedenes gehirnspezifisches protein das von prostata- und blasen-krebszellen exprimiert und ausgeschieden wird |
| US7052856B2 (en) | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| WO2004024893A2 (en) | 2002-09-13 | 2004-03-25 | The Regents Of The University Of California | Nell-1 enhanced bone mineralization |
| US20030039968A1 (en) | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
| DE602004032107D1 (de) * | 2003-02-07 | 2011-05-19 | Univ California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
| TWI296483B (en) * | 2005-12-07 | 2008-05-01 | Marketech Int Corp | Apparatus and method for adjusting input image based on characteristics of display system |
-
2004
- 2004-02-09 DE DE602004032107T patent/DE602004032107D1/de not_active Expired - Lifetime
- 2004-02-09 ES ES04709500T patent/ES2366950T3/es not_active Expired - Lifetime
- 2004-02-09 AT AT04709500T patent/ATE504649T1/de not_active IP Right Cessation
- 2004-02-09 US US10/544,553 patent/US7544486B2/en not_active Expired - Lifetime
- 2004-02-09 JP JP2006503442A patent/JP2007524360A/ja active Pending
- 2004-02-09 CA CA002515208A patent/CA2515208A1/en not_active Abandoned
- 2004-02-09 EP EP04709500A patent/EP1594889B1/en not_active Expired - Lifetime
- 2004-02-09 WO PCT/US2004/003808 patent/WO2004072100A2/en not_active Ceased
- 2004-02-09 CN CNA2004800094501A patent/CN101018562A/zh active Pending
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2009
- 2009-03-09 US US12/400,714 patent/US7807787B2/en not_active Expired - Lifetime
- 2009-03-09 US US12/400,715 patent/US8048646B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004032107D1 (de) | 2011-05-19 |
| ATE504649T1 (de) | 2011-04-15 |
| US8048646B2 (en) | 2011-11-01 |
| WO2004072100A2 (en) | 2004-08-26 |
| EP1594889A2 (en) | 2005-11-16 |
| EP1594889A4 (en) | 2008-03-19 |
| JP2007524360A (ja) | 2007-08-30 |
| US20060292670A1 (en) | 2006-12-28 |
| EP1594889B1 (en) | 2011-04-06 |
| US20100249376A1 (en) | 2010-09-30 |
| CN101018562A (zh) | 2007-08-15 |
| US20090226505A1 (en) | 2009-09-10 |
| WO2004072100A3 (en) | 2007-03-15 |
| US7544486B2 (en) | 2009-06-09 |
| US7807787B2 (en) | 2010-10-05 |
| CA2515208A1 (en) | 2004-08-26 |
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