CA2515208A1 - Nell peptide expression systems and bone formation activity of nell peptide - Google Patents

Nell peptide expression systems and bone formation activity of nell peptide Download PDF

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Publication number
CA2515208A1
CA2515208A1 CA002515208A CA2515208A CA2515208A1 CA 2515208 A1 CA2515208 A1 CA 2515208A1 CA 002515208 A CA002515208 A CA 002515208A CA 2515208 A CA2515208 A CA 2515208A CA 2515208 A1 CA2515208 A1 CA 2515208A1
Authority
CA
Canada
Prior art keywords
seq
peptide
cys
nell1
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002515208A
Other languages
English (en)
French (fr)
Inventor
Kang Ting
Shunichi Kuroda
Ben Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2515208A1 publication Critical patent/CA2515208A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002515208A 2003-02-07 2004-02-09 Nell peptide expression systems and bone formation activity of nell peptide Abandoned CA2515208A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44567203P 2003-02-07 2003-02-07
US60/445,672 2003-02-07
USPCT/US03/29281 2003-09-15
PCT/US2004/003808 WO2004072100A2 (en) 2003-02-07 2004-02-09 Nell peptide expression systems and bone formation activity of nell peptide

Publications (1)

Publication Number Publication Date
CA2515208A1 true CA2515208A1 (en) 2004-08-26

Family

ID=32869406

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002515208A Abandoned CA2515208A1 (en) 2003-02-07 2004-02-09 Nell peptide expression systems and bone formation activity of nell peptide

Country Status (9)

Country Link
US (3) US7544486B2 (https=)
EP (1) EP1594889B1 (https=)
JP (1) JP2007524360A (https=)
CN (1) CN101018562A (https=)
AT (1) ATE504649T1 (https=)
CA (1) CA2515208A1 (https=)
DE (1) DE602004032107D1 (https=)
ES (1) ES2366950T3 (https=)
WO (1) WO2004072100A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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JP3646191B2 (ja) * 1996-03-19 2005-05-11 大塚製薬株式会社 ヒト遺伝子
US6005088A (en) 1996-03-19 1999-12-21 Otsuka Pharmaceutical Co., Ltd. Human NPIK gene
US7884066B2 (en) 1999-10-05 2011-02-08 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
DE602004032107D1 (de) * 2003-02-07 2011-05-19 Univ California Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids
EP1694352A2 (en) * 2003-11-19 2006-08-30 DeveloGen Aktiengesellschaft Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
US7691607B2 (en) 2004-02-09 2010-04-06 The Regents Of The University Of California Expression system of NELL peptide
CN101115839B (zh) * 2004-08-30 2011-05-04 杨梦甦 通过rh核心蛋白聚糖-Fc融合蛋白抑制纤维发生的方法
US7833968B2 (en) 2005-02-16 2010-11-16 The Regents Of The University Of California Pharmaceutical compositions for treating or preventing bone conditions
US8206735B2 (en) * 2006-07-11 2012-06-26 Foresee Pharmaceuticals, Llc Pharmaceutical compositions for sustained release delivery of peptides
JP2008212265A (ja) * 2007-03-01 2008-09-18 Niigata Univ 培養人工骨及びその作製方法
EP2200630B1 (en) 2007-09-28 2013-05-01 Ut-Battelle, Llc Nell1 for use in treating cardiovascular disorders
WO2009042859A1 (en) * 2007-09-28 2009-04-02 Ut-Battelle, Llc Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell 1
EP2214697A4 (en) * 2007-10-30 2011-05-18 Univ California NELL-1 COMPOSITIONS
JP2011016723A (ja) * 2007-11-02 2011-01-27 Katayama Kagaku Kogyo Kk 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具
JP5641477B2 (ja) * 2008-08-04 2014-12-17 学校法人昭和大学 Ｎｅｌｌ−１による組織・臓器異所再生制御技術
GB2463474B (en) * 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
CA2739608A1 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
US20110002893A1 (en) * 2008-11-03 2011-01-06 Ut-Battelle, Llc Diagnosis and treatment of congenital heart defects using nell1
US9447155B2 (en) 2009-03-25 2016-09-20 The Regents Of The University Of California Isoform Nell-1 peptide
WO2011022071A2 (en) * 2009-08-20 2011-02-24 The Regents Of The University Of California Cardiac compositions
EP2525808A2 (en) 2010-01-19 2012-11-28 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for male reproductive disorders
WO2011091244A1 (en) * 2010-01-21 2011-07-28 NellOne Therapeutics, Inc. Methods to treat or prevent a skin condition using a nell1 peptide
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2014152497A2 (en) 2013-03-15 2014-09-25 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for cognitive disorders
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
JP7175608B2 (ja) 2014-11-19 2022-11-21 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 加齢に伴うフレイルのための治療としてのオステオカルシン
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US10973953B1 (en) 2016-08-18 2021-04-13 Musculoskeletal Transplant Foundation Methods and compositions for preparing transplant tissue
US10752663B2 (en) 2016-08-29 2020-08-25 NellOne Therapeutics, Inc. Methods and compositions for regenerating tissues
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11364323B2 (en) 2018-09-17 2022-06-21 Rejuvablast LLC Combination grafts for tissue repair or regeneration applications
AU2019204031A1 (en) 2019-05-31 2020-12-17 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN110420350B (zh) * 2019-08-28 2021-10-22 深圳先进技术研究院 复合生物玻璃的粘附温敏水凝胶及其制备方法和应用

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US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4409332A (en) * 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
US5395502A (en) * 1988-11-14 1995-03-07 Anthony R. Torres Apparatus for performing and universally detecting capillary isoelectric focusing without mobilization using concentration gradient imaging systems
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5674725A (en) * 1991-07-11 1997-10-07 British Technology Group Limited Implant materials having a phosphatase and an organophosphorus compound for in vivo mineralization of bone
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6083690A (en) * 1995-06-02 2000-07-04 Osteoscreen, Inc. Methods and compositions for identifying osteogenic agents
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
JP3646191B2 (ja) * 1996-03-19 2005-05-11 大塚製薬株式会社 ヒト遺伝子
US6005088A (en) * 1996-03-19 1999-12-21 Otsuka Pharmaceutical Co., Ltd. Human NPIK gene
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US6462019B1 (en) * 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
DE69934694T2 (de) * 1998-08-10 2007-10-04 Agensys, Inc., Santa Monica Bpc-1: ein ausgeschiedenes gehirnspezifisches protein das von prostata- und blasen-krebszellen exprimiert und ausgeschieden wird
US7052856B2 (en) 1999-10-05 2006-05-30 The Regents Of The University Of California NELL-1 enhanced bone mineralization
WO2004024893A2 (en) 2002-09-13 2004-03-25 The Regents Of The University Of California Nell-1 enhanced bone mineralization
US20030039968A1 (en) 2001-07-10 2003-02-27 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
DE602004032107D1 (de) * 2003-02-07 2011-05-19 Univ California Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids
TWI296483B (en) * 2005-12-07 2008-05-01 Marketech Int Corp Apparatus and method for adjusting input image based on characteristics of display system

Also Published As

Publication number Publication date
DE602004032107D1 (de) 2011-05-19
ATE504649T1 (de) 2011-04-15
US8048646B2 (en) 2011-11-01
WO2004072100A2 (en) 2004-08-26
EP1594889A2 (en) 2005-11-16
EP1594889A4 (en) 2008-03-19
JP2007524360A (ja) 2007-08-30
US20060292670A1 (en) 2006-12-28
EP1594889B1 (en) 2011-04-06
US20100249376A1 (en) 2010-09-30
CN101018562A (zh) 2007-08-15
US20090226505A1 (en) 2009-09-10
WO2004072100A3 (en) 2007-03-15
US7544486B2 (en) 2009-06-09
US7807787B2 (en) 2010-10-05
ES2366950T3 (es) 2011-10-26

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20111110