JP2007523862A5 - - Google Patents
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- JP2007523862A5 JP2007523862A5 JP2006517404A JP2006517404A JP2007523862A5 JP 2007523862 A5 JP2007523862 A5 JP 2007523862A5 JP 2006517404 A JP2006517404 A JP 2006517404A JP 2006517404 A JP2006517404 A JP 2006517404A JP 2007523862 A5 JP2007523862 A5 JP 2007523862A5
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- JP
- Japan
- Prior art keywords
- cancer
- growth
- tumor
- neoplastic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 4
- 230000001613 neoplastic effect Effects 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 201000003076 Angiosarcoma Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 208000001258 Hemangiosarcoma Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000008385 Urogenital Neoplasms Diseases 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 208000011571 secondary malignant neoplasm Diseases 0.000 description 1
- 208000011581 secondary neoplasm Diseases 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48027003P | 2003-06-20 | 2003-06-20 | |
| US56695204P | 2004-04-30 | 2004-04-30 | |
| PCT/US2004/019543 WO2005002572A2 (en) | 2003-06-20 | 2004-06-18 | Use of [3.2.0] heterocyclic compounds and analogs thereof for the treatment of cancer, inflammation and infectious diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011238014A Division JP2012031198A (ja) | 2003-06-20 | 2011-10-28 | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523862A JP2007523862A (ja) | 2007-08-23 |
| JP2007523862A5 true JP2007523862A5 (https=) | 2011-06-23 |
Family
ID=33567612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517404A Withdrawn JP2007523862A (ja) | 2003-06-20 | 2004-06-18 | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
| JP2011238014A Withdrawn JP2012031198A (ja) | 2003-06-20 | 2011-10-28 | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011238014A Withdrawn JP2012031198A (ja) | 2003-06-20 | 2011-10-28 | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20050049294A1 (https=) |
| EP (1) | EP1638552B1 (https=) |
| JP (2) | JP2007523862A (https=) |
| KR (1) | KR20060026052A (https=) |
| CN (1) | CN102151261A (https=) |
| AT (1) | ATE499934T1 (https=) |
| AU (1) | AU2004253478A1 (https=) |
| BR (1) | BRPI0411677A (https=) |
| CA (1) | CA2532066C (https=) |
| DE (1) | DE602004031614D1 (https=) |
| IL (1) | IL172705A (https=) |
| MX (1) | MXPA05013982A (https=) |
| NZ (1) | NZ544588A (https=) |
| WO (1) | WO2005002572A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| US7179834B2 (en) * | 2002-06-24 | 2007-02-20 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| KR20060026052A (ko) | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| EP2441767B1 (en) * | 2003-06-20 | 2015-06-10 | The Regents of The University of California | Salinosporamides and methods for use thereof |
| JP4691041B2 (ja) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | Ｇｔｐアーゼ阻害剤および使用方法 |
| WO2005099687A2 (en) * | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| BRPI0509824A (pt) * | 2004-04-30 | 2007-10-09 | Nereus Pharmaceuticals Inc | compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos |
| MX2007000392A (es) * | 2004-07-12 | 2007-06-15 | Bayer Cropscience Ag | Derivados de 2-pirrolidona sustituida como fungicidas e insecticidas. |
| CA2590334A1 (en) * | 2004-12-03 | 2006-06-08 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| SG157365A1 (en) * | 2004-12-03 | 2009-12-29 | Dana Farber Cancer Inst Inc | Compositions and methods for treating neoplastic diseases |
| US7826982B2 (en) | 2005-07-29 | 2010-11-02 | Children's Hospital Medical Center | Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE |
| US7691896B2 (en) | 2005-08-10 | 2010-04-06 | President And Fellows Of Harvard College | Analogs of salinosporamide A |
| WO2007021897A1 (en) * | 2005-08-10 | 2007-02-22 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| US7572606B1 (en) * | 2005-09-09 | 2009-08-11 | Nereus Pharmaceuticals, Inc. | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs |
| US7465720B2 (en) | 2005-09-12 | 2008-12-16 | President And Fellows Of Harvard College | Proteasome inhibiting β-lactam compounds |
| BRPI0618198A2 (pt) * | 2005-11-04 | 2018-06-26 | Nereus Pharmaceuticals Inc | métodos de tratamento, prevenção ou inibição de câncer e de linfoma, composição, kit, e, método de tratamento de câncer resistente a terapia |
| NZ572026A (en) | 2006-04-06 | 2011-12-22 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
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| WO2008095195A2 (en) | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
| WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
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| JP2011514352A (ja) | 2008-03-07 | 2011-05-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | サリノスポラミドａおよびその類似体の全合成 |
| US20090285836A1 (en) * | 2008-04-14 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Use of salinosporamide a to inhibit metastasis |
| CN102089312A (zh) * | 2008-05-12 | 2011-06-08 | 尼瑞斯药品公司 | 作为蛋白酶体抑制剂的Salinosporamide衍生物 |
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| US8073633B2 (en) * | 2008-12-30 | 2011-12-06 | The Invention Science Fund I, Llc | Computational methods and systems for suggesting modulators of CYP450 as treatment options |
| US8321151B2 (en) | 2008-12-30 | 2012-11-27 | The Invention Science Fund I, Llc | Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity |
| US8315815B2 (en) | 2008-12-30 | 2012-11-20 | The Invention Science Fund I, Llc | Computational methods and systems for suggesting modulators of CYP450 as treatment options |
| WO2010096574A1 (en) | 2009-02-20 | 2010-08-26 | Lisanti Michael P | A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| US9272014B2 (en) | 2011-03-29 | 2016-03-01 | Texas Tech University System | Galectin-3C combination therapy for human cancer |
| JP6238900B2 (ja) | 2011-10-28 | 2017-11-29 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎａｅ阻害物質に対する応答のバイオマーカー |
| CN104126017A (zh) | 2011-11-11 | 2014-10-29 | 米伦纽姆医药公司 | 对蛋白酶体抑制剂的反应的生物标记 |
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| EA201590916A1 (ru) | 2012-11-09 | 2016-02-29 | Корнэлл Юниверсити | Низкомолекулярные ингибиторы malt1 |
| US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| JP7171550B2 (ja) | 2016-06-01 | 2022-11-15 | セルジュヌ アンテルナシオナル ドゥジエム ソシエテ ア レスポンサビリテ リミティー | 中枢神経系（ｃｎｓ）がんの処置のためのマリゾミブの使用 |
| US10703760B2 (en) | 2016-08-19 | 2020-07-07 | Celgene International Ii Sàrl | Morphic forms of marizomib and uses thereof |
| KR101953671B1 (ko) * | 2017-08-21 | 2019-03-04 | 충남대학교산학협력단 | 프로테아좀 억제제를 유효성분으로 함유하는 아토피성 피부질환의 예방, 개선 또는 치료용 조성물 |
| EP3546447A1 (en) * | 2018-03-29 | 2019-10-02 | Heidelberg Pharma GmbH | Synthesis of (2s,3r,4r)-4,5-dihydroxyisoleucine and derivatives |
| CN115006532A (zh) * | 2021-03-05 | 2022-09-06 | 广州医科大学 | 蛋白酶体抑制剂的应用 |
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| GB0605217D0 (en) * | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
| NZ572026A (en) | 2006-04-06 | 2011-12-22 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
| US8088923B2 (en) * | 2006-07-07 | 2012-01-03 | The Texas A&M University System | Cyclic-fused beta-lactones and their synthesis |
| WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| JP2011514352A (ja) | 2008-03-07 | 2011-05-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | サリノスポラミドａおよびその類似体の全合成 |
| CN102089312A (zh) * | 2008-05-12 | 2011-06-08 | 尼瑞斯药品公司 | 作为蛋白酶体抑制剂的Salinosporamide衍生物 |
-
2004
- 2004-06-18 KR KR1020057024503A patent/KR20060026052A/ko not_active Ceased
- 2004-06-18 AT AT04776757T patent/ATE499934T1/de not_active IP Right Cessation
- 2004-06-18 CN CN2010102534518A patent/CN102151261A/zh active Pending
- 2004-06-18 NZ NZ544588A patent/NZ544588A/en not_active IP Right Cessation
- 2004-06-18 WO PCT/US2004/019543 patent/WO2005002572A2/en not_active Ceased
- 2004-06-18 AU AU2004253478A patent/AU2004253478A1/en not_active Abandoned
- 2004-06-18 BR BRPI0411677-1A patent/BRPI0411677A/pt not_active IP Right Cessation
- 2004-06-18 EP EP04776757A patent/EP1638552B1/en not_active Expired - Lifetime
- 2004-06-18 US US10/871,368 patent/US20050049294A1/en not_active Abandoned
- 2004-06-18 MX MXPA05013982A patent/MXPA05013982A/es not_active Application Discontinuation
- 2004-06-18 JP JP2006517404A patent/JP2007523862A/ja not_active Withdrawn
- 2004-06-18 CA CA2532066A patent/CA2532066C/en not_active Expired - Lifetime
- 2004-06-18 DE DE602004031614T patent/DE602004031614D1/de not_active Expired - Lifetime
-
2005
- 2005-12-20 IL IL172705A patent/IL172705A/en active IP Right Grant
-
2008
- 2008-06-10 US US12/136,688 patent/US8168803B2/en not_active Expired - Lifetime
-
2011
- 2011-10-28 JP JP2011238014A patent/JP2012031198A/ja not_active Withdrawn
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