JP2007523209A5 - - Google Patents
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- Publication number
- JP2007523209A5 JP2007523209A5 JP2007500232A JP2007500232A JP2007523209A5 JP 2007523209 A5 JP2007523209 A5 JP 2007523209A5 JP 2007500232 A JP2007500232 A JP 2007500232A JP 2007500232 A JP2007500232 A JP 2007500232A JP 2007523209 A5 JP2007523209 A5 JP 2007523209A5
- Authority
- JP
- Japan
- Prior art keywords
- measured
- bone
- marker
- bone resorption
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims 19
- 208000006386 Bone Resorption Diseases 0.000 claims 16
- 230000024279 bone resorption Effects 0.000 claims 16
- 239000003550 marker Substances 0.000 claims 12
- 210000002966 serum Anatomy 0.000 claims 10
- 230000011164 ossification Effects 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000008416 bone turnover Effects 0.000 claims 4
- 210000002700 urine Anatomy 0.000 claims 4
- 108010022452 Collagen Type I Proteins 0.000 claims 2
- 102000012422 Collagen Type I Human genes 0.000 claims 2
- 102100036213 Collagen alpha-2(I) chain Human genes 0.000 claims 2
- 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 claims 2
- 108010048038 N-propeptide type I collagen Proteins 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 108010050808 Procollagen Proteins 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 108010045624 glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- LUMKNAVTFCDUIE-VHXPQNKSSA-N ospemifene Chemical group C1=CC(OCCO)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 LUMKNAVTFCDUIE-VHXPQNKSSA-N 0.000 claims 1
- 229960003969 ospemifene Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/783,092 US20050187302A1 (en) | 2004-02-23 | 2004-02-23 | Method for treatment or prevention of osteoporosis in individuals with high bone turnover |
| PCT/FI2005/000034 WO2005079776A1 (en) | 2004-02-23 | 2005-01-19 | Method for treatment or prevention of osteoporosis in individuals with high bone turnover |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523209A JP2007523209A (ja) | 2007-08-16 |
| JP2007523209A5 true JP2007523209A5 (enExample) | 2008-03-06 |
Family
ID=34861145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500232A Abandoned JP2007523209A (ja) | 2004-02-23 | 2005-01-19 | 骨代謝回転が高い個体において骨粗鬆症を治療または予防する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050187302A1 (enExample) |
| EP (1) | EP1718287A1 (enExample) |
| JP (1) | JP2007523209A (enExample) |
| CN (1) | CN1972680A (enExample) |
| AU (1) | AU2005215173A1 (enExample) |
| BR (1) | BRPI0507912A (enExample) |
| CA (1) | CA2557116A1 (enExample) |
| MX (1) | MXPA06009549A (enExample) |
| NO (1) | NO20064007L (enExample) |
| RU (1) | RU2006133903A (enExample) |
| WO (1) | WO2005079776A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236861B2 (en) | 2004-02-13 | 2012-08-07 | Hormos Medical Corporation | Method for enhancing the bioavailablity of ospemifene |
| CA2641315A1 (en) * | 2006-02-06 | 2007-08-16 | Tethys Bioscience, Inc. | Osteoporosis associated markers and methods of use thereof |
| JP5363344B2 (ja) * | 2007-02-14 | 2013-12-11 | ホルモス メディカル リミテッド | 治療に有用なトリフェニルブテン誘導体の調製方法 |
| US7504530B2 (en) * | 2007-02-14 | 2009-03-17 | Hormos Medical Ltd. | Methods for the preparation of fispemifene from ospemifene |
| JP5010034B2 (ja) | 2007-12-28 | 2012-08-29 | エフ．ホフマン−ラ ロシュ アーゲー | 生理学的状態の評価 |
| CN102690347B (zh) * | 2012-05-18 | 2014-06-25 | 北京北方生物技术研究所 | 分离i型前胶原氨基末端肽的方法 |
| US9321712B2 (en) | 2012-10-19 | 2016-04-26 | Fermion Oy | Process for the preparation of ospemifene |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9418067D0 (en) * | 1994-09-07 | 1994-10-26 | Orion Yhtymae Oy | Triphenylethylenes for the prevention and treatment of osteoporosis |
| US6245819B1 (en) * | 2000-07-21 | 2001-06-12 | Hormos Medical Oy, Ltd. | Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause |
-
2004
- 2004-02-23 US US10/783,092 patent/US20050187302A1/en not_active Abandoned
-
2005
- 2005-01-19 CA CA002557116A patent/CA2557116A1/en not_active Abandoned
- 2005-01-19 RU RU2006133903/14A patent/RU2006133903A/ru not_active Application Discontinuation
- 2005-01-19 MX MXPA06009549A patent/MXPA06009549A/es unknown
- 2005-01-19 JP JP2007500232A patent/JP2007523209A/ja not_active Abandoned
- 2005-01-19 BR BRPI0507912-8A patent/BRPI0507912A/pt not_active IP Right Cessation
- 2005-01-19 EP EP05708122A patent/EP1718287A1/en not_active Ceased
- 2005-01-19 CN CNA2005800049712A patent/CN1972680A/zh active Pending
- 2005-01-19 WO PCT/FI2005/000034 patent/WO2005079776A1/en not_active Ceased
- 2005-01-19 AU AU2005215173A patent/AU2005215173A1/en not_active Abandoned
-
2006
- 2006-09-06 NO NO20064007A patent/NO20064007L/no not_active Application Discontinuation
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