JP2008514561A5 - - Google Patents

Info

Publication number

JP2008514561A5

JP2008514561A5 JP2007532808A JP2007532808A JP2008514561A5 JP 2008514561 A5 JP2008514561 A5 JP 2008514561A5 JP 2007532808 A JP2007532808 A JP 2007532808A JP 2007532808 A JP2007532808 A JP 2007532808A JP 2008514561 A5 JP2008514561 A5 JP 2008514561A5

Authority

JP

Japan

Prior art keywords

independently

represents hydrogen

methyl

formula

hydrogen

Prior art date

2005-09-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims 86
• 239000001257 hydrogen Substances 0.000 claims 86
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 42
• 150000002431 hydrogen Chemical class 0.000 claims 40
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 36
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 34
• 229910052757 nitrogen Inorganic materials 0.000 claims 34
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 34
• 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 32
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 29
• 229910052799 carbon Inorganic materials 0.000 claims 21
• 125000004432 carbon atom Chemical group C* 0.000 claims 21
• 239000012453 solvate Substances 0.000 claims 16
• 150000003839 salts Chemical class 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 13
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
• 125000004193 piperazinyl group Chemical group 0.000 claims 9
• 238000000034 method Methods 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 230000006806 disease prevention Effects 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 238000007327 hydrogenolysis reaction Methods 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 208000019802 Sexually transmitted disease Diseases 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 231100000252 nontoxic Toxicity 0.000 claims 1
• 230000003000 nontoxic effect Effects 0.000 claims 1
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 0 CCCC(*)C(C)(C)CC(C)(C)N* Chemical compound CCCC(*)C(C)(C)CC(C)(C)N* 0.000 description 2