JP2007523187A - 癌を処置または予防するためのβ−ラパコンの使用 - Google Patents

癌を処置または予防するためのβ−ラパコンの使用 Download PDF

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Publication number
JP2007523187A
JP2007523187A JP2006554258A JP2006554258A JP2007523187A JP 2007523187 A JP2007523187 A JP 2007523187A JP 2006554258 A JP2006554258 A JP 2006554258A JP 2006554258 A JP2006554258 A JP 2006554258A JP 2007523187 A JP2007523187 A JP 2007523187A
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Prior art keywords
cancer
lapachone
cell
cells
administration
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JP2006554258A
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English (en)
Japanese (ja)
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JP2007523187A5 (https=
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チャン リー，
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アルキュール， インコーポレイテッド
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Application filed by アルキュール， インコーポレイテッド filed Critical アルキュール， インコーポレイテッド
Priority claimed from PCT/US2005/005354 external-priority patent/WO2005082353A2/en
Publication of JP2007523187A publication Critical patent/JP2007523187A/ja
Publication of JP2007523187A5 publication Critical patent/JP2007523187A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2006554258A 2004-02-20 2005-02-16 癌を処置または予防するためのβ−ラパコンの使用 Pending JP2007523187A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US54591504P 2004-02-20 2004-02-20
US54591704P 2004-02-20 2004-02-20
US54591404P 2004-02-20 2004-02-20
US54591604P 2004-02-20 2004-02-20
US54595004P 2004-02-20 2004-02-20
US10/846,980 US20050187288A1 (en) 2004-02-20 2004-05-14 Beta-lapachone and methods of treating cancer
PCT/US2005/005354 WO2005082353A2 (en) 2004-02-20 2005-02-16 Use of beta-lapachone for treating or preventing cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008033775A Division JP2008169220A (ja) 2004-02-20 2008-02-14 癌を処置または予防するためのβ−ラパコンの使用

Publications (2)

Publication Number Publication Date
JP2007523187A true JP2007523187A (ja) 2007-08-16
JP2007523187A5 JP2007523187A5 (https=) 2008-04-03

Family

ID=56290562

Family Applications (2)

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JP2006554258A Pending JP2007523187A (ja) 2004-02-20 2005-02-16 癌を処置または予防するためのβ−ラパコンの使用
JP2008033775A Pending JP2008169220A (ja) 2004-02-20 2008-02-14 癌を処置または予防するためのβ−ラパコンの使用

Family Applications After (1)

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JP2008033775A Pending JP2008169220A (ja) 2004-02-20 2008-02-14 癌を処置または予防するためのβ−ラパコンの使用

Country Status (4)

Country Link
US (1) US20050187288A1 (https=)
EP (1) EP1727537A2 (https=)
JP (2) JP2007523187A (https=)
CA (1) CA2556758A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008169220A (ja) * 2004-02-20 2008-07-24 Arqule Inc 癌を処置または予防するためのβ−ラパコンの使用
JP2016516007A (ja) * 2013-02-26 2016-06-02 トリアクト セラピューティクス，インク． 癌治療

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101752697B1 (ko) * 2015-04-17 2017-07-03 (주)나디안바이오 나프토퀴논계 화합물을 유효성분으로 포함하는 췌장염 예방 및 치료용 조성물

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763625A (en) * 1995-04-25 1998-06-09 Wisconsin Alumni Research Foundation Synthesis and use of β-lapachone analogs
US6245807B1 (en) * 1995-08-24 2001-06-12 Dana-Farber Cancer Institute Treatment of human prostate disease
JP2002541200A (ja) * 1999-04-14 2002-12-03 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 癌の処置のための方法および組成物
WO2003011224A2 (en) * 2001-07-31 2003-02-13 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US20030036515A1 (en) * 2000-11-07 2003-02-20 Pardee Arthur B. Method of treating hematologic tumors and cancers
US20040001871A1 (en) * 2002-04-23 2004-01-01 David Boothman Lapachone delivery systems, compositions and uses related thereto
WO2004050033A2 (en) * 2002-12-02 2004-06-17 Arqule, Inc. Method of treating cancers
JP2004535363A (ja) * 2000-11-07 2004-11-25 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 血液腫瘍および血液癌を処置する方法
JP2005538981A (ja) * 2002-07-17 2005-12-22 アーキュル， インコーポレイテッド 活性化チェックポイント療法およびこれらの使用方法
JP2006508147A (ja) * 2002-11-18 2006-03-09 アルキュール， インコーポレイテッド 新規ラパコン化合物およびその使用方法
JP2007523192A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 広域スペクトラム抗癌剤としてのβ−ラパコンの使用
JP2007523191A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 血液腫瘍の治療のためのβ−ラパコンの使用
JP2007523215A (ja) * 2004-02-23 2007-08-16 アークル・インコーポレーテツド 癌治療のためのβ−ラパコンおよびＳ期薬組み合わせ
JP2007523189A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 結腸癌の治療のためのβ−ラパコンの使用
JP2007523193A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 膵癌の治療のためのβ−ラパコンの使用
JP2007523190A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 肺癌の治療のためのβ−ラパコンの使用
JP2008169220A (ja) * 2004-02-20 2008-07-24 Arqule Inc 癌を処置または予防するためのβ−ラパコンの使用

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ATE194767T1 (de) * 1992-03-23 2000-08-15 Univ Georgetown In liposomen verkapseltes taxol und verwendungsverfahren
US5440056A (en) * 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5919816A (en) * 1994-11-14 1999-07-06 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5760072A (en) * 1995-12-29 1998-06-02 Pharmachemie B.V. Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy
US5824700A (en) * 1996-02-20 1998-10-20 Wisconsin Alumni Research Foundation Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth
US5773461A (en) * 1996-06-06 1998-06-30 Bristol-Myers Squibb Company 7-deoxy-6-substituted paclitaxels
CA2245029A1 (en) * 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
US20050192361A1 (en) * 1999-04-14 2005-09-01 Li Chiang J. Method of treatment of colon cancer
US20050222246A1 (en) * 1999-04-14 2005-10-06 Li Chiang J Beta-lapachone is a broad spectrum anti-cancer agent
US20050197406A1 (en) * 1999-04-14 2005-09-08 Li Chiang J. Method of treatment of lung cancer
US20050192360A1 (en) * 1999-04-14 2005-09-01 Li Chiang J. Method of treatment of pancreatic cancer
US20050197405A1 (en) * 2000-11-07 2005-09-08 Li Chiang J. Treatment of hematologic tumors and cancers with beta-lapachone, a broad spectrum anti-cancer agent
US6458974B1 (en) * 2001-01-25 2002-10-01 Cyclis Pharmaceuticals, Inc. Synthesis of β-lapachone and its intermediates
TW200420515A (en) * 2002-07-23 2004-10-16 Ppg Ind Ohio Inc Glass fiber sizing compositions, sized glass fibers, and polyolefin composites
US20060142271A1 (en) * 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
EP1877097B1 (en) * 2004-08-11 2012-06-20 Arqule, Inc. Aminoacid conjugates of beta-lapachone for tumor targeting

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763625A (en) * 1995-04-25 1998-06-09 Wisconsin Alumni Research Foundation Synthesis and use of β-lapachone analogs
US6245807B1 (en) * 1995-08-24 2001-06-12 Dana-Farber Cancer Institute Treatment of human prostate disease
JP2002541200A (ja) * 1999-04-14 2002-12-03 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 癌の処置のための方法および組成物
JP2004535363A (ja) * 2000-11-07 2004-11-25 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 血液腫瘍および血液癌を処置する方法
US20030036515A1 (en) * 2000-11-07 2003-02-20 Pardee Arthur B. Method of treating hematologic tumors and cancers
WO2003011224A2 (en) * 2001-07-31 2003-02-13 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US20040001871A1 (en) * 2002-04-23 2004-01-01 David Boothman Lapachone delivery systems, compositions and uses related thereto
JP2005538981A (ja) * 2002-07-17 2005-12-22 アーキュル， インコーポレイテッド 活性化チェックポイント療法およびこれらの使用方法
JP2006508147A (ja) * 2002-11-18 2006-03-09 アルキュール， インコーポレイテッド 新規ラパコン化合物およびその使用方法
WO2004050033A2 (en) * 2002-12-02 2004-06-17 Arqule, Inc. Method of treating cancers
JP2007523192A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 広域スペクトラム抗癌剤としてのβ−ラパコンの使用
JP2007523191A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 血液腫瘍の治療のためのβ−ラパコンの使用
JP2007523189A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 結腸癌の治療のためのβ−ラパコンの使用
JP2007523193A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 膵癌の治療のためのβ−ラパコンの使用
JP2007523190A (ja) * 2004-02-20 2007-08-16 アークル・インコーポレーテツド 肺癌の治療のためのβ−ラパコンの使用
JP2008169220A (ja) * 2004-02-20 2008-07-24 Arqule Inc 癌を処置または予防するためのβ−ラパコンの使用
JP2007523215A (ja) * 2004-02-23 2007-08-16 アークル・インコーポレーテツド 癌治療のためのβ−ラパコンおよびＳ期薬組み合わせ

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008169220A (ja) * 2004-02-20 2008-07-24 Arqule Inc 癌を処置または予防するためのβ−ラパコンの使用
JP2016516007A (ja) * 2013-02-26 2016-06-02 トリアクト セラピューティクス，インク． 癌治療
US9834575B2 (en) 2013-02-26 2017-12-05 Triact Therapeutics, Inc. Cancer therapy

Also Published As

Publication number Publication date
US20050187288A1 (en) 2005-08-25
EP1727537A2 (en) 2006-12-06
JP2008169220A (ja) 2008-07-24
CA2556758A1 (en) 2005-09-09

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