JP2007522178A - 心臓血管疾患の治療に有用なベンゾフランおよびベンゾチオフェン誘導体 - Google Patents

心臓血管疾患の治療に有用なベンゾフランおよびベンゾチオフェン誘導体 Download PDF

Info

Publication number
JP2007522178A
JP2007522178A JP2006552575A JP2006552575A JP2007522178A JP 2007522178 A JP2007522178 A JP 2007522178A JP 2006552575 A JP2006552575 A JP 2006552575A JP 2006552575 A JP2006552575 A JP 2006552575A JP 2007522178 A JP2007522178 A JP 2007522178A
Authority
JP
Japan
Prior art keywords
methyl
oxy
trifluoromethyl
benzothien
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006552575A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007522178A5 (enExample
Inventor
ハーリング，ジョン，デヴィッド
ランベス，ポール，フランシス
リバーモア，デヴィッド，ジョージ
Original Assignee
スミスクライン ビーチャム コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スミスクライン ビーチャム コーポレーション filed Critical スミスクライン ビーチャム コーポレーション
Publication of JP2007522178A publication Critical patent/JP2007522178A/ja
Publication of JP2007522178A5 publication Critical patent/JP2007522178A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006552575A 2004-02-12 2005-02-10 心臓血管疾患の治療に有用なベンゾフランおよびベンゾチオフェン誘導体 Pending JP2007522178A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0403148.0A GB0403148D0 (en) 2004-02-12 2004-02-12 Chemical compounds
PCT/EP2005/001540 WO2005077926A2 (en) 2004-02-12 2005-02-10 Benzofuran and benzothiophene derivatives useful for the treatment of cardiovascular disease

Publications (2)

Publication Number Publication Date
JP2007522178A true JP2007522178A (ja) 2007-08-09
JP2007522178A5 JP2007522178A5 (enExample) 2007-11-15

Family

ID=32011809

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006552575A Pending JP2007522178A (ja) 2004-02-12 2005-02-10 心臓血管疾患の治療に有用なベンゾフランおよびベンゾチオフェン誘導体

Country Status (8)

Country Link
US (1) US20070155805A1 (enExample)
EP (1) EP1740568B1 (enExample)
JP (1) JP2007522178A (enExample)
AT (1) ATE415395T1 (enExample)
DE (1) DE602005011267D1 (enExample)
ES (1) ES2317192T3 (enExample)
GB (1) GB0403148D0 (enExample)
WO (1) WO2005077926A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128558A1 (ja) * 2008-04-15 2009-10-22 日本ケミファ株式会社 ペルオキシソーム増殖剤活性化受容体の活性化剤
JP2012250979A (ja) * 2011-05-10 2012-12-20 Sumitomo Chemical Co Ltd 植物の生長を促進する方法
JP2012250978A (ja) * 2011-05-10 2012-12-20 Sumitomo Chemical Co Ltd 植物の生長を促進する方法
JP2022516922A (ja) * 2019-01-02 2022-03-03 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ フッ素含有置換ベンゾチオフェン化合物ならびにその医薬組成物および応用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2565205A1 (en) * 2004-05-03 2005-11-24 Janssen Pharmaceutica N.V. Benzofuran derivatives as selective androgen receptor modulators (sarms)
TWI359810B (en) * 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
AU2007239283B2 (en) 2006-04-18 2013-02-07 Nippon Chemiphar Co., Ltd. Activating agent for peroxisome proliferator activated receptor delta
US20090163481A1 (en) * 2007-12-13 2009-06-25 Murphy Brian J Ppar-delta ligands and methods of their use
EP2464349A2 (en) * 2009-08-14 2012-06-20 Cerenis Therapeutics S.A. Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000504021A (ja) * 1996-02-02 2000-04-04 メルク エンド カンパニー インコーポレーテッド 糖尿病及び関連疾患状態を治療する方法
JP2001511767A (ja) * 1996-12-23 2001-08-14 メルク エンド カンパニー インコーポレーテッド 糖尿病薬
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
WO2002092590A1 (en) * 2001-05-11 2002-11-21 Glaxo Group Limited Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors
JP2003520838A (ja) * 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造および使用。
WO2003084916A2 (en) * 2002-04-05 2003-10-16 Warner-Lambert Company Llc Compounds that modulate ppar activity and methods for their preparation
WO2004010936A2 (en) * 2002-07-30 2004-02-05 Merck & Co., Inc. Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents
WO1997028149A1 (en) * 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
BR0315667A (pt) * 2002-10-28 2005-09-06 Novo Nordisk As Composto, uso de um composto, composição farmacêutica, e, método para o tratamento

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000504021A (ja) * 1996-02-02 2000-04-04 メルク エンド カンパニー インコーポレーテッド 糖尿病及び関連疾患状態を治療する方法
JP2001511767A (ja) * 1996-12-23 2001-08-14 メルク エンド カンパニー インコーポレーテッド 糖尿病薬
JP2003520838A (ja) * 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造および使用。
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
WO2002092590A1 (en) * 2001-05-11 2002-11-21 Glaxo Group Limited Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors
WO2003084916A2 (en) * 2002-04-05 2003-10-16 Warner-Lambert Company Llc Compounds that modulate ppar activity and methods for their preparation
WO2004010936A2 (en) * 2002-07-30 2004-02-05 Merck & Co., Inc. Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128558A1 (ja) * 2008-04-15 2009-10-22 日本ケミファ株式会社 ペルオキシソーム増殖剤活性化受容体の活性化剤
JP5474769B2 (ja) * 2008-04-15 2014-04-16 日本ケミファ株式会社 ペルオキシソーム増殖剤活性化受容体の活性化剤
KR20170021918A (ko) * 2008-04-15 2017-02-28 닛뽕 케미파 가부시키가이샤 퍼옥시좀 증식제 활성화 수용체의 활성화제
KR101871665B1 (ko) * 2008-04-15 2018-06-27 닛뽕 케미파 가부시키가이샤 퍼옥시좀 증식제 활성화 수용체의 활성화제
JP2012250979A (ja) * 2011-05-10 2012-12-20 Sumitomo Chemical Co Ltd 植物の生長を促進する方法
JP2012250978A (ja) * 2011-05-10 2012-12-20 Sumitomo Chemical Co Ltd 植物の生長を促進する方法
JP2022516922A (ja) * 2019-01-02 2022-03-03 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ フッ素含有置換ベンゾチオフェン化合物ならびにその医薬組成物および応用
JP7329052B2 (ja) 2019-01-02 2023-08-17 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ フッ素含有置換ベンゾチオフェン化合物ならびにその医薬組成物および応用

Also Published As

Publication number Publication date
US20070155805A1 (en) 2007-07-05
DE602005011267D1 (de) 2009-01-08
EP1740568B1 (en) 2008-11-26
GB0403148D0 (en) 2004-03-17
WO2005077926A2 (en) 2005-08-25
EP1740568A2 (en) 2007-01-10
ES2317192T3 (es) 2009-04-16
WO2005077926A3 (en) 2005-12-08
ATE415395T1 (de) 2008-12-15

Similar Documents

Publication Publication Date Title
JP4209681B2 (ja) Ｐｐａｒ関連障害治療用のチアゾール誘導体
JP4234431B2 (ja) ヒトペルオキシソーム増殖因子活性化受容体の活性化剤としてのチアゾール及びオキサゾール誘導体
JP4383177B2 (ja) ｈＰＰＡＲ活性化剤
EP1513526B1 (en) Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hppar activators
JP3255930B2 (ja) ＰＰＡＲ―γに対するアゴニスト活性を有する置換４―ヒドロキシフェニルアルカン酸誘導体
EP1685113B1 (en) Substituted pyrazoles as ppar agonists
KR101174982B1 (ko) 1,1,1-트라이플루오로-2-하이드록시-4-페닐프로판 유도체
AU2002246713A1 (en) Thiazole derivatives for treating PPAR related disorders
JP2004534035A (ja) ヒト・ペルオキシソーム増殖因子活性化受容体を活性化するフランおよびチオフェン誘導体
JP2005534673A (ja) 化学化合物
KR20040007633A (ko) 심혈관 질환 및 이와 관련된 질환의 치료에 유용한 티아졸또는 옥사졸 유도체
US20040102493A1 (en) Thia-and oxazoles and their use as ppars activators
JP2005529965A (ja) ｈＰＰＡＲ活性化物質としてのフェニルオキシアルカン酸誘導体
JP2007522178A (ja) 心臓血管疾患の治療に有用なベンゾフランおよびベンゾチオフェン誘導体
WO1990005132A1 (fr) Derives d'allylamine substitues, procede de preparation et utilisation
JP2004532267A (ja) ｈＰＰＡＲα受容体のオキサゾール／チアゾール誘導体アクチベーター
US7105551B2 (en) Thiazole derivatives for treating PPAR related disorders
JP4627298B2 (ja) チアゾール環で置換されたインドリル誘導体およびｐｐａｒ調整剤としてのその使用
US20040072838A1 (en) Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
HK1059925B (en) Thiazole derivatives for treating ppar related disorders
HK1076712B (en) Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hppar activators

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070928

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070928

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101130

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110419