JP2007518822A - 抗癌剤としてのテトラヒドロカルボリン化合物 - Google Patents

抗癌剤としてのテトラヒドロカルボリン化合物 Download PDF

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JP2007518822A
JP2007518822A JP2006551391A JP2006551391A JP2007518822A JP 2007518822 A JP2007518822 A JP 2007518822A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2007518822 A JP2007518822 A JP 2007518822A
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substituted
group
unsubstituted
hydrogen
compound
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JP2007518822A5 (https=
Inventor
ウェイボー ワン，
ジー−ジエ ニー，
パウル バルサンティ，
サビナ ペッチ，
イー シャー，
ナタン ブラムマイアー，
ミーガン トロイトル，
エリサ ジャーザン，
ケリー ウェイマン，
デイビッド ディブル，
ジエ−カイ チェン，
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カイロン コーポレイション
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Publication of JP2007518822A publication Critical patent/JP2007518822A/ja
Publication of JP2007518822A5 publication Critical patent/JP2007518822A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006551391A 2004-01-23 2005-01-24 抗癌剤としてのテトラヒドロカルボリン化合物 Pending JP2007518822A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53898004P 2004-01-23 2004-01-23
PCT/US2005/002270 WO2005070930A2 (en) 2004-01-23 2005-01-24 Tetrahydrocarboline compounds as anticancer agents

Publications (2)

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JP2007518822A true JP2007518822A (ja) 2007-07-12
JP2007518822A5 JP2007518822A5 (https=) 2008-01-31

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ID=34807249

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JP2006551391A Pending JP2007518822A (ja) 2004-01-23 2005-01-24 抗癌剤としてのテトラヒドロカルボリン化合物

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US (1) US7855295B2 (https=)
EP (1) EP1706404A2 (https=)
JP (1) JP2007518822A (https=)
CN (1) CN1910183A (https=)
AU (1) AU2005206570A1 (https=)
BR (1) BRPI0506977A (https=)
CA (1) CA2554150A1 (https=)
MX (1) MXPA06008211A (https=)
WO (1) WO2005070930A2 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536876A (ja) * 2005-04-18 2008-09-11 ピーティーシー セラピューティクス，インコーポレーテッド 癌の治療に有用なカルボリン誘導体
WO2012005227A1 (ja) * 2010-07-06 2012-01-12 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
JP2013513649A (ja) * 2009-12-14 2013-04-22 サノフイ 新規（複素環／縮合ピペリジン）−（ピペラジニル）−１−アルカノンまたは（複素環／縮合ピロリジン）−（ピペラジニル）−１−アルカノン誘導体およびｐ７５阻害剤としてのこれらの使用
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
JP2016522835A (ja) * 2013-05-28 2016-08-04 アストラゼネカ アクチボラグ 化合物
WO2017073743A1 (ja) * 2015-10-30 2017-05-04 協和発酵キリン株式会社 三環性化合物
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers
US11613538B2 (en) 2009-05-27 2023-03-28 Ptc Therapeutics, Inc. Method of inhibiting or reducing a viral infection

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ES2427166T3 (es) 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
MXPA06010543A (es) 2004-03-15 2007-03-26 Ptc Therapeutics Inc Derivados de carbolina utiles en la inhibicion de la angiogenesis.
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
WO2006068164A1 (ja) 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
WO2009042815A1 (en) * 2007-09-25 2009-04-02 Minerva Biotechnologies Corp. Methods for treatment of cancer
US11202775B2 (en) 2007-09-25 2021-12-21 Minerva Biotechnologies Corporation Methods for treatment of cancer
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
US8697662B2 (en) 2009-05-27 2014-04-15 Ptc Therapeutics, Inc. Methods for treating Kaposi sarcoma
MX2011012517A (es) 2009-05-27 2012-01-27 Ptc Therapeutics Inc Procesos para la preparacion de tetrahidro beta - carbolina sustituidas.
WO2010138685A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US8637501B2 (en) * 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en) * 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
JP6248048B2 (ja) 2012-01-09 2017-12-13 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
CN103087062B (zh) * 2013-01-19 2015-06-03 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
JP2019515643A (ja) * 2015-09-23 2019-06-13 ミネルバ バイオテクノロジーズ コーポレーション 幹細胞分化剤のスクリーニング方法
US10519148B2 (en) * 2015-11-12 2019-12-31 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
CN106967063B (zh) * 2017-03-21 2019-01-11 浙江大学 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法
US11485734B2 (en) 2018-10-02 2022-11-01 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)
CN110791389B (zh) * 2019-09-30 2021-06-01 义乌欧风汽车用品有限公司 一种除胶剂及其制备方法和应用
CA3237691A1 (en) * 2021-12-31 2023-07-06 Ptc Therapeutics, Inc. Carboline compounds and use thereof
CN120265629A (zh) * 2022-11-07 2025-07-04 默克专利股份公司 被取代的双环和三环hset抑制剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02111772A (ja) * 1988-08-29 1990-04-24 Duphar Internatl Res Bv β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体並びにこれらの調剤上許容される酸付加塩、β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体を製造する方法、静細胞特性を有する組成物、腫瘍の治療方法
JPH05246987A (ja) * 1991-12-05 1993-09-24 Whitby Res Inc 抗増殖剤として有用な化合物
US5606060A (en) * 1992-04-14 1997-02-25 The United States Of America As Represented By The Department Of Health & Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
US20030040527A1 (en) * 2001-04-03 2003-02-27 Yeh Sheau Farn 1-substituted 1,2,3,4-tetrahydro-beta-carboline and 3,4-dihydro-beta-carboline and analogs as antitumor agents
WO2003033496A1 (en) * 2001-10-19 2003-04-24 Transtech Pharma, Inc. Beta-carbolin derivatives as ptp-inhibitors

Family Cites Families (5)

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EP0300541B1 (en) 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
JPH03287586A (ja) 1990-04-02 1991-12-18 Taisho Pharmaceut Co Ltd テトラヒドロ―β―カルボリン誘導体
JP3287586B2 (ja) 1991-07-09 2002-06-04 キヤノン株式会社 カラー画像処理方法、及びカラー画像処理装置
FR2796644B1 (fr) 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02111772A (ja) * 1988-08-29 1990-04-24 Duphar Internatl Res Bv β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体並びにこれらの調剤上許容される酸付加塩、β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体を製造する方法、静細胞特性を有する組成物、腫瘍の治療方法
JPH05246987A (ja) * 1991-12-05 1993-09-24 Whitby Res Inc 抗増殖剤として有用な化合物
US5606060A (en) * 1992-04-14 1997-02-25 The United States Of America As Represented By The Department Of Health & Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
US20030040527A1 (en) * 2001-04-03 2003-02-27 Yeh Sheau Farn 1-substituted 1,2,3,4-tetrahydro-beta-carboline and 3,4-dihydro-beta-carboline and analogs as antitumor agents
WO2003033496A1 (en) * 2001-10-19 2003-04-24 Transtech Pharma, Inc. Beta-carbolin derivatives as ptp-inhibitors

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536876A (ja) * 2005-04-18 2008-09-11 ピーティーシー セラピューティクス，インコーポレーテッド 癌の治療に有用なカルボリン誘導体
US11613538B2 (en) 2009-05-27 2023-03-28 Ptc Therapeutics, Inc. Method of inhibiting or reducing a viral infection
JP2013513649A (ja) * 2009-12-14 2013-04-22 サノフイ 新規（複素環／縮合ピペリジン）−（ピペラジニル）−１−アルカノンまたは（複素環／縮合ピロリジン）−（ピペラジニル）−１−アルカノン誘導体およびｐ７５阻害剤としてのこれらの使用
JP2015214544A (ja) * 2010-07-06 2015-12-03 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
JP5821848B2 (ja) * 2010-07-06 2015-11-24 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
CN102971318B (zh) * 2010-07-06 2015-11-25 小野药品工业株式会社 四氢咔啉衍生物
CN102971318A (zh) * 2010-07-06 2013-03-13 小野药品工业株式会社 四氢咔啉衍生物
US9636330B2 (en) 2010-07-06 2017-05-02 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US9974777B2 (en) 2010-07-06 2018-05-22 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
WO2012005227A1 (ja) * 2010-07-06 2012-01-12 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US9862721B2 (en) 2011-03-18 2018-01-09 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
JP2016522835A (ja) * 2013-05-28 2016-08-04 アストラゼネカ アクチボラグ 化合物
WO2017073743A1 (ja) * 2015-10-30 2017-05-04 協和発酵キリン株式会社 三環性化合物
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers

Also Published As

Publication number Publication date
EP1706404A2 (en) 2006-10-04
CA2554150A1 (en) 2005-08-04
AU2005206570A1 (en) 2005-08-04
MXPA06008211A (es) 2006-08-31
US20050215580A1 (en) 2005-09-29
WO2005070930A3 (en) 2006-01-19
WO2005070930A2 (en) 2005-08-04
CN1910183A (zh) 2007-02-07
BRPI0506977A (pt) 2007-07-03
US7855295B2 (en) 2010-12-21

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