CN1910183A - 四氢咔啉化合物作为抗癌药 - Google Patents

四氢咔啉化合物作为抗癌药 Download PDF

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Publication number
CN1910183A
CN1910183A CNA2005800030203A CN200580003020A CN1910183A CN 1910183 A CN1910183 A CN 1910183A CN A2005800030203 A CNA2005800030203 A CN A2005800030203A CN 200580003020 A CN200580003020 A CN 200580003020A CN 1910183 A CN1910183 A CN 1910183A
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China
Prior art keywords
substituted
compound
hydrogen
unsubstituted
alkyl
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CNA2005800030203A
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English (en)
Chinese (zh)
Inventor
王为波
Z·-J·倪
P·巴杉蒂
S·佩奇
夏奕
N·布拉默尔
M·特罗托
E·加赞
K·威曼
D·蒂伯
程捷恺
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NOVARTIS VACCINES and DIAGNOSTIC Inc
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Chiron Corp
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Publication of CN1910183A publication Critical patent/CN1910183A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA2005800030203A 2004-01-23 2005-01-24 四氢咔啉化合物作为抗癌药 Pending CN1910183A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53898004P 2004-01-23 2004-01-23
US60/538,980 2004-01-23

Publications (1)

Publication Number Publication Date
CN1910183A true CN1910183A (zh) 2007-02-07

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CNA2005800030203A Pending CN1910183A (zh) 2004-01-23 2005-01-24 四氢咔啉化合物作为抗癌药

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US (1) US7855295B2 (https=)
EP (1) EP1706404A2 (https=)
JP (1) JP2007518822A (https=)
CN (1) CN1910183A (https=)
AU (1) AU2005206570A1 (https=)
BR (1) BRPI0506977A (https=)
CA (1) CA2554150A1 (https=)
MX (1) MXPA06008211A (https=)
WO (1) WO2005070930A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
CN103087062A (zh) * 2013-01-19 2013-05-08 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN106967063A (zh) * 2017-03-21 2017-07-21 浙江大学 1‑三氟甲基‑1,2,3,4‑四氢‑β‑咔啉衍生物及其制备方法
CN110791389A (zh) * 2019-09-30 2020-02-14 义乌欧风汽车用品有限公司 一种环保型除胶剂及其制备方法和应用
CN113527289A (zh) * 2015-09-23 2021-10-22 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法

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US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
MXPA06010543A (es) 2004-03-15 2007-03-26 Ptc Therapeutics Inc Derivados de carbolina utiles en la inhibicion de la angiogenesis.
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
WO2006068164A1 (ja) 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
WO2009042815A1 (en) * 2007-09-25 2009-04-02 Minerva Biotechnologies Corp. Methods for treatment of cancer
US11202775B2 (en) 2007-09-25 2021-12-21 Minerva Biotechnologies Corporation Methods for treatment of cancer
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
US8697662B2 (en) 2009-05-27 2014-04-15 Ptc Therapeutics, Inc. Methods for treating Kaposi sarcoma
MX373926B (es) 2009-05-27 2020-07-10 Ptc Therapeutics Inc Metodos para tratar cancer y estados no neoplasicos.
MX2011012517A (es) 2009-05-27 2012-01-27 Ptc Therapeutics Inc Procesos para la preparacion de tetrahidro beta - carbolina sustituidas.
WO2010138685A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US8637501B2 (en) * 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en) * 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
KR101831005B1 (ko) * 2010-07-06 2018-02-21 오노 야꾸힝 고교 가부시키가이샤 테트라히드로카르볼린 유도체
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
JP6248048B2 (ja) 2012-01-09 2017-12-13 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
TWI653235B (zh) * 2013-05-28 2019-03-11 阿斯特捷利康公司 作為抗癌劑之吲哚衍生物
JP2019001715A (ja) * 2015-10-30 2019-01-10 協和発酵キリン株式会社 三環性化合物
US10519148B2 (en) * 2015-11-12 2019-12-31 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
WO2019028171A1 (en) 2017-08-01 2019-02-07 Ptc Therapeutics, Inc. DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS
US11485734B2 (en) 2018-10-02 2022-11-01 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)
CA3237691A1 (en) * 2021-12-31 2023-07-06 Ptc Therapeutics, Inc. Carboline compounds and use thereof
CN120265629A (zh) * 2022-11-07 2025-07-04 默克专利股份公司 被取代的双环和三环hset抑制剂

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EP0300541B1 (en) 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
EP0357122A3 (en) 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
JPH03287586A (ja) 1990-04-02 1991-12-18 Taisho Pharmaceut Co Ltd テトラヒドロ―β―カルボリン誘導体
JP3287586B2 (ja) 1991-07-09 2002-06-04 キヤノン株式会社 カラー画像処理方法、及びカラー画像処理装置
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5622960A (en) * 1992-04-14 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Topoisomerase II inhibitors and therapeutic uses therefor
DE69710182T2 (de) * 1996-04-04 2002-08-29 F. Hoffmann-La Roche Ag, Basel Verwendung von tetrahydrobetacarbolin-derivaten zur vorbeugung der metastasenbildung
FR2796644B1 (fr) 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6720331B2 (en) * 2001-04-03 2004-04-13 National Sun Yat-Sen University 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents
ATE348828T1 (de) 2001-10-19 2007-01-15 Transtech Pharma Inc Beta-carbolin-derivate als ptp-inhibitoren

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
CN103087062A (zh) * 2013-01-19 2013-05-08 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN103087062B (zh) * 2013-01-19 2015-06-03 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN113527289A (zh) * 2015-09-23 2021-10-22 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法
CN106967063A (zh) * 2017-03-21 2017-07-21 浙江大学 1‑三氟甲基‑1,2,3,4‑四氢‑β‑咔啉衍生物及其制备方法
CN106967063B (zh) * 2017-03-21 2019-01-11 浙江大学 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法
CN110791389A (zh) * 2019-09-30 2020-02-14 义乌欧风汽车用品有限公司 一种环保型除胶剂及其制备方法和应用
CN110791389B (zh) * 2019-09-30 2021-06-01 义乌欧风汽车用品有限公司 一种除胶剂及其制备方法和应用

Also Published As

Publication number Publication date
EP1706404A2 (en) 2006-10-04
CA2554150A1 (en) 2005-08-04
AU2005206570A1 (en) 2005-08-04
MXPA06008211A (es) 2006-08-31
JP2007518822A (ja) 2007-07-12
US20050215580A1 (en) 2005-09-29
WO2005070930A3 (en) 2006-01-19
WO2005070930A2 (en) 2005-08-04
BRPI0506977A (pt) 2007-07-03
US7855295B2 (en) 2010-12-21

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