JP2007513877A5 - - Google Patents

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Publication number
JP2007513877A5
JP2007513877A5 JP2006539731A JP2006539731A JP2007513877A5 JP 2007513877 A5 JP2007513877 A5 JP 2007513877A5 JP 2006539731 A JP2006539731 A JP 2006539731A JP 2006539731 A JP2006539731 A JP 2006539731A JP 2007513877 A5 JP2007513877 A5 JP 2007513877A5
Authority
JP
Japan
Prior art keywords
methyl
sulfinyl
ethene
chlorophenyl
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006539731A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007513877A (ja
JP5196787B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/037293 external-priority patent/WO2005046599A2/en
Publication of JP2007513877A publication Critical patent/JP2007513877A/ja
Publication of JP2007513877A5 publication Critical patent/JP2007513877A5/ja
Application granted granted Critical
Publication of JP5196787B2 publication Critical patent/JP5196787B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006539731A 2003-11-14 2004-11-08 増殖性疾患を治療するためのα，β−不飽和スルホキシド Expired - Fee Related JP5196787B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52052303P 2003-11-14 2003-11-14
US60/520,523 2003-11-14
PCT/US2004/037293 WO2005046599A2 (en) 2003-11-14 2004-11-08 Alpha, beta-unsaturated sulfoxides for treating proliferative disorders

Publications (3)

Publication Number Publication Date
JP2007513877A JP2007513877A (ja) 2007-05-31
JP2007513877A5 true JP2007513877A5 (enExample) 2007-12-27
JP5196787B2 JP5196787B2 (ja) 2013-05-15

Family

ID=34590471

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006539731A Expired - Fee Related JP5196787B2 (ja) 2003-11-14 2004-11-08 増殖性疾患を治療するためのα，β−不飽和スルホキシド

Country Status (12)

Country Link
US (1) US7744889B2 (enExample)
EP (1) EP1689706B1 (enExample)
JP (1) JP5196787B2 (enExample)
KR (1) KR20060109871A (enExample)
AU (1) AU2004289281C1 (enExample)
CA (1) CA2546495C (enExample)
DK (1) DK1689706T3 (enExample)
ES (1) ES2621802T3 (enExample)
HU (1) HUE032523T2 (enExample)
IL (1) IL174426A (enExample)
NZ (1) NZ545995A (enExample)
WO (1) WO2005046599A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005222947B2 (en) * 2004-03-16 2010-12-23 Onconova Therapeutics Inc. Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
US20090306207A1 (en) * 2005-01-05 2009-12-10 Reddy M V Ramana Treatment of Drug-Resistant Proliferative Disorders
WO2006104668A2 (en) * 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
WO2007005670A2 (en) * 2005-06-30 2007-01-11 The Research Foundation Of The State University Of New York Natural and synthetic sulfoxide, selenone and selenoxide analogs and polymer conjugated forms thereof for the modulation of angiogenesis
JP5734869B2 (ja) * 2008-12-16 2015-06-17 オンコノバ・セラピューティックス・インコーポレーテッド ヒトにおける細胞毒性物質の有害作用に対する治療レジメンの有効性を決定する方法
GB201010359D0 (en) 2010-06-21 2010-08-04 Univ Nottingham Compounds for treating proliferative disorders
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
CA2885217C (en) 2012-09-20 2019-10-08 Temple University - Of The Commonwealth System Of Higher Education Substituted alkyl diaryl derivatives, methods of preparation and uses
SG11201509194SA (en) * 2013-05-07 2015-12-30 Univ California Radiomitigating pharmaceutical formulations
CN104892471B (zh) * 2015-05-15 2020-03-27 中国人民解放军军事医学科学院放射与辐射医学研究所 具有蛋白酪氨酸激酶抑制活性的物质、其制备方法及用途
US10383831B2 (en) * 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
CN106432011B (zh) * 2016-09-18 2018-11-02 中国医学科学院放射医学研究所 一类具有辐射防护作用的新化合物、其制备方法及其药物应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865867A (en) * 1967-06-19 1975-02-11 Monsanto Co Meta-bifunctional benzenes
US3975435A (en) * 1974-03-06 1976-08-17 Givaudan Corporation Substituted cinnamanilides
DK586175A (da) * 1974-12-28 1976-06-29 Asahi Chemical Ind Cephalosporin-forbindelser
JPH05262733A (ja) * 1992-03-23 1993-10-12 Sapporo Breweries Ltd 含硫黄化合物，その製造法及びそれを有効成分とする抗潰瘍剤
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
EA200800375A1 (ru) * 1997-05-14 2008-06-30 Атеродженикс, Инк. Соединения и способы ингибирования экспрессии vcam-1
ATE284386T1 (de) * 1997-10-03 2004-12-15 Univ Temple Styrolsulfone als antikrebsmittel
US6548553B2 (en) * 1997-10-03 2003-04-15 Temple University-Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
US6201154B1 (en) * 1999-03-31 2001-03-13 Temple University-Of The Commonwealth Of Higher Education Z-styryl sulfone anticancer agents
WO2000059495A1 (en) * 1999-04-02 2000-10-12 Temple University - Of The Commonwealth System Of Higher Education (e)-styryl sulfone anticancer agents
WO2000059494A1 (en) * 1999-04-02 2000-10-12 Temple University- Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
US6762207B1 (en) * 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
US6117364A (en) * 1999-05-27 2000-09-12 Nalco/Exxon Energy Chemicals, L.P. Acid corrosion inhibitor
CA2375511A1 (en) * 1999-06-16 2000-12-21 Temple University - Of The Commonwealth System Of Higher Education (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors
US6767926B1 (en) * 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
IL149064A0 (en) * 1999-10-12 2002-11-10 Univ Temple Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6541475B2 (en) * 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
US6486210B2 (en) * 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
CA2424884C (en) * 2000-10-05 2009-12-15 E. Premkumar Reddy Substituted (e)-styryl benzylsulfones for treating proliferative disorders
CN1401055A (zh) * 2000-10-12 2003-03-05 雅马哈发动机株式会社 气体燃料混合器
WO2002067913A1 (en) * 2001-02-27 2002-09-06 Temple University-Of The Commonwealth System Of Higher Education (z)-styrylbenzylsulfones and pharmaceutical uses thereof
US6667346B2 (en) * 2001-02-28 2003-12-23 Temple University - Of The Commonwealth System Of Higher Education Method for protecting cells and tissues from ionizing radiation toxicity with α, β unsaturated aryl sulfones
DK1379508T3 (da) * 2001-02-28 2011-01-03 Univ Temple N-(aryl)-2arylethensulfonamider og terapeutiske anvendelser deraf
NZ535232A (en) * 2002-02-28 2007-05-31 Univ Temple Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
AU2005222947B2 (en) * 2004-03-16 2010-12-23 Onconova Therapeutics Inc. Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
WO2006104668A2 (en) * 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases

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