JP2007509928A5 - - Google Patents
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- Publication number
- JP2007509928A5 JP2007509928A5 JP2006537921A JP2006537921A JP2007509928A5 JP 2007509928 A5 JP2007509928 A5 JP 2007509928A5 JP 2006537921 A JP2006537921 A JP 2006537921A JP 2006537921 A JP2006537921 A JP 2006537921A JP 2007509928 A5 JP2007509928 A5 JP 2007509928A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- bromoethyl
- bis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(cc1*)c(*)cc1[N+]([O-])=O Chemical compound *c(cc1*)c(*)cc1[N+]([O-])=O 0.000 description 3
- XXEFQXVRUXNVIK-UHFFFAOYSA-N CCCN(C)CCNCC Chemical compound CCCN(C)CCNCC XXEFQXVRUXNVIK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ529249A NZ529249A (en) | 2003-10-31 | 2003-10-31 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic |
| NZ529249 | 2003-10-31 | ||
| NZ53561804 | 2004-09-28 | ||
| NZ535618 | 2004-09-28 | ||
| PCT/NZ2004/000275 WO2005042471A1 (en) | 2003-10-31 | 2004-10-29 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007509928A JP2007509928A (ja) | 2007-04-19 |
| JP2007509928A5 true JP2007509928A5 (enExample) | 2007-10-11 |
| JP4760712B2 JP4760712B2 (ja) | 2011-08-31 |
Family
ID=34555019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006537921A Expired - Fee Related JP4760712B2 (ja) | 2003-10-31 | 2004-10-29 | 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7629332B2 (enExample) |
| EP (1) | EP1680394A4 (enExample) |
| JP (1) | JP4760712B2 (enExample) |
| KR (1) | KR101167335B1 (enExample) |
| AU (1) | AU2004285831B2 (enExample) |
| BR (1) | BRPI0416085A (enExample) |
| CA (1) | CA2544335A1 (enExample) |
| IL (1) | IL175000A0 (enExample) |
| RU (1) | RU2372324C2 (enExample) |
| WO (1) | WO2005042471A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004285831B2 (en) * | 2003-10-31 | 2011-09-15 | Auckland Uniservices Limited | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
| NZ549659A (en) * | 2006-09-04 | 2008-12-24 | Auckland Uniservices Ltd | Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom |
| NZ549831A (en) * | 2006-09-11 | 2009-03-31 | Auckland Uniservices Ltd | Combination of docetaxel and a nitrophenyl phosphate derivative for the treatment of cancer |
| WO2008033039A1 (en) * | 2006-09-11 | 2008-03-20 | Adam Vorn Patterson | Cancer treatment |
| WO2008033041A1 (en) * | 2006-09-11 | 2008-03-20 | Auckland Uniservices Limited | Cancer treatment |
| US8552048B2 (en) | 2006-12-26 | 2013-10-08 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
| US8309554B2 (en) * | 2008-05-15 | 2012-11-13 | Threshold Pharmaceuticals | Hypoxia activated drugs of nitrogen mustard alkylators |
| WO2010044685A1 (en) * | 2008-10-17 | 2010-04-22 | Auckland Uniservices Limited | Nitrophenyl mustard alcohols, their corresponding phosphates and their use as targeted cytotoxic agents |
| WO2010048330A1 (en) | 2008-10-21 | 2010-04-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer using hypoxia activated prodrugs |
| CN101723932B (zh) | 2008-10-31 | 2013-11-20 | 北京以岭生物工程技术有限公司 | 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途 |
| RU2597844C2 (ru) | 2010-07-12 | 2016-09-20 | Тресхолд Фармасьютикалз, Инк. | Введение гипоксически активируемых пролекарств и средств, препятствующих ангиогенезу, для лечения рака |
| WO2012008860A2 (en) * | 2010-07-16 | 2012-01-19 | Auckland Uniservices Limited | Bacterial nitroreductase enzymes and methods relating thereto |
| CN104039328B (zh) * | 2011-11-11 | 2018-10-09 | 米伦纽姆医药公司 | 对蛋白酶体抑制剂的反应的生物标记 |
| EP2793882A4 (en) | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
| EP2793871A4 (en) * | 2011-12-23 | 2015-07-22 | Auckland Uniservices Ltd | COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION |
| EP2888227B1 (en) * | 2012-08-23 | 2020-07-29 | Convert Pharmaceuticals SA | Novel prodrugs and methods of use thereof |
| US10202408B2 (en) | 2012-08-23 | 2019-02-12 | Health Innovation Ventures B.V. | Prodrugs and methods of use thereof |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| US20160158253A1 (en) | 2013-07-26 | 2016-06-09 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-activated prodrug and a taxane |
| US20180169064A1 (en) | 2015-06-24 | 2018-06-21 | Threshold Pharmaceuticals, Inc. | Aziridine containing dna alkylating agents |
| US10348685B2 (en) * | 2016-04-29 | 2019-07-09 | Nicira, Inc. | Priority allocation for distributed service rules |
| CN108571241B (zh) * | 2017-03-14 | 2021-08-17 | 福特环球技术公司 | 用于推按式闩锁类型车辆抽屉的惯性锁系统 |
| WO2019125184A1 (en) | 2017-12-19 | 2019-06-27 | Auckland Uniservices Limited | Use of biomarker in cancer therapy |
| WO2019190331A1 (en) * | 2018-03-29 | 2019-10-03 | Achilles Medical Limited | Prodrug compounds activated by akr1c3 and their use for treating hyperproliferative disorders |
| EP3801481A1 (en) * | 2018-05-30 | 2021-04-14 | Convert Pharmaceuticals SA | Prodrugs and medical uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ240785A (en) * | 1991-11-28 | 1995-08-28 | Cancer Res Campaign Tech | Substituted nitro aniline derivatives and medicaments |
| GB9819472D0 (en) * | 1998-09-07 | 1998-10-28 | Cancer Soc Auckland Div Nz Inc | Novel nitrophenylaziridine compounds and their use as prodrugs |
| WO2003022274A2 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| NZ521851A (en) | 2002-10-08 | 2005-02-25 | Auckland Uniservices Ltd | Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy |
| AU2004285831B2 (en) * | 2003-10-31 | 2011-09-15 | Auckland Uniservices Limited | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
-
2004
- 2004-10-29 AU AU2004285831A patent/AU2004285831B2/en not_active Ceased
- 2004-10-29 RU RU2006118785/04A patent/RU2372324C2/ru not_active IP Right Cessation
- 2004-10-29 KR KR1020067010566A patent/KR101167335B1/ko not_active Expired - Fee Related
- 2004-10-29 US US10/577,078 patent/US7629332B2/en not_active Expired - Fee Related
- 2004-10-29 CA CA002544335A patent/CA2544335A1/en not_active Abandoned
- 2004-10-29 BR BRPI0416085-1A patent/BRPI0416085A/pt not_active IP Right Cessation
- 2004-10-29 WO PCT/NZ2004/000275 patent/WO2005042471A1/en not_active Ceased
- 2004-10-29 JP JP2006537921A patent/JP4760712B2/ja not_active Expired - Fee Related
- 2004-10-29 EP EP04817434A patent/EP1680394A4/en not_active Withdrawn
-
2006
- 2006-04-11 IL IL175000A patent/IL175000A0/en unknown
-
2009
- 2009-08-11 US US12/461,419 patent/US20100010094A1/en not_active Abandoned
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