JP2007509928A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007509928A5 JP2007509928A5 JP2006537921A JP2006537921A JP2007509928A5 JP 2007509928 A5 JP2007509928 A5 JP 2007509928A5 JP 2006537921 A JP2006537921 A JP 2006537921A JP 2006537921 A JP2006537921 A JP 2006537921A JP 2007509928 A5 JP2007509928 A5 JP 2007509928A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- bromoethyl
- bis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 37
- -1 hydroxy, amino Chemical group 0.000 claims description 33
- 150000001875 compounds Chemical class 0.000 claims description 29
- 229910052736 halogen Inorganic materials 0.000 claims description 23
- 150000002367 halogens Chemical class 0.000 claims description 14
- 150000001204 N-oxides Chemical group 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 6
- 210000004881 tumor cell Anatomy 0.000 claims description 5
- 230000002194 synthesizing effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 27
- 102000004459 Nitroreductase Human genes 0.000 claims 21
- 108020001162 nitroreductase Proteins 0.000 claims 21
- 229940002612 prodrug Drugs 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 10
- 238000002560 therapeutic procedure Methods 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 238000011282 treatment Methods 0.000 claims 8
- 241000588724 Escherichia coli Species 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 101150091037 nfsB gene Proteins 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 241000193403 Clostridium Species 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000005855 radiation Effects 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- DCZSXGUQCDCNKB-UHFFFAOYSA-N 2-iodoethyl methanesulfonate Chemical compound CS(=O)(=O)OCCI DCZSXGUQCDCNKB-UHFFFAOYSA-N 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 238000002679 ablation Methods 0.000 claims 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000001146 hypoxic effect Effects 0.000 claims 2
- 229940098779 methanesulfonic acid Drugs 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 230000000865 phosphorylative effect Effects 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- TVGZVOAGMXONFJ-UHFFFAOYSA-N 2-[2-(2-hydroxyethylcarbamoyl)-n-(2-iodoethyl)-4,6-dinitroanilino]ethyl methanesulfonate Chemical compound CS(=O)(=O)OCCN(CCI)C1=C(C(=O)NCCO)C=C([N+]([O-])=O)C=C1[N+]([O-])=O TVGZVOAGMXONFJ-UHFFFAOYSA-N 0.000 claims 1
- ALNMHZYCWFICCG-UHFFFAOYSA-N 2-[[2-[bis(2-bromoethyl)amino]-3,5-dinitrobenzoyl]amino]ethyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr ALNMHZYCWFICCG-UHFFFAOYSA-N 0.000 claims 1
- LILVPOWBAKZYDQ-UHFFFAOYSA-N 2-[[2-[bis(2-bromopropyl)amino]-3,5-dinitrobenzoyl]amino]ethyl dihydrogen phosphate Chemical compound CC(Br)CN(CC(C)Br)C1=C(C(=O)NCCOP(O)(O)=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O LILVPOWBAKZYDQ-UHFFFAOYSA-N 0.000 claims 1
- CCQRILWYQGCXNU-UHFFFAOYSA-N 2-[[2-[bis(2-chloroethyl)amino]-3,5-dinitrobenzoyl]amino]ethyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl CCQRILWYQGCXNU-UHFFFAOYSA-N 0.000 claims 1
- AJUYDWUWNBPUND-UHFFFAOYSA-N 2-[[2-[bis(2-iodoethyl)amino]-3,5-dinitrobenzoyl]amino]ethyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCI)CCI AJUYDWUWNBPUND-UHFFFAOYSA-N 0.000 claims 1
- IJYNUMYBOYALMH-UHFFFAOYSA-N 2-[bis(2-bromoethyl)amino]-n-(2-hydroxyethyl)-3,5-dinitrobenzamide Chemical compound OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr IJYNUMYBOYALMH-UHFFFAOYSA-N 0.000 claims 1
- KAMGTSLQSBBUOX-UHFFFAOYSA-N 2-[bis(2-bromoethyl)amino]-n-(3-hydroxypropyl)-3,5-dinitrobenzamide Chemical compound OCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr KAMGTSLQSBBUOX-UHFFFAOYSA-N 0.000 claims 1
- YJXGHZYJSXIZRO-UHFFFAOYSA-N 2-[bis(2-bromoethyl)amino]-n-(4-hydroxybutyl)-3,5-dinitrobenzamide Chemical compound OCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr YJXGHZYJSXIZRO-UHFFFAOYSA-N 0.000 claims 1
- GVSDYERACHELST-UHFFFAOYSA-N 2-[bis(2-bromoethyl)amino]-n-(5-hydroxypentyl)-3,5-dinitrobenzamide Chemical compound OCCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr GVSDYERACHELST-UHFFFAOYSA-N 0.000 claims 1
- LMMQRTKFKKWFGJ-UHFFFAOYSA-N 2-[bis(2-bromoethyl)amino]-n-(6-hydroxyhexyl)-3,5-dinitrobenzamide Chemical compound OCCCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCBr LMMQRTKFKKWFGJ-UHFFFAOYSA-N 0.000 claims 1
- NLUQLEFRHZFTCD-UHFFFAOYSA-N 2-[bis(2-bromopropyl)amino]-n-(2-hydroxyethyl)-3,5-dinitrobenzamide Chemical compound CC(Br)CN(CC(C)Br)C1=C(C(=O)NCCO)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NLUQLEFRHZFTCD-UHFFFAOYSA-N 0.000 claims 1
- DFYAFJCWUNPOIY-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-n-(2-hydroxyethyl)-3,5-dinitrobenzamide Chemical compound OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl DFYAFJCWUNPOIY-UHFFFAOYSA-N 0.000 claims 1
- YYZBUYWUBHHJFU-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-n-(3-hydroxypropyl)-3,5-dinitrobenzamide Chemical compound OCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl YYZBUYWUBHHJFU-UHFFFAOYSA-N 0.000 claims 1
- NWCOIJDSOQLQRX-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-n-(4-hydroxybutyl)-3,5-dinitrobenzamide Chemical compound OCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl NWCOIJDSOQLQRX-UHFFFAOYSA-N 0.000 claims 1
- UQKGQYMOCZIRKR-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-n-(5-hydroxypentyl)-3,5-dinitrobenzamide Chemical compound OCCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl UQKGQYMOCZIRKR-UHFFFAOYSA-N 0.000 claims 1
- NVPJUYVBHQGMFU-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-n-(6-hydroxyhexyl)-3,5-dinitrobenzamide Chemical compound OCCCCCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCCl)CCCl NVPJUYVBHQGMFU-UHFFFAOYSA-N 0.000 claims 1
- SJAJUOFQUYSSDO-UHFFFAOYSA-N 2-[bis(2-iodoethyl)amino]-n-(2-hydroxyethyl)-3,5-dinitrobenzamide Chemical compound OCCNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCI)CCI SJAJUOFQUYSSDO-UHFFFAOYSA-N 0.000 claims 1
- AZICEEZSDKZDHX-UHFFFAOYSA-N 2-[n-(2-bromoethyl)-2-(2-hydroxyethylcarbamoyl)-4,6-dinitroanilino]ethyl methanesulfonate Chemical compound CS(=O)(=O)OCCN(CCBr)C1=C(C(=O)NCCO)C=C([N+]([O-])=O)C=C1[N+]([O-])=O AZICEEZSDKZDHX-UHFFFAOYSA-N 0.000 claims 1
- KQNJLOZYSLLLQE-UHFFFAOYSA-N 2-[n-(2-bromoethyl)-2-(2-hydroxypropylcarbamoyl)-4,6-dinitroanilino]ethyl methanesulfonate Chemical compound CC(O)CNC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(C)(=O)=O KQNJLOZYSLLLQE-UHFFFAOYSA-N 0.000 claims 1
- KLXBGKUCXSYKDM-UHFFFAOYSA-N 2-[n-(2-chloroethyl)-2-(2-hydroxyethylcarbamoyl)-4,6-dinitroanilino]ethyl methanesulfonate Chemical compound CS(=O)(=O)OCCN(CCCl)C1=C(C(=O)NCCO)C=C([N+]([O-])=O)C=C1[N+]([O-])=O KLXBGKUCXSYKDM-UHFFFAOYSA-N 0.000 claims 1
- HFZHSYXJPOMEFV-UHFFFAOYSA-N 3-[[5-[bis(2-bromoethyl)amino]-2,4-dinitrobenzoyl]amino]propyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCCNC(=O)C1=CC(N(CCBr)CCBr)=C([N+]([O-])=O)C=C1[N+]([O-])=O HFZHSYXJPOMEFV-UHFFFAOYSA-N 0.000 claims 1
- PJTGFDFFOIQANN-UHFFFAOYSA-N 3-[[5-[bis(2-chloroethyl)amino]-2,4-dinitrobenzoyl]amino]propyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCCNC(=O)C1=CC(N(CCCl)CCCl)=C([N+]([O-])=O)C=C1[N+]([O-])=O PJTGFDFFOIQANN-UHFFFAOYSA-N 0.000 claims 1
- CVTYNFXNXZNIBO-UHFFFAOYSA-N 3-[bis(2-bromoethyl)amino]-n-(2-hydroxyethyl)-2,6-dinitrobenzamide Chemical compound OCCNC(=O)C1=C([N+]([O-])=O)C=CC(N(CCBr)CCBr)=C1[N+]([O-])=O CVTYNFXNXZNIBO-UHFFFAOYSA-N 0.000 claims 1
- NEUBBTOZYMPZDY-UHFFFAOYSA-N 3-[bis(2-bromoethyl)amino]-n-(3-hydroxypropyl)-2,6-dinitrobenzamide Chemical compound OCCCNC(=O)C1=C([N+]([O-])=O)C=CC(N(CCBr)CCBr)=C1[N+]([O-])=O NEUBBTOZYMPZDY-UHFFFAOYSA-N 0.000 claims 1
- PQZYUKHJQHLDGU-UHFFFAOYSA-N 3-[bis(2-bromoethyl)amino]-n-(4-hydroxybutyl)-2,6-dinitrobenzamide Chemical compound OCCCCNC(=O)C1=C([N+]([O-])=O)C=CC(N(CCBr)CCBr)=C1[N+]([O-])=O PQZYUKHJQHLDGU-UHFFFAOYSA-N 0.000 claims 1
- RYKLZUPYJFFNRR-UHFFFAOYSA-N 3-hydroxypiperidin-2-one Chemical compound OC1CCCNC1=O RYKLZUPYJFFNRR-UHFFFAOYSA-N 0.000 claims 1
- KWDWDDQGKFJIGK-UHFFFAOYSA-N 5-[bis(2-bromoethyl)amino]-n-(2-hydroxyethyl)-2,4-dinitrobenzamide Chemical compound OCCNC(=O)C1=CC(N(CCBr)CCBr)=C([N+]([O-])=O)C=C1[N+]([O-])=O KWDWDDQGKFJIGK-UHFFFAOYSA-N 0.000 claims 1
- RWHLJEPQZVSJIM-UHFFFAOYSA-N 5-[bis(2-bromoethyl)amino]-n-(2-hydroxyethyl)-4-methylsulfonyl-2-nitrobenzamide Chemical compound CS(=O)(=O)C1=CC([N+]([O-])=O)=C(C(=O)NCCO)C=C1N(CCBr)CCBr RWHLJEPQZVSJIM-UHFFFAOYSA-N 0.000 claims 1
- YPQZBNKRNYHFDB-UHFFFAOYSA-N 5-[bis(2-bromoethyl)amino]-n-(4-hydroxybutyl)-2,4-dinitrobenzamide Chemical compound OCCCCNC(=O)C1=CC(N(CCBr)CCBr)=C([N+]([O-])=O)C=C1[N+]([O-])=O YPQZBNKRNYHFDB-UHFFFAOYSA-N 0.000 claims 1
- YYFOYVYDSJOTCE-UHFFFAOYSA-N 5-[bis(2-bromoethyl)amino]-n-(5-hydroxypentyl)-2,4-dinitrobenzamide Chemical compound OCCCCCNC(=O)C1=CC(N(CCBr)CCBr)=C([N+]([O-])=O)C=C1[N+]([O-])=O YYFOYVYDSJOTCE-UHFFFAOYSA-N 0.000 claims 1
- IKGCFTIKZPYPPH-UHFFFAOYSA-N 5-[bis(2-bromoethyl)amino]-n-(6-hydroxyhexyl)-2,4-dinitrobenzamide Chemical compound OCCCCCCNC(=O)C1=CC(N(CCBr)CCBr)=C([N+]([O-])=O)C=C1[N+]([O-])=O IKGCFTIKZPYPPH-UHFFFAOYSA-N 0.000 claims 1
- OSFMLWVTNPALCT-UHFFFAOYSA-N 5-[bis(2-iodoethyl)amino]-n-(2-hydroxyethyl)-2,4-dinitrobenzamide Chemical compound OCCNC(=O)C1=CC(N(CCI)CCI)=C([N+]([O-])=O)C=C1[N+]([O-])=O OSFMLWVTNPALCT-UHFFFAOYSA-N 0.000 claims 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 238000011394 anticancer treatment Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000003880 polar aprotic solvent Substances 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- 0 *c(cc1*)c(*)cc1[N+]([O-])=O Chemical compound *c(cc1*)c(*)cc1[N+]([O-])=O 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- XXEFQXVRUXNVIK-UHFFFAOYSA-N CCCN(C)CCNCC Chemical compound CCCN(C)CCNCC XXEFQXVRUXNVIK-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ529249A NZ529249A (en) | 2003-10-31 | 2003-10-31 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic |
| NZ529249 | 2003-10-31 | ||
| NZ53561804 | 2004-09-28 | ||
| NZ535618 | 2004-09-28 | ||
| PCT/NZ2004/000275 WO2005042471A1 (en) | 2003-10-31 | 2004-10-29 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007509928A JP2007509928A (ja) | 2007-04-19 |
| JP2007509928A5 true JP2007509928A5 (enExample) | 2007-10-11 |
| JP4760712B2 JP4760712B2 (ja) | 2011-08-31 |
Family
ID=34555019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006537921A Expired - Fee Related JP4760712B2 (ja) | 2003-10-31 | 2004-10-29 | 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7629332B2 (enExample) |
| EP (1) | EP1680394A4 (enExample) |
| JP (1) | JP4760712B2 (enExample) |
| KR (1) | KR101167335B1 (enExample) |
| AU (1) | AU2004285831B2 (enExample) |
| BR (1) | BRPI0416085A (enExample) |
| CA (1) | CA2544335A1 (enExample) |
| IL (1) | IL175000A0 (enExample) |
| RU (1) | RU2372324C2 (enExample) |
| WO (1) | WO2005042471A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4760712B2 (ja) * | 2003-10-31 | 2011-08-31 | オークランド ユニサーヴィスィズ リミテッド | 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用 |
| NZ549659A (en) * | 2006-09-04 | 2008-12-24 | Auckland Uniservices Ltd | Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom |
| WO2008033041A1 (en) * | 2006-09-11 | 2008-03-20 | Auckland Uniservices Limited | Cancer treatment |
| WO2008033039A1 (en) * | 2006-09-11 | 2008-03-20 | Adam Vorn Patterson | Cancer treatment |
| NZ549831A (en) * | 2006-09-11 | 2009-03-31 | Auckland Uniservices Ltd | Combination of docetaxel and a nitrophenyl phosphate derivative for the treatment of cancer |
| ES2884044T3 (es) | 2006-12-26 | 2021-12-10 | Immunogenesis Inc | Profármaco alquilante de fosforamidato para el tratamiento del cáncer |
| US8309554B2 (en) * | 2008-05-15 | 2012-11-13 | Threshold Pharmaceuticals | Hypoxia activated drugs of nitrogen mustard alkylators |
| WO2010044685A1 (en) * | 2008-10-17 | 2010-04-22 | Auckland Uniservices Limited | Nitrophenyl mustard alcohols, their corresponding phosphates and their use as targeted cytotoxic agents |
| JP5765634B2 (ja) | 2008-10-21 | 2015-08-19 | スレッシュホールド ファーマシューティカルズ， インコーポレイテッド | 低酸素活性化型プロドラッグを用いるがんの処置 |
| CN101723932B (zh) | 2008-10-31 | 2013-11-20 | 北京以岭生物工程技术有限公司 | 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途 |
| RU2597844C2 (ru) | 2010-07-12 | 2016-09-20 | Тресхолд Фармасьютикалз, Инк. | Введение гипоксически активируемых пролекарств и средств, препятствующих ангиогенезу, для лечения рака |
| WO2012008860A2 (en) * | 2010-07-16 | 2012-01-19 | Auckland Uniservices Limited | Bacterial nitroreductase enzymes and methods relating thereto |
| JP6397765B2 (ja) * | 2011-11-11 | 2018-09-26 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤に応答するバイオマーカー |
| WO2013096687A1 (en) | 2011-12-22 | 2013-06-27 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer |
| US20150010474A1 (en) * | 2011-12-23 | 2015-01-08 | Auckland Uniservices Limited | Compounds And Methods For Selective Imaging And/Or Ablation |
| US10202408B2 (en) | 2012-08-23 | 2019-02-12 | Health Innovation Ventures B.V. | Prodrugs and methods of use thereof |
| US9505791B2 (en) | 2012-08-23 | 2016-11-29 | Health Innovation Ventures B.V. | Prodrugs and methods of use thereof |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| WO2015013448A1 (en) | 2013-07-26 | 2015-01-29 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-acti vated prodrug and a taxane |
| CA2990665A1 (en) | 2015-06-24 | 2016-12-29 | Threshold Pharmaceuticals, Inc. | Aziridine containing dna alkylating agents |
| US10348685B2 (en) * | 2016-04-29 | 2019-07-09 | Nicira, Inc. | Priority allocation for distributed service rules |
| CN108571241B (zh) * | 2017-03-14 | 2021-08-17 | 福特环球技术公司 | 用于推按式闩锁类型车辆抽屉的惯性锁系统 |
| WO2019125184A1 (en) | 2017-12-19 | 2019-06-27 | Auckland Uniservices Limited | Use of biomarker in cancer therapy |
| EP3774743B1 (en) * | 2018-03-29 | 2023-11-22 | Achilles Medical Limited | Prodrug compounds activated by akr1c3 and their use for treating hyperproliferative disorders |
| JP7541512B2 (ja) * | 2018-05-30 | 2024-08-28 | コンバート ファーマシューティカルズ エス．エー． | プロドラッグおよびその医学的使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ240785A (en) * | 1991-11-28 | 1995-08-28 | Cancer Res Campaign Tech | Substituted nitro aniline derivatives and medicaments |
| GB9819472D0 (en) * | 1998-09-07 | 1998-10-28 | Cancer Soc Auckland Div Nz Inc | Novel nitrophenylaziridine compounds and their use as prodrugs |
| JP2005504789A (ja) * | 2001-09-13 | 2005-02-17 | シンタ ファーマスーティカルズ コーポレイション | 癌治療のための２−アロイルイミダゾール化合物 |
| NZ521851A (en) * | 2002-10-08 | 2005-02-25 | Auckland Uniservices Ltd | Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy |
| JP4760712B2 (ja) * | 2003-10-31 | 2011-08-31 | オークランド ユニサーヴィスィズ リミテッド | 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用 |
-
2004
- 2004-10-29 JP JP2006537921A patent/JP4760712B2/ja not_active Expired - Fee Related
- 2004-10-29 CA CA002544335A patent/CA2544335A1/en not_active Abandoned
- 2004-10-29 RU RU2006118785/04A patent/RU2372324C2/ru not_active IP Right Cessation
- 2004-10-29 WO PCT/NZ2004/000275 patent/WO2005042471A1/en not_active Ceased
- 2004-10-29 KR KR1020067010566A patent/KR101167335B1/ko not_active Expired - Fee Related
- 2004-10-29 AU AU2004285831A patent/AU2004285831B2/en not_active Ceased
- 2004-10-29 BR BRPI0416085-1A patent/BRPI0416085A/pt not_active IP Right Cessation
- 2004-10-29 US US10/577,078 patent/US7629332B2/en not_active Expired - Fee Related
- 2004-10-29 EP EP04817434A patent/EP1680394A4/en not_active Withdrawn
-
2006
- 2006-04-11 IL IL175000A patent/IL175000A0/en unknown
-
2009
- 2009-08-11 US US12/461,419 patent/US20100010094A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007509928A5 (enExample) | ||
| RU2006118785A (ru) | Новые нитрофенилипритные и нитрофенилазиридиновые спирты и их соответствующие фосфаты и их применение в качестве нацеленных цитотоксическихих средств | |
| US20220153738A1 (en) | Compositions and methods for modulating hair growth | |
| RU2414475C2 (ru) | Пролекарства фосфорамидатных алкилаторов | |
| US11147889B2 (en) | Albumin-binding PSMA inhibitors | |
| TWI665178B (zh) | 作為化療劑的β－取代的β－氨基酸和類似物及其應用 | |
| HUP0301169A2 (hu) | 9-Helyzetben helyettesített minociklinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| ES2988059T3 (es) | Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos | |
| JP2017537940A (ja) | 増殖性疾患の処置に有用な融合１，３−アゾール誘導体 | |
| CN109071459B (zh) | Ppar激动剂、化合物、药物组合物以及它们的使用方法 | |
| JP2011057693A5 (enExample) | ||
| KR20140095105A (ko) | 대장염 치료용 조성물 및 방법 | |
| CN1249036C (zh) | 铁螯合剂及其用途 | |
| WO2020142413A1 (en) | Compositions and methods for modulating hair growth | |
| US20230302144A1 (en) | Porphyrin Compounds and Compositions Useful for Treating Cancer | |
| BRPI0712938A2 (pt) | mÉtodo para modular excrescÊncia de neurito pelo uso de um antagonista de receptor de galanina-3 | |
| US11312737B2 (en) | Amide-linked EP4 agonist-bisphosphonate compounds and uses thereof | |
| CN110325508A (zh) | 雄激素受体的n-末端结构域的抑制剂 | |
| JPH05262775A (ja) | ヘマトポルフィリン及びその誘導体の錯塩、それらの合成及び治療剤 | |
| TW201710251A (zh) | 作為抗癌藥劑之經官能化及取代之吲哚 | |
| CA2504496A1 (en) | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor | |
| JP2020518649A5 (enExample) | ||
| US20170029452A1 (en) | Phenanthroline phosphonic acid derivative and preparation method therefor and application thereof | |
| CN1317265C (zh) | 氰基丙烯酸酯衍生物及制备方法和生物活性 | |
| US20250263428A2 (en) | Amide-linked conjugate compounds and uses thereof |