KR101167335B1 - 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 - Google Patents

니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 Download PDF

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Publication number
KR101167335B1
KR101167335B1 KR1020067010566A KR20067010566A KR101167335B1 KR 101167335 B1 KR101167335 B1 KR 101167335B1 KR 1020067010566 A KR1020067010566 A KR 1020067010566A KR 20067010566 A KR20067010566 A KR 20067010566A KR 101167335 B1 KR101167335 B1 KR 101167335B1
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amino
compound
ethyl
carbonyl
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KR20070006677A (ko
Inventor
윌리암 알렉산더 덴니
그래햄 존 애트웰
샹진 양
윌리암 로버트 윌슨
아담 보른 패터슨
누알라 안 헬스비
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오클랜드 유니서비시즈 리미티드
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Publication of KR20070006677A publication Critical patent/KR20070006677A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Radiation-Therapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020067010566A 2003-10-31 2004-10-29 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 Expired - Fee Related KR101167335B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ529249A NZ529249A (en) 2003-10-31 2003-10-31 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic
NZ529249 2003-10-31
NZ53561804 2004-09-28
NZ535618 2004-09-28
PCT/NZ2004/000275 WO2005042471A1 (en) 2003-10-31 2004-10-29 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents

Publications (2)

Publication Number Publication Date
KR20070006677A KR20070006677A (ko) 2007-01-11
KR101167335B1 true KR101167335B1 (ko) 2012-07-19

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KR1020067010566A Expired - Fee Related KR101167335B1 (ko) 2003-10-31 2004-10-29 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도

Country Status (10)

Country Link
US (2) US7629332B2 (enExample)
EP (1) EP1680394A4 (enExample)
JP (1) JP4760712B2 (enExample)
KR (1) KR101167335B1 (enExample)
AU (1) AU2004285831B2 (enExample)
BR (1) BRPI0416085A (enExample)
CA (1) CA2544335A1 (enExample)
IL (1) IL175000A0 (enExample)
RU (1) RU2372324C2 (enExample)
WO (1) WO2005042471A1 (enExample)

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JP4760712B2 (ja) * 2003-10-31 2011-08-31 オークランド ユニサーヴィスィズ リミテッド 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用
NZ549659A (en) * 2006-09-04 2008-12-24 Auckland Uniservices Ltd Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom
WO2008033041A1 (en) * 2006-09-11 2008-03-20 Auckland Uniservices Limited Cancer treatment
WO2008033039A1 (en) * 2006-09-11 2008-03-20 Adam Vorn Patterson Cancer treatment
NZ549831A (en) * 2006-09-11 2009-03-31 Auckland Uniservices Ltd Combination of docetaxel and a nitrophenyl phosphate derivative for the treatment of cancer
ES2884044T3 (es) 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
US8309554B2 (en) * 2008-05-15 2012-11-13 Threshold Pharmaceuticals Hypoxia activated drugs of nitrogen mustard alkylators
WO2010044685A1 (en) * 2008-10-17 2010-04-22 Auckland Uniservices Limited Nitrophenyl mustard alcohols, their corresponding phosphates and their use as targeted cytotoxic agents
JP5765634B2 (ja) 2008-10-21 2015-08-19 スレッシュホールド ファーマシューティカルズ， インコーポレイテッド 低酸素活性化型プロドラッグを用いるがんの処置
CN101723932B (zh) 2008-10-31 2013-11-20 北京以岭生物工程技术有限公司 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途
RU2597844C2 (ru) 2010-07-12 2016-09-20 Тресхолд Фармасьютикалз, Инк. Введение гипоксически активируемых пролекарств и средств, препятствующих ангиогенезу, для лечения рака
WO2012008860A2 (en) * 2010-07-16 2012-01-19 Auckland Uniservices Limited Bacterial nitroreductase enzymes and methods relating thereto
JP6397765B2 (ja) * 2011-11-11 2018-09-26 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤に応答するバイオマーカー
WO2013096687A1 (en) 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
US20150010474A1 (en) * 2011-12-23 2015-01-08 Auckland Uniservices Limited Compounds And Methods For Selective Imaging And/Or Ablation
US10202408B2 (en) 2012-08-23 2019-02-12 Health Innovation Ventures B.V. Prodrugs and methods of use thereof
US9505791B2 (en) 2012-08-23 2016-11-29 Health Innovation Ventures B.V. Prodrugs and methods of use thereof
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
WO2015013448A1 (en) 2013-07-26 2015-01-29 Threshold Pharmaceuticals, Inc. Treatment of pancreatic cancer with a combination of a hypoxia-acti vated prodrug and a taxane
CA2990665A1 (en) 2015-06-24 2016-12-29 Threshold Pharmaceuticals, Inc. Aziridine containing dna alkylating agents
US10348685B2 (en) * 2016-04-29 2019-07-09 Nicira, Inc. Priority allocation for distributed service rules
CN108571241B (zh) * 2017-03-14 2021-08-17 福特环球技术公司 用于推按式闩锁类型车辆抽屉的惯性锁系统
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy
EP3774743B1 (en) * 2018-03-29 2023-11-22 Achilles Medical Limited Prodrug compounds activated by akr1c3 and their use for treating hyperproliferative disorders
JP7541512B2 (ja) * 2018-05-30 2024-08-28 コンバート ファーマシューティカルズ エス．エー． プロドラッグおよびその医学的使用

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WO1993011099A1 (en) * 1991-11-28 1993-06-10 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as antitumor agents

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GB9819472D0 (en) * 1998-09-07 1998-10-28 Cancer Soc Auckland Div Nz Inc Novel nitrophenylaziridine compounds and their use as prodrugs
JP2005504789A (ja) * 2001-09-13 2005-02-17 シンタ ファーマスーティカルズ コーポレイション 癌治療のための２−アロイルイミダゾール化合物
NZ521851A (en) * 2002-10-08 2005-02-25 Auckland Uniservices Ltd Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy
JP4760712B2 (ja) * 2003-10-31 2011-08-31 オークランド ユニサーヴィスィズ リミテッド 新規ニトロフェニルマスタードおよびニトロフェニルアジリジンアルコールおよびそれらの対応するリン酸エステルおよびターゲットが決められた細胞毒性剤としてのそれらの使用

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WO1993011099A1 (en) * 1991-11-28 1993-06-10 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as antitumor agents

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Journal of Medicinal Chemistry, vol.40(8), pp.1270-1275(Web. 1997.04.11.)*

Also Published As

Publication number Publication date
RU2372324C2 (ru) 2009-11-10
KR20070006677A (ko) 2007-01-11
US20070032455A1 (en) 2007-02-08
US20100010094A1 (en) 2010-01-14
AU2004285831A1 (en) 2005-05-12
US7629332B2 (en) 2009-12-08
AU2004285831B2 (en) 2011-09-15
CA2544335A1 (en) 2005-05-12
EP1680394A1 (en) 2006-07-19
JP2007509928A (ja) 2007-04-19
EP1680394A4 (en) 2006-10-11
RU2006118785A (ru) 2007-12-10
BRPI0416085A (pt) 2007-01-02
IL175000A0 (en) 2006-08-20
WO2005042471A1 (en) 2005-05-12
JP4760712B2 (ja) 2011-08-31

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