JP2007513170A5 - - Google Patents
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- JP2007513170A5 JP2007513170A5 JP2006542750A JP2006542750A JP2007513170A5 JP 2007513170 A5 JP2007513170 A5 JP 2007513170A5 JP 2006542750 A JP2006542750 A JP 2006542750A JP 2006542750 A JP2006542750 A JP 2006542750A JP 2007513170 A5 JP2007513170 A5 JP 2007513170A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- heterocyclyl
- alkylenyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 99
- 125000005466 alkylenyl group Chemical group 0.000 claims 60
- 125000000623 heterocyclic group Chemical group 0.000 claims 60
- 125000001072 heteroaryl group Chemical group 0.000 claims 51
- 125000003118 aryl group Chemical group 0.000 claims 38
- 125000000304 alkynyl group Chemical group 0.000 claims 36
- 125000003342 alkenyl group Chemical group 0.000 claims 33
- 125000002947 alkylene group Chemical group 0.000 claims 31
- 125000004450 alkenylene group Chemical group 0.000 claims 24
- 125000004419 alkynylene group Chemical group 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 19
- 239000011780 sodium chloride Substances 0.000 claims 19
- 125000004104 aryloxy group Chemical group 0.000 claims 18
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 150000002431 hydrogen Chemical class 0.000 claims 14
- -1 nitro, hydroxy Chemical group 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 13
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 125000000732 arylene group Chemical group 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000004432 carbon atoms Chemical group C* 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims 12
- 125000005549 heteroarylene group Chemical group 0.000 claims 12
- 125000004043 oxo group Chemical group O=* 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000005842 heteroatoms Chemical group 0.000 claims 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims 7
- 125000005529 alkyleneoxy group Chemical group 0.000 claims 6
- 125000005532 aryl alkyleneoxy group Chemical group 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 5
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 4
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000005418 aryl aryl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 230000037348 biosynthesis Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 0 CC1(*)C=Nc2c3[n](*)c(*)nc3c(N)nc2C=C1 Chemical compound CC1(*)C=Nc2c3[n](*)c(*)nc3c(N)nc2C=C1 0.000 description 2
- SMBYUOXUISCLCF-UHFFFAOYSA-N CCCN(C)CC Chemical compound CCCN(C)CC SMBYUOXUISCLCF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52677203P | 2003-12-04 | 2003-12-04 | |
| PCT/US2004/040383 WO2005076783A2 (en) | 2003-12-04 | 2004-12-03 | Sulfone substituted imidazo ring ethers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513170A JP2007513170A (ja) | 2007-05-24 |
| JP2007513170A5 true JP2007513170A5 (US06894165-20050517-C00155.png) | 2008-01-31 |
Family
ID=34860172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542750A Pending JP2007513170A (ja) | 2003-12-04 | 2004-12-03 | スルホン置換イミダゾ環エーテル |
Country Status (9)
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| CA2534625A1 (en) | 2003-08-05 | 2005-02-24 | 3M Innovative Properties Company | Infection prophylaxis using immune response modifier compounds |
| BRPI0412902A (pt) | 2003-08-12 | 2006-09-26 | 3M Innovative Properties Co | compostos contendo imidazo substituìdo por oxima |
| WO2005020999A1 (en) | 2003-08-27 | 2005-03-10 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| US20050054665A1 (en) | 2003-09-05 | 2005-03-10 | 3M Innovative Properties Company | Treatment for CD5+ B cell lymphoma |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| ES2584863T3 (es) | 2003-10-03 | 2016-09-29 | 3M Innovative Properties Company | Pirazolopiridinas y análogos de las mismas |
| ES2544477T3 (es) | 2003-10-03 | 2015-08-31 | 3M Innovative Properties Company | Imidazoquinolinas sustituidas con alcoxi |
| CN1906193A (zh) | 2003-11-14 | 2007-01-31 | 3M创新有限公司 | 肟取代的咪唑环化合物 |
| CA2545825A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo ring compounds |
| NZ547467A (en) | 2003-11-25 | 2010-06-25 | 3M Innovative Properties Co | Substituted imidazo ring system and methods |
| WO2005066170A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| JP2007517044A (ja) | 2003-12-30 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド |
| AU2005228150A1 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| WO2005123080A2 (en) | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
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| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| US7943609B2 (en) | 2004-12-30 | 2011-05-17 | 3M Innovative Proprerties Company | Chiral fused [1,2]imidazo[4,5-C] ring compounds |
| ES2538498T3 (es) | 2004-12-30 | 2015-06-22 | Meda Ab | Utilización de Imiquimod para el tratamiento de metástasis cutáneas provenientes de un tumor de cáncer de mama |
| WO2006083440A2 (en) | 2004-12-30 | 2006-08-10 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
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| US8343993B2 (en) | 2005-02-23 | 2013-01-01 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazonaphthyridines |
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| KR20080048551A (ko) * | 2005-09-23 | 2008-06-02 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 1Ｈ-이미다조[4,5-ｃ]피리딘 및 그의 유사체의 제조법 |
| US8088790B2 (en) | 2005-11-04 | 2012-01-03 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods |
| KR20080077982A (ko) * | 2005-12-16 | 2008-08-26 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 치환된 이미다조퀴놀린, 이미다조나프티리딘 및이미다조피리딘, 조성물 및 방법 |
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| WO2007106854A2 (en) | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| US8178539B2 (en) | 2006-09-06 | 2012-05-15 | 3M Innovative Properties Company | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| ES2617451T3 (es) | 2010-08-17 | 2017-06-19 | 3M Innovative Properties Company | Composiciones lipidadas de compuestos modificadores de la respuesta inmunitaria, formulaciones, y métodos |
| US9107958B2 (en) | 2011-06-03 | 2015-08-18 | 3M Innovative Properties Company | Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom |
| JP6460789B2 (ja) | 2011-06-03 | 2019-01-30 | スリーエム イノベイティブ プロパティズ カンパニー | ポリエチレングリコールセグメントを有するヘテロ２官能性リンカー及び該リンカーから調製された免疫反応調節複合体 |
| RS61101B1 (sr) | 2013-01-07 | 2020-12-31 | Univ Pennsylvania | Preparati i postupci za lečenje kožnog limfoma t-ćelija |
| RS60430B1 (sr) * | 2014-04-22 | 2020-07-31 | Hoffmann La Roche | Jedinjenja 4-amino-imidazohinolina |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| PL3265458T3 (pl) | 2015-03-06 | 2019-05-31 | Hoffmann La Roche | Związki benzazepinodikarboksyamidowe |
| US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
| US10533007B2 (en) | 2016-04-19 | 2020-01-14 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
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| EP3464274B1 (en) | 2016-05-23 | 2020-05-27 | H. Hoffnabb-La Roche Ag | Benzazepine dicarboxamide compounds with secondary amide function |
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| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
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| SG11202007518RA (en) | 2018-02-28 | 2020-09-29 | Pfizer | Il-15 variants and uses thereof |
| EP3796983A2 (en) | 2018-05-23 | 2021-03-31 | Pfizer Inc. | Antibodies specific for gucy2c and uses thereof |
| EP3797121B1 (en) | 2018-05-23 | 2024-06-19 | Pfizer Inc. | Antibodies specific for cd3 and uses thereof |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
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2004
- 2004-12-03 AU AU2004315771A patent/AU2004315771A1/en not_active Abandoned
- 2004-12-03 JP JP2006542750A patent/JP2007513170A/ja active Pending
- 2004-12-03 EP EP04821353A patent/EP1694674A4/en not_active Withdrawn
- 2004-12-03 AR ARP040104518A patent/AR048289A1/es unknown
- 2004-12-03 TW TW093137541A patent/TW200533352A/zh unknown
- 2004-12-03 CA CA002549216A patent/CA2549216A1/en not_active Abandoned
- 2004-12-03 WO PCT/US2004/040383 patent/WO2005076783A2/en active Application Filing
- 2004-12-03 CN CNA2004800414001A patent/CN1914203A/zh active Pending
- 2004-12-03 US US10/596,117 patent/US7939526B2/en not_active Expired - Fee Related
