JP2007512011A5 - - Google Patents
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- Publication number
- JP2007512011A5 JP2007512011A5 JP2006540410A JP2006540410A JP2007512011A5 JP 2007512011 A5 JP2007512011 A5 JP 2007512011A5 JP 2006540410 A JP2006540410 A JP 2006540410A JP 2006540410 A JP2006540410 A JP 2006540410A JP 2007512011 A5 JP2007512011 A5 JP 2007512011A5
- Authority
- JP
- Japan
- Prior art keywords
- nitric oxide
- cgmp
- nos
- oxide synthase
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 27
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 20
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 20
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 20
- ZOOGRGPOEVQQDX-KHLHZJAASA-N cyclic guanosine monophosphate Chemical compound C([C@H]1O2)O[P@](O)(=O)O[C@@H]1[C@H](O)[C@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-KHLHZJAASA-N 0.000 claims 19
- 230000000694 effects Effects 0.000 claims 9
- XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XKMLYUALXHKNFT-UUOKFMHZSA-N 0.000 claims 8
- 108010078321 Guanylate Cyclase Proteins 0.000 claims 7
- 102000014469 Guanylate cyclase Human genes 0.000 claims 7
- 230000015572 biosynthetic process Effects 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 238000003786 synthesis reaction Methods 0.000 claims 6
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 4
- 108010012715 Superoxide dismutase Proteins 0.000 claims 4
- 238000013537 high throughput screening Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 238000000691 measurement method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03027159 | 2003-11-26 | ||
| EP03027159.7 | 2003-11-26 | ||
| PCT/EP2004/013707 WO2005052185A1 (en) | 2003-11-26 | 2004-11-25 | Detection of no by using guanylyl cyclase and cgmp production as a readout system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007512011A JP2007512011A (ja) | 2007-05-17 |
| JP2007512011A5 true JP2007512011A5 (cg-RX-API-DMAC7.html) | 2008-01-17 |
| JP5671194B2 JP5671194B2 (ja) | 2015-02-18 |
Family
ID=34626376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006540410A Expired - Lifetime JP5671194B2 (ja) | 2003-11-26 | 2004-11-25 | 読み取りシステムとしてグアニリルシクラーゼ及びｃＧＭＰ生成を使用するＮＯの検出 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1689880B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5671194B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE429508T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2540822C (cg-RX-API-DMAC7.html) |
| DE (1) | DE602004020795D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1689880T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2324477T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005052185A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006038942A1 (de) * | 2006-08-18 | 2008-02-21 | Bayer Healthcare Ag | Verfahren zur Identifizierung von Stickstoffmonoxid Modulatoren |
| JP5350607B2 (ja) * | 2007-06-14 | 2013-11-27 | キッコーマン株式会社 | グアニル酸シクラーゼ活性測定法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
-
2004
- 2004-11-25 WO PCT/EP2004/013707 patent/WO2005052185A1/en not_active Ceased
- 2004-11-25 ES ES04819231T patent/ES2324477T3/es not_active Expired - Lifetime
- 2004-11-25 DE DE602004020795T patent/DE602004020795D1/de not_active Expired - Lifetime
- 2004-11-25 JP JP2006540410A patent/JP5671194B2/ja not_active Expired - Lifetime
- 2004-11-25 CA CA2540822A patent/CA2540822C/en not_active Expired - Lifetime
- 2004-11-25 DK DK04819231T patent/DK1689880T3/da active
- 2004-11-25 EP EP04819231A patent/EP1689880B1/en not_active Expired - Lifetime
- 2004-11-25 AT AT04819231T patent/ATE429508T1/de active
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