JP5671194B2 - 読み取りシステムとしてグアニリルシクラーゼ及びcGMP生成を使用するNOの検出 - Google Patents

読み取りシステムとしてグアニリルシクラーゼ及びcGMP生成を使用するNOの検出 Download PDF

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JP5671194B2
JP5671194B2 JP2006540410A JP2006540410A JP5671194B2 JP 5671194 B2 JP5671194 B2 JP 5671194B2 JP 2006540410 A JP2006540410 A JP 2006540410A JP 2006540410 A JP2006540410 A JP 2006540410A JP 5671194 B2 JP5671194 B2 JP 5671194B2
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cgmp
nitric oxide
nos
solution
oxide synthase
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JP2007512011A (ja
JP2007512011A5 (cg-RX-API-DMAC7.html
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フランク ビュットナー
フランク ビュットナー
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2006540410A 2003-11-26 2004-11-25 読み取りシステムとしてグアニリルシクラーゼ及びcGMP生成を使用するNOの検出 Expired - Lifetime JP5671194B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03027159 2003-11-26
EP03027159.7 2003-11-26
PCT/EP2004/013707 WO2005052185A1 (en) 2003-11-26 2004-11-25 Detection of no by using guanylyl cyclase and cgmp production as a readout system

Publications (3)

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JP2007512011A JP2007512011A (ja) 2007-05-17
JP2007512011A5 JP2007512011A5 (cg-RX-API-DMAC7.html) 2008-01-17
JP5671194B2 true JP5671194B2 (ja) 2015-02-18

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JP2006540410A Expired - Lifetime JP5671194B2 (ja) 2003-11-26 2004-11-25 読み取りシステムとしてグアニリルシクラーゼ及びcGMP生成を使用するNOの検出

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EP (1) EP1689880B1 (cg-RX-API-DMAC7.html)
JP (1) JP5671194B2 (cg-RX-API-DMAC7.html)
AT (1) ATE429508T1 (cg-RX-API-DMAC7.html)
CA (1) CA2540822C (cg-RX-API-DMAC7.html)
DE (1) DE602004020795D1 (cg-RX-API-DMAC7.html)
DK (1) DK1689880T3 (cg-RX-API-DMAC7.html)
ES (1) ES2324477T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005052185A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006038942A1 (de) * 2006-08-18 2008-02-21 Bayer Healthcare Ag Verfahren zur Identifizierung von Stickstoffmonoxid Modulatoren
JP5350607B2 (ja) * 2007-06-14 2013-11-27 キッコーマン株式会社 グアニル酸シクラーゼ活性測定法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10043845A1 (de) * 2000-09-06 2002-03-14 Gruenenthal Gmbh Verfahren zur Messung der Aktivität der NO-Synthase

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WO2005052185A1 (en) 2005-06-09
JP2007512011A (ja) 2007-05-17
EP1689880B1 (en) 2009-04-22
ATE429508T1 (de) 2009-05-15
DE602004020795D1 (de) 2009-06-04
CA2540822C (en) 2010-09-21
CA2540822A1 (en) 2005-06-09
ES2324477T3 (es) 2009-08-07
DK1689880T3 (da) 2009-07-27
EP1689880A1 (en) 2006-08-16

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