DE602004020795D1 - Nachweis von no unter verwendung von guanylylcyclase und cgmp-produktion als readout-system - Google Patents
Nachweis von no unter verwendung von guanylylcyclase und cgmp-produktion als readout-systemInfo
- Publication number
- DE602004020795D1 DE602004020795D1 DE602004020795T DE602004020795T DE602004020795D1 DE 602004020795 D1 DE602004020795 D1 DE 602004020795D1 DE 602004020795 T DE602004020795 T DE 602004020795T DE 602004020795 T DE602004020795 T DE 602004020795T DE 602004020795 D1 DE602004020795 D1 DE 602004020795D1
- Authority
- DE
- Germany
- Prior art keywords
- guanylylcyclase
- proof
- readout system
- cgmp production
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010078321 Guanylate Cyclase Proteins 0.000 title abstract 2
- 102000014469 Guanylate cyclase Human genes 0.000 title abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03027159 | 2003-11-26 | ||
| PCT/EP2004/013707 WO2005052185A1 (en) | 2003-11-26 | 2004-11-25 | Detection of no by using guanylyl cyclase and cgmp production as a readout system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004020795D1 true DE602004020795D1 (de) | 2009-06-04 |
Family
ID=34626376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004020795T Active DE602004020795D1 (de) | 2003-11-26 | 2004-11-25 | Nachweis von no unter verwendung von guanylylcyclase und cgmp-produktion als readout-system |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1689880B1 (de) |
| JP (1) | JP5671194B2 (de) |
| AT (1) | ATE429508T1 (de) |
| CA (1) | CA2540822C (de) |
| DE (1) | DE602004020795D1 (de) |
| DK (1) | DK1689880T3 (de) |
| ES (1) | ES2324477T3 (de) |
| WO (1) | WO2005052185A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006038942A1 (de) * | 2006-08-18 | 2008-02-21 | Bayer Healthcare Ag | Verfahren zur Identifizierung von Stickstoffmonoxid Modulatoren |
| JP5350607B2 (ja) * | 2007-06-14 | 2013-11-27 | キッコーマン株式会社 | グアニル酸シクラーゼ活性測定法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
-
2004
- 2004-11-25 EP EP04819231A patent/EP1689880B1/de active Active
- 2004-11-25 CA CA2540822A patent/CA2540822C/en active Active
- 2004-11-25 DE DE602004020795T patent/DE602004020795D1/de active Active
- 2004-11-25 DK DK04819231T patent/DK1689880T3/da active
- 2004-11-25 ES ES04819231T patent/ES2324477T3/es active Active
- 2004-11-25 JP JP2006540410A patent/JP5671194B2/ja active Active
- 2004-11-25 WO PCT/EP2004/013707 patent/WO2005052185A1/en not_active Application Discontinuation
- 2004-11-25 AT AT04819231T patent/ATE429508T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2540822C (en) | 2010-09-21 |
| JP5671194B2 (ja) | 2015-02-18 |
| CA2540822A1 (en) | 2005-06-09 |
| EP1689880B1 (de) | 2009-04-22 |
| ATE429508T1 (de) | 2009-05-15 |
| EP1689880A1 (de) | 2006-08-16 |
| DK1689880T3 (da) | 2009-07-27 |
| WO2005052185A1 (en) | 2005-06-09 |
| ES2324477T3 (es) | 2009-08-07 |
| JP2007512011A (ja) | 2007-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |