JP2007511837A - プロテオームエピトームタグ及びそれらのタンパク質修飾分析における利用方法 - Google Patents

プロテオームエピトームタグ及びそれらのタンパク質修飾分析における利用方法 Download PDF

Info

Publication number
JP2007511837A
JP2007511837A JP2006539990A JP2006539990A JP2007511837A JP 2007511837 A JP2007511837 A JP 2007511837A JP 2006539990 A JP2006539990 A JP 2006539990A JP 2006539990 A JP2006539990 A JP 2006539990A JP 2007511837 A JP2007511837 A JP 2007511837A
Authority
JP
Japan
Prior art keywords
pet
protein
array
sample
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006539990A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007511837A5 (https=
Inventor
ディー．リー フランク
メング ジュン
リビングストン デイビッド
Original Assignee
イピトミ バイオシステムズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イピトミ バイオシステムズ インコーポレイテッド filed Critical イピトミ バイオシステムズ インコーポレイテッド
Publication of JP2007511837A publication Critical patent/JP2007511837A/ja
Publication of JP2007511837A5 publication Critical patent/JP2007511837A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006539990A 2003-11-13 2004-11-15 プロテオームエピトームタグ及びそれらのタンパク質修飾分析における利用方法 Pending JP2007511837A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/712,425 US7460960B2 (en) 2002-05-10 2003-11-13 Proteome epitope tags and methods of use thereof in protein modification analysis
PCT/US2004/038283 WO2005050223A2 (en) 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis

Publications (2)

Publication Number Publication Date
JP2007511837A true JP2007511837A (ja) 2007-05-10
JP2007511837A5 JP2007511837A5 (https=) 2008-01-10

Family

ID=34619853

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006539990A Pending JP2007511837A (ja) 2003-11-13 2004-11-15 プロテオームエピトームタグ及びそれらのタンパク質修飾分析における利用方法

Country Status (6)

Country Link
US (2) US7460960B2 (https=)
EP (1) EP1683065A2 (https=)
JP (1) JP2007511837A (https=)
AU (2) AU2004292226B2 (https=)
CA (1) CA2545899A1 (https=)
WO (1) WO2005050223A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012026309A1 (ja) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 抗ｐａｄ４抗体医薬の創成
JP2017020957A (ja) * 2015-07-14 2017-01-26 地方独立行政法人東京都立産業技術研究センター 表面プラズモン共鳴測定装置及びそのチップ
JP2018206374A (ja) * 2017-05-19 2018-12-27 富士通株式会社 予測される部位特異的なタンパク質リン酸化候補の発見のためのシステムおよび方法
JP2020064626A (ja) * 2018-10-18 2020-04-23 富士通株式会社 生体エンティティの特性を推測するコンピュータにより実施される方法及び機器
WO2023157457A1 (ja) * 2022-02-21 2023-08-24 株式会社日立製作所 検体の前処理方法及びその応用

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113744A1 (en) * 2001-05-11 2003-06-19 O' Toole Margot M. Methods for diagnosing and treating ischemia and reperfusion injury and compositions thereof
EP1415156B1 (en) 2001-07-10 2009-09-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of multiple proteins in single cells
US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
US7381535B2 (en) * 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
FI118061B (fi) * 2001-09-24 2007-06-15 Beanor Oy Menetelmä ja bioanturi analyysiä varten
FI115166B (fi) * 2001-12-31 2005-03-15 Biofons Oy Diagnostisia menetelmiä
WO2004039830A2 (en) 2002-05-07 2004-05-13 Regents Of The University Of California Bioactivation of particles
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
JP2007526213A (ja) * 2003-04-28 2007-09-13 セコイア、ファーマシューティカルズ、インコーポレイテッド コロナウイルスによる感染症の治療、管理および予防用の抗ウイルス剤
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US7790473B2 (en) * 2003-11-05 2010-09-07 The United States Of America As Represented By The Department Of Health And Human Services Biofunctionalized quantum dots for biological imaging
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
US20060154318A1 (en) * 2004-06-09 2006-07-13 Anderson Norman L Stable isotope labeled polypeptide standards for protein quantitation
US7943396B2 (en) * 2004-06-22 2011-05-17 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US20060240227A1 (en) * 2004-09-23 2006-10-26 Zhijun Zhang Nanocrystal coated surfaces
JP2008516249A (ja) * 2004-10-12 2008-05-15 ショット アクチエンゲゼルシャフト マルチプレックスタンパク質吸着アッセイ
AU2006206159A1 (en) * 2005-01-24 2006-07-27 Massachusetts Institute Of Technology Method for modeling cell signaling systems by means of bayesian networks
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20060223194A1 (en) * 2005-04-01 2006-10-05 Viorica Lopez-Avila Methods of screening for post-translationally modified proteins
US20060223130A1 (en) * 2005-04-04 2006-10-05 Dan-Hui Yang Detection of post-translationally modified analytes
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
EP1960364A2 (en) * 2005-12-07 2008-08-27 Ramot at Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US20100331200A1 (en) * 2006-03-31 2010-12-30 Gordon Neal F Post translational modification pattern analysis
US20090269773A1 (en) * 2008-04-29 2009-10-29 Nodality, Inc. A Delaware Corporation Methods of determining the health status of an individual
US20090291458A1 (en) * 2008-05-22 2009-11-26 Nodality, Inc. Method for Determining the Status of an Individual
US8227202B2 (en) 2008-07-10 2012-07-24 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010045651A1 (en) * 2008-10-17 2010-04-22 Nodality, Inc. Methods for analyzing drug response
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
KR101061017B1 (ko) * 2009-10-23 2011-08-31 (주) 수파드엘릭사 암세포의 성장 및/또는 전이 억제용 약학 조성물
KR101341640B1 (ko) * 2010-02-05 2013-12-16 한국전자통신연구원 단백질 미세 구조 분석 방법 및 단백질 미세 구조 분석용 어레이
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US9068006B2 (en) 2010-08-25 2015-06-30 President And Fellows Of Harvard College Glycated CD59 peptides, their preparation, and uses thereof
US9383367B1 (en) 2010-12-07 2016-07-05 Chunli Liu Methods of detecting conjugation site-specific and hidden epitope/antigen
BR112013020274A2 (pt) 2011-02-10 2016-11-22 Harvard College substitutos de proteínas pós-traducionalmente modificadas e usos dos mesmos
US9023599B2 (en) * 2011-09-25 2015-05-05 Chang Gung Medical Foundation, Linkou Branch Method of detecting the presence of pneumococcal neuraminidases in Streptococcus pneumoniae-infected samples
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9975922B2 (en) 2013-10-21 2018-05-22 The Research Foundation For The State University Of New York Peptide inhibitor of HIV reverse transcription
CN103698509B (zh) * 2014-01-08 2017-02-08 青岛科技大学 基于纳米多孔金片电极的电化学免疫传感器对巯基乙酸的检测
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
KR101750407B1 (ko) 2014-11-10 2017-06-27 한양대학교 산학협력단 프로틴 카이네이즈 a 기질 인산화펩타이드에 결합하는 알엔에이 앱타머
WO2016138381A1 (en) * 2015-02-27 2016-09-01 Regents Of The University Of Minnesota Detection assays and methods
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US10520514B2 (en) * 2017-02-01 2019-12-31 Korea Institute Of Science And Technology Method for monitoring post-translational modification of protein
SG11201909708VA (en) 2017-04-21 2019-11-28 Mellitus Llc Methods and antibodies for diabetes-related applications
EP3661958A2 (en) * 2017-08-04 2020-06-10 Abcam Plc Methods and compositions for the development of antibodies specific to epitope post-translational modification status
CN108776231B (zh) * 2018-09-06 2020-12-29 长沙文瀚生物技术有限责任公司 一种人尿白蛋白胶乳增强二抗竞争免疫比浊检测试剂盒及其制作和使用方法
CN110209770B (zh) * 2019-06-03 2022-04-15 北京邮电大学 一种基于策略价值网络和树搜索增强的命名实体识别方法
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
US12285437B2 (en) 2019-10-30 2025-04-29 The Research Foundation For The State University Of New York Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法
CN112305041B (zh) * 2020-09-15 2022-05-27 东莞东阳光医疗智能器件研发有限公司 多重定量电化学免疫传感器及其构建方法
WO2022066992A1 (en) * 2020-09-24 2022-03-31 University Of Cincinnati Continuous sensing with adapters and aptamers
US11617741B1 (en) 2021-08-12 2023-04-04 Health Research, Inc. Method for inhibiting growth of bacteria
WO2023025263A1 (en) * 2021-08-25 2023-03-02 Ensem Therapeutics Holding (Singapore) Pte. Ltd. Systems and methods for post-translational modification-inspired drug design and screening

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04223270A (ja) * 1990-03-27 1992-08-13 Boehringer Mannheim Gmbh ホスホリル化されたチロシンを含有する蛋白質を検出する方法及び組み合せ試薬
JP2002360278A (ja) * 2001-01-14 2002-12-17 Emil Israel Katz 目的ポリペプチドのペプチド標本および抗原に対する抗体、その生成および利用のための方法、システムおよびキット

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
US4658022A (en) * 1985-08-08 1987-04-14 Molecular Diagnostics, Inc. Binding of antibody reagents to denatured protein analytes
US5223441A (en) * 1986-10-09 1993-06-29 Syntex (U.S.A.) Inc. Receptors for immune complexes
EP0267355B1 (de) 1986-11-10 1991-09-18 PROGEN Biotechnik GmbH Verfahren zum Identifizieren gewebstypischer, unlöslicher Cytoskelettproteine
DE3815932A1 (de) 1988-01-26 1989-08-03 Progen Biotechnik Gmbh Verfahren zur identifizierung des ursprungs einer zellgewebsprobe
US4970171A (en) * 1987-11-09 1990-11-13 Miles Inc. Denaturant reagents for convenient determination of hemoglobin derivatives in blood
US5849531A (en) * 1989-04-07 1998-12-15 University Of Saskatchewan Compositions and treatments for pneumonia in animals
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5061790A (en) * 1989-07-10 1991-10-29 Molecular Diagnostics, Inc. Oxidative denaturation of protein analytes
FR2660757B1 (fr) * 1990-04-06 1994-05-27 Immunotech Sa Procede d'identification ou de dosage de proteines et applications.
DE4023945A1 (de) 1990-07-27 1992-01-30 Progen Biotechnik Gmbh Verfahren zur reinigung von cytokeratin 20 und dessen verwendung zur erzeugung von antikoerpern
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5723129A (en) * 1991-10-16 1998-03-03 University Of Saskatchewan GnRH-leukotoxin chimeras
WO1993008290A1 (en) * 1991-10-16 1993-04-29 University Of Saskatchewan Enhanced immunogenicity using leukotoxin chimeras
HUT71860A (en) * 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
WO1994008597A1 (en) 1992-10-14 1994-04-28 The Scripps Research Institute Methods for the detection of antigen-specific immune complexes
US5955317A (en) * 1993-01-25 1999-09-21 Takeda Chemical Industries, Ltd. Antibodies to β-amyloids or their derivatives and use thereof
JPH07285999A (ja) 1993-03-30 1995-10-31 Prima Meat Packers Ltd Ｅｌｉｓａを用いた食品中の乳蛋白質含量の定量分析方法及びその分析用に選別されたモノクローナル抗体及びそのモノクローナル抗体の選別方法
JP3393889B2 (ja) * 1993-06-11 2003-04-07 柳川精工株式会社 無潤滑軸受の製造方法および無潤滑軸受
EP0767379A1 (de) 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Kolonkarzinomen
WO1996005847A1 (en) 1994-08-22 1996-02-29 The Trustees Of The University Of Pennsylvania A method of sequencing proteins by epitope ordering and protein restriction mapping
EP0812434B1 (en) 1995-03-01 2013-09-18 President and Fellows of Harvard College Microcontact printing on surfaces and derivative articles
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
AUPN480095A0 (en) 1995-08-15 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Epitope tagging system
JP3452111B2 (ja) * 1995-11-10 2003-09-29 セイコーエプソン株式会社 インクジェット式記録ヘッド
US6420125B1 (en) * 1996-03-21 2002-07-16 Osteometer Biotech A/S Assaying fragments of collagen in body fluids
US5763158A (en) * 1997-02-06 1998-06-09 The United States Of America As Represented By The Secretary Of The Army Detection of multiple antigens or antibodies
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5872234A (en) * 1997-06-27 1999-02-16 Incyte Pharmaceuticals, Inc. Human extracellular matrix proteins
US6253456B1 (en) * 1997-11-17 2001-07-03 Phillip Cooksey Basketball court layout device and method
US6809184B1 (en) * 1997-12-01 2004-10-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
DE19802576B4 (de) 1998-01-23 2004-10-28 Xerion Pharmaceuticals Ag Verfahren zur gleichzeitigen Identifizierung von Proteinen und ihren Bindungspartnern
CA2319828A1 (en) 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
JP2002535676A (ja) 1999-01-28 2002-10-22 ユニヴェルシテ ドゥ ジュネーブ ポリペプチドを同定または特徴付けるための方法およびキット
CA2365431A1 (en) 1999-03-10 2000-09-14 Hui Ge Universal protein array system
US20020132753A1 (en) * 2000-01-31 2002-09-19 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020009740A1 (en) 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
WO2002006834A2 (en) 2000-07-19 2002-01-24 Pointilliste, Inc. Nested sorting and high throughput screening
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
DE10054055A1 (de) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
WO2002039083A2 (en) * 2000-11-08 2002-05-16 Science & Technology Corporation @ Unm Fluorescence and fret based assays for biomolecules on beads
GB0103389D0 (en) * 2001-02-12 2001-03-28 Novartis Ag Organic compounds
WO2002086081A2 (en) * 2001-04-20 2002-10-31 Carnegie Mellon University Methods and systems for identifying proteins
US20030044862A1 (en) * 2001-06-22 2003-03-06 The Board Of Trustees Of The Leland Stanford Jr. University Diagnostic marker for tumor hypoxia and prognosis
IL159550A0 (en) 2001-06-26 2004-06-01 Mds Proteomics Inc Methods and systems for identifying kinases, phosphatases and substrates thereof
EP1417626A2 (en) * 2001-07-13 2004-05-12 Pharmacopeia, Inc. System and method for aqueous solubility prediction
US20030143612A1 (en) 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
WO2003016904A2 (en) * 2001-08-13 2003-02-27 Campbell Douglas A Peptide sequence tags and method of using same
US20050153298A1 (en) * 2001-10-23 2005-07-14 Gembitsky Dmitry S. Protein micro-arrays and multi-layered affinity interaction detection
GB0200595D0 (en) 2002-01-11 2002-02-27 Oxford Glycosciences Uk Ltd Quantitation of differential expression
US20040038307A1 (en) * 2002-05-10 2004-02-26 Engeneos, Inc. Unique recognition sequences and methods of use thereof in protein analysis
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US20060014212A1 (en) * 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US20040229284A1 (en) * 2003-02-19 2004-11-18 The Regents Of The University Of California Multiplex analysis of proteins
US20050255491A1 (en) * 2003-11-13 2005-11-17 Lee Frank D Small molecule and peptide arrays and uses thereof
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US20100331200A1 (en) 2006-03-31 2010-12-30 Gordon Neal F Post translational modification pattern analysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04223270A (ja) * 1990-03-27 1992-08-13 Boehringer Mannheim Gmbh ホスホリル化されたチロシンを含有する蛋白質を検出する方法及び組み合せ試薬
JP2002360278A (ja) * 2001-01-14 2002-12-17 Emil Israel Katz 目的ポリペプチドのペプチド標本および抗原に対する抗体、その生成および利用のための方法、システムおよびキット

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012026309A1 (ja) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 抗ｐａｄ４抗体医薬の創成
JP2017020957A (ja) * 2015-07-14 2017-01-26 地方独立行政法人東京都立産業技術研究センター 表面プラズモン共鳴測定装置及びそのチップ
JP2018206374A (ja) * 2017-05-19 2018-12-27 富士通株式会社 予測される部位特異的なタンパク質リン酸化候補の発見のためのシステムおよび方法
JP7155604B2 (ja) 2017-05-19 2022-10-19 富士通株式会社 予測される部位特異的なタンパク質リン酸化候補の発見のためのシステムおよび方法
JP2020064626A (ja) * 2018-10-18 2020-04-23 富士通株式会社 生体エンティティの特性を推測するコンピュータにより実施される方法及び機器
JP7400319B2 (ja) 2018-10-18 2023-12-19 富士通株式会社 生体エンティティの特性を推測するコンピュータにより実施される方法及び機器
WO2023157457A1 (ja) * 2022-02-21 2023-08-24 株式会社日立製作所 検体の前処理方法及びその応用

Also Published As

Publication number Publication date
AU2004292226A1 (en) 2005-06-02
EP1683065A2 (en) 2006-07-26
AU2008227063A1 (en) 2008-10-16
US7964362B2 (en) 2011-06-21
CA2545899A1 (en) 2005-06-02
WO2005050223A3 (en) 2006-02-09
US20040180380A1 (en) 2004-09-16
US20090023157A1 (en) 2009-01-22
US7460960B2 (en) 2008-12-02
AU2004292226B2 (en) 2008-06-26
WO2005050223A2 (en) 2005-06-02

Similar Documents

Publication Publication Date Title
AU2004292226B2 (en) Proteome epitope tags and methods of use thereof in protein modification analysis
US8244484B2 (en) Proteome epitope tags and methods of use thereof in protein modification analysis
US20060014212A1 (en) Proteome epitope tags and methods of use thereof in protein modification analysis
US7645586B2 (en) Protein isoform discrimination and quantitative measurements thereof
JP2006511819A (ja) ユニーク認識配列及びタンパク質分析におけるその利用方法
US20050255491A1 (en) Small molecule and peptide arrays and uses thereof
US20100331200A1 (en) Post translational modification pattern analysis
Zhu et al. Protein chip technology
Wingren et al. Antibody microarrays: current status and key technological advances
JP2004511753A (ja) タンパク質活性のスクリーニング用タンパク質チップ
JP2004506201A (ja) 機能性生体分子のマイクロアレイおよびその使用
Li et al. Adapting cDNA microarray format to cytokine detection protein arrays
US20260029416A1 (en) Systems, methods and compositions for analysis of proteoforms
Humphery-Smith Protein biochips and array-based proteomics
Chen et al. Protein microarray technologies
HUMPHERY-SMITH Protein Biochips and Array-Based
Baptista et al. Protein microarrays

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071113

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20090605

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20090605

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110202

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110224

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110830