JP2007509978A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007509978A5 JP2007509978A5 JP2006538354A JP2006538354A JP2007509978A5 JP 2007509978 A5 JP2007509978 A5 JP 2007509978A5 JP 2006538354 A JP2006538354 A JP 2006538354A JP 2006538354 A JP2006538354 A JP 2006538354A JP 2007509978 A5 JP2007509978 A5 JP 2007509978A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- compound
- therapeutic drug
- composition
- tocopherol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 229940126585 therapeutic drug Drugs 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 17
- 125000005647 linker group Chemical group 0.000 claims 13
- 239000000839 emulsion Substances 0.000 claims 9
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 239000012071 phase Substances 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 125000002640 tocopherol group Chemical group 0.000 claims 6
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 5
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 5
- 229930012538 Paclitaxel Natural products 0.000 claims 5
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 claims 5
- 229960003668 docetaxel Drugs 0.000 claims 5
- 229960001592 paclitaxel Drugs 0.000 claims 5
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 5
- 229940123237 Taxane Drugs 0.000 claims 4
- -1 camptothecins Chemical class 0.000 claims 4
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 150000003900 succinic acid esters Chemical group 0.000 claims 3
- 229960001295 tocopherol Drugs 0.000 claims 3
- 229930003799 tocopherol Natural products 0.000 claims 3
- 235000010384 tocopherol Nutrition 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 claims 2
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims 2
- HAWSQZCWOQZXHI-UHFFFAOYSA-N CPT-OH Natural products C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-UHFFFAOYSA-N 0.000 claims 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 2
- 229940127093 camptothecin Drugs 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51536403P | 2003-10-29 | 2003-10-29 | |
| US55613704P | 2004-03-24 | 2004-03-24 | |
| US55876204P | 2004-04-01 | 2004-04-01 | |
| US62165504P | 2004-10-26 | 2004-10-26 | |
| PCT/US2004/036127 WO2005042539A1 (en) | 2003-10-29 | 2004-10-29 | Tocopherol-modified therapeutic drug compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509978A JP2007509978A (ja) | 2007-04-19 |
| JP2007509978A5 true JP2007509978A5 (enExample) | 2007-12-13 |
Family
ID=34557676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538354A Pending JP2007509978A (ja) | 2003-10-29 | 2004-10-29 | トコフェロール修飾治療薬化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7223770B2 (enExample) |
| EP (1) | EP1682552B1 (enExample) |
| JP (1) | JP2007509978A (enExample) |
| KR (1) | KR20060110872A (enExample) |
| AT (1) | ATE472551T1 (enExample) |
| AU (1) | AU2004285037B2 (enExample) |
| BR (1) | BRPI0415858A (enExample) |
| CA (1) | CA2543722C (enExample) |
| DE (1) | DE602004027936D1 (enExample) |
| IL (1) | IL175158A0 (enExample) |
| TW (1) | TW200522978A (enExample) |
| WO (1) | WO2005042539A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| ES2391775T3 (es) * | 2004-11-05 | 2012-11-29 | Samyang Biopharmaceuticals Corporation | Formulación farmacéutica para aumentar la solubilidad de compuestos de 10-hidroxicamptotecina en disolventes polares no acuosos |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| EP1853250B1 (en) | 2005-02-18 | 2011-11-02 | Abraxis BioScience, LLC | Combinations and modes of administration of therapeutic agents and combination therapy |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| BRPI0613631A8 (pt) * | 2005-07-18 | 2017-12-26 | Univ Massachusetts Lowell | nanoemulsão e método, |
| AU2016244292A1 (en) * | 2005-07-18 | 2016-11-03 | University Of Massachusetts Lowell | Compositions and methods for making and using nanoemulsions |
| WO2007035311A2 (en) * | 2005-09-16 | 2007-03-29 | University Of Massachusetts Lowell | Anti-oxidant synergy formulation nanoemulsions to treat cancer |
| US7727514B2 (en) * | 2005-10-03 | 2010-06-01 | Biotechnology Research & Development Corporation | Compositions comprising a UV-absorbing chromophore |
| US7744856B2 (en) * | 2005-10-03 | 2010-06-29 | Biotech Research And Development Corporation | Formulations with feruloyl glycerides and methods of preparation |
| US7572610B2 (en) * | 2005-10-03 | 2009-08-11 | Biotechnology Research & Development Corporation | Methods of making compositions comprising a UV-Absorbing chromophore |
| CN103919690B (zh) | 2005-12-01 | 2020-07-31 | 麻萨诸塞州洛厄尔大学 | 肉毒杆菌纳米乳液 |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| WO2007075492A1 (en) * | 2005-12-16 | 2007-07-05 | Sonus Pharmaceuticals, Inc. | Lipophilic anticancer drug compounds |
| CZ300305B6 (cs) * | 2005-12-20 | 2009-04-15 | Heaton, A. S. | Farmaceutická kompozice obsahující derivát taxanu se zlepšenou terapeutickou úcinností |
| US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
| TWI376239B (en) * | 2006-02-01 | 2012-11-11 | Andrew Xian Chen | Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof |
| CA2656091A1 (en) * | 2006-06-29 | 2008-01-03 | Biotech Research And Development Corporation | Formulations with feruloyl glycerides and methods of preparation |
| WO2008016664A2 (en) * | 2006-08-02 | 2008-02-07 | University Of Massachusetts Lowell | Compositions and methods for treating cancer with dacarbazine nanoemulsions |
| CA2671133C (en) | 2006-12-01 | 2015-11-24 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
| US20100150994A1 (en) | 2006-12-01 | 2010-06-17 | Anterios, Inc. | Amphiphilic entity nanoparticles |
| ES2660906T3 (es) | 2007-05-31 | 2018-03-26 | Anterios, Inc. | Nanopartículas de ácido nucleico y usos de las mismas |
| CA2686225A1 (en) * | 2007-06-22 | 2008-12-31 | Scidose Llc | Solubilized formulation of docetaxel without tween 80 |
| EP2222278B1 (en) | 2007-11-28 | 2015-04-08 | Celator Pharmaceuticals, Inc. | Improved taxane delivery system |
| CA2715018C (en) * | 2008-03-20 | 2012-11-13 | Virun, Inc. | Vitamin e derivatives and their uses |
| MX2010010050A (es) | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| US7670894B2 (en) * | 2008-04-30 | 2010-03-02 | Intel Corporation | Selective high-k dielectric film deposition for semiconductor device |
| CA3042777A1 (en) * | 2008-06-26 | 2009-12-30 | Anterios, Inc. | Dermal delivery |
| WO2010124223A1 (en) * | 2009-04-23 | 2010-10-28 | First Tech International Limited | Anti-cancer tocotrienol analogues and associated methods |
| US9180113B2 (en) * | 2009-09-01 | 2015-11-10 | First Tech International Limited | Tocotrienol compositions |
| US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
| US20110092579A1 (en) * | 2009-10-19 | 2011-04-21 | Scidose Llc | Solubilized formulation of docetaxel |
| US8541465B2 (en) * | 2009-10-19 | 2013-09-24 | Scidose, Llc | Docetaxel formulations with lipoic acid and/or dihydrolipoic acid |
| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
| EP2531028B1 (en) * | 2010-02-05 | 2014-12-31 | First Tech International Limited | Tocotrienol esters |
| WO2011103512A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha free fatty acid emulsions |
| CN103037708B (zh) * | 2010-03-23 | 2015-05-20 | 维尔恩公司 | 含有蔗糖脂肪酸酯的纳米乳液 |
| KR20190109593A (ko) | 2010-03-29 | 2019-09-25 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| ES2600912T3 (es) | 2010-03-29 | 2017-02-13 | Abraxis Bioscience, Llc | Métodos para tratar el cáncer |
| KR20180049180A (ko) | 2010-06-04 | 2018-05-10 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| US9731025B2 (en) | 2010-08-20 | 2017-08-15 | National University Corporation Tokyo Medical And Dental University | Pharmaceutical composition for transcolonic absorption |
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| CN102516258B (zh) * | 2011-11-11 | 2014-06-25 | 正大天晴药业集团股份有限公司 | 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用 |
| CA2863544C (en) | 2012-02-10 | 2019-03-26 | Virun, Inc. | Beverage compositions containing non-polar compounds |
| CN102731518B (zh) * | 2012-06-26 | 2014-12-03 | 济南精合医药科技有限公司 | 用于抗肿瘤药物的邻硝基芳甲氧基喜树碱缺氧激活前药 |
| CN102731519B (zh) * | 2012-06-26 | 2014-12-17 | 济南精合医药科技有限公司 | 用于抗肿瘤药物的对硝基芳甲氧基喜树碱缺氧激活前药 |
| US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
| US20140314672A1 (en) * | 2013-04-06 | 2014-10-23 | Igdrasol, Inc. | Nanoparticle therapeutic agents, their formulations, and methods of their use |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| CA2947741A1 (en) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| US10172961B2 (en) | 2014-05-07 | 2019-01-08 | Cornell University | Inhibitors of fusion between viral and cell membranes as well as compositions and methods of using them |
| US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
| EA201692548A1 (ru) | 2014-06-18 | 2017-10-31 | ТЕТИС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи | Минеральные аминокислотные комплексы активных веществ |
| US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
| CA2963819A1 (en) | 2014-10-08 | 2016-04-14 | Epigenetics Pharma Llc | Vitamin e-nucleoside prodrugs |
| CN105777770B (zh) * | 2014-12-26 | 2018-05-25 | 中国人民解放军第二军医大学 | 一种饱和长链脂肪酸修饰的7-乙基-10-羟基喜树碱化合物及其长循环脂质体 |
| CN104800858B (zh) * | 2015-04-27 | 2017-11-21 | 中国医学科学院基础医学研究所 | Hsp90抑制肽偶联物及其在肿瘤治疗中的应用 |
| GB2550346B (en) * | 2016-05-13 | 2021-02-24 | Phytoceutical Ltd | Micelles |
| JP6906047B2 (ja) | 2016-06-03 | 2021-07-21 | テティス・ファーマシューティカルズ・エルエルシー | 特異的炎症収束性メディエーターの塩に関連する組成物及び方法 |
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING NON-AGE-ASSOCIATED HEARING DEFICIENCY IN A HUMAN SUBJECT |
| WO2018093465A1 (en) | 2016-11-21 | 2018-05-24 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
| GB201812972D0 (en) | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| GB201812980D0 (en) | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| CN112996533B (zh) | 2018-09-17 | 2025-01-10 | 费城儿童医院 | 基于聚合物的大分子前药 |
| BR112021010982A2 (pt) | 2018-12-07 | 2021-08-31 | Oxford University Innovation Limited | Ligantes |
| CA3168055A1 (en) | 2020-02-21 | 2021-08-26 | Emmanuel John Simons | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| CA3229030A1 (en) * | 2021-09-05 | 2023-03-09 | Yi-Wen Chu | Formulations with enhanced sn-38 solubility and oral absorption |
| CN117098536A (zh) | 2021-10-15 | 2023-11-21 | 昆山新蕴达生物科技有限公司 | 包含抗肿瘤药物的组合物及其制备方法和用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395994A (en) | 1972-08-23 | 1975-05-29 | Delmar Chem | Tocopherol derivative processes for making it and pharmaceutical compositions containing it |
| GB1409612A (en) | 1973-09-13 | 1975-10-08 | Ahrens G W | Phenylpropyl-d-alpha-tocopherol-succinate the method for making the same and preparations |
| WO1979000401A1 (fr) | 1977-12-16 | 1979-07-12 | Nisshin Flour Milling Co | Agent anti-tumeur |
| JPS5484034A (en) * | 1977-12-16 | 1979-07-04 | Nisshin Flour Milling Co Ltd | Anti-tumor agent |
| US4665204A (en) * | 1985-06-27 | 1987-05-12 | Henkel Corporation | Diester derivatives of tocopherol |
| US5610180A (en) * | 1988-01-29 | 1997-03-11 | Virginia Commonwealth University | Ionizable congeners of aromatic and aliphatic alcohols as anti-leukemia agents |
| US5234695A (en) * | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
| JP3644543B2 (ja) | 1993-10-22 | 2005-04-27 | ヘクサル・アーゲー | シクロスポリンＡ及びα−トコフェロールを含有する医薬組成物 |
| GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
| CA2148148A1 (en) * | 1994-05-20 | 1995-11-21 | Kazumi Ogata | Tocopherol derivatives |
| DE4423915A1 (de) | 1994-07-07 | 1996-01-11 | Carl Heinrich Dr Weischer | Derivate des Salazosulfapyridins, deren Herstellung und Verwendung als Arzneimittel |
| US5858398A (en) * | 1994-11-03 | 1999-01-12 | Isomed Inc. | Microparticular pharmaceutical compositions |
| US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
| US5912078A (en) * | 1996-05-02 | 1999-06-15 | Milliken & Company | Lubricant finish for textiles |
| US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| EP0914116B1 (en) * | 1996-05-22 | 2000-10-11 | Protarga Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| AU735648B2 (en) * | 1996-07-12 | 2001-07-12 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| US5891469A (en) * | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| US6727280B2 (en) * | 1997-01-07 | 2004-04-27 | Sonus Pharmaceuticals, Inc. | Method for treating colorectal carcinoma using a taxane/tocopherol formulation |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| GB9715759D0 (en) | 1997-07-26 | 1997-10-01 | Danbiosyst Uk | New emulsion formulations |
| WO1999025729A1 (fr) * | 1997-11-18 | 1999-05-27 | Chugai Seiyaku Kabushiki Kaisha | Composes possedant une activite antitumorale |
| US5917060A (en) * | 1997-12-17 | 1999-06-29 | Basf Aktiengesellschaft | Preparation of chromanyl derivatives |
| DE69805334T2 (de) * | 1997-12-24 | 2002-12-05 | Senju Pharmaceutical Co., Ltd. | Derivate des vitamin e |
| US6086915A (en) * | 1998-04-01 | 2000-07-11 | Bioresponse L.L.C. | Compositions and methods of adjusting steroid hormone metabolism through phytochemicals |
| WO2000016772A1 (en) * | 1998-09-23 | 2000-03-30 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| US6045826A (en) * | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
| BR0010794A (pt) * | 1999-05-24 | 2002-06-04 | Sonus Pharma Inc | Emulsão-veìculo para drogas com fraca solubilidade |
| EP1208150A4 (en) * | 1999-06-11 | 2005-01-26 | Sydney Hyman | IMAGE FORMING MATERIAL |
| MXPA02003203A (es) * | 1999-09-27 | 2004-03-16 | Sonus Pharma Inc | Composiciones terapeuticas solubles en tocol. |
| US6136846A (en) * | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
| WO2002076970A2 (en) * | 2001-03-23 | 2002-10-03 | Sonus Pharmaceuticals, Inc. | Tocopherol succinate derivatives and compositions |
| US6774116B2 (en) * | 2001-04-17 | 2004-08-10 | Cryolife, Inc. | Prodrugs via acylation with cinnamate |
| US6858227B1 (en) * | 2001-11-21 | 2005-02-22 | Sonus Pharmaceuticals, Inc. | Vitamin E conjugates |
| US6683194B2 (en) * | 2002-02-05 | 2004-01-27 | Sonus Pharmaceuticals, Inc. | Tocopherol derivatives |
-
2004
- 2004-10-29 CA CA2543722A patent/CA2543722C/en not_active Expired - Fee Related
- 2004-10-29 US US10/978,222 patent/US7223770B2/en not_active Expired - Fee Related
- 2004-10-29 JP JP2006538354A patent/JP2007509978A/ja active Pending
- 2004-10-29 AU AU2004285037A patent/AU2004285037B2/en not_active Ceased
- 2004-10-29 DE DE602004027936T patent/DE602004027936D1/de not_active Expired - Lifetime
- 2004-10-29 AT AT04817489T patent/ATE472551T1/de not_active IP Right Cessation
- 2004-10-29 KR KR1020067008232A patent/KR20060110872A/ko not_active Ceased
- 2004-10-29 EP EP04817489A patent/EP1682552B1/en not_active Expired - Lifetime
- 2004-10-29 BR BRPI0415858-0A patent/BRPI0415858A/pt not_active IP Right Cessation
- 2004-10-29 TW TW093132975A patent/TW200522978A/zh unknown
- 2004-10-29 WO PCT/US2004/036127 patent/WO2005042539A1/en not_active Ceased
-
2006
- 2006-04-25 IL IL175158A patent/IL175158A0/en unknown
- 2006-06-08 US US11/450,795 patent/US20060229359A1/en not_active Abandoned
-
2007
- 2007-03-22 US US11/690,005 patent/US20070207196A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007509978A5 (enExample) | ||
| Liu et al. | Gambogic acid as a candidate for cancer therapy: a review | |
| JP2013503174A5 (enExample) | ||
| Beckers et al. | Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy | |
| CA2543722A1 (en) | Tocopherol-modified therapeutic drug compounds | |
| Wu et al. | Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment | |
| Ojima et al. | Tumor-specific novel taxoid− monoclonal antibody conjugates | |
| Zhang et al. | Polymeric micelles: nanocarriers for cancer-targeted drug delivery | |
| Zou et al. | Novel ligustrazine-based analogs of piperlongumine potently suppress proliferation and metastasis of colorectal cancer cells in vitro and in vivo | |
| JP2015501833A5 (enExample) | ||
| Lu et al. | Hyaluronic acid-coated, prodrug-based nanostructured lipid carriers for enhanced pancreatic cancer therapy | |
| JP2014508804A5 (enExample) | ||
| Wang et al. | Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents | |
| WO2014023081A1 (zh) | 青嵩素衍生物及其制法和应用 | |
| Wang et al. | Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer | |
| JP2005506298A5 (enExample) | ||
| US20040019088A1 (en) | Use of Epothilones in the treatment of brain diseases associated with proliferative processes | |
| CN1950376A (zh) | 莪术醇衍生物、含该衍生物的组合物及所述衍生物的制药用途 | |
| Borys et al. | Development of novel derivatives of stilbene and macrocyclic compounds as potent of anti-microtubule factors | |
| JP2012506443A5 (enExample) | ||
| JP2009541387A5 (enExample) | ||
| Ferlini et al. | New taxanes in development | |
| JP2004523478A5 (enExample) | ||
| HRP20140215T1 (hr) | Kombinacija koja sadrži paklitaksel za lijeäśenje raka jajnika | |
| Iqubal et al. | A technical note on emerging combination approach involved in the onconanotherapeutics |