BRPI0415858A - compostos de medicamentos terapêuticos modificados por tocoferol - Google Patents
compostos de medicamentos terapêuticos modificados por tocoferolInfo
- Publication number
- BRPI0415858A BRPI0415858A BRPI0415858-0A BRPI0415858A BRPI0415858A BR PI0415858 A BRPI0415858 A BR PI0415858A BR PI0415858 A BRPI0415858 A BR PI0415858A BR PI0415858 A BRPI0415858 A BR PI0415858A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- tocopherol
- modified therapeutic
- therapeutic drugs
- formulations
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 229940126585 therapeutic drug Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- 239000004530 micro-emulsion Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51536403P | 2003-10-29 | 2003-10-29 | |
| US55613704P | 2004-03-24 | 2004-03-24 | |
| US55876204P | 2004-04-01 | 2004-04-01 | |
| US62165504P | 2004-10-26 | 2004-10-26 | |
| PCT/US2004/036127 WO2005042539A1 (en) | 2003-10-29 | 2004-10-29 | Tocopherol-modified therapeutic drug compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0415858A true BRPI0415858A (pt) | 2007-01-09 |
Family
ID=34557676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0415858-0A BRPI0415858A (pt) | 2003-10-29 | 2004-10-29 | compostos de medicamentos terapêuticos modificados por tocoferol |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7223770B2 (enExample) |
| EP (1) | EP1682552B1 (enExample) |
| JP (1) | JP2007509978A (enExample) |
| KR (1) | KR20060110872A (enExample) |
| AT (1) | ATE472551T1 (enExample) |
| AU (1) | AU2004285037B2 (enExample) |
| BR (1) | BRPI0415858A (enExample) |
| CA (1) | CA2543722C (enExample) |
| DE (1) | DE602004027936D1 (enExample) |
| IL (1) | IL175158A0 (enExample) |
| TW (1) | TW200522978A (enExample) |
| WO (1) | WO2005042539A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| ES2391775T3 (es) * | 2004-11-05 | 2012-11-29 | Samyang Biopharmaceuticals Corporation | Formulación farmacéutica para aumentar la solubilidad de compuestos de 10-hidroxicamptotecina en disolventes polares no acuosos |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| EP1853250B1 (en) | 2005-02-18 | 2011-11-02 | Abraxis BioScience, LLC | Combinations and modes of administration of therapeutic agents and combination therapy |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| BRPI0613631A8 (pt) * | 2005-07-18 | 2017-12-26 | Univ Massachusetts Lowell | nanoemulsão e método, |
| AU2016244292A1 (en) * | 2005-07-18 | 2016-11-03 | University Of Massachusetts Lowell | Compositions and methods for making and using nanoemulsions |
| WO2007035311A2 (en) * | 2005-09-16 | 2007-03-29 | University Of Massachusetts Lowell | Anti-oxidant synergy formulation nanoemulsions to treat cancer |
| US7727514B2 (en) * | 2005-10-03 | 2010-06-01 | Biotechnology Research & Development Corporation | Compositions comprising a UV-absorbing chromophore |
| US7744856B2 (en) * | 2005-10-03 | 2010-06-29 | Biotech Research And Development Corporation | Formulations with feruloyl glycerides and methods of preparation |
| US7572610B2 (en) * | 2005-10-03 | 2009-08-11 | Biotechnology Research & Development Corporation | Methods of making compositions comprising a UV-Absorbing chromophore |
| CN103919690B (zh) | 2005-12-01 | 2020-07-31 | 麻萨诸塞州洛厄尔大学 | 肉毒杆菌纳米乳液 |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| WO2007075492A1 (en) * | 2005-12-16 | 2007-07-05 | Sonus Pharmaceuticals, Inc. | Lipophilic anticancer drug compounds |
| CZ300305B6 (cs) * | 2005-12-20 | 2009-04-15 | Heaton, A. S. | Farmaceutická kompozice obsahující derivát taxanu se zlepšenou terapeutickou úcinností |
| US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
| TWI376239B (en) * | 2006-02-01 | 2012-11-11 | Andrew Xian Chen | Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof |
| CA2656091A1 (en) * | 2006-06-29 | 2008-01-03 | Biotech Research And Development Corporation | Formulations with feruloyl glycerides and methods of preparation |
| WO2008016664A2 (en) * | 2006-08-02 | 2008-02-07 | University Of Massachusetts Lowell | Compositions and methods for treating cancer with dacarbazine nanoemulsions |
| CA2671133C (en) | 2006-12-01 | 2015-11-24 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
| US20100150994A1 (en) | 2006-12-01 | 2010-06-17 | Anterios, Inc. | Amphiphilic entity nanoparticles |
| ES2660906T3 (es) | 2007-05-31 | 2018-03-26 | Anterios, Inc. | Nanopartículas de ácido nucleico y usos de las mismas |
| CA2686225A1 (en) * | 2007-06-22 | 2008-12-31 | Scidose Llc | Solubilized formulation of docetaxel without tween 80 |
| EP2222278B1 (en) | 2007-11-28 | 2015-04-08 | Celator Pharmaceuticals, Inc. | Improved taxane delivery system |
| CA2715018C (en) * | 2008-03-20 | 2012-11-13 | Virun, Inc. | Vitamin e derivatives and their uses |
| MX2010010050A (es) | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| US7670894B2 (en) * | 2008-04-30 | 2010-03-02 | Intel Corporation | Selective high-k dielectric film deposition for semiconductor device |
| CA3042777A1 (en) * | 2008-06-26 | 2009-12-30 | Anterios, Inc. | Dermal delivery |
| WO2010124223A1 (en) * | 2009-04-23 | 2010-10-28 | First Tech International Limited | Anti-cancer tocotrienol analogues and associated methods |
| US9180113B2 (en) * | 2009-09-01 | 2015-11-10 | First Tech International Limited | Tocotrienol compositions |
| US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
| US20110092579A1 (en) * | 2009-10-19 | 2011-04-21 | Scidose Llc | Solubilized formulation of docetaxel |
| US8541465B2 (en) * | 2009-10-19 | 2013-09-24 | Scidose, Llc | Docetaxel formulations with lipoic acid and/or dihydrolipoic acid |
| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
| EP2531028B1 (en) * | 2010-02-05 | 2014-12-31 | First Tech International Limited | Tocotrienol esters |
| WO2011103512A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha free fatty acid emulsions |
| CN103037708B (zh) * | 2010-03-23 | 2015-05-20 | 维尔恩公司 | 含有蔗糖脂肪酸酯的纳米乳液 |
| KR20190109593A (ko) | 2010-03-29 | 2019-09-25 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| ES2600912T3 (es) | 2010-03-29 | 2017-02-13 | Abraxis Bioscience, Llc | Métodos para tratar el cáncer |
| KR20180049180A (ko) | 2010-06-04 | 2018-05-10 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| US9731025B2 (en) | 2010-08-20 | 2017-08-15 | National University Corporation Tokyo Medical And Dental University | Pharmaceutical composition for transcolonic absorption |
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| CN102516258B (zh) * | 2011-11-11 | 2014-06-25 | 正大天晴药业集团股份有限公司 | 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用 |
| CA2863544C (en) | 2012-02-10 | 2019-03-26 | Virun, Inc. | Beverage compositions containing non-polar compounds |
| CN102731518B (zh) * | 2012-06-26 | 2014-12-03 | 济南精合医药科技有限公司 | 用于抗肿瘤药物的邻硝基芳甲氧基喜树碱缺氧激活前药 |
| CN102731519B (zh) * | 2012-06-26 | 2014-12-17 | 济南精合医药科技有限公司 | 用于抗肿瘤药物的对硝基芳甲氧基喜树碱缺氧激活前药 |
| US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
| US20140314672A1 (en) * | 2013-04-06 | 2014-10-23 | Igdrasol, Inc. | Nanoparticle therapeutic agents, their formulations, and methods of their use |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| CA2947741A1 (en) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| US10172961B2 (en) | 2014-05-07 | 2019-01-08 | Cornell University | Inhibitors of fusion between viral and cell membranes as well as compositions and methods of using them |
| US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
| EA201692548A1 (ru) | 2014-06-18 | 2017-10-31 | ТЕТИС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи | Минеральные аминокислотные комплексы активных веществ |
| US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
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| CN104800858B (zh) * | 2015-04-27 | 2017-11-21 | 中国医学科学院基础医学研究所 | Hsp90抑制肽偶联物及其在肿瘤治疗中的应用 |
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| GB201812972D0 (en) | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| GB201812980D0 (en) | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| CN112996533B (zh) | 2018-09-17 | 2025-01-10 | 费城儿童医院 | 基于聚合物的大分子前药 |
| BR112021010982A2 (pt) | 2018-12-07 | 2021-08-31 | Oxford University Innovation Limited | Ligantes |
| CA3168055A1 (en) | 2020-02-21 | 2021-08-26 | Emmanuel John Simons | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| CA3229030A1 (en) * | 2021-09-05 | 2023-03-09 | Yi-Wen Chu | Formulations with enhanced sn-38 solubility and oral absorption |
| CN117098536A (zh) | 2021-10-15 | 2023-11-21 | 昆山新蕴达生物科技有限公司 | 包含抗肿瘤药物的组合物及其制备方法和用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395994A (en) | 1972-08-23 | 1975-05-29 | Delmar Chem | Tocopherol derivative processes for making it and pharmaceutical compositions containing it |
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-
2004
- 2004-10-29 CA CA2543722A patent/CA2543722C/en not_active Expired - Fee Related
- 2004-10-29 US US10/978,222 patent/US7223770B2/en not_active Expired - Fee Related
- 2004-10-29 JP JP2006538354A patent/JP2007509978A/ja active Pending
- 2004-10-29 AU AU2004285037A patent/AU2004285037B2/en not_active Ceased
- 2004-10-29 DE DE602004027936T patent/DE602004027936D1/de not_active Expired - Lifetime
- 2004-10-29 AT AT04817489T patent/ATE472551T1/de not_active IP Right Cessation
- 2004-10-29 KR KR1020067008232A patent/KR20060110872A/ko not_active Ceased
- 2004-10-29 EP EP04817489A patent/EP1682552B1/en not_active Expired - Lifetime
- 2004-10-29 BR BRPI0415858-0A patent/BRPI0415858A/pt not_active IP Right Cessation
- 2004-10-29 TW TW093132975A patent/TW200522978A/zh unknown
- 2004-10-29 WO PCT/US2004/036127 patent/WO2005042539A1/en not_active Ceased
-
2006
- 2006-04-25 IL IL175158A patent/IL175158A0/en unknown
- 2006-06-08 US US11/450,795 patent/US20060229359A1/en not_active Abandoned
-
2007
- 2007-03-22 US US11/690,005 patent/US20070207196A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060229359A1 (en) | 2006-10-12 |
| CA2543722A1 (en) | 2005-05-12 |
| US20050096340A1 (en) | 2005-05-05 |
| AU2004285037A1 (en) | 2005-05-12 |
| KR20060110872A (ko) | 2006-10-25 |
| TW200522978A (en) | 2005-07-16 |
| US20070207196A1 (en) | 2007-09-06 |
| IL175158A0 (en) | 2006-09-05 |
| ATE472551T1 (de) | 2010-07-15 |
| DE602004027936D1 (de) | 2010-08-12 |
| US7223770B2 (en) | 2007-05-29 |
| EP1682552B1 (en) | 2010-06-30 |
| CA2543722C (en) | 2011-01-04 |
| AU2004285037B2 (en) | 2010-07-22 |
| JP2007509978A (ja) | 2007-04-19 |
| EP1682552A1 (en) | 2006-07-26 |
| WO2005042539A1 (en) | 2005-05-12 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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