JP2007507222A5 - - Google Patents

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Publication number

JP2007507222A5

JP2007507222A5 JP2006533426A JP2006533426A JP2007507222A5 JP 2007507222 A5 JP2007507222 A5 JP 2007507222A5 JP 2006533426 A JP2006533426 A JP 2006533426A JP 2006533426 A JP2006533426 A JP 2006533426A JP 2007507222 A5 JP2007507222 A5 JP 2007507222A5

Authority

JP

Japan

Prior art keywords

expression

cancer

array

chemotherapy

following

Prior art date

2004-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000000034 method Methods 0.000 claims 53
• 230000014509 gene expression Effects 0.000 claims 35
• 206010028980 Neoplasm Diseases 0.000 claims 14
• 108091033319 polynucleotide Proteins 0.000 claims 14
• 102000040430 polynucleotide Human genes 0.000 claims 14
• 239000002157 polynucleotide Substances 0.000 claims 14
• 108090000623 proteins and genes Proteins 0.000 claims 13
• 201000011510 cancer Diseases 0.000 claims 11
• 238000002512 chemotherapy Methods 0.000 claims 9
• 239000002246 antineoplastic agent Substances 0.000 claims 8
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 6
• 210000001519 tissue Anatomy 0.000 claims 5
• 206010006187 Breast cancer Diseases 0.000 claims 4
• 208000026310 Breast neoplasm Diseases 0.000 claims 4
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 4
• 238000001574 biopsy Methods 0.000 claims 4
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 4
• 239000000523 sample Substances 0.000 claims 4
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 4
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
• 229940123237 Taxane Drugs 0.000 claims 3
• 229940127089 cytotoxic agent Drugs 0.000 claims 3
• 229960003668 docetaxel Drugs 0.000 claims 3
• 238000011227 neoadjuvant chemotherapy Methods 0.000 claims 3
• 239000007787 solid Substances 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 229930012538 Paclitaxel Natural products 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 229940127093 camptothecin Drugs 0.000 claims 2
• 229960004679 doxorubicin Drugs 0.000 claims 2
• 238000010195 expression analysis Methods 0.000 claims 2
• 206010017758 gastric cancer Diseases 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• 229960001592 paclitaxel Drugs 0.000 claims 2
• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 201000011549 stomach cancer Diseases 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 claims 1
• 108091093088 Amplicon Proteins 0.000 claims 1
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 238000011226 adjuvant chemotherapy Methods 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
• 239000002299 complementary DNA Substances 0.000 claims 1
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
• 238000003364 immunohistochemistry Methods 0.000 claims 1
• 208000030776 invasive breast carcinoma Diseases 0.000 claims 1
• 229960004768 irinotecan Drugs 0.000 claims 1
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 238000013188 needle biopsy Methods 0.000 claims 1
• 230000001717 pathogenic effect Effects 0.000 claims 1
• 238000003757 reverse transcription PCR Methods 0.000 claims 1
• 229950009213 rubitecan Drugs 0.000 claims 1
• VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 1
• 229960000303 topotecan Drugs 0.000 claims 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
• 238000011277 treatment modality Methods 0.000 claims 1