AU2004248120B2 - Gene expression markers for predicting response to chemotherapy - Google Patents
Gene expression markers for predicting response to chemotherapy Download PDFInfo
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- AU2004248120B2 AU2004248120B2 AU2004248120A AU2004248120A AU2004248120B2 AU 2004248120 B2 AU2004248120 B2 AU 2004248120B2 AU 2004248120 A AU2004248120 A AU 2004248120A AU 2004248120 A AU2004248120 A AU 2004248120A AU 2004248120 B2 AU2004248120 B2 AU 2004248120B2
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Families Citing this family (69)
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| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| ES2787475T3 (es) * | 2003-06-24 | 2020-10-16 | Genomic Health Inc | Predicción de probabilidad de recurrencia del cáncer |
| US7871769B2 (en) | 2004-04-09 | 2011-01-18 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| US8420603B2 (en) * | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
| AU2006249235B2 (en) | 2004-05-14 | 2010-11-11 | Abraxis Bioscience, Llc | Sparc and methods of use thereof |
| PL1836629T3 (pl) * | 2004-11-05 | 2020-06-15 | Genomic Health, Inc. | Przewidywanie odpowiedzi na chemioterapię z zastosowaniem markerów ekspresji genu |
| WO2006105642A1 (en) * | 2005-04-05 | 2006-10-12 | British Columbia Cancer Agency | Biomarkers for the detection of lung cancer and uses thereof |
| CA2604549A1 (en) * | 2005-04-13 | 2006-10-19 | Oncotest Gmbh | Gene expression profiles being predictive for the response of tumors to pharmaceutically effective compounds |
| US20070026424A1 (en) * | 2005-04-15 | 2007-02-01 | Powell Charles A | Gene profiles correlating with histology and prognosis |
| WO2007039128A1 (en) * | 2005-09-21 | 2007-04-12 | Epigenomics Ag | Markers for the prediction of outcome of anthracycline treatment |
| US7598052B2 (en) * | 2005-10-11 | 2009-10-06 | The Regents Of The University Of Michigan | Expression profile of thyroid cancer |
| WO2007085497A2 (en) * | 2006-01-30 | 2007-08-02 | Epigenomics Ag | Markers for the prediction of outcome of anthracycline treatment |
| US20070207467A1 (en) * | 2006-03-01 | 2007-09-06 | Ming Xu | Detection of lymph node metastasis from gastric carcinoma |
| US20110104664A1 (en) * | 2006-03-31 | 2011-05-05 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to micortubule-stabilizing agents |
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| US20070281305A1 (en) * | 2006-06-05 | 2007-12-06 | Sean Wuxiong Cao | Detection of lymph node metastasis from gastric carcinoma |
| EP2032989B2 (en) * | 2006-06-30 | 2015-10-28 | Merck Sharp & Dohme Corp. | Igfbp2 biomarker |
| JP2010500577A (ja) * | 2006-08-07 | 2010-01-07 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 癌の予後および予測シグナチャーのプロテオミクスパターン |
| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| US20110178154A1 (en) * | 2007-02-06 | 2011-07-21 | Birrer Michael J | gene expression profile that predicts ovarian cancer subject response to chemotherapy |
| WO2008115561A2 (en) * | 2007-03-21 | 2008-09-25 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| AU2008289148A1 (en) * | 2007-08-16 | 2009-02-26 | Aventis Inc. | Gene expression markers of recurrence risk in cancer patients after chemotherapy |
| NZ562237A (en) * | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
| EP2065475A1 (en) * | 2007-11-30 | 2009-06-03 | Siemens Healthcare Diagnostics GmbH | Method for therapy prediction in tumors having irregularities in the expression of at least one VEGF ligand and/or at least one ErbB-receptor |
| EP2568053B1 (en) * | 2008-05-12 | 2014-04-16 | Genomic Health, Inc. | Tests to predict responsiveness of cancer patients to chemotherapy treatment options |
| US20110136683A1 (en) * | 2008-05-28 | 2011-06-09 | Genomedx Biosciences, Inc. | Systems and Methods for Expression-Based Discrimination of Distinct Clinical Disease States in Prostate Cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| ES2650610T3 (es) | 2008-05-30 | 2018-01-19 | The University Of North Carolina At Chapel Hill | Perfiles de expresión génica para predecir desenlaces en cáncer de mama |
| US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US20120041274A1 (en) | 2010-01-07 | 2012-02-16 | Myriad Genetics, Incorporated | Cancer biomarkers |
| WO2010118782A1 (en) * | 2009-04-17 | 2010-10-21 | Universite Libre De Bruxelles | Methods and tools for predicting the efficiency of anthracyclines in cancer |
| GB0908467D0 (en) * | 2009-05-15 | 2009-06-24 | Univ Gent | Use of the gtpase rab27b as biomarker to stratify patients with estrogen-receptor-positive breast cancer and to monitor their disease progression |
| ES2351327B1 (es) * | 2009-07-01 | 2011-11-28 | Para La Investigacion Biomedica Del Hospital Universitario La Paz Fundacion | Método de obtención de datos útiles para la predicción de respuesta clínica a un tratamiento de un paciente con cáncer. |
| ES2351328B1 (es) * | 2009-07-10 | 2011-11-28 | Para La Investigacion Biomedica Del Hospital Universitario La Paz Fundacion | Método de obtención de datos útiles para la predicción de respuesta patológica a un tratamiento de un paciente con cáncer. |
| GB0917457D0 (en) * | 2009-10-06 | 2009-11-18 | Glaxosmithkline Biolog Sa | Method |
| EP2502077B1 (en) * | 2009-11-20 | 2016-08-03 | The Governors of the University of Alberta | Predictive markers for taxane responsiveness and methods of use thereof |
| CN101760557B (zh) * | 2010-03-04 | 2013-08-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种辅助诊断肝细胞癌的试剂盒 |
| CA2804391A1 (en) | 2010-07-07 | 2012-01-12 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| EP2611941A4 (en) | 2010-08-30 | 2014-01-22 | Myriad Genetics Inc | GENESIS OF CANCER DIAGNOSIS AND PROGNOSIS |
| US9309556B2 (en) | 2010-09-24 | 2016-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target DNA using immobilized primers |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| JP6170925B2 (ja) | 2011-09-30 | 2017-07-26 | サーコーティン ダイアグノスティックス エルエルシー | 癌のマーカーとしてのｂｉｎ１の発現 |
| WO2013082440A2 (en) * | 2011-11-30 | 2013-06-06 | The University Of North Carolina At Chapel Hill | Methods of treating breast cancer with taxane therapy |
| US10513737B2 (en) | 2011-12-13 | 2019-12-24 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| AU2013284448B2 (en) | 2012-06-27 | 2019-04-18 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
| DK2880447T3 (da) * | 2012-07-31 | 2019-08-12 | Novartis Ag | Markører forbundet med følsomhed for hæmmere af human double minute 2 (MDM2) |
| CA2881627C (en) | 2012-08-16 | 2024-09-10 | Mayo Foundation For Medical Education And Research | CANCER DIAGNOSIS USING BIOMARKERS |
| EP2920322B1 (en) | 2012-11-16 | 2023-01-11 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| US10460831B2 (en) | 2012-12-03 | 2019-10-29 | Koninklijke Philips N.V. | Predictive outcome assessment for chemotherapy with neoadjuvant bevacizumab |
| US9535055B2 (en) | 2013-03-28 | 2017-01-03 | Samsung Electronics Co., Ltd. | Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker |
| WO2014210611A1 (en) * | 2013-06-28 | 2014-12-31 | Nantomics, Llc | Pathway analysis for identification of diagnostic tests |
| AU2014286237B2 (en) * | 2013-07-03 | 2020-08-20 | F. Hoffmann-La Roche Ag | mRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist |
| US9657351B2 (en) | 2013-12-06 | 2017-05-23 | Hoffman-La Roche Inc. | MRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist |
| KR20150088433A (ko) | 2014-01-24 | 2015-08-03 | 삼성전자주식회사 | c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1 |
| WO2015175692A1 (en) | 2014-05-13 | 2015-11-19 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| WO2016094425A1 (en) | 2014-12-08 | 2016-06-16 | Berg Llc | Use of markers including filamin a in the diagnosis and treatment of prostate cancer |
| CN107850589B (zh) | 2015-03-02 | 2020-07-24 | 萨克特恩诊断有限责任公司 | 13+/17+ bin1表达作为心脏病症的标记 |
| US11092603B2 (en) * | 2015-10-29 | 2021-08-17 | The Research Foundation For The State University Of New York | Keratin 17 as a prognostic marker for pancreatic cancer |
| CN105986034A (zh) * | 2016-06-15 | 2016-10-05 | 南京卡迪睿伯生物技术有限公司 | 一组胃癌基因的应用 |
| US11414708B2 (en) | 2016-08-24 | 2022-08-16 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| AU2018210695B2 (en) | 2017-01-20 | 2024-07-18 | The University Of British Columbia | Molecular subtyping, prognosis, and treatment of bladder cancer |
| CA3055925A1 (en) | 2017-03-09 | 2018-09-13 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| CA3062716A1 (en) | 2017-05-12 | 2018-11-15 | Decipher Biosciences, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
| WO2019028285A2 (en) | 2017-08-04 | 2019-02-07 | Genomedx, Inc. | USE OF SPECIFIC GENE EXPRESSION OF IMMUNE CELLS FOR THE PROGNOSIS OF PROSTATE CANCER AND THE PREDICTION OF SENSITIVITY TO RADIOTHERAPY |
| GB201716712D0 (en) | 2017-10-12 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Prognostic and treatment response predictive method |
| CN107808377B (zh) * | 2017-10-31 | 2019-02-12 | 北京青燕祥云科技有限公司 | 一种肺叶中病灶的定位装置 |
| EP4382911B1 (en) * | 2022-12-07 | 2026-01-28 | Oncomatryx Biopharma, S.L. | Combining the expression levels of krt19 and col1a2 to produce a score for screening and diagnosing cancer |
Family Cites Families (23)
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| US4699877A (en) * | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
| USRE35491E (en) * | 1982-11-04 | 1997-04-08 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
| US7838216B1 (en) * | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5858678A (en) * | 1994-08-02 | 1999-01-12 | St. Louis University | Apoptosis-regulating proteins |
| US5821082A (en) * | 1996-05-23 | 1998-10-13 | St. Louis University Health Sciences Center | Anti-proliferation domain of a human Bcl-2 and DNA encoding the same |
| EP1084273A1 (en) * | 1998-06-06 | 2001-03-21 | Genostic Pharma Limited | Probes used for genetic profiling |
| US6960439B2 (en) * | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US6271002B1 (en) * | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
| WO2001051661A2 (en) * | 2000-01-13 | 2001-07-19 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| US6322986B1 (en) * | 2000-01-18 | 2001-11-27 | Albany Medical College | Method for colorectal cancer prognosis and treatment selection |
| WO2001055454A1 (en) * | 2000-01-28 | 2001-08-02 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| WO2001075162A2 (en) * | 2000-03-31 | 2001-10-11 | University Of Louisville Research Foundation, Inc. | Microarrays to screen regulatory genes |
| US20030165952A1 (en) * | 2000-07-21 | 2003-09-04 | Sten Linnarsson | Method and an alggorithm for mrna expression analysis |
| US6602670B2 (en) * | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6582919B2 (en) * | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
| CA2430981A1 (en) * | 2000-12-08 | 2002-06-13 | Francois Bertucci | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| EP1373896A2 (en) * | 2001-03-12 | 2004-01-02 | MonoGen, Inc. | Cell-based detection and differentiation of disease states |
| US20040009489A1 (en) * | 2001-09-28 | 2004-01-15 | Golub Todd R. | Classification of lung carcinomas using gene expression analysis |
| EP2241636A1 (en) * | 2002-03-13 | 2010-10-20 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| WO2004046386A1 (en) * | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Gene expression profiling of egfr positive cancer |
| DE602004017426D1 (de) * | 2003-02-20 | 2008-12-11 | Genomic Health Inc | Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression |
-
2004
- 2004-05-24 WO PCT/US2004/016553 patent/WO2004111603A2/en not_active Ceased
- 2004-05-24 CA CA002527285A patent/CA2527285A1/en not_active Abandoned
- 2004-05-24 US US10/852,797 patent/US20050064455A1/en not_active Abandoned
- 2004-05-24 JP JP2006533426A patent/JP2007507222A/ja active Pending
- 2004-05-24 EP EP04776118A patent/EP1631689A2/en not_active Withdrawn
- 2004-05-24 AU AU2004248120A patent/AU2004248120B2/en not_active Expired
Non-Patent Citations (2)
| Title |
|---|
| Kato J et al, INT. J. CANCER (PRED. ONOCOL), 2001, 95:92-95 * |
| Tanaka K et al, CLINICAL CANCER RESEARCH, 2000, 6:127-132 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021026085A3 (en) * | 2019-08-07 | 2021-03-11 | University Of Massachusetts | Prediction of cancer therapy efficacy |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1631689A2 (en) | 2006-03-08 |
| AU2004248120A1 (en) | 2004-12-23 |
| US20050064455A1 (en) | 2005-03-24 |
| WO2004111603A3 (en) | 2005-07-21 |
| WO2004111603A2 (en) | 2004-12-23 |
| JP2007507222A (ja) | 2007-03-29 |
| CA2527285A1 (en) | 2004-12-23 |
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