JP2007506792A5 - - Google Patents
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- Publication number
- JP2007506792A5 JP2007506792A5 JP2006528316A JP2006528316A JP2007506792A5 JP 2007506792 A5 JP2007506792 A5 JP 2007506792A5 JP 2006528316 A JP2006528316 A JP 2006528316A JP 2006528316 A JP2006528316 A JP 2006528316A JP 2007506792 A5 JP2007506792 A5 JP 2007506792A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- acid
- olefin
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 4
- 150000001336 alkenes Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 0 CCC(*)CC1OC[C@@]1(C)[C@](C[C@@](*)[C@@](*C(*)=O)C(C1(C)C)=C(C)[C@](C2)OC(C[C@](*)NC(*)=O)=O)[C@@](C)C12O Chemical compound CCC(*)CC1OC[C@@]1(C)[C@](C[C@@](*)[C@@](*C(*)=O)C(C1(C)C)=C(C)[C@](C2)OC(C[C@](*)NC(*)=O)=O)[C@@](C)C12O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50668003P | 2003-09-25 | 2003-09-25 | |
| US60/506,680 | 2003-09-25 | ||
| PCT/US2004/031816 WO2005030150A2 (en) | 2003-09-25 | 2004-09-27 | 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010200399A Division JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Division JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506792A JP2007506792A (ja) | 2007-03-22 |
| JP2007506792A5 true JP2007506792A5 (OSRAM) | 2010-10-28 |
| JP4874102B2 JP4874102B2 (ja) | 2012-02-15 |
Family
ID=34393186
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528316A Expired - Lifetime JP4874102B2 (ja) | 2003-09-25 | 2004-09-27 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2010200399A Expired - Lifetime JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Expired - Lifetime JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2014141964A Expired - Lifetime JP6106634B2 (ja) | 2003-09-25 | 2014-07-10 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2016137271A Expired - Lifetime JP6216417B2 (ja) | 2003-09-25 | 2016-07-12 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010200399A Expired - Lifetime JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Expired - Lifetime JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2014141964A Expired - Lifetime JP6106634B2 (ja) | 2003-09-25 | 2014-07-10 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2016137271A Expired - Lifetime JP6216417B2 (ja) | 2003-09-25 | 2016-07-12 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7745650B2 (OSRAM) |
| EP (2) | EP1785416A3 (OSRAM) |
| JP (5) | JP4874102B2 (OSRAM) |
| CN (1) | CN1886400A (OSRAM) |
| AT (1) | ATE377593T1 (OSRAM) |
| AU (1) | AU2004275881A1 (OSRAM) |
| CA (1) | CA2539975C (OSRAM) |
| DE (1) | DE602004009943T2 (OSRAM) |
| DK (1) | DK1664033T3 (OSRAM) |
| ES (1) | ES2295937T3 (OSRAM) |
| HR (1) | HRP20080057T3 (OSRAM) |
| PL (1) | PL1664033T3 (OSRAM) |
| PT (1) | PT1664033E (OSRAM) |
| WO (1) | WO2005030150A2 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1664033T3 (pl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa, alfa-OH-taksanu i sposoby ich wytwarzania |
| JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
| MX2008008120A (es) * | 2005-12-21 | 2008-09-24 | Tapestry Pharmaceuticals Inc | Nuevos compuestos y metodos para formar taxanos y uso de los mismos. |
| CA2634746A1 (en) * | 2005-12-21 | 2007-07-05 | Tapestry Pharmaceuticals, Inc. | Processes for taxane derivatives and intermediates useful therein |
| RU2008142363A (ru) * | 2006-03-27 | 2010-05-10 | Тэпистри Фармасьютикалз, Инк. (Us) | Конвергентный способ синтеза таксановых производных |
| EP2029156A4 (en) * | 2006-05-01 | 2010-07-21 | Univ Southern California | COMBINATION THERAPY FOR CANCER TREATMENT |
| WO2007143839A1 (en) * | 2006-06-12 | 2007-12-21 | 6570763 Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii |
| US7847111B2 (en) | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| US9227983B2 (en) | 2011-04-07 | 2016-01-05 | Arbor Therapeutics, LLC | Taxane and abeo-taxane analogs |
| SG10201602309VA (en) * | 2011-04-07 | 2016-05-30 | Arbor Therapeutics Llc | Taxane and abeo-taxane analogs |
| MX337464B (es) * | 2011-06-06 | 2016-03-07 | Arbor Therapeutics Llc | Profarmacos lipofilicos labiles al acido de los agentes quimioterapeuticos contra el cancer. |
| EP4096588B1 (en) | 2020-03-04 | 2024-08-21 | Aquedeon Medical, Inc. | Vascular and aortic graft connector deployment tool with telescoping sheath |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| US5352806A (en) * | 1992-04-17 | 1994-10-04 | Abbott Laboratories | Taxol derivatives |
| FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| EP0668762B1 (en) * | 1992-11-13 | 2003-09-17 | Florida State University | Isobutenyl-substituted taxanes and their pharmaceutical compositions |
| EP0687260B1 (en) * | 1993-03-05 | 2003-02-19 | Florida State University | Process for the preparation of 9-desoxotaxanes |
| US6710191B2 (en) * | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
| ES2179070T3 (es) | 1993-03-05 | 2003-01-16 | Univ Florida State | Derivados del taxano c9 y composiciones farmaceuticas que las contienen. |
| DE69433355T2 (de) * | 1993-03-22 | 2004-05-27 | Florida State University, Tallahassee | Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate |
| FR2707293A1 (fr) | 1993-07-08 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2715846A1 (fr) * | 1994-02-07 | 1995-08-11 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmceutique à base de taxoïdes. |
| IT1275936B1 (it) | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| US6048990A (en) * | 1998-05-01 | 2000-04-11 | Napro Biotherapeutics, Inc. | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| ATE381328T1 (de) * | 2000-02-02 | 2008-01-15 | Univ Florida State Res Found | Heterosubstituierte taxan-c10-acetate als antitumormittel |
| US6825166B2 (en) | 2001-03-23 | 2004-11-30 | Tapestry Pharmaceuticals, Inc. | Molecular conjugates for use in treatment of cancer |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2470826A1 (en) | 2001-12-20 | 2003-07-03 | Bristol-Myers Squibb Company | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| US6898834B1 (en) * | 2003-03-03 | 2005-05-31 | Westbridge Pty Ltd | Barrel stave reclaim |
| EP1894921A3 (en) | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof |
| PL1664033T3 (pl) | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa, alfa-OH-taksanu i sposoby ich wytwarzania |
| WO2006124737A2 (en) | 2005-05-12 | 2006-11-23 | Tapestry Pharmaceuticals, Inc. | Molecular constructs suitable for targeted conjugates |
| CA2634746A1 (en) | 2005-12-21 | 2007-07-05 | Tapestry Pharmaceuticals, Inc. | Processes for taxane derivatives and intermediates useful therein |
| MX2008008120A (es) | 2005-12-21 | 2008-09-24 | Tapestry Pharmaceuticals Inc | Nuevos compuestos y metodos para formar taxanos y uso de los mismos. |
| RU2008142363A (ru) | 2006-03-27 | 2010-05-10 | Тэпистри Фармасьютикалз, Инк. (Us) | Конвергентный способ синтеза таксановых производных |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
-
2004
- 2004-09-27 PL PL04789167T patent/PL1664033T3/pl unknown
- 2004-09-27 EP EP06026009A patent/EP1785416A3/en not_active Withdrawn
- 2004-09-27 WO PCT/US2004/031816 patent/WO2005030150A2/en not_active Ceased
- 2004-09-27 US US10/951,555 patent/US7745650B2/en not_active Expired - Lifetime
- 2004-09-27 ES ES04789167T patent/ES2295937T3/es not_active Expired - Lifetime
- 2004-09-27 DK DK04789167T patent/DK1664033T3/da active
- 2004-09-27 HR HR20080057T patent/HRP20080057T3/xx unknown
- 2004-09-27 AU AU2004275881A patent/AU2004275881A1/en not_active Abandoned
- 2004-09-27 CA CA2539975A patent/CA2539975C/en not_active Expired - Lifetime
- 2004-09-27 CN CNA2004800346381A patent/CN1886400A/zh active Pending
- 2004-09-27 PT PT04789167T patent/PT1664033E/pt unknown
- 2004-09-27 DE DE602004009943T patent/DE602004009943T2/de not_active Expired - Fee Related
- 2004-09-27 JP JP2006528316A patent/JP4874102B2/ja not_active Expired - Lifetime
- 2004-09-27 AT AT04789167T patent/ATE377593T1/de not_active IP Right Cessation
- 2004-09-27 EP EP04789167A patent/EP1664033B1/en not_active Expired - Lifetime
-
2010
- 2010-06-02 US US12/792,427 patent/US7879904B2/en not_active Expired - Lifetime
- 2010-09-07 JP JP2010200399A patent/JP5525394B2/ja not_active Expired - Lifetime
- 2010-11-24 US US12/954,253 patent/US8962870B2/en active Active
-
2011
- 2011-04-08 JP JP2011086840A patent/JP5629632B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-10 JP JP2014141964A patent/JP6106634B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-23 US US14/604,147 patent/US9402824B2/en not_active Expired - Lifetime
-
2016
- 2016-07-12 JP JP2016137271A patent/JP6216417B2/ja not_active Expired - Lifetime
- 2016-07-27 US US15/220,975 patent/US9820962B2/en not_active Expired - Lifetime
-
2017
- 2017-10-09 US US15/728,049 patent/US10238621B2/en not_active Expired - Lifetime
-
2019
- 2019-01-14 US US16/247,425 patent/US10639293B2/en not_active Expired - Lifetime
-
2020
- 2020-04-15 US US16/849,879 patent/US20200237708A1/en not_active Abandoned
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