|
EA012451B1
(ru)
|
2004-03-11 |
2009-10-30 |
4Сц Аг |
Новые амидозамещённые гидрокси-6-фенилфенантридины
|
|
EP2261218B1
(en)
*
|
2004-05-26 |
2013-04-03 |
Eisai R&D Management Co., Ltd. |
Imidazole compound for use as an intermediate in the production of cinnamide compounds
|
|
US7781478B2
(en)
|
2004-07-14 |
2010-08-24 |
Ptc Therapeutics, Inc. |
Methods for treating hepatitis C
|
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
|
ES2338904T3
(es)
*
|
2004-10-26 |
2010-05-13 |
EISAI R&D MANAGEMENT CO., LTD. |
Forma amorfa de compuestos de cinamida.
|
|
AU2006204724A1
(en)
|
2005-01-14 |
2006-07-20 |
Millennium Pharmaceuticals, Inc. |
Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
|
|
PT1861365E
(pt)
|
2005-03-15 |
2009-09-22 |
4Sc Ag |
N-sulfonilpirroles e a sua utilização como inibidores de histona-desacetilase
|
|
CR9465A
(es)
*
|
2005-03-25 |
2008-06-19 |
Surface Logix Inc |
Compuestos mejorados farmacocineticamente
|
|
FR2886844B1
(fr)
*
|
2005-06-09 |
2007-09-14 |
Oreal |
Utilisation de composes 2-oxy-acetamide pour favoriser et/ou induire et/ou stimuler la pigmentation des matieres keratiniques et/ou limiter leur depigmentation et/ou leur blanchiment
|
|
US7470787B2
(en)
|
2005-07-11 |
2008-12-30 |
Aerie Pharmaceuticals, Inc. |
Isoquinoline compounds
|
|
EA018698B1
(ru)
|
2005-09-21 |
2013-10-30 |
4Сц Аг |
Сульфонилпирролгидрохлориды как ингибиторы гистондезацетилазы
|
|
WO2007039404A1
(en)
|
2005-09-21 |
2007-04-12 |
Nycomed Gmbh |
Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles
|
|
JPWO2007058304A1
(ja)
*
|
2005-11-18 |
2009-05-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
シンナミド化合物の塩またはそれらの溶媒和物
|
|
AU2006316005A1
(en)
*
|
2005-11-18 |
2007-05-24 |
Eisai R & D Management Co., Ltd. |
Process for production of cinnamamide derivative
|
|
MY144960A
(en)
*
|
2005-11-24 |
2011-11-30 |
Eisai R&D Man Co Ltd |
Morpholine type cinnamide compound
|
|
TWI370130B
(en)
|
2005-11-24 |
2012-08-11 |
Eisai R&D Man Co Ltd |
Two cyclic cinnamide compound
|
|
PT3184526T
(pt)
|
2005-12-13 |
2018-12-19 |
Incyte Holdings Corp |
Derivados de pirrolo[2,3-d]pirimidina como inibidores da cinase janus
|
|
US7989461B2
(en)
|
2005-12-23 |
2011-08-02 |
Amgen Inc. |
Substituted quinazolinamine compounds for the treatment of cancer
|
|
JP5583346B2
(ja)
*
|
2006-01-18 |
2014-09-03 |
エルジー ハウスホールド アンド ヘルスケア リミテッド |
ｃ−Ｋｉｔ活性阻害剤、及び、肌美白剤
|
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
|
DK3421471T3
(da)
|
2006-04-25 |
2021-06-14 |
Astex Therapeutics Ltd |
Purin- og deazapurinderivater som farmaceutiske forbindelser
|
|
AU2007252644A1
(en)
*
|
2006-05-19 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
Heterocyclic type cinnamide derivative
|
|
US7737141B2
(en)
*
|
2006-07-28 |
2010-06-15 |
Eisai R&D Management Co., Ltd. |
Prodrug of cinnamide compound
|
|
WO2008036540A2
(en)
|
2006-09-20 |
2008-03-27 |
Boehringer Ingelheim International Gmbh |
Rho kinase inhibitors
|
|
US8314119B2
(en)
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
US8455513B2
(en)
|
2007-01-10 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-aminoisoquinoline compounds
|
|
US20080207900A1
(en)
*
|
2007-02-28 |
2008-08-28 |
Teiji Kimura |
Two cyclic oxomorphorin derivatives
|
|
PE20090044A1
(es)
|
2007-04-06 |
2009-01-23 |
Neurocrine Biosciences Inc |
Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
|
|
WO2008124614A1
(en)
|
2007-04-06 |
2008-10-16 |
Neurocrine Biosciences, Inc. |
Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
|
|
AU2008250119A1
(en)
*
|
2007-05-16 |
2008-11-20 |
Eisai R & D Management Co., Ltd. |
One-pot production process for cinnamide derivative
|
|
US20080312259A1
(en)
|
2007-06-13 |
2008-12-18 |
Incyte Corporation |
SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
|
|
PT2190825E
(pt)
|
2007-08-22 |
2014-07-16 |
Irm Llc |
Compostos e composições de 5-(4- (haloalcoxi)fenil)pirimidina-2-amina como inibidores de cinases
|
|
EP2559693B1
(en)
|
2007-08-31 |
2014-11-26 |
Eisai R&D Management Co., Ltd. |
Polycyclic compound
|
|
US7935815B2
(en)
*
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
|
AU2008309383B2
(en)
|
2007-10-11 |
2012-04-19 |
Astrazeneca Ab |
Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors
|
|
NZ585298A
(en)
|
2007-11-16 |
2012-08-31 |
Rigel Pharmaceuticals Inc |
Carboxamide, sulfonamide and amine compounds for metabolic disorders
|
|
JP5650540B2
(ja)
|
2007-12-12 |
2015-01-07 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物
|
|
US8487121B2
(en)
*
|
2007-12-18 |
2013-07-16 |
Glenmark Pharmaceuticals S.A. |
Chromane derivatives as TRPV3 modulators
|
|
US8455514B2
(en)
|
2008-01-17 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-and 7-amino isoquinoline compounds and methods for making and using the same
|
|
US20100317860A1
(en)
*
|
2008-01-28 |
2010-12-16 |
Ikuo Kushida |
Crystalline cinnamide compounds or salts thereof
|
|
AU2009239500B2
(en)
|
2008-04-21 |
2014-01-30 |
Lexicon Pharmaceuticals, Inc. |
LIMK2 inhibitors, compositions comprising them, and methods of their use
|
|
ES2552549T3
(es)
|
2008-04-23 |
2015-11-30 |
Rigel Pharmaceuticals, Inc. |
Compuestos de carboxamida para el tratamiento de trastornos metabólicos
|
|
NZ595780A
(en)
|
2008-06-17 |
2013-07-26 |
Glenmark Pharmaceuticals Sa |
Chromane derivatives as trpv3 modulators
|
|
US8450344B2
(en)
|
2008-07-25 |
2013-05-28 |
Aerie Pharmaceuticals, Inc. |
Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
|
|
PT2384326E
(pt)
*
|
2008-08-20 |
2014-06-09 |
Zoetis Llc |
Compostos de pirrolo[2,3-d]pirimidina
|
|
WO2010052448A2
(en)
*
|
2008-11-05 |
2010-05-14 |
Ucb Pharma S.A. |
Fused pyrazine derivatives as kinase inhibitors
|
|
JP2012525386A
(ja)
|
2009-05-01 |
2012-10-22 |
アエリエ・ファーマシューティカルズ・インコーポレーテッド |
疾患の治療のための二重機構阻害剤
|
|
CN106967070A
(zh)
|
2009-05-22 |
2017-07-21 |
因塞特控股公司 |
作为jak抑制剂的化合物
|
|
ES2487542T3
(es)
|
2009-05-22 |
2014-08-21 |
Incyte Corporation |
Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus
|
|
AR078012A1
(es)
|
2009-09-01 |
2011-10-05 |
Incyte Corp |
Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
|
|
KR20120083452A
(ko)
*
|
2009-10-15 |
2012-07-25 |
화이자 인코포레이티드 |
피롤로［2,3-ｄ］피리미딘 화합물
|
|
WO2011068898A1
(en)
|
2009-12-01 |
2011-06-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
CA2786520A1
(en)
|
2010-01-19 |
2011-07-28 |
Astrazeneca Ab |
Pyrazine derivatives
|
|
TWI766281B
(zh)
|
2010-03-10 |
2022-06-01 |
美商英塞特控股公司 |
作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物
|
|
PE20130216A1
(es)
|
2010-05-21 |
2013-02-27 |
Incyte Corp |
Formulacion topica para un inhibidor de jak
|
|
AU2011305462B2
(en)
|
2010-09-23 |
2015-11-26 |
Abbvie Bahamas Ltd. |
Monohydrate of an azaadamantane derivative
|
|
JP5917544B2
(ja)
|
2010-11-19 |
2016-05-18 |
インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン
|
|
AR083933A1
(es)
|
2010-11-19 |
2013-04-10 |
Incyte Corp |
Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
|
|
SG193505A1
(en)
|
2011-04-01 |
2013-10-30 |
Astrazeneca Ab |
Therapeutic treatment
|
|
EA201490042A1
(ru)
|
2011-06-20 |
2014-10-30 |
Инсайт Корпорейшн |
Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
AU2012321110B2
(en)
|
2011-11-30 |
2014-10-23 |
Astrazeneca Ab |
Combination treatment
|
|
EP2791108B1
(en)
|
2011-12-15 |
2016-07-27 |
Pfizer Limited |
Sulfonamide derivatives
|
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
|
AR091079A1
(es)
|
2012-05-18 |
2014-12-30 |
Incyte Corp |
Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
|
|
EP2858501A4
(en)
*
|
2012-05-22 |
2015-12-09 |
Merck Sharp & Dohme |
TRK-A KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
|
SG11201503695XA
(en)
|
2012-11-15 |
2015-06-29 |
Incyte Corp |
Sustained-release dosage forms of ruxolitinib
|
|
WO2014134391A1
(en)
|
2013-02-28 |
2014-09-04 |
Bristol-Myers Squibb Company |
Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
|
|
TW201444798A
(zh)
|
2013-02-28 |
2014-12-01 |
必治妥美雅史谷比公司 |
作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
|
|
HUE057262T2
(hu)
|
2013-03-06 |
2022-04-28 |
Incyte Holdings Corp |
Eljárás és köztitermékek JAK inhibitor elõállítására
|
|
CN109528721B
(zh)
|
2013-03-15 |
2021-10-01 |
爱瑞制药公司 |
联合治疗
|
|
US9655854B2
(en)
|
2013-08-07 |
2017-05-23 |
Incyte Corporation |
Sustained release dosage forms for a JAK1 inhibitor
|
|
CN103910715B
(zh)
*
|
2014-03-26 |
2016-03-02 |
深圳翰宇药业股份有限公司 |
一种别嘌醇杂质c的合成方法
|
|
US9527812B2
(en)
|
2014-05-01 |
2016-12-27 |
Northwestern University |
N-heterocyclic carbene-catalyzed synthesis of 2-aryl indoles
|
|
EP3140298A1
(en)
|
2014-05-07 |
2017-03-15 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
EP3193611B1
(en)
|
2014-09-17 |
2021-03-24 |
Celgene Car Llc |
Mk2 inhibitors and uses thereof
|
|
MX2018004643A
(es)
|
2015-10-21 |
2018-08-01 |
Otsuka Pharma Co Ltd |
Compuestos de benzolactama como inhibidores de la proteina cinasa.
|
|
US10550087B2
(en)
|
2015-11-17 |
2020-02-04 |
Aerie Pharmaceuticals, Inc. |
Process for the preparation of kinase inhibitors and intermediates thereof
|
|
US9643927B1
(en)
|
2015-11-17 |
2017-05-09 |
Aerie Pharmaceuticals, Inc. |
Process for the preparation of kinase inhibitors and intermediates thereof
|
|
US10894784B2
(en)
|
2015-12-18 |
2021-01-19 |
Bayer Pharma Aktiengesellschaft |
Heteroarylbenzimidazole compounds
|
|
WO2017194453A1
(en)
*
|
2016-05-12 |
2017-11-16 |
Boehringer Ingelheim International Gmbh |
Pyridinyl derivatives, pharmaceutical compositions and uses thereof as aoc3 inhibitors
|
|
WO2017207534A1
(en)
|
2016-06-03 |
2017-12-07 |
Bayer Pharma Aktiengesellschaft |
Substituted heteroarylbenzimidazole compounds
|
|
CN107663202B
(zh)
*
|
2016-07-29 |
2020-09-04 |
西华大学 |
3-(脲基-甲基)-4-芳基-吡啶衍生物及其制备方法和作为抗肝癌药物的应用
|
|
KR102568082B1
(ko)
|
2016-08-31 |
2023-08-17 |
에어리 파마슈티컬즈, 인코포레이티드 |
안과용 조성물
|
|
BR112019004468A2
(pt)
|
2016-09-02 |
2019-05-28 |
Ironwood Pharmaceuticals Inc |
estimulantes de sgc
|
|
WO2018165520A1
(en)
|
2017-03-10 |
2018-09-13 |
Vps-3, Inc. |
Metalloenzyme inhibitor compounds
|
|
AU2018243687C1
(en)
|
2017-03-31 |
2020-12-24 |
Aerie Pharmaceuticals, Inc. |
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
|
|
GB201706327D0
(en)
|
2017-04-20 |
2017-06-07 |
Otsuka Pharma Co Ltd |
A pharmaceutical compound
|
|
CN111132673A
(zh)
*
|
2017-05-03 |
2020-05-08 |
维瓦斯治疗公司 |
非稠合三环化合物
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
CN112105608B
(zh)
|
2018-01-30 |
2023-07-14 |
因赛特公司 |
制备(1-(3-氟-2-(三氟甲基)异烟碱基)哌啶-4-酮)的方法
|
|
CN112384515A
(zh)
|
2018-02-27 |
2021-02-19 |
因赛特公司 |
作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
|
|
AU2019245420A1
(en)
|
2018-03-30 |
2020-11-12 |
Incyte Corporation |
Treatment of hidradenitis suppurativa using JAK inhibitors
|
|
US11168089B2
(en)
|
2018-05-18 |
2021-11-09 |
Incyte Corporation |
Fused pyrimidine derivatives as A2A / A2B inhibitors
|
|
GEP20237548B
(en)
|
2018-07-05 |
2023-10-10 |
Incyte Corp |
Fused pyrazine derivatives as a2a /a2b inhibitors
|
|
US11427563B2
(en)
|
2018-09-14 |
2022-08-30 |
Aerie Pharmaceuticals, Inc. |
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
TWI829857B
(zh)
|
2019-01-29 |
2024-01-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
|
|
US11384083B2
(en)
|
2019-02-15 |
2022-07-12 |
Incyte Corporation |
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
|
|
WO2020180959A1
(en)
|
2019-03-05 |
2020-09-10 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
WO2020223469A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
|
|
AR119765A1
(es)
|
2019-08-14 |
2022-01-12 |
Incyte Corp |
Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
|
|
MX2022004390A
(es)
|
2019-10-11 |
2022-08-08 |
Incyte Corp |
Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2).
|
|
PE20230376A1
(es)
|
2019-12-24 |
2023-03-06 |
Carna Biosciences Inc |
Compuestos moduladores de la diacilglicerol quinasa
|
|
US11692038B2
(en)
|
2020-02-14 |
2023-07-04 |
Gilead Sciences, Inc. |
Antibodies that bind chemokine (C-C motif) receptor 8 (CCR8)
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
WO2022271650A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
EP4359415A1
(en)
|
2021-06-23 |
2024-05-01 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CN117480155A
(zh)
|
2021-06-23 |
2024-01-30 |
吉利德科学公司 |
二酰基甘油激酶调节化合物
|
|
CA3222439A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
WO2023076983A1
(en)
|
2021-10-28 |
2023-05-04 |
Gilead Sciences, Inc. |
Pyridizin-3(2h)-one derivatives
|
|
CA3235986A1
(en)
|
2021-10-29 |
2023-05-04 |
Gilead Science, Inc. |
Cd73 compounds
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
AU2022419982A1
(en)
|
2021-12-22 |
2024-06-06 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
AU2022417491A1
(en)
|
2021-12-22 |
2024-05-23 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
TW202340168A
(zh)
|
2022-01-28 |
2023-10-16 |
美商基利科學股份有限公司 |
Ｐａｒｐ７抑制劑
|
|
TW202346277A
(zh)
|
2022-03-17 |
2023-12-01 |
美商基利科學股份有限公司 |
Ｉｋａｒｏｓ鋅指家族降解劑及其用途
|
|
TW202400138A
(zh)
|
2022-04-21 |
2024-01-01 |
美商基利科學股份有限公司 |
Ｋｒａｓ ｇ１２ｄ調節化合物
|
|
WO2024006929A1
(en)
|
2022-07-01 |
2024-01-04 |
Gilead Sciences, Inc. |
Cd73 compounds
|
