JP2007504159A - プロテインキナーゼ阻害剤としての化合物および組成物 - Google Patents

プロテインキナーゼ阻害剤としての化合物および組成物 Download PDF

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Publication number
JP2007504159A
JP2007504159A JP2006524903A JP2006524903A JP2007504159A JP 2007504159 A JP2007504159 A JP 2007504159A JP 2006524903 A JP2006524903 A JP 2006524903A JP 2006524903 A JP2006524903 A JP 2006524903A JP 2007504159 A JP2007504159 A JP 2007504159A
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JP
Japan
Prior art keywords
methyl
phenyl
pyrrolo
pyrimidine
amide
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Pending
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JP2006524903A
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English (en)
Japanese (ja)
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JP2007504159A5 (cg-RX-API-DMAC7.html
Inventor
キアン・ディン
ナサニエル・シアンダー・グレイ
リ・ビン
リュー・イ
哲郎 宇野
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IRM LLC
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IRM LLC
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Publication date
Application filed by IRM LLC filed Critical IRM LLC
Publication of JP2007504159A publication Critical patent/JP2007504159A/ja
Publication of JP2007504159A5 publication Critical patent/JP2007504159A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006524903A 2003-08-28 2004-08-27 プロテインキナーゼ阻害剤としての化合物および組成物 Pending JP2007504159A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49853203P 2003-08-28 2003-08-28
PCT/US2004/027997 WO2005039486A2 (en) 2003-08-28 2004-08-27 Compounds and compositions as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2007504159A true JP2007504159A (ja) 2007-03-01
JP2007504159A5 JP2007504159A5 (cg-RX-API-DMAC7.html) 2007-10-11

Family

ID=34519982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006524903A Pending JP2007504159A (ja) 2003-08-28 2004-08-27 プロテインキナーゼ阻害剤としての化合物および組成物

Country Status (9)

Country Link
US (2) US7338957B2 (cg-RX-API-DMAC7.html)
EP (1) EP1658290A4 (cg-RX-API-DMAC7.html)
JP (1) JP2007504159A (cg-RX-API-DMAC7.html)
CN (1) CN100439365C (cg-RX-API-DMAC7.html)
AU (1) AU2004283093B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0414049A (cg-RX-API-DMAC7.html)
CA (1) CA2536535A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06002347A (cg-RX-API-DMAC7.html)
WO (1) WO2005039486A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505166A (ja) * 2004-07-01 2008-02-21 アストラゼネカ アクチボラグ 抗癌剤としてのアジン−カルボキサミド
JP2010535798A (ja) * 2007-08-08 2010-11-25 グラクソスミスクライン エルエルシー 癌の治療用のＩＧＨ−１Ｒ阻害剤としての２−［（２−｛フェニルアミノ｝−１Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）アミノ］ベンズアミド誘導体

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
PL1891066T3 (pl) * 2005-05-13 2011-05-31 Irm Llc Związki i kompozycje jako inhibitory kinazy białkowej
EP1999249B8 (en) * 2006-03-30 2012-02-15 The University Court Of The University of Edinburgh Culture medium containing kinase inhibitors. and uses thereof
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
KR20090023561A (ko) 2006-04-07 2009-03-05 노파르티스 아게 ａ) 피리미딜아미노벤즈아미드 화합물과 ｂ) Ｔｈｒ３１５Ｉｌｅ 키나제 억제제를 포함하는 조합물
WO2008147831A1 (en) * 2007-05-23 2008-12-04 Smithkline Beecham Corporation Anthranilamides
CA2949336C (en) 2007-08-02 2018-11-06 Lei Zhu Process for the synthesis of e1 activating enzyme inhibitors
EA019869B1 (ru) * 2007-11-28 2014-06-30 Дана Фарбер Кансер Инститьют, Инк. Низкомолекулярные миристатные ингибиторы тирозинкиназы bcr-abl и способы их применения
JP2011510004A (ja) * 2008-01-22 2011-03-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング タンパク質キナーゼ阻害剤及びその使用
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
UA108986C2 (uk) 2009-05-14 2015-07-10 Мілленніум Фармасьютікалз, Інк. Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти)
US8728763B2 (en) 2009-08-11 2014-05-20 Response Genetics Methods, primers, probes and kits useful for the detection of BRAF mutations
EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
CN104876879B (zh) * 2015-04-14 2018-05-18 中国科学院合肥物质科学研究院 一种bcr-abl激酶抑制剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508875A (ja) * 1995-06-07 1998-09-02 ファイザー・インコーポレーテッド 複素環式の縮合環ピリミジン誘導体
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2003518123A (ja) * 1999-12-21 2003-06-03 スージェン・インコーポレーテッド ４−置換７−アザ−インドリン−２−オンおよびその蛋白質キナーゼ阻害剤としての使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017203A1 (en) * 1998-09-18 2000-03-30 Basf Aktiengesellschaft Pyrrolopyrimidines as protein kinase inhibitors
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508875A (ja) * 1995-06-07 1998-09-02 ファイザー・インコーポレーテッド 複素環式の縮合環ピリミジン誘導体
JP2003518123A (ja) * 1999-12-21 2003-06-03 スージェン・インコーポレーテッド ４−置換７−アザ−インドリン−２−オンおよびその蛋白質キナーゼ阻害剤としての使用
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505166A (ja) * 2004-07-01 2008-02-21 アストラゼネカ アクチボラグ 抗癌剤としてのアジン−カルボキサミド
JP2010535798A (ja) * 2007-08-08 2010-11-25 グラクソスミスクライン エルエルシー 癌の治療用のＩＧＨ−１Ｒ阻害剤としての２−［（２−｛フェニルアミノ｝−１Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）アミノ］ベンズアミド誘導体

Also Published As

Publication number Publication date
US7338957B2 (en) 2008-03-04
AU2004283093B2 (en) 2009-02-26
CN100439365C (zh) 2008-12-03
CA2536535A1 (en) 2005-05-06
EP1658290A2 (en) 2006-05-24
CN1842529A (zh) 2006-10-04
AU2004283093A1 (en) 2005-05-06
BRPI0414049A (pt) 2006-10-24
WO2005039486A2 (en) 2005-05-06
EP1658290A4 (en) 2009-04-15
US20050159391A1 (en) 2005-07-21
WO2005039486A3 (en) 2006-03-16
MXPA06002347A (es) 2006-05-19
US20080108616A1 (en) 2008-05-08

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