BRPI0414049A - compostos e composições como inibidores de proteìna cinase - Google Patents
compostos e composições como inibidores de proteìna cinaseInfo
- Publication number
- BRPI0414049A BRPI0414049A BRPI0414049-4A BRPI0414049A BRPI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- compositions
- protein kinase
- kinase inhibitors
- sapk2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS E COMPOSIçõES COMO INIBIDORES DE PROTEìNA CINASE". A presente invenção fornece uma nova classe de compostos, composições farmacêuticas compreendendo tais compostos e métodos de emprego de tais compostos para tratar ou prevenir doenças ou distúrbios associados com atividade de cinase anormal ou desregulada, particularmente doenças ou distúrbios que envolvem a ativação anormal das Abl, BCRAbl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2<244> e SAPK2<225> cinases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49853203P | 2003-08-28 | 2003-08-28 | |
PCT/US2004/027997 WO2005039486A2 (en) | 2003-08-28 | 2004-08-27 | Compounds and compositions as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414049A true BRPI0414049A (pt) | 2006-10-24 |
Family
ID=34519982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414049-4A BRPI0414049A (pt) | 2003-08-28 | 2004-08-27 | compostos e composições como inibidores de proteìna cinase |
Country Status (9)
Country | Link |
---|---|
US (2) | US7338957B2 (pt) |
EP (1) | EP1658290A4 (pt) |
JP (1) | JP2007504159A (pt) |
CN (1) | CN100439365C (pt) |
AU (1) | AU2004283093B2 (pt) |
BR (1) | BRPI0414049A (pt) |
CA (1) | CA2536535A1 (pt) |
MX (1) | MXPA06002347A (pt) |
WO (1) | WO2005039486A2 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
TW200616974A (en) * | 2004-07-01 | 2006-06-01 | Astrazeneca Ab | Chemical compounds |
ATE492545T1 (de) * | 2005-05-13 | 2011-01-15 | Irm Llc | Verbindungen und zusammensetzungen als proteinkinase-hemmer |
GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
CA2645170A1 (en) * | 2006-03-30 | 2007-10-11 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
PT2007391E (pt) | 2006-04-07 | 2013-03-11 | Novartis Ag | Combinação compreendendo: a) um composto de pirimidil-aminobenzamida e b) um inibidor da cinase thr315ile |
WO2008147831A1 (en) * | 2007-05-23 | 2008-12-04 | Smithkline Beecham Corporation | Anthranilamides |
CN101868461B (zh) | 2007-08-02 | 2013-09-25 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
US7981903B2 (en) * | 2007-08-08 | 2011-07-19 | Glaxosmithkline Llc | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer |
CN104311563B (zh) * | 2007-11-28 | 2016-12-07 | 达那-法伯癌症研究所 | Bcr-abl的小分子豆蔻酸酯抑制剂及其使用方法 |
CN101918079A (zh) * | 2008-01-22 | 2010-12-15 | 默克专利有限公司 | 蛋白激酶抑制剂及其用途 |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
HUE035029T2 (en) | 2008-05-21 | 2018-03-28 | Ariad Pharma Inc | Kinase inhibitor phosphorus derivatives |
CN104016987A (zh) | 2009-05-14 | 2014-09-03 | 米伦纽姆医药公司 | 氨基磺酸((1s,2s,4r)-4-{4-[(1s)-2,3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2,3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐 |
US8728763B2 (en) | 2009-08-11 | 2014-05-20 | Response Genetics | Methods, primers, probes and kits useful for the detection of BRAF mutations |
EA201391626A1 (ru) | 2011-05-04 | 2014-03-31 | Ариад Фармасьютикалз, Инк. | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака |
US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
CN104876879B (zh) * | 2015-04-14 | 2018-05-18 | 中国科学院合肥物质科学研究院 | 一种bcr-abl激酶抑制剂 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2203642T3 (es) * | 1995-06-07 | 2004-04-16 | Pfizer Inc. | Derivados de pirimidina heterociclicos con anillos condensados. |
NZ510588A (en) * | 1998-09-18 | 2003-08-29 | Abbott Gmbh & Co | Pyrrolopyrimidines as protein kinase inhibitors |
ES2245955T3 (es) * | 1999-12-21 | 2006-02-01 | Sugen, Inc. | 7-aza-indolin-2-onas 4-sustituidas y su utilizacion como inhibidores de proteina-quinasa. |
UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
US20040235867A1 (en) * | 2001-07-24 | 2004-11-25 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
-
2004
- 2004-08-26 US US10/927,992 patent/US7338957B2/en not_active Expired - Fee Related
- 2004-08-27 CN CNB2004800245751A patent/CN100439365C/zh not_active Expired - Fee Related
- 2004-08-27 BR BRPI0414049-4A patent/BRPI0414049A/pt not_active IP Right Cessation
- 2004-08-27 EP EP04816834A patent/EP1658290A4/en not_active Withdrawn
- 2004-08-27 WO PCT/US2004/027997 patent/WO2005039486A2/en active Application Filing
- 2004-08-27 AU AU2004283093A patent/AU2004283093B2/en not_active Ceased
- 2004-08-27 MX MXPA06002347A patent/MXPA06002347A/es active IP Right Grant
- 2004-08-27 JP JP2006524903A patent/JP2007504159A/ja active Pending
- 2004-08-27 CA CA002536535A patent/CA2536535A1/en not_active Abandoned
-
2008
- 2008-01-07 US US11/970,278 patent/US20080108616A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007504159A (ja) | 2007-03-01 |
US20050159391A1 (en) | 2005-07-21 |
AU2004283093B2 (en) | 2009-02-26 |
US20080108616A1 (en) | 2008-05-08 |
AU2004283093A1 (en) | 2005-05-06 |
US7338957B2 (en) | 2008-03-04 |
EP1658290A4 (en) | 2009-04-15 |
MXPA06002347A (es) | 2006-05-19 |
WO2005039486A2 (en) | 2005-05-06 |
CN100439365C (zh) | 2008-12-03 |
CA2536535A1 (en) | 2005-05-06 |
CN1842529A (zh) | 2006-10-04 |
WO2005039486A3 (en) | 2006-03-16 |
EP1658290A2 (en) | 2006-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. C07D 471/04, 487/04; A61K 31/519, 31/4355; A61P 35/00 Ipc: C07D 471/04 (2011.01), C07D 487/04 (2011.01), A61K |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |