BRPI0414049A - compostos e composições como inibidores de proteìna cinase - Google Patents

compostos e composições como inibidores de proteìna cinase

Info

Publication number
BRPI0414049A
BRPI0414049A BRPI0414049-4A BRPI0414049A BRPI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A BR PI0414049 A BRPI0414049 A BR PI0414049A
Authority
BR
Brazil
Prior art keywords
compounds
compositions
protein kinase
kinase inhibitors
sapk2
Prior art date
Application number
BRPI0414049-4A
Other languages
English (en)
Inventor
Qiang Ding
Nathanael Schiander Gray
Bing Li
Yi Liu
Tetsuo Uno
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of BRPI0414049A publication Critical patent/BRPI0414049A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS E COMPOSIçõES COMO INIBIDORES DE PROTEìNA CINASE". A presente invenção fornece uma nova classe de compostos, composições farmacêuticas compreendendo tais compostos e métodos de emprego de tais compostos para tratar ou prevenir doenças ou distúrbios associados com atividade de cinase anormal ou desregulada, particularmente doenças ou distúrbios que envolvem a ativação anormal das Abl, BCRAbl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2<244> e SAPK2<225> cinases.
BRPI0414049-4A 2003-08-28 2004-08-27 compostos e composições como inibidores de proteìna cinase BRPI0414049A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49853203P 2003-08-28 2003-08-28
PCT/US2004/027997 WO2005039486A2 (en) 2003-08-28 2004-08-27 Compounds and compositions as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0414049A true BRPI0414049A (pt) 2006-10-24

Family

ID=34519982

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414049-4A BRPI0414049A (pt) 2003-08-28 2004-08-27 compostos e composições como inibidores de proteìna cinase

Country Status (9)

Country Link
US (2) US7338957B2 (pt)
EP (1) EP1658290A4 (pt)
JP (1) JP2007504159A (pt)
CN (1) CN100439365C (pt)
AU (1) AU2004283093B2 (pt)
BR (1) BRPI0414049A (pt)
CA (1) CA2536535A1 (pt)
MX (1) MXPA06002347A (pt)
WO (1) WO2005039486A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
TW200616974A (en) * 2004-07-01 2006-06-01 Astrazeneca Ab Chemical compounds
MX2007014066A (es) 2005-05-13 2008-02-11 Irm Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
AU2007232393A1 (en) * 2006-03-30 2007-10-11 The University Court Of The University Of Edinburgh Culture medium containing kinase inhibitors. and uses thereof
EP2007391B8 (en) 2006-04-07 2013-05-29 Novartis AG Combination comprising a) a pyrimidylaminobenzamide compound, and b) a thr315ile kinase inhibitor
WO2008147831A1 (en) * 2007-05-23 2008-12-04 Smithkline Beecham Corporation Anthranilamides
KR20100066475A (ko) * 2007-08-02 2010-06-17 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ1 활성화 효소 억제제의 합성 방법
CN101827848B (zh) * 2007-08-08 2012-11-07 葛兰素史密丝克莱恩有限责任公司 作为IGF-1R抑制剂用于治疗癌症的2-[(2-{苯基氨基}-1H-吡咯并[2,3-d]嘧啶-4-基)氨基]苯甲酰胺衍生物
EA019869B1 (ru) 2007-11-28 2014-06-30 Дана Фарбер Кансер Инститьют, Инк. Низкомолекулярные миристатные ингибиторы тирозинкиназы bcr-abl и способы их применения
AU2009206775A1 (en) * 2008-01-22 2009-07-30 Merck Patent Gmbh Protein kinase inhibitors and use thereof
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
LT2300013T (lt) 2008-05-21 2017-12-27 Ariad Pharmaceuticals, Inc. Fosforo dariniai kaip kinazių inhibitoriai
KR20120024715A (ko) 2009-05-14 2012-03-14 밀레니엄 파머슈티컬스 인코퍼레이티드 （（1ｓ，2ｓ，4ｒ）?4?｛4?〔（1ｓ)?2，3?디하이드로?1ｈ?인덴?1?일아미노〕?7ｈ?피롤로〔2，3?ｄ〕피리미딘?7?일｝?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염
US8728763B2 (en) 2009-08-11 2014-05-20 Response Genetics Methods, primers, probes and kits useful for the detection of BRAF mutations
CN103501612B (zh) 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
WO2013169401A1 (en) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
CN104876879B (zh) * 2015-04-14 2018-05-18 中国科学院合肥物质科学研究院 一种bcr-abl激酶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT831829E (pt) * 1995-06-07 2003-12-31 Pfizer Derivados de pirimidina heterociclicos de aneis fundidos
PL346700A1 (en) * 1998-09-18 2002-02-25 Basf Ag Pyrrolopyrimidines as protein kinase inhibitors
EP1244672B1 (en) * 1999-12-21 2005-07-20 Sugen, Inc. 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
AU2004283093A1 (en) 2005-05-06
US7338957B2 (en) 2008-03-04
CN1842529A (zh) 2006-10-04
US20080108616A1 (en) 2008-05-08
JP2007504159A (ja) 2007-03-01
EP1658290A4 (en) 2009-04-15
WO2005039486A2 (en) 2005-05-06
EP1658290A2 (en) 2006-05-24
CA2536535A1 (en) 2005-05-06
WO2005039486A3 (en) 2006-03-16
AU2004283093B2 (en) 2009-02-26
CN100439365C (zh) 2008-12-03
US20050159391A1 (en) 2005-07-21
MXPA06002347A (es) 2006-05-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 471/04, 487/04; A61K 31/519, 31/4355; A61P 35/00

Ipc: C07D 471/04 (2011.01), C07D 487/04 (2011.01), A61K

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.