JP2007504148A

JP2007504148A - 置換イソキノリン誘導体および使用方法

置換イソキノリン誘導体および使用方法 Download PDF

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Publication number: JP2007504148A
Authority: JP; Japan
Prior art keywords: optionally substituted; substituted; piperidin; boc; ylmethoxy
Prior art date: 2003-08-25
Legal status : Withdrawn

Application number

JP2006524851A

Other languages

English (en)

Japanese (ja)

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JP2007504148A5 (https=

Inventor

テグリー，クリストフアー

Original Assignee

アムジエン・インコーポレーテツド

Priority date

2003-08-25

Filing date

2004-08-25

Publication date

2007-03-01

2004-08-25 Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド

2007-03-01 Publication of JP2007504148A publication Critical patent/JP2007504148A/ja

2007-07-19 Publication of JP2007504148A5 publication Critical patent/JP2007504148A5/ja

Status Withdrawn legal-status Critical Current

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238000000034 method Methods 0.000 title claims abstract description 61
125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 251
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 43
238000011282 treatment Methods 0.000 claims abstract description 40
206010028980 Neoplasm Diseases 0.000 claims abstract description 36
150000003839 salts Chemical class 0.000 claims abstract description 35
230000033115 angiogenesis Effects 0.000 claims abstract description 20
201000011510 cancer Diseases 0.000 claims abstract description 9
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
-1 —OR 3 Chemical group 0.000 claims description 961
125000000623 heterocyclic group Chemical group 0.000 claims description 151
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 111
125000000217 alkyl group Chemical group 0.000 claims description 81
125000001424 substituent group Chemical group 0.000 claims description 65
125000005843 halogen group Chemical group 0.000 claims description 53
125000002757 morpholinyl group Chemical group 0.000 claims description 39
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125000004093 cyano group Chemical group *C#N 0.000 claims description 35
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 33
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 33
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 29
125000003118 aryl group Chemical group 0.000 claims description 28
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 27
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 26
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 25
125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims description 24
125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims description 24
239000003814 drug Substances 0.000 claims description 23
125000003545 alkoxy group Chemical group 0.000 claims description 22
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 22
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims description 21
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 21
125000001153 fluoro group Chemical group F* 0.000 claims description 21
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 21
238000002360 preparation method Methods 0.000 claims description 21
125000004043 oxo group Chemical group O=* 0.000 claims description 20
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
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125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
229910052799 carbon Inorganic materials 0.000 claims description 18
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 18
125000001072 heteroaryl group Chemical group 0.000 claims description 17
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125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims description 16
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239000003795 chemical substances by application Substances 0.000 claims description 15
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SZPWXAOBLNYOHY-UHFFFAOYSA-N [C]1=CC=NC2=CC=CC=C12 Chemical group [C]1=CC=NC2=CC=CC=C12 SZPWXAOBLNYOHY-UHFFFAOYSA-N 0.000 claims description 7
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 7
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125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 6
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125000002541 furyl group Chemical group 0.000 claims description 6
125000003884 phenylalkyl group Chemical group 0.000 claims description 6
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125000004076 pyridyl group Chemical group 0.000 claims description 6
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125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 5
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