JP2007503469A5 - - Google Patents
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- Publication number
- JP2007503469A5 JP2007503469A5 JP2006533311A JP2006533311A JP2007503469A5 JP 2007503469 A5 JP2007503469 A5 JP 2007503469A5 JP 2006533311 A JP2006533311 A JP 2006533311A JP 2006533311 A JP2006533311 A JP 2006533311A JP 2007503469 A5 JP2007503469 A5 JP 2007503469A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- aryl
- group
- alkyl
- fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C)*C(*)(*)*(C)CC(C)c1nc2c(*)c(*)c(*)c(*)c2[n]1 Chemical compound CC(C)*C(*)(*)*(C)CC(C)c1nc2c(*)c(*)c(*)c(*)c2[n]1 0.000 description 11
- VACVKVBYWDDASX-UHFFFAOYSA-N CCCC[n]1c(-c(ccc(Oc(cc2)cc(C(F)(F)F)c2F)c2)c2OCCN2CCCC2)nc(c(OCCCN(CC)CC)c2)c1cc2OCCCN(CC)CC Chemical compound CCCC[n]1c(-c(ccc(Oc(cc2)cc(C(F)(F)F)c2F)c2)c2OCCN2CCCC2)nc(c(OCCCN(CC)CC)c2)c1cc2OCCCN(CC)CC VACVKVBYWDDASX-UHFFFAOYSA-N 0.000 description 2
- BHZZLGGAQOIGCQ-UHFFFAOYSA-N CCN[N](C)(CCOCC)OC Chemical compound CCN[N](C)(CCOCC)OC BHZZLGGAQOIGCQ-UHFFFAOYSA-N 0.000 description 1
- BKJVBHJVNBHTTA-UHFFFAOYSA-N CNS(N(C)C)(=O)=O Chemical compound CNS(N(C)C)(=O)=O BKJVBHJVNBHTTA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47196903P | 2003-05-20 | 2003-05-20 | |
| PCT/US2004/016104 WO2005000295A1 (en) | 2003-05-20 | 2004-05-20 | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007503469A JP2007503469A (ja) | 2007-02-22 |
| JP2007503469A5 true JP2007503469A5 (https=) | 2007-07-05 |
Family
ID=33551437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533311A Withdrawn JP2007503469A (ja) | 2003-05-20 | 2004-05-20 | アミロイド症およびそれに関連した疾患を改善するための作用物質としてのrageアンタゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050026811A1 (https=) |
| EP (1) | EP1635823A1 (https=) |
| JP (1) | JP2007503469A (https=) |
| CN (1) | CN1805743A (https=) |
| AU (1) | AU2004251599A1 (https=) |
| BR (1) | BRPI0410436A (https=) |
| CA (1) | CA2522275A1 (https=) |
| MX (1) | MXPA05012350A (https=) |
| WO (1) | WO2005000295A1 (https=) |
| ZA (1) | ZA200508300B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749537B1 (en) * | 1995-12-14 | 2004-06-15 | Hickman Paul L | Method and apparatus for remote interactive exercise and health equipment |
| US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US7423177B2 (en) | 2001-03-05 | 2008-09-09 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| CN1235583C (zh) * | 2001-03-05 | 2006-01-11 | 特兰斯泰克制药公司 | 用作治疗剂的苯并咪唑衍生物 |
| DK1482931T3 (da) * | 2002-03-05 | 2011-12-19 | Transtech Pharma Inc | Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE |
| WO2005000295A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
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| WO2006119510A2 (en) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same |
| BRPI0612287A8 (pt) * | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
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| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
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| US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
| WO2009015183A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Utah Research Foundation | Method for blocking ligation of the receptor for advanced glycation end-products (rage) |
| CA2685540C (en) * | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| GB0715937D0 (en) * | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment og duchenne muscular dystrophy |
| EP2116556B1 (en) | 2008-05-09 | 2016-03-23 | AbbVie Deutschland GmbH & Co KG | Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof |
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| US20100167711A1 (en) * | 2008-12-30 | 2010-07-01 | Motorola, Inc. | Method and system for creating communication groups |
| US20100278835A1 (en) * | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| JP5805646B2 (ja) | 2009-09-30 | 2015-11-04 | ブイティーブイ・セラピューティクス・エルエルシー | アルツハイマー病の治療のための置換イミダゾール誘導体 |
| WO2011103091A1 (en) | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Phenyl-heteroaryl derivatives and methods of use thereof |
| WO2011102845A1 (en) | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| US9339691B2 (en) | 2012-01-05 | 2016-05-17 | Icon Health & Fitness, Inc. | System and method for controlling an exercise device |
| CN104411316B (zh) | 2012-05-09 | 2018-05-01 | 坎泰克斯制药股份有限公司 | 骨髓抑制的治疗 |
| NZ705813A (en) * | 2012-10-05 | 2018-02-23 | Vtv Therapeutics Llc | Treatment of mild and moderate alzheimer’s disease |
| US9717710B2 (en) * | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| US9254409B2 (en) | 2013-03-14 | 2016-02-09 | Icon Health & Fitness, Inc. | Strength training apparatus with flywheel and related methods |
| EP3623020B1 (en) | 2013-12-26 | 2024-05-01 | iFIT Inc. | Magnetic resistance mechanism in a cable machine |
| WO2015138339A1 (en) | 2014-03-10 | 2015-09-17 | Icon Health & Fitness, Inc. | Pressure sensor to quantify work |
| US10426989B2 (en) | 2014-06-09 | 2019-10-01 | Icon Health & Fitness, Inc. | Cable system incorporated into a treadmill |
| WO2015195965A1 (en) | 2014-06-20 | 2015-12-23 | Icon Health & Fitness, Inc. | Post workout massage device |
| US10052346B2 (en) | 2015-02-17 | 2018-08-21 | Cantex Pharmaceuticals, Inc. | Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids |
| US10391361B2 (en) | 2015-02-27 | 2019-08-27 | Icon Health & Fitness, Inc. | Simulating real-world terrain on an exercise device |
| EP3822291A1 (en) | 2015-06-10 | 2021-05-19 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| AU2017225537B2 (en) | 2016-03-01 | 2020-07-30 | Vtv Therapeutics Llc | Piperidine derivative and methods of use thereof |
| US10493349B2 (en) | 2016-03-18 | 2019-12-03 | Icon Health & Fitness, Inc. | Display on exercise device |
| US10272317B2 (en) | 2016-03-18 | 2019-04-30 | Icon Health & Fitness, Inc. | Lighted pace feature in a treadmill |
| US10625137B2 (en) | 2016-03-18 | 2020-04-21 | Icon Health & Fitness, Inc. | Coordinated displays in an exercise device |
| CN108349903B (zh) * | 2016-09-27 | 2021-07-13 | 杭州领业医药科技有限公司 | Ttp488加成盐及其晶型、制备方法及药物组合物 |
| US10671705B2 (en) | 2016-09-28 | 2020-06-02 | Icon Health & Fitness, Inc. | Customizing recipe recommendations |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2020076668A1 (en) | 2018-10-10 | 2020-04-16 | Vtv Therapeutics Llc | Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine |
| CN115594642B (zh) * | 2021-06-28 | 2024-12-27 | 广西医科大学 | 阿齐瑞格三氮唑衍生物及其抗乳腺癌用途 |
| CN118615283A (zh) * | 2024-05-31 | 2024-09-10 | 中南大学湘雅三医院 | Ttp488在制备抑制淋巴细胞耗竭的药物中的应用 |
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| WO2005000295A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
-
2004
- 2004-05-20 WO PCT/US2004/016104 patent/WO2005000295A1/en not_active Ceased
- 2004-05-20 MX MXPA05012350A patent/MXPA05012350A/es not_active Application Discontinuation
- 2004-05-20 AU AU2004251599A patent/AU2004251599A1/en not_active Abandoned
- 2004-05-20 ZA ZA200508300A patent/ZA200508300B/xx unknown
- 2004-05-20 BR BRPI0410436-6A patent/BRPI0410436A/pt not_active IP Right Cessation
- 2004-05-20 US US10/850,238 patent/US20050026811A1/en not_active Abandoned
- 2004-05-20 JP JP2006533311A patent/JP2007503469A/ja not_active Withdrawn
- 2004-05-20 CA CA002522275A patent/CA2522275A1/en not_active Abandoned
- 2004-05-20 CN CNA2004800137916A patent/CN1805743A/zh active Pending
- 2004-05-20 EP EP04753004A patent/EP1635823A1/en not_active Withdrawn
-
2008
- 2008-09-25 US US12/238,087 patent/US20090035302A1/en not_active Abandoned
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