JP2007503388A5 - - Google Patents
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- Publication number
- JP2007503388A5 JP2007503388A5 JP2006523903A JP2006523903A JP2007503388A5 JP 2007503388 A5 JP2007503388 A5 JP 2007503388A5 JP 2006523903 A JP2006523903 A JP 2006523903A JP 2006523903 A JP2006523903 A JP 2006523903A JP 2007503388 A5 JP2007503388 A5 JP 2007503388A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- alkyl
- hydrogen
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49744303P | 2003-08-22 | 2003-08-22 | |
| PCT/US2004/025683 WO2005021546A1 (en) | 2003-08-22 | 2004-08-09 | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007503388A JP2007503388A (ja) | 2007-02-22 |
| JP2007503388A5 true JP2007503388A5 (cg-RX-API-DMAC7.html) | 2007-09-27 |
Family
ID=34272569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523903A Pending JP2007503388A (ja) | 2003-08-22 | 2004-08-09 | マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20050124604A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1656376A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007503388A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1839133A (cg-RX-API-DMAC7.html) |
| AR (1) | AR045471A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004268941A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0413695A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2531506A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXJL06000006A (cg-RX-API-DMAC7.html) |
| PE (1) | PE20051112A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200524928A (cg-RX-API-DMAC7.html) |
| UY (1) | UY28483A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005021546A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140679A (en) * | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| JP2008534502A (ja) * | 2005-03-24 | 2008-08-28 | アバニール・ファーマシューティカルズ | マクロファージ遊走阻止因子の阻害剤としてのチエノピリジノン誘導体 |
| GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| WO2008076427A2 (en) | 2006-12-18 | 2008-06-26 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| AU2007334321B2 (en) | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| EP2155680B1 (en) | 2007-04-18 | 2013-12-04 | Amgen, Inc | Indanone derivatives that inhibit prolyl hydroxylase |
| JP2010524942A (ja) | 2007-04-18 | 2010-07-22 | アムジエン・インコーポレーテツド | プロリルヒドロキシラーゼを阻害するキノロン及びアザキノロン |
| WO2008137084A2 (en) | 2007-05-04 | 2008-11-13 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| CA2685216C (en) | 2007-05-04 | 2014-07-08 | Amgen Inc. | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US8470817B2 (en) * | 2009-10-26 | 2013-06-25 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
| PT2592933T (pt) | 2010-07-16 | 2017-05-23 | Gaweco Anderson | Inibidores de mif e suas utilizações |
| WO2012031383A1 (zh) * | 2010-09-06 | 2012-03-15 | 中国科学院广州生物医药与健康研究院 | 酰胺类化合物 |
| EP3354640A3 (en) * | 2011-04-13 | 2018-10-31 | Innovimmune Biotherapeutics, Inc. | Mif inhibitors and their uses |
| CN103360388B (zh) * | 2012-04-10 | 2017-11-14 | 江苏先声药业有限公司 | 5‑氨基‑1，4‑二氢‑1，8‑萘啶衍生物及其药物组合物和用途 |
| WO2015095052A1 (en) | 2013-12-17 | 2015-06-25 | Controlled Chemicals, Inc. | Isoindolin-1-ones as macrophage migration inhibitory factor (mif) inhibitors |
| KR20250152110A (ko) | 2016-12-22 | 2025-10-22 | 암젠 인크 | 폐암, 췌장암 또는 대장암을 치료하기 위한 kras g12c 억제제로서의 벤즈이소티아졸, 이소티아졸로[3,4-b]피리딘, 퀴나졸린, 프탈라진, 피리도[2,3-d]피리다진 및 피리도[2,3-d]피리미딘 유도체 |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| CN107556309B (zh) * | 2017-09-11 | 2020-12-01 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
| CA3099118A1 (en) | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| US11090304B2 (en) | 2018-05-04 | 2021-08-17 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| EP3790886B1 (en) | 2018-05-10 | 2024-06-26 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
| ES2938987T3 (es) | 2018-06-01 | 2023-04-18 | Amgen Inc | Inhibidores de KRAS G12c y métodos de uso de los mismos |
| EP3802537A1 (en) * | 2018-06-11 | 2021-04-14 | Amgen Inc. | Kras g12c inhibitors for treating cancer |
| EP3807276B1 (en) | 2018-06-12 | 2025-12-10 | Amgen Inc. | Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer |
| EA202190137A1 (ru) * | 2018-06-27 | 2021-05-17 | Бристол-Маерс Сквибб Компани | Нафтиридиноновые соединения для применения в качестве активаторов t-клеток |
| CN112654621B (zh) * | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| WO2020106640A1 (en) | 2018-11-19 | 2020-05-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| CN111471059B (zh) * | 2019-01-23 | 2022-12-02 | 药捷安康(南京)科技股份有限公司 | Pde9抑制剂及其用途 |
| CN111658653B (zh) * | 2019-03-08 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制剂的用途 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| PH12021552922A1 (en) | 2019-05-21 | 2022-04-04 | Amgen Inc | Solid state forms |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| AU2020415377A1 (en) | 2019-12-23 | 2022-08-18 | Bristol-Myers Squibb Company | Substituted quinazolinyl compounds useful as T cell activators |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| KR20220120624A (ko) | 2019-12-23 | 2022-08-30 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 피페라진 유도체 |
| JP7588224B2 (ja) | 2020-10-05 | 2024-11-21 | エンライブン インコーポレイテッド | Ｂｃｒ－ａｂｌチロシンキナーゼの阻害のための５－及び６－アザインドール化合物 |
| EP4232027A4 (en) * | 2020-10-26 | 2024-12-25 | Yale University | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR, AND METHODS OF MAKING AND USING THE SAME |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324893A (en) * | 1979-04-18 | 1982-04-13 | American Home Products Corporation | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives |
| US4299814A (en) * | 1979-05-25 | 1981-11-10 | Monsanto Company | Radioimmunoassay of MIF |
| US4284768A (en) * | 1980-07-02 | 1981-08-18 | American Home Products Corporation | 1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives |
| ZW2485A1 (en) | 1984-02-22 | 1986-09-24 | Wellcome Found | Cloning of dna for protozoal antigens |
| US5700447A (en) * | 1992-05-21 | 1997-12-23 | The Picowder Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
| US5801200A (en) * | 1984-03-19 | 1998-09-01 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
| US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
| US5733933A (en) * | 1984-03-19 | 1998-03-31 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
| US5733524A (en) * | 1984-03-19 | 1998-03-31 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
| AU592753B2 (en) | 1984-05-24 | 1990-01-25 | Ciba-Geigy Ag | Lymphokine in pure foem, novel monoclonal antibodies hybridoma cell lines, processes and applications |
| US4708937A (en) * | 1984-10-15 | 1987-11-24 | Brigham & Women's Hospital | Purified migration inhibitory factor also having colony stimulating factor activity |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8602626D0 (en) * | 1986-02-04 | 1986-03-12 | Ciba Geigy Ag | Neurite-promoting factor |
| DE3789413T2 (de) | 1986-10-03 | 1994-07-28 | Ciba Geigy Ag | Lymphokin-ähnliche Peptide. |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| FI82144C (fi) * | 1989-03-22 | 1991-01-10 | Wallac Oy | Foerfarande foer samtidig bestaemning av flera ligander. |
| GB8915414D0 (en) * | 1989-07-05 | 1989-08-23 | Ciba Geigy | Novel cytokines |
| US5328990A (en) * | 1991-04-26 | 1994-07-12 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of macrophage migration inhibition factor from ocular lens |
| CA2054602C (en) * | 1991-10-31 | 2003-04-22 | Anthony Pawson | Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system |
| US5624804A (en) * | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
| US6774227B1 (en) | 1993-05-17 | 2004-08-10 | Cytokine Pharmasciences, Inc. | Therapeutic uses of factors which inhibit or neutralize MIF activity |
| JP4708510B2 (ja) | 1993-05-17 | 2011-06-22 | サイトカイン ファーマサイエンシズ，インコーポレーテッド | サイトカイン媒介毒性に関係する疾患の治療における遊走阻止因子の抑制 |
| US6645493B1 (en) * | 1993-05-17 | 2003-11-11 | The Picower Institute For Medical Research | Composition containing anti-MIF antibody |
| US5650295A (en) * | 1995-06-02 | 1997-07-22 | Human Genone Sciences, Inc. | Macrophage migration inhibitory factor-3 |
| US6420188B1 (en) * | 1996-02-16 | 2002-07-16 | The Picower Institute For Medical Research | Screening assay for the identification of inhibitors for macrophage migration inhibitory factor |
| US6492428B1 (en) | 2000-07-26 | 2002-12-10 | The Picower Institute For Medical Research | Compounds having MIF antagonist activity |
| JP2000512737A (ja) | 1996-04-18 | 2000-09-26 | アリアッド ファーマスーティカルズ，インク． | 試験管内蛍光偏光検定法 |
| US5883224A (en) * | 1996-04-19 | 1999-03-16 | Cytokine Sciences, Inc. | Characterization of transfer factors and methods of use |
| JPH1171351A (ja) | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
| US6413939B1 (en) * | 1997-10-31 | 2002-07-02 | The Picower Institute For Medical Research | Inducible phosphofructokinase and the Warburg effect |
| WO1999029894A1 (en) | 1997-12-05 | 1999-06-17 | Pharmacia & Upjohn Company | Fluorescence-based high throughput screening assays for protein kinases and phosphatases |
| WO2000007007A1 (en) * | 1998-07-28 | 2000-02-10 | Biometric Imaging, Inc. | Device and method for cell motility assay |
| US6214343B1 (en) * | 1999-05-24 | 2001-04-10 | Ophidian Pharmaceuticals, Inc. | Prevention and treatment of necrotizing enterocolitis |
| WO2001028993A2 (en) * | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Tyrosine kinase inhibitors |
| EP1228037A4 (en) * | 1999-10-29 | 2004-06-02 | Picower Inst Med Res | COMPOUNDS HAVING ANTIAGONIST ACTIVITY OF MIF |
| EP1345603A4 (en) * | 2000-12-20 | 2004-09-08 | Merck & Co Inc | (HALO-BENZO-CARBONYL) HETEROCYCLO-CONDENSED PHENYL-P38-KINASE INHIBITING AGENTS |
| MY140679A (en) * | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
| JP4117462B2 (ja) * | 2001-07-03 | 2008-07-16 | 株式会社大塚製薬工場 | ナフチリジンおよびキノリン誘導体 |
| US6822097B1 (en) * | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| JP2006511445A (ja) * | 2002-06-07 | 2006-04-06 | コーティカル・ピーティーワイ・リミテッド | マクロファージ遊走阻止因子（ｍｉｆ）のサイトカインまたは生物学的活性を阻害するナフタレン誘導体 |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
-
2004
- 2004-08-09 MX MXJL06000006A patent/MXJL06000006A/es unknown
- 2004-08-09 JP JP2006523903A patent/JP2007503388A/ja active Pending
- 2004-08-09 EP EP04780510A patent/EP1656376A1/en not_active Ceased
- 2004-08-09 BR BRPI0413695-0A patent/BRPI0413695A/pt not_active IP Right Cessation
- 2004-08-09 CN CNA2004800241375A patent/CN1839133A/zh active Pending
- 2004-08-09 WO PCT/US2004/025683 patent/WO2005021546A1/en not_active Ceased
- 2004-08-09 AU AU2004268941A patent/AU2004268941A1/en not_active Abandoned
- 2004-08-09 CA CA002531506A patent/CA2531506A1/en not_active Abandoned
- 2004-08-17 US US10/920,031 patent/US20050124604A1/en not_active Abandoned
- 2004-08-18 TW TW093124762A patent/TW200524928A/zh unknown
- 2004-08-20 AR ARP040102991A patent/AR045471A1/es not_active Application Discontinuation
- 2004-08-20 UY UY28483A patent/UY28483A1/es not_active Application Discontinuation
- 2004-08-21 PE PE2004000808A patent/PE20051112A1/es not_active Application Discontinuation
-
2007
- 2007-03-16 US US11/687,601 patent/US7361760B2/en not_active Expired - Fee Related