JP2007502777A - 腫瘍の処置のための白金錯体 - Google Patents

腫瘍の処置のための白金錯体 Download PDF

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Publication number
JP2007502777A
JP2007502777A JP2006523414A JP2006523414A JP2007502777A JP 2007502777 A JP2007502777 A JP 2007502777A JP 2006523414 A JP2006523414 A JP 2006523414A JP 2006523414 A JP2006523414 A JP 2006523414A JP 2007502777 A JP2007502777 A JP 2007502777A
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alkyl
heteroaryl
platinum complex
aryl
heterocycloalkyl
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JP2007502777A5 (enExample
Inventor
ハイディー カイ
ジェイ ダブリュー. パーマー
ジョセフ エイ. スタンコ
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ユニバーシティー オブ サウス フロリダ
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086Platinum compounds
    • C07F15/0093Platinum compounds without a metal-carbon linkage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/08Antibacterial agents for leprosy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • A61P33/12Schistosomicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006523414A 2003-08-13 2004-08-13 腫瘍の処置のための白金錯体 Pending JP2007502777A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48122603P 2003-08-13 2003-08-13
US51558003P 2003-10-30 2003-10-30
US51994303P 2003-11-14 2003-11-14
US52529503P 2003-11-25 2003-11-25
PCT/US2004/026393 WO2005016946A2 (en) 2003-08-13 2004-08-13 Platinum complexes for the treatment of tumors

Publications (2)

Publication Number Publication Date
JP2007502777A true JP2007502777A (ja) 2007-02-15
JP2007502777A5 JP2007502777A5 (enExample) 2007-09-27

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JP2006523414A Pending JP2007502777A (ja) 2003-08-13 2004-08-13 腫瘍の処置のための白金錯体
JP2006523413A Pending JP2007502301A (ja) 2003-08-13 2004-08-13 腫瘍細胞の増殖を阻害するための方法

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JP2006523413A Pending JP2007502301A (ja) 2003-08-13 2004-08-13 腫瘍細胞の増殖を阻害するための方法

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US (6) US7238372B2 (enExample)
EP (2) EP1675864B1 (enExample)
JP (2) JP2007502777A (enExample)
AT (2) ATE453653T1 (enExample)
AU (3) AU2004270655B2 (enExample)
CA (2) CA2535762A1 (enExample)
DE (2) DE602004024909D1 (enExample)
WO (2) WO2005023824A2 (enExample)

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EP1748772A2 (en) * 2004-04-09 2007-02-07 University Of South Florida Combination therapies for cancer and proliferative angiopathies
WO2007008247A2 (en) 2004-11-10 2007-01-18 University Of South Florida Platinum complexes for targeted drug delivery
US7951374B2 (en) 2004-12-14 2011-05-31 University Of South Florida Methods for inhibiting STAT3 signaling in immune cells
DE102004060934A1 (de) * 2004-12-17 2006-06-29 Wacker Chemie Ag Vernetzbare Polyorganosiloxanmassen
JP5193032B2 (ja) * 2005-06-30 2013-05-08 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド モノアゾールリガンド白金類似体
US20100190180A1 (en) * 2005-07-06 2010-07-29 Heidi Kay Materials and Methods for Screening, Diagnosis and Prognosis of Conditions Associated With Stat Protein Expression
WO2007013946A2 (en) * 2005-07-20 2007-02-01 University Of South Florida Method of predicting responsiveness to chemotherapy and selecting treatments
WO2007047623A2 (en) * 2005-10-14 2007-04-26 University Of South Florida Methods of inhibiting cell growth and methods of enhancing radiation responses
DE102006040647A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Handwerkzeugmaschine
US8026382B2 (en) 2007-05-18 2011-09-27 Heidi Kay Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods
US8895610B1 (en) 2007-05-18 2014-11-25 Heldi Kay Platinum (IV) compounds targeting zinc finger domains
CA2691047A1 (en) * 2007-06-18 2008-12-24 Platco Technologies (Proprietary) Limited Platinum (iv) complexes
CA2736563C (en) * 2007-09-10 2016-01-26 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
WO2010067335A1 (en) 2008-12-12 2010-06-17 Platco Technologies (Proprietary) Limited Platinum (iv) complexes for use in the treatment of proliferative diseases such as cancer
DK3012329T3 (da) 2010-06-18 2017-11-20 Myriad Genetics Inc Fremgangsmåder og materialer til at vurdere tab af heterozygositet
ES2588979T3 (es) 2010-08-24 2016-11-08 Dana-Farber Cancer Institute, Inc. Procedimientos para la predicción de una respuesta contra el cáncer
EP2721181B1 (en) 2011-06-17 2019-12-18 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
RU2491936C2 (ru) * 2011-07-11 2013-09-10 Борис Николаевич Анисимов Способ комплексного лечения больных паразитарными заболеваниями
EP4497824A3 (en) 2011-12-21 2025-04-16 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
AU2013226400B2 (en) 2012-02-23 2018-09-06 Dana-Farber Cancer Institute, Inc. Methods for predicting anti-cancer response
ES2658867T3 (es) 2012-06-07 2018-03-12 Institut Curie Métodos para detectar la inactivación de la ruta de recombinación homóloga (BRCA1/2) en tumores humanos
WO2014160080A1 (en) 2013-03-14 2014-10-02 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
US10766915B2 (en) 2013-03-15 2020-09-08 Sherri Ann McFARLAND Metal-based coordination complexes as photodynamic compounds and their use
WO2014165785A2 (en) 2013-04-05 2014-10-09 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
WO2014198140A1 (zh) * 2013-06-13 2014-12-18 上海医药工业研究院 一种铂(ⅱ)配合物、其制备方法、药物组合物及应用
WO2015013565A1 (en) * 2013-07-25 2015-01-29 Nemucore Medical Innovations, Inc. Platinum derivatives for hydrophobic formulations
ES2909899T3 (es) 2013-12-09 2022-05-10 Inst Curie Métodos para detectar inactivación de la ruta de recombinación homóloga (BRCA1/2) en tumores humanos
DK3180447T3 (da) 2014-08-15 2020-06-15 Myriad Genetics Inc Fremgangsmåder og materialer til analyse af homolog rekombinationsdeficiens
BR112017027285A2 (pt) 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
KR20180014834A (ko) 2015-06-19 2018-02-09 신-낫 프로덕츠 엔터프라이즈 엘엘씨 카보플라틴을 함유하는 조성물 및 용도
CA2989001A1 (en) 2015-06-25 2016-12-29 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
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US20200361973A1 (en) 2017-11-21 2020-11-19 Medoncare Pharmaceutical Co., Ltd. Combination product comprising dicycloplatin and preparation method and use thereof
CN112175014B (zh) * 2020-10-10 2021-08-20 中国药科大学 一种一氧化氮供体型四价铂衍生物、制备方法及其医药用途
EP4141127B1 (en) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Method for assessing homologous recombination deficiency in ovarian cancer cells
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US4177263A (en) * 1972-02-28 1979-12-04 Research Corporation Anti-animal tumor method
JPH01156989A (ja) * 1987-09-25 1989-06-20 Ss Pharmaceut Co Ltd 新規白金錯体
JPH01294684A (ja) * 1988-02-02 1989-11-28 Johnson Matthey Inc Pt(IV)錯体
JPH08176175A (ja) * 1994-12-22 1996-07-09 Agency Of Ind Science & Technol 白金ニトロアンミン系錯体の製造方法
WO1996026949A1 (en) * 1995-02-28 1996-09-06 Debiopharm Sa Novel platinum (iv) complexes, process for producing the same, and carcinostatic agents containing the same
US5849790A (en) * 1995-11-17 1998-12-15 The University Of South Florida (Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents

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WO2007008247A2 (en) 2004-11-10 2007-01-18 University Of South Florida Platinum complexes for targeted drug delivery
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US4177263A (en) * 1972-02-28 1979-12-04 Research Corporation Anti-animal tumor method
JPS4913317A (enExample) * 1972-04-10 1974-02-05
JPH01156989A (ja) * 1987-09-25 1989-06-20 Ss Pharmaceut Co Ltd 新規白金錯体
JPH01294684A (ja) * 1988-02-02 1989-11-28 Johnson Matthey Inc Pt(IV)錯体
JPH08176175A (ja) * 1994-12-22 1996-07-09 Agency Of Ind Science & Technol 白金ニトロアンミン系錯体の製造方法
WO1996026949A1 (en) * 1995-02-28 1996-09-06 Debiopharm Sa Novel platinum (iv) complexes, process for producing the same, and carcinostatic agents containing the same
US5849790A (en) * 1995-11-17 1998-12-15 The University Of South Florida (Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents

Also Published As

Publication number Publication date
EP1664070A2 (en) 2006-06-07
DE602004015811D1 (de) 2008-09-25
AU2004264421B2 (en) 2011-02-24
US7763585B2 (en) 2010-07-27
ATE404574T1 (de) 2008-08-15
AU2004264421A1 (en) 2005-02-24
US20050080131A1 (en) 2005-04-14
WO2005016946A2 (en) 2005-02-24
AU2011202386A1 (en) 2011-06-09
AU2004270655B2 (en) 2011-03-24
US7238372B2 (en) 2007-07-03
US20050074502A1 (en) 2005-04-07
US8247445B2 (en) 2012-08-21
US7566798B2 (en) 2009-07-28
CA2535762A1 (en) 2005-03-17
JP2007502301A (ja) 2007-02-08
US20080187992A1 (en) 2008-08-07
EP1664070B1 (en) 2008-08-13
US20100310645A1 (en) 2010-12-09
EP1675864A2 (en) 2006-07-05
US20090285884A1 (en) 2009-11-19
DE602004024909D1 (de) 2010-02-11
WO2005023824A3 (en) 2005-06-09
US8598230B2 (en) 2013-12-03
WO2005023824A2 (en) 2005-03-17
WO2005016946A3 (en) 2005-09-29
CA2535584A1 (en) 2005-02-24
AU2004270655A1 (en) 2005-03-17
US20100316704A1 (en) 2010-12-16
US7759510B2 (en) 2010-07-20
ATE453653T1 (de) 2010-01-15
EP1675864B1 (en) 2009-12-30

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